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| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation显示文摘AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma.METHODS: In 70 patients with histologically proven nonneoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion.RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years.A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected.Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P = 0.0004).CONCLUSION: The long-term relapse rate of nonneoplastic BE following complete ablation with high-power APC is low (3% per year). | Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz | 2005 | World Journal of Gastroenterology2005，11，8： | 14 |
| 3 | Therapy of gastric mucosa associated lymphoid tissue lymphoma显示文摘Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success. | Andrea Morgner Renate Schmelz Christian Thiede Manfred Stolte Stephan Miehlke | 2007 | World Journal of Gastroenterology2007，13，26： | 14 |
| 4 | Elevated risk for gastric adenocarcinoma can be predicted from histomorphology显示文摘The number of patients with gastric cancer has more than doubled since 1985 in developing countries. Thus, the questions of whether it can be predicted from gastritis morphology, who is at risk and who has a lower risk of developing gastric carcinoma are raised. H pylori-infection leads to erosions, ulcerations, carcinoma, mucosa associated lymphoid tissue (MALT)- lymphoma and extragastric diseases only in some individuals. The frequency of ulcerations among H pylori-infected individuals is estimated to be 13%, gastric cancer about 1% and MALT lymphoma around 0.1%. In the literature a multistep model from chronic active H pylori -infection through multifocal atrophy, intestinal metaplasia, dysplasia (intraepithelial neoplasia) and carcinoma has been described. But this model cannot be applied to all routine cases. Since risk factors such as metaplasia and atrophy are paracancerous rather than precancerous conditions, this raises the question whether there is a better morphological marker. Differences in topography, grade and activity of Helicobacter gastritis in the antrum and corpus might be good markers for identifying those who are at risk of developing gastric cancer. It is known that the so-called corpus dominant H pylori gastritis is found more frequently among individuals with early and advanced gastric cancer and within high risk populations. This is valid both for first- degree relatives of gastric cancer patients and for patients with gastric adenoma and hyperplastic polyps. In conclusion, corpus-dominant H pylori gastritis is significantly more common in patients with advanced and early gastric cancer, first-degree relatives of patients with gastric cancer, patients with gastric adenoma and gastric hyperplastic polyps. Therefore, all these patients are at risk of developing gastric cancer. Next, the question of who is at risk of developing corpus-dominant gastritis is raised. It appears that patients with a low acid output more frequently develop gastric cancer. Eradication therapy is never performed too early but probably sometimes too late after the patients pass a “point of no return”. Large prospective long term studiesare necessary to prove this and identify new reliable markers for gastric cancer development. | Michael Vieth Mandred Stolte | 2006 | World Journal of Gastroenterology2006，12，38： | 8 |
| 5 | Is there an association of microscopic colitis and irritable bowel syndrome-A subgroup analysis of placebo-controlled trials显示文摘TO THE EDITOR
With great interest we read the recent retrospectice study by Barta et al (1) dealing with the clinical presentation of patients with microscopic colitis. They investigated in a cohort of 53 patients with microscopic colitis (46 with collagenous colitis, 7 with lymphocytic colitis)the relationship between microscopic colitis and both constipation and diarrhea. One of their mean finding was that abdominal pain, diarrhea and constipation was a common symptom complex of patients with microscopic colitis, thus the face of microcopic colitis resembles the subgroups of irritable bowel syndrome (IBS). | Ahmed Madisch Birgit Bethke Manfred Stolte Stephan Miehlke | 2005 | World Journal of Gastroenterology2005，11，41： | 4 |
| 6 | Eradication of H pylori for the prevention of gastric cancer显示文摘有 H pylori 的感染是与胃的癌症联系的最重要的已知的病因学的因素。当有 H pylori 的胃粘膜的殖民导致活跃、长期的胃炎在时几乎,所有个人感染了,得胃的癌症的可能性取决于环境、细菌的毒力和主人 specific 因素。所有胃的癌症盒子的多数对 H pylori 感染并且因此可归因理论上可防止。从在一个早时间点的 H pylori 的根除能阻止的动物模型有证据胃的癌症开发。然而,使随机化在人在胃的癌症的发生上探索 H pylori 根除的预防效果的临床的审判仍然保持稀少并且让步了冲突结果。为在为 H pylori 的风险的病人的鉴定的更好的标记导致了胃的恶意被需要允许更有效的公共根除策略的发展。同时,屏蔽并且在胃的癌症病人以及某些高风险的人口的一度的亲戚的 H pylori 的治疗可能是有益的。 | Karolin Trautmann Manfred Stolte Stephan Miehlke | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 7 | Helicobacter pyloriin gastric corpus of patients 20 years after partial gastric resection显示文摘AIM: To determine the long-term prevalence of Helicobacter pylori (H pylori) gastritis in patients after partial gastric resection due to peptic ulcer, and to compare the severity of Hpylori-positive gastritis in the corpus mucosa between partial gastrectomy patients and matched controls.METHODS: Endoscopic biopsies were obtained from 57 patients after partial gastric resection for histological examination using hematoxylin/eosin and Warthin-Starry staining. Gastritis was graded according to the updated Sydney system. Severity of corpus gastritis was compared between H pylori-positive partial gastrectomy patients and H pylori-positive duodenal ulcer patients matched for age and gender.RESULTS: In partial gastrectomy patients, surgery was performed 20 years (median) prior to evaluation. In 25 patients (43.8%) H pyloriwas detected histologically in the gastric remnant. Gastric atrophy was more common in H pylori-positive compared to H pylori-negative partial gastrectomy patients (P<0.05). The severity of corpus gastritis was significantly lower in H pylori-positive partial gastrectomy patients compared to duodenal ulcer patients (P<0.01). There were no significant differences in the activity of gastritis, atrophy and intestinal metaplasla between the two groups.CONCLUSION: The long-term prevalence of H pylori gastritis in the gastric corpus of patients who underwent partial gastric resection due to peptic ulcer disease is comparable to the general population. The expression of Hpylori gastritis in the gastric remnant does not resemble the gastric cancer phenotype. | Christian Kirsch Ahmed Madisch Petja Piehler Ekkehard Bayerdrffer Manfred Stolte Stephan Miehlke | 2004 | World Journal of Gastroenterology2004，10，17： | 3 |
| 8 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 3 |
| 9 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 10 | The new Vienna classification of epithelial neoplasia of the gastrointestinal tract: advantages and disadvantages显示文摘 | Manfred Stolte | 2003 | Virchows Archiv2003，，2： | 2 |
| 11 | Prevalence of Barrett’s Esophagus in the General Population: An Endoscopic Study显示文摘 | Jukka Ronkainen Pertti Aro Tom Storskrubb Sven–Erik Johansson Tore Lind Elisabeth Bolling–Sternevald Michael Vieth Manfred Stolte Nicholas J. Talley Lars Agréus | 2005 | Gastroenterology2005，，： | 2 |
| 12 | A Comparison of Helicobacter pylori and H. heilmannii Gastritis: A Matched Control Study Involving 404 Patients显示文摘 | M. Stolte G. Kroher A. Meining A. Morgner E. Bayerd?rffer B. Bethke | 1997 | Scandinavian Journal of Gastroenterology1997，，1： | 2 |
| 13 | The effect of Ga-grading in CIGS thin film solar cells显示文摘 | O. Lundberg M. Edoff L. Stolt | 2004 | Thin Solid Films2004，，： | 2 |
| 14 | Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer)显示文摘 | Christian Ell Andrea May Oliver Pech Liebwin Gossner Erwin Guenter Angelika Behrens Lars Nachbar Josephus Huijsmans Michael Vieth Manfred Stolte | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 15 | Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis显示文摘 | Ralf Kiesslich Johannes Fritsch Martin Holtmann Heinz H. Koehler Manfred Stolte Stephan Kanzler Bernhard Nafe Michael Jung Peter R. Galle Markus F. Neurath | 2003 | Gastroenterology2003，，4： | 2 |
| 16 | Review of histological classifications of gastrointestinal epithelial neoplasia: differences in diagnosis of early carcinomas between Japanese and Western pathologists显示文摘 | Ronald J. Schlemper Yo Kato Manfred Stolte | 2001 | Journal of Gastroenterology2001，，7： | 2 |
| 17 | Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis显示文摘 | Ralf Kiesslich Martin Goetz Katharina Lammersdorf Constantin Schneider Juergen Burg Manfred Stolte Michael Vieth Bernhard Nafe Peter R. Galle Markus F. Neurath | 2007 | Gastroenterology2007，，3： | 2 |
| 18 | Endoscopic lithotripsy in the common bile duct显示文摘 | Koch H Stolte M Walz V | 1977 | Endoscopy1977，9，2： | 1 |
| 19 | Migration by Fourier transform显示文摘 | | 1978 | Geophysics1978，43，1： | 1 |
| 20 | Measurement of index modulation along an optical fiber Bragg grating显示文摘 | Krug P A Stolte R Ulrich R | 1995 | Opt Lett1995，20，17： | 1 |
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