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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 3 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 4 | ABC1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation显示文摘 | Wellington CL Walker EK Suarez A Kwok A Bissada N Singaraja R | 2002 | Lab invest2002，82，3： | 1 |
| 5 | A bifunctional TPS- TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis显示文摘 | Miranda J A Avonce N Suarez R | 2007 | Planta2007，226，6： | 1 |
| 6 | Dendritic cells take up and present antigens from viable and apoptotic polymor- phonuclear leukocytes显示文摘 | Alfaro C Suarez N Ofiate C | 2011 | PLoS ONE2011，6，29： | 1 |
| 7 | Persistence of HPV infection and risk of high-grade cervical intraepithelial neo plasia in a cohort of Colombian women显示文摘 | Munoz N Hernandez Suarez G Mendez F | 2009 | British J Cancer2009，，100： | 1 |
| 8 | Comparision of highly virulent H5N1 influenza A virus isolated from Human and chickens from HongKong显示文摘 | Suarez D L Perdue M L Cox N | 1998 | J Virol1998，72，8： | 1 |
| 9 | Intraspecific evolution of Canary Island Pleeotine bats, based on mtDNA sequences 显示文摘 | PESTANO J BROWN R P SUAREZ N M | 2003 | Heredity2003，90，： | 1 |
| 10 | Concentrations of polyehlorinated biphenyls (PCBs) in water, sediment, and aquatic biota in the Houston Ship Channel, Texas 显示文摘 | Howell N L Suarez M P Rifai H S | 2008 | Chemosphere2008，70，： | 1 |
| 11 | Synthesis and photocatalytic properties of dense and porous TiO2 -anatase thin films prepared by sol-gel 显示文摘 | ARCONADA N DURAN A SUAREZ S | 2009 | Applied Catalysis B : Environmental2009，86，12： | 1 |
| 12 | 显示文摘 | Areonada N Duran A Suarez S | 2009 | Appl Catal 13: Environmental2009，86，： | 1 |
| 13 | Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘 | Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold | 2015 | Int. J. Cancer2015，，1： | 1 |
| 14 | Relationships among native and introduced populations of theArgentine ant (Linepithema humile) and the source of introduced populations显示文摘 | TSUTSUI N D SUAREZ A V HOLWAY D A | 2001 | Molecular Ecology2001，10，9： | 1 |
| 15 | Role of taurine uptake on the induction of hmg-term synaptic potentiation显示文摘 | Del Olmo N Suarez L M Orensanz I M | 2004 | Eu- ropean Journal of Neuroscience2004，19，7： | 1 |
| 16 | Relationships among native and introduced populations of the Argentine ant (Linepithema humile) and the source of introduced populations显示文摘 | TSUTSUI N D SUAREZ A V HOLWAY D A | 2001 | Molecular Ecology2001，10，9： | 1 |
| 17 | Quantitative determination of pneumococcal capsular polysaccharideserotype 14 using a modification of phenol -sulfuric acid method 显示文摘 | Cuesta G Suarez N Bessio M I | 2003 | Journal of Microbiological Methods2003，52，1： | 1 |
| 18 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 1 |
| 19 | Concentrations of polychlorinated biphenyls (PCBs) in water, sediment, and aquatic biota in the Houston Ship Channel, Texas 显示文摘 | Howell N L Suarez M P Rifai H S | 2008 | Chemosphere2008，70，4： | 1 |
| 20 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
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