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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | Effective simulation of flexible lateral boundaries in two-and three-dimensional DEM simulations显示文摘Discrete element method (DEM) models to simulate laboratory element tests play an important role in advancing our understanding of the mechanics of granular material response, including bonded or cemented, particulate materials. Comparisons of the macro-scale response observed in a real physical test and a 'virtual' DEM-simulated test can calibrate or validate DEM models. The detailed, particle scale information provided in the DEM simulation can then be used to develop our understanding of the material behaviour. It is important to accurately model the physical test boundary conditions in these DEM simulations. This paper specifically considers triaxial tests as these tests are commonly used in soil mechanics. In a triaxial test, the test specimen of granular material is enclosed within a flexible latex membrane that allows the material to deform freely during testing, while maintaining a specified stress condition. Triaxial tests can only be realistically simulated in 3D DEM codes, however analogue, 2D, biaxial DEM simulations are also often considered as it is easier to visualize particle interactions in two dimensions. This paper describes algorithms to simulate the lateral boundary conditions imposed by the latex membrane used in physical triaxial tests in both 2D and 3D DEM simulations. The importance of carefully considering the lateral boundary conditions in DEM simulations is illustrated by considering a 2D biaxial test on a specimen of frictional unbonded disks and a 3D triaxial test on a bonded (cemented) specimen of spheres. The comparisons indicate that the lateral boundary conditions have a more significant influence on the local, particle-scale response in comparison with the overall macro-scale observations. | Geraldine Cheung Catherine O'Sullivan | 2008 | Particuology2008，6，6： | 17 |
| 3 | 儿童早期发展综合干预策略对改善贫困农村地区0~35月龄儿童养育照护的效果显示文摘目的 分析儿童早期发展综合干预策略对改善贫困地区0~35月龄儿童早期家庭养育照护的效果.方法 儿童早期发展综合干预项目(IECD)于2014年开始在4个贫困县农村地区试点开展,通过多种途径为项目地区0~35月龄儿童及其看护人提供儿童养育照护多维度综合干预.采用人群干预对照设计,评价干预对看护人健康与心理、儿童营养、早期学习、儿童保护和社会保障等方面的改善效果,分别于2013年和2016年开展基线和中期调查,采用双重差分模型估计干预效果,并控制社会人口学特征等混杂因素.结果 基线调查纳入0~35月龄儿童干预组1 468名、对照组1 485名,中期调查分别纳入1 384名和1 361名.干预组通过2年的干预,看护人抑郁患病率下降9.1%[中期34.8% (479/1 377)比基线43.9% (621/1 414)],对照组下降1.6%[34.3% (464/1 353)比35.9%(509/1 419)],双重差分模型控制因素混杂后,结果显示干预组下降幅度较同期对照组高7.0%(P=0.008);6~23月龄儿童辅食添加频次合格的比例上升10.4%[69.0% (532/771)比58.6%(481/821)],对照组上升幅度2.9%[66.4% (469/706)比63.5%(508/800)],双重差分模型控制混杂因素后,干预组上升幅度比对照组高8.2%(P=0.021);干预组儿童遭受暴力管教的比例下降6.2% [49.1% (478/973)比55.3%(554/1 001)],同期对照组上升4.5%[58.4% (560/959)比53.9%(558/1 036)],双重差分模型控制混杂因素后,两组变化幅度相差11.0%(P=0.001);干预组家庭拥有儿童图书≥3本的比例上升12.7%[42.7% (588/1 378)比30.0% (432/1 440)],同期对照组上升幅度4.2%[25.7% (349/1 357)比21.5%(298/1 388)]双重差分模型控制混杂因素后,干预组比对照组幅度高6.1%(P=0.007).结论 多部门合作儿童早期发展综合干预策略可以有效改善看护人心理状况、促进儿童喂养、支持儿童早期学习,并减少暴力管教等不恰当的养育行为,从而为儿童早期健康发展创造良好养育照护环境. | 石慧峰 张敬旭 王晓莉 徐媛媛 董胜利 赵春霞 黄小娜 赵颀 陈学锋 周烨 Mayo O'Sullivan Ron Pouwels Robert W.Scherpbier | 2018 | 中华儿科杂志2018，56，2： | 17 |
| 4 | 嗜酸性粒细胞及嗜酸性粒细胞相关疾病研究进展显示文摘本系列专栏为临床医生和科学家提供最新的文献纵览,将近期有关变态反应及免疫学领域的重要研究进展列成清单。本次内容主要涵盖嗜酸性粒细胞。为了着重突出嗜酸性粒细胞生物学基础及临床研究方面的主要概念、主题、趋势和进展,对2015年以来发表在《变态反应及临床免疫学杂志(the Journal of Allergy and Clinical Immunology)》以及其他高影响力期刊上的相关文章进行综述和和总结。由于篇幅有限,许多优秀的文章无法包括在内,但仍希望下面的内容能够涵盖近期发表的文献的概述,这些文献大大增加了我们对嗜酸性粒细胞及相关疾病的了解。 | Jeremy A. O'Sullivan, PhD Bruces. Bochner, MD 王子熹(翻译) 支玉香(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，3： | 12 |
| 5 | Effect of sample size on the response of DEM samples with a realistic grading显示文摘This paper shows that for DEM simulations of triaxial tests using samples with a grading that is representative of a real soil,the sample size significantly influences the observed material response.Four DEM samples with identical initial states were produced:three cylindrical samples bounded by rigid walls and one bounded by a cubical periodic cell.When subjected to triaxial loading,the samples with rigid boundaries were more dilative,stiffer and reached a higher peak stress ratio than the sample enclosed by periodic boundaries.For the rigid-wall samples,dilatancy increased and stiffness decreased with increasing sample size.The periodic sample was effectively homogeneous.The void ratio increased and the contact density decreased close to the rigid walls.This heterogeneity reduced with increasing sample size.The positions of the critical state lines(CSLs) of the overall response in e-log p' space were sensitive to the sample size,although no difference was observed between their slopes.The critical states of the interior regions of the rigid-wall-bounded samples approached that of the homogeneous periodic sample with increasing sample size.The ultimate strength of the material at the critical state is independent of sample size. | Xin Huang Kevin J.Hanley Catherine O'Sullivan Fiona C.Y.Kwok | 2014 | Particuology2014，12，4： | 12 |
| 6 | Imaging of bone metastasis: An update显示文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard. | Gerard J O'Sullivan Fiona L Carty Carmel G Cronin | 2015 | World Journal of Radiology2015，7，8： | 10 |
| 7 | Influence of heterogeneity on rock strength and stiffness using discrete element method and parallel bond model显示文摘The particulate discrete element method(DEM) can be employed to capture the response of rock,provided that appropriate bonding models are used to cement the particles to each other.Simulations of laboratory tests are important to establish the extent to which those models can capture realistic rock behaviors.Hitherto the focus in such comparison studies has either been on homogeneous specimens or use of two-dimensional(2D) models.In situ rock formations are often heterogeneous,thus exploring the ability of this type of models to capture heterogeneous material behavior is important to facilitate their use in design analysis.In situ stress states are basically three-dimensional(3D),and therefore it is important to develop 3D models for this purpose.This paper revisits an earlier experimental study on heterogeneous specimens,of which the relative proportions of weaker material(siltstone) and stronger,harder material(sandstone) were varied in a controlled manner.Using a 3D DEM model with the parallel bond model,virtual heterogeneous specimens were created.The overall responses in terms of variations in strength and stiffness with different percentages of weaker material(siltstone) were shown to agree with the experimental observations.There was also a good qualitative agreement in the failure patterns observed in the experiments and the simulations,suggesting that the DEM data enabled analysis of the initiation of localizations and micro fractures in the specimens. | Spyridon Liakas Catherine O’Sullivan Charalampos Saroglou | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 7 |
| 8 | Cancer of the uncinate process of the pancreas:surgical anatomy and clinicopathological features显示文摘BACKGROUND:The clinicopathological features of uncinate process pancreatic cancer(UPPC) are poorly described.Furthermore the anatomy of the uncinate process and its division during surgery are central to pancreaticoduodenectomy for UPPC.We set out to describe the embryology and anatomy of the uncinate process and the clinicopathological features of UPPC.DATA SOURCES:All published case series of UPPC were reviewed and included in this review.RESULTS:The true incidence of UPPC is difficult to quantify,with the reported incidence ranging from 2.5% to 10.7% of pancreatic cancer.There are 5 published series of UPPC including 117 patients,72 males and 45 females,aged from 45-53 years to 61-84 years.The median survival was 5 or 5.5 months in 3 of the series,12.1 months in another based only on potentially resectable lesions and 17 months in another based only on resected cases.CONCLUSIONS:The number of reported series of UPPC is limited,with vague symptoms as the predominant presenting features of the disease.The prognosis is poor with synchronous venous resection demonstrating a survival advantage. | Adrian W. O'Sullivan Nigel Heaton Mohamed Rela | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 6 |
| 9 | Implementation of rotational resistance models' A critical appraisal显示文摘 | Xin Huang Kevin J. Hanley Catherine O'Sullivan Chung-Yee Kwok | 2017 | Particuology2017，15，5： | 4 |
| 10 | 老年人处方遗漏筛查工具第2版(中文版)显示文摘近年来我国老年人口数量迅速增加,2013年老年人口突破2亿大关。老年人常伴有多种疾病且同时服用多种药物,容易出现药物相互作用和药物不良反应,所以老年人用药问题是医务人员关注的重点。老年人不适当用药问题主要包括两个方面:老年人需要避免使用的药物和老年人需要使用而未使用的药物。 | Denis O'Mahony David O'Sullivan Stephen Byrne Marie Noelle O'Connor Cristin Ryan Paul Gallagher 侯凯旋 邢晓璇 闫素英 | 2017 | 药物不良反应杂志2017，19，5： | 4 |
| 11 | Characterization of artificial spherical particles for DEM validation studies显示文摘This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method (DEM) simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were considered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted. | Ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood | 2012 | Particuology2012，10，2： | 3 |
| 12 | Fabrication of Noble metal-semiconductor hybrid nanostructures using phase transfer显示文摘 | Tanushree Bala Ajay Singh Ambarish Sanyal Catriona O'Sullivan Fathima Laffir Claudia Coughlan Kevin M. Ryan | 2013 | Nano Research2013，6，2： | 3 |
| 13 | Vitamin D deficiency in Crohn’s disease: Prevalence, risk factors and supplement use in an outpatient setting显示文摘 | Treasa Nic Suibhne Gerry Cox Martin Healy Colm O’Morain Maria O’Sullivan | 2011 | Journal of Crohn’s and Colitis2011，，2： | 3 |
| 14 | Novel en-bloc resection of locally advanced hilar cholangiocarcinoma: the Rex recess approach显示文摘Loco-regional recurrence after potentially curative resection remains a problem in hilar cholangiocarcinoma. Hilar dissection risks local spillage of tumor cells leading to suboptimal disease free survival. We have developed a new technique of radical resection for hilar cholangiocarcinoma based on the distinctive anatomy of the Rex recess of the liver, which has been assessed in two patients with locally advanced hilar cholangiocarcinoma. This technique included a right hepatectomy with en-bloc resection of the hepatoduodenal ligament and portal venous reconstruction to the left portal vein at the Rex recess. Both patients had R0 resection and have been disease-free for 26 and 38 months, respectively. | Mohamed Rela Rajesh Rajalingam Vivekanandan Shanmugam Adrian O' Sullivan Mettu S Reddy Nigel Heaton | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 3 |
| 15 | Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system显示文摘Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)signaling.However,the post-translational mechanisms involved and the role of signaling proteins in this activation are unknown.In the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 mice.THP-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase TRAF6.At the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 macrophages.While MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 production.Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase activation.Importantly,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 inhibitors.Administration of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 mice.Our study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation. | Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 16 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 17 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 18 | 利用数字隔离器技术增强工业电机控制性能显示文摘本文介绍了数字隔离器技术,来增强工业电机控制性能并对其进行分类,介绍了隔离方法、进行了延迟特性比较,缝隙数字隔离器技术对电子控制系统的系统影响,给出应用实例,予以工程师参考。 | Dara O'Sullivan Maurice Moroney | 2015 | 电子产品世界2015，22，7： | 2 |
| 19 | A framework for mapping industrial emergence显示文摘 | R. Phaal E. O’Sullivan M. Routley S. Ford D. Probert | 2010 | Technological Forecasting & Social Change2010，，2： | 2 |
| 20 | Risk factor management and depression post-stroke: The value of an integrated model of care显示文摘 | Jacques Joubert Chris Reid Lynette Joubert David Barton Denise Ruth David Jackson John O’. Sullivan Stephen M. Davis | 2005 | Journal of Clinical Neuroscience2005，，1： | 2 |
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