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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells显示文摘 | Khan N Afaq F Syed DN | 2008 | Carcinogenesis2008，29，5： | 1 |
| 3 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Sere Cancer Biol2007，，17： | 1 |
| 4 | Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts显示文摘 | Han SY Zhao W Sun H Zhou N Zhou F An G | 2015 | Phytomedicine2015，22，5： | 1 |
| 5 | Occurrence of polycyelie aromatic hydrocarbons in the Soan River, Pakistan : Insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 6 | Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-l hairless mouse epidermis显示文摘 | Afaq F Khan N Syed ON | 2010 | Photochem Photobiol2010，86，6： | 1 |
| 7 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | | 0，，： | 1 |
| 8 | Chemoprevention of prostate cancer through dietary agents: progress and promise 显示文摘 | Syed DN Khan N Afaq F | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，11： | 1 |
| 9 | Occurrence of polycyclic aromatic hydrocarbons in the Soan River, Pakistan: insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 10 | Pomegranate derived products for cancer chemoprevention显示文摘 | SYED D N AFAQ F MUKHTAR H | 2007 | Seminars in Cancer Biology2007，17，5： | 1 |
| 11 | Interobserver variability in HER-2/neu reporting on immunohistoehemistry in breast carci- nomas显示文摘 | Mamoon N Syed F N Mushtaq S | 2014 | JPakMed Assoc2014，64，2： | 1 |
| 12 | Family conflict and academic performance of first - year asian American undergraduates显示文摘 | Bahrassa N F Syed M Su J Lee R M | 2011 | Cultural Diversity and Ethnic Minority Psychology2011，17，4： | 1 |
| 13 | Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/beta-catenin signaling and decreased Mitf levels显示文摘 | Syed D N Afaq F Maddodi N | | 0，，06： | 1 |
| 14 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Seminars in Cancer Biology2007，17，5： | 1 |
| 15 | Dietary agents for chemoprevention of prostate cancer 显示文摘 | SYED D N SUH Y AFAQ F | 2009 | Cancer Letters2009，265，2： | 1 |
| 16 | Pomegranate derived products for cancer chemoprevention显示文摘 | Syed D N Afaq F Mukhtar H | 2007 | Seminars in Cancer Biology2007，173，： | 1 |
| 17 | Cutaneous silent pe- riods in patients with Fabry disease 显示文摘 | Syed N A Sandbfink F Lueiano C A | 2000 | Muscle Nerve2000，23，8： | 1 |
| 18 | Dietary agents for chemoprevention of prostate cancer显示文摘 | Syed D N Suh Y Afaq F | 2008 | Cancer Lett2008，265，： | 1 |
| 19 | Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes 显示文摘 | I SYED D N AFAQ F MUKHTAR H | 2012 | Photochem Photobiol2012，88，5： | 1 |
| 20 | Identification and Non-linear Control Strategy for Industrial Pneumatic Actuator 显示文摘 | M F Rahmat Sy Najib Sy Salim N H Sunar | 2012 | International Journal of Physical Sciences2012，7，17： | 1 |
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