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| 1 | Late-onset acute rejection after living donor liver transplantation显示文摘AIM: To investigate the incidence and risk factors of late-onset acute rejection (LAR) and to clarify the effectiveness of our immunosuppressive regime consisting of life-long administration of tacrolimus and steroids. METHODS: Adult living donor liver transplantation recipients (n = 204) who survived more than 6 mo after living donor liver transplantation were enrolled. Immunosuppression was achieved using tacrolimus and methylprednisolone. When adverse effects of tacrolimus were detected, the patient was switched to cyclosporine. Six months after transplantation, tacrolimus or cyclosporine was carefully maintained at a therapeutic level. The methylprednisolone dosage was maintained at 0.05 mg/kg per day by oral administration. Acute rejections that occurred more than 6 mo after the operation were defined as late-onset. The median follow- up period was 34 mo. RESULTS: LAR was observed in 15 cases (7%) and no chronic rejection was observed. The incidence of hyperlipidemia, chronic renal failure, new-onset post- transplantation diabetes, and deep fungal infection were 13%, 2%, 24%, and 17%, respectively. Conversion from tacrolimus to cyclosporine was required in 38 patients (19%). Multivariate analysis revealed that a cyclosporine- based regimen was significantly associated with LAR. CONCLUSION: Both LAR and drug-induced adverseevents happen at a low incidence, supporting the safety and efficacy of the present immunosuppression regimen for living donor liver transplantation. | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Junichi Keneko Yuichi Matsui Kiyoshi Hasegawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，41： | 4 |
| 2 | Efficacy of mycofenolate mofetil for steroid-resistant acute rejection after living donor liver transplantation显示文摘瞄准:在类固醇作为抑制免疫力的药讨论 mycophenolate mofetil (MMF ) 的使用在肝移植以后的抵抗拒绝。方法:经历了生活施主肝移植(LDLT ) 的 260 个成年病人的临床的记录被考察。Tacrolimus 和甲基氢化尼松被用于主要免疫力的抑制。尖锐拒绝首先与类固醇被对待。当类固醇抵抗发生了时,病人与类固醇和 MMF 的联合被对待。Anti-T-cell 单音的同种细胞的抗体予不对在有 MMF 的联合的类固醇应答的病人被以。结果:90 的一个总数(35%) 病人们开发了尖锐拒绝。第一个事件的从移植的中部的间隔时间是 15 d。54 个病人是类固醇抵抗。44 个病人与 MMF 并且留下被对待 10 要求的 anti-T-cell 单音的同种细胞的抗体治疗。到长期的拒绝的前进在一个病人被观察。骨髓抑制和胃肠的症状是与 MMF 使用联系的最普通的副作用。机会主义的感染没有重要增加。结论:我们的结果证明 MMF 为在有在 LDLT 以后的尖锐拒绝的病人的营救治疗是一个有势力和安全抑制免疫力的代理人。 | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Yuichi Matsui Junichi Kaneko Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，30： | 3 |
| 3 | Signal transducer and activator of transcription 3 regulation by novel binding partners显示文摘Signal transducers and activators of transcription(STATs) mediate essential signals for various biological processes,including immune responses,hematopoiesis,and neurogenesis. STAT3,for example,is involved in the pathogenesis of various human diseases,including cancers,autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX,zipperinteracting protein kinase,Krüppel-associated box-associated protein 1,Y14,PDZ and LIM domain 2 and signal transducing adaptor protein-2,in the regulation of STAT3-mediated signaling. | Tadashi Matsuda Ryuta Muromoto Yuichi Sekine Sumihito Togi Yuichi Kitai Shigeyuki Kon Kenji Oritani | 2015 | World Journal of Biological Chemistry2015，6，4： | 2 |
| 4 | Clostridium difficile-associated diarrhea after living donor liver transplantation显示文摘瞄准:估计发生并且在成年人在生活施主肝移植(LDLT ) 以后为梭状芽胞杆菌顽固伙伴的腹泻(CDAD ) 分析风险因素。方法:micobiological 数据和在东京大学医院经历了 LDLT 的 242 个成年接受者的医药记录回顾地被分析。为手术后的 CDAD 的独立风险因素被识别。结果:手术后的 CDAD 发生在 11 (5%) 病人。CDAD 的中部的发作是手术后的 d 19 (范围, 5-54 ) 。在里面多,变量分析,男性(机会比率, 4.56 ) 并且浆液肌酸酐(>= 1.5 mg/dL,机会比率, 16.0 ) 独立地预言的手术后的 CDAD。结论:CDAD 应该在 LDLT 以后与手术后的腹泻在病人的鉴别诊断被考虑。 | Masao Hashimoto Yasuhiko Sugawara Sumihito Tamura Junichi Kaneko Yuichi Matsui Junichi Togashi Masatoshi Makuuchi | 2007 | World Journal of Gastroenterology2007，13，14： | 2 |
| 5 | Evaluation methods for pretransplant oncologic markers and their prognostic impacts in patient undergoing living donor liver transplantation for hepatocellular carcinoma显示文摘 | Junichi Shindoh Yasuhiko Sugawara Rihito Nagata Junichi Kaneko Sumihito Tamura Taku Aoki Yoshihiro Sakamoto Kiyoshi Hasegawa Tomohiro Tanaka Norihiro Kokudo | 2014 | Transpl Int2014，，4： | 1 |
| 6 | Portal vein reconstruction in adult living donor liver transplantation using cryopreserved vein grafts显示文摘 | Yasuhiko Sugawara Masatoshi Makuuchi Sumihito Tamura Yuichi Matsui Junichi Kaneko Kiyoshi Hasegawa Hiroshi Imamura Norihiro Kokudo Noboru Motomura Shinichi Takamoto | 2006 | Liver Transpl2006，，8： | 1 |
| 7 | Noninvasive Estimation of Hepatic Steatosis in Living Liver Donors: Usefulness of Visceral Fat Area Measurement显示文摘 | Noriyo Yamashiki Yasuhiko Sugawara Sumihito Tamura Junichi Kaneko Yuichi Matsui Junichi Togashi Takamasa Ohki Haruhiko Yoshida Masao Omata Masatoshi Makuuchi Norihiro Kokudo | 2009 | Transplantation2009，，4： | 1 |
| 8 | Portal vein complications after adult‐to‐adult living donor liver transplantation显示文摘 | Yusuke Kyoden Sumihito Tamura Yasuhiko Sugawara Yuichi Matsui Junichi Togashi Junichi Kaneko Norihiro Kokudo Masatoshi Makuuchi | 2008 | Transplant International2008，，12： | 1 |
| 9 | Microstructure of mesocarbon microbeads prepared from synthetic isotropic naphthalene pitch in the presence of carbon black显示文摘 | Yong-Gang Wang Minato Egashira Sumihito Ishida | 1998 | Carbon1998，，37： | 1 |
| 10 | Stabilization and carbonizationproperties of mesocarbon microbeads (MCMB) prepared from a synthetic naphthalene isotropicpitch显示文摘 | YONGGANG WANG YONGCHUL CHANG SUMIHITO ISHIDA | 1999 | Carbon1999，37，： | 1 |
| 11 | Slug, twist, and E-cadherin as immunohistochmical biomarkers in meningal tumors 显示文摘 | MASAYA N SUMIHITO N YUKO T | 2012 | PLoS One2012，7，46： | 1 |
| 12 | Pitch-based carbon fiber of high compressive strength prepared from synthetic isotropic pitch containing mesophase spheres 显示文摘 | Fumitaka W Sumihito I Korai Y | 1999 | Carbon1999，37，6： | 1 |
| 13 | Microstructure of mesocarbon microbeads prepared from synthetic isotropic naphthalene pitch in the presence of carbon black显示文摘 | ONG- GANG WANG MINATO EGASHIRA SUMIHITO ISHIDA | 1998 | carbon1998，37，： | 1 |
| 14 | Donor evaluation and hepatectomy for living-donor liver transplantation显示文摘 | Sumihito Tamura Yasuhiko Sugawara Norihiro Kokudo | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，2： | 1 |
| 15 | Pitchbased carbon fiber of high compressive strength prepared from synthetic isotropic pitch containing mesophase spheres显示文摘 | Fumitaka Watanabe Sumihito Ishida Yozo Korai Isao Mochida Isao Kato Yukio Sakai Makoto Kamatsu | 1999 | Carbon1999，37，： | 1 |
| 16 | Postoperative surveillance with monthly serum tumor markers after living‐donor liver transplantation for hepatocellular carcinoma显示文摘 | Noriyo Yamashiki Yasuhiko Sugawara Sumihito Tamura Ryosuke Tateishi Haruhiko Yoshida Junichi Kaneko Yuichi Matsui Junichi Togashi Masaaki Akahane Masatoshi Makuuchi Masao Omata Norihiro Kokudo | 2010 | Hepatology Research2010，，3： | 1 |
| 17 | Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor显示文摘 | Fanghua Qi Anyuan Li Yoshinori Inagaki Norihiro Kokudo Sumihito Tamura Munehiro Nakata Wei Tang | 2010 | International Immunopharmacology2010，，3： | 1 |
| 18 | Intraoperative Fluorescent Cholangiography Using Indocyanine Green: A Biliary Road Map for Safe Surgery显示文摘 | Takeaki Ishizawa Sumihito Tamura Koichi Masuda Taku Aoki Kiyoshi Hasegawa Hiroshi Imamura Yoshifumi Beck Norihiro Kokudo | 2008 | Journal of the American College of Surgeons2008，，1： | 1 |
| 19 | Intraoperative Fluorescent Cholangiography Using Indocyanine Green: A Biliary Road Map for Safe Surgery显示文摘 | Takeaki Ishizawa Sumihito Tamura Koichi Masuda Taku Aoki Kiyoshi Hasegawa Hiroshi Imamura Yoshifumi Beck Norihiro Kokudo | 2008 | Journal of the American College of Surgeons2008，，1： | 1 |
| 20 | Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas显示文摘 | Manila Antonelli Francesca Romana Buttarelli Antonietta Arcella Sumihito Nobusawa Vittoria Donofrio Hiroko Oghaki Felice Giangaspero | 2010 | Journal of Neuro-Oncology2010，，2： | 1 |
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