|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Full Outline of Unresponsiveness score and the Glasgow Coma Scale in prediction of pediatric coma显示文摘BACKGROUND: This study was done to compare the admission Full Outline of Unresponsiveness(FOUR) score and Glasgow Coma Scale(GCS) as predictors of outcome in children with impaired consciousness.METHODS: In this observational study, children(5–12 years) with impaired consciousness of <7 days were included. Children with traumatic brain injury, on sedatives or neuromuscular blockade; with pre-existing cerebral palsy, mental retardation, degenerative brain disease, vision/hearing impairment; and seizure within last 1 hour were excluded. Primary outcomes: comparison of area under curve(AUC) of receiver operating characteristic(ROC) curve for in-hospital mortality. Secondary outcomes: comparison of AUC of ROC curve for mortality and poor outcome on Pediatric Overall Performance Category Scale at 3 months.RESULTS: Of the 63 children, 20 died during hospital stay. AUC for in-hospital mortality for GCS was 0.83(CI 0.7 to 0.9) and FOUR score was 0.8(CI 0.7 to 0.9) [difference between areas –0.0250(95%CI 0.0192 to 0.0692), Z statistic 1.109, P=0.2674]. AUC for mortality at 3 months for GCS was 0.78(CI 0.67 to 0.90) and FOUR score was 0.74(CI 0.62 to 0.87)(P=0.1102) and AUC for poor functional outcome for GCS was 0.82(CI 0.72 to 0.93) and FOUR score was 0.79(CI 0.68 to 0.9)(P=0.2377), which were also comparable. Inter-rater reliability for GCS was 0.96 and for FOUR score 0.98.CONCLUSION: FOUR score was as good as GCS in prediction of in-hospital and 3-month mortality and functional outcome at 3 months. FOUR score had a good inter-rater reliability. | Atahar Jamal Naveen Sankhyan Murlidharan Jayashree Sunit Singhi Pratibha Singhi | 2017 | World Journal of Emergency Medicine2017，8，1： | 10 |
| 2 | Effects of α-mangostin on apoptosis induction of human colon cancer显示文摘AIM:To investigate the effect of α-mangostin on the growth and apoptosis induction of human colon cancer cells.METHODS:The three colorectal adenocarcinoma cell lines tested (COLO 205,MIP-101 and SW 620) were treated with α-mangostin to determine the effect on cell proliferation by MTT assay,cell morphology,chromatin condensation,cell cycle analysis,DNA fragmentation,phosphatidylserine exposure and changing of mitochondrial membrane potential.The molecular mechanisms of α-mangostin mediated apoptosis were further investigated by Western blotting analysis including activation of caspase cascade,cytochrome c release,Bax,Bid,p53 and Bcl-2 modifying factor.RESULTS:The highest inhibitory effect of α-mangostin on cell proliferation of COLO 205,MIP-101 and SW 620 were 9.74 ± 0.85 μg/mL,11.35 ± 1.12 μg/mL and 19.6 ± 1.53 μg/mL,respectively.Further study showed that α-mangostin induced apoptotic cell death in COLO 205 cells as indicated by membrane blebbing,chromatin condensation,DNA fragmentation,cell cycle analysis,sub-G1 peak (P < 0.05) and phosphatidylserine exposure.The executioner caspase,caspase-3,the initiator caspase,caspase-8,and caspase-9 were expressed upon treatment with α-mangostin.Further studies of apoptotic proteins were determined by Western blotting analysis showing increased mitochondrial cytochrome c release,Bax,p53 and Bmf as well as reduced mitochondrial membrane potential (P < 0.05).In addition,up-regulation of tBid and Fas were evident upon treatment with α-mangostin (P < 0.01).CONCLUSION:α-Mangostin may be effective as an anti-cancer agent that induced apoptotic cell death in COLO 205 via a link between extrinsic and intrinsic pathways. | Ramida Watanapokasin Faongchat Jarinthanan Yukio Nakamura Nitisak Sawasjirakij Amornmart Jaratrungtawee Sunit Suksamrarn | 2011 | World Journal of Gastroenterology2011，17，16： | 5 |
| 3 | Resuscitation of extremely preterm infants- controversies and current evidence显示文摘Despite significant advances in perinatal medicine, the management of extremely preterm infants in the delivery room remains a challenge. There is an increasing evidence for improved outcomes regarding the resuscitation and stabilisation of extremely preterm infants but there is a lack of evidence in the periviable(gestational age 23-25 wk) preterm subgroup. Presence of an experienced team during the delivery of extremely preterm infant to improve outcome is reviewed. Adaptation from foetal to neonatal cardiorespiratory haemodynamics is dependent on establishing an optimal functional residual capacity in the extremely preterm infants, thus enabling adequate gas exchange. There is sufficient evidence for a gentle approach to stabilisation of these fragile infants in the delivery room. Evidence for antenatal steroids especially in the periviable infants, delayed cord clamping, strategies to establish optimal functional residual capacity, importance of temperature control and oxygenation in delivery room in extremely premature infants is reviewed in this article. | Pooja N Patel Jayanta Banerjee Sunit V Godambe | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 2 |
| 4 | Antiseptic use in the neonatal intensive care unit-a dilemma in clinical practice: An evidence based review显示文摘Infants in the neonatal intensive care unit are highly susceptible to healthcare associated infections(HAI), with a substantial impact on mortality, morbidity and healthcare costs. Effective skin disinfection with topical antiseptic agents is an important intervention in the prevention or reduction of HAI. A wide array of antiseptic preparations in varying concentrations and combinations has been used in neonatal units worldwide. In this article we have reviewed the current evidence of a preferred antiseptic of choice over other agents for topical skin disinfection in neonates. Chlorhexidine(CHG) appears to be a promising antiseptic agent; however there exists a significant concern regarding the safety of all agents used including CHG especially in preterm and very low birth weight infants. There is substantial evidence to support the use of CHG for umbilical cord cleansing and some evidence to support the use of topical emollients in reducing the mortality in infants born in developing countries. Well-designed large multicentre randomized clinical trials are urgently needed to guide us on the most appropriate and safe antiseptic to use in neonates undergoing intensive care, especially preterm infants. | Sundar Sathiyamurthy Jayanta Banerjee Sunit V Godambe | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 2 |
| 5 | Recent experience with fungaemia: change in species distribution and azole resistance显示文摘 | Arunaloke Chakrabarti Shiv Sekhar Chatterjee K.L.N. Rao M.M. Zameer M.R. Shivaprakash Sunit Singhi Rajinder Singh Shubhash Chandra Varma | 2009 | Scandinavian Journal of Infectious Diseases2009，，4： | 1 |
| 6 | Hyponatremia in hospitalized critically ill children:cur-rent concepts显示文摘 | Sunit S | 2004 | Indian J Pediatr2004，71，9： | 1 |
| 7 | Development of ultraviolet spectrophotometric method for analysis of lornoxicam in solid dosage forms显示文摘 | Sunit Kumar Sahoo Ranjit Kumar Giri Sachin V Patil | 2012 | Tropi- cal J Pharma Res2012，11，2： | 1 |
| 8 | A study on sintering and microstructure development of fritless silver thickfilm conductors显示文摘 | Vijaya Puri Dinesh Amalnerkar | 2000 | Journal of Materials Science2000，11，9： | 1 |
| 9 | Continuous Mi-daeohtm Versus Diazepam Infusion for refractory convulsive sta-tus epileptieus显示文摘 | Sunit Singhi Anlna Murthy MD Pratibha | 2002 | Child Neuml2002，17，2： | 1 |
| 10 | EFFICACY AND SAFETY OF DOPAMINE VERSUS NOREPINEPHRINE IN THE MANAGEMENT OF SEPTIC SHOCK显示文摘 | Gourang P. Patel Jaime Simon Grahe Mathew Sperry Sunit Singla Ellen Elpern Omar Lateef Robert A. Balk | 2010 | Shock2010，，4： | 1 |
| 11 | Gene prioritization through genomie data fusion显示文摘 | STEIN A DIETHER L SUNIT M et ol | 2006 | Nature Biotechnology2006，24，： | 1 |
| 12 | Digestive enzyme activities in grouper, Epinephelus coioides from first feeding through larva development显示文摘 | Vichai V Sunit R Poonsin P | 1997 | Sonkhla1997，1，： | 1 |
| 13 | Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus显示文摘 | Sunit S Atuna M Pratibha SM | 2002 | Child Neurol2002，17，： | 1 |
| 14 | C-Triazoly j3-D-furanosides as LpxC inhihitors: stereoselective synthesis and biological evalu- ation显示文摘 | Sunit K J Marius L Gonstantin G D | 2014 | Tetrahedron2014，70，： | 1 |
| 15 | Continuous Midazolam Versus Diazepam Infusion for refractory convulsive status epilepticus显示文摘 | Sunit Singhi Aruna Murthy MD Pratibha | 2002 | Child Neurol2002，17，： | 1 |
| 16 | Preparation,characterization and electrical properties of spinel-type environment friendly thick film NTC thermistors显示文摘 | SHWETA J SUNIT R SURESH G | 2008 | J Eur Ceram Soc2008，28，： | 1 |
| 17 | Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana显示文摘 | Panomwan Panseeta Kanlaya Lomchoey Samran Prabpai Palangpon Kongsaeree Apichart Suksamrarn Somsak Ruchirawat Sunit Suksamrarn | 2011 | Phytochemistry2011，，9： | 1 |
| 18 | A subspace blind channel estimation method for OFDM systems without cyclic prefix显示文摘 | Sunit R Li C Y | 2002 | IEEE Transactions on Wireless Communications2002，1，4： | 1 |
| 19 | Japanese encephalitis virus: from genome to infectome显示文摘 | Salini Krishnan Unni Daniel R??ek Chintan Chhatbar Ritu Mishra Manish K. Johri Sunit K. Singh | 2011 | Microbes and Infection2011，，4： | 1 |
| 20 | Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana显示文摘 | Sunit Suksamrarn Narisara Suwannapoch Natthachai Aunchai Mayuso Kuno Piniti Ratananukul Rachada Haritakun Chawewan Jansakul Somsak Ruchirawat | 2004 | Tetrahedron2004，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员