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| 1 | Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus–Di?erences in Etiology, Epidemiology and Prevention显示文摘In Germany, esophageal carcinoma is one of the ten most frequent causes of death. Normally the disease is found in men over the age of 50. Although squamous cell carcinoma (SCC) of the esophagus has been more commonly diagnosed over the past 30 years, there is increasing incidence of esophageal adenocarcinoma (AC) in Western industrialized countries. For SCC the known etiological risk factors are nicotine and alcohol abuse. For AC, they are moderate nicotine and alcohol consumption as well as gastro-esophageal re?ux and obesity. | Elfriede Bollschweiler Eva Wolfgarten | 2004 | The Chinese-German Journal of Clinical Oncology2004，3，4： | 8 |
| 2 | Treatment of early gastric cancer in the Western World显示文摘The incidence rate of gastric cancer is much higher in Asia than in the Western industrial nations.According to the different screening programs in Japan and Korea about fifty percent of treated patients had an early tumor stage.In contrast,European and American patients with gastric cancer had an advanced tumor stage.Therefore,the experience for the various therapeutic options for gastric cancer may be different between these regions.In this review we tried to point out the treatment modalities in Western industrial countries for early gastric cancer. | Elfriede Bollschweiler Felix Berlth Christoph Baltin Stefan Mnig Arnulf H Hlscher | 2014 | World Journal of Gastroenterology2014，20，19： | 8 |
| 3 | Pathohistological classification systems in gastric cancer:Diagnostic relevance and prognostic value显示文摘Several pathohistological classification systems exist for the diagnosis of gastric cancer.Many studies have investigated the correlation between the pathohistological characteristics in gastric cancer and patient characteristics,disease specific criteria and overall outcome.It is still controversial as to which classification system imparts the most reliable information,and therefore,the choice of system may vary in clinical routine.In addition to the most common classification systems,such as the Laurén and the World Health Organization(WHO)classifications,other authors have tried to characterize and classify gastric cancer based on the microscopic morphology and in reference to the clinical outcome of the patients.In more than 50 years of systematic classification of the pathohistological characteristics of gastric cancer,there is no sole classification system that is consistently used worldwide in diagnostics and research.However,several national guidelines for the treatment of gastric cancer refer to the Laurén or the WHO classifications regarding therapeutic decision-making,which underlines the importance of a reliable classification system for gastric cancer.The latest results from gastric cancer studies indicate that it might be useful to integrate DNA-and RNA-based features of gastric cancer into the classification systems to establish prognostic relevance.This article reviews the diagnostic relevance and the prognostic value of different pathohistological classification systems in gastric cancer. | Felix Berlth Elfriede Bollschweiler Uta Drebber Arnulf H Hoelscher Stefan Moenig | 2014 | World Journal of Gastroenterology2014，20，19： | 6 |
| 4 | Neoadjuvant treatment for advanced esophageal cancer: response assessment before surgery and how to predict response to chemoradiation before starting treatment显示文摘Patients with advanced esophageal cancer(T3-4, N) have a poor prognosis. Chemoradiation or chemotherapy before esophagectomy with adequate lymphadenectomy is the standard treatment for patients with resectable advanced esophageal carcinoma. However, only patients with major histopathologic response(regression to less than 10% of the primary tumor) after preoperative treatment will have a prognostic benefit of preoperative chemoradiation. Using current therapy regimens about 40% to 50% of the patients show major histopathological response. The remaining cohort does not benefit from this neoadjuvant approach but might benefit from earlier surgical resection. Therefore, it is an aim to develop tools for response prediction before starting the treatment and for early response assessment identifying responders. The current review discusses the different imaging techniques and the most recent studies about molecular markers for early response prediction. The results show that [18F]-fluorodeoxyglucose-positron emission tomography(FDGPET) has a good sensitivity but the specificity is not robust enough for routine clinical use. Newer positron emission tomography detector technology, the combination of FDG-PET with computed tomography, additional evaluation criteria and standardization of evaluation may improve the predictive value. There exist a great number of retrospective studies using molecular markers for prediction of response. Until now the clinical use is missing. But the results of first prospective studies are promising. A future perspective may be the combination of imaging technics and special molecular markers for individualized therapy. Another aspect is the response assessment after finishing neoadjuvant treatment protocol. The different clinical methods are discussed. The results show that until now no non-invasive method is valid enough to assess complete histopathological response. | Elfriede Bollschweiler Arnulf H.Hlscher Matthias Schmidt Ute Warnecke-Eberz | 2015 | Chinese Journal of Cancer Research2015，27，3： | 3 |
| 5 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 6 | Histomorphologic Tumor Regression and Lymph Node Metastases Determine Prognosis Following Neoadjuvant Radiochemotherapy for Esophageal Cancer: Implications for Response Classification显示文摘 | Paul M. Schneider Stephan E. Baldus Ralf Metzger Martin Kocher Rudolf Bongartz Elfriede Bollschweiler Hartmut Schaefer Juergen Thiele Hans P. Dienes Rolf P. Mueller Arnulf H. Hoelscher | 2005 | Annals of Surgery2005，，5： | 2 |
| 7 | Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy显示文摘 | Uta Drebber Max Lay Inga Wedemeyer Daniel Vallb?hmer Elfriede Bollschweiler Jan Brabender Stefan M?nig Arnulf H?lscher Hans Dienes Margarete Odenthal | 2011 | International Journal of Oncology2011，，： | 2 |
| 8 | The role of land administration in the accession of Central European countries to the European Union显示文摘 | Theo Bogaerts Ian P. Williamson Elfriede M. Fendel | 2002 | Land Use Policy2002，，1： | 2 |
| 9 | Fetal transabdominal anatomy scanning using standard views at 11 to 14 weeks’ gestation显示文摘 | Constantin S. von Kaisenberg Heidi Kuhling-von Kaisenberg Elfriede Fritzer Sandra Schemm Ivo Meinhold-Heerlein Walter Jonat | 2005 | American Journal of Obstetrics and Gynecology2005，，2： | 1 |
| 10 | Antiulcer activity of Sapindus saponaria L in the rat 显示文摘 | Adriana L A Jayme A A S Elfriede M B | 2002 | Journal of Et hnopharmacology2002，82，： | 1 |
| 11 | Frequency of Lymph Node Metastasis in Submucosal Esophageal Cancer显示文摘 | Arnulf H. H?lscher Elfriede Bollschweiler | 2014 | Annals of Surgery2014，，6： | 1 |
| 12 | γ-Glutamyl-transferase as a Risk Factor for Cardiovascular Disease Mortality显示文摘 | Elfriede Rutmann Larry J Brant Hans Concin | | 0，，： | 1 |
| 13 | N-athyl-pyridinium-chlorid als losungsmittel und reaktionsmedium fur cellulose显示文摘 | Husemann Elfriede Seifert E | 1969 | Makromol Chem1969，128，： | 1 |
| 14 | Differential onset of infantile deprivation produces distinctive long-term effects in adult ex-laboratory chimpanzees(Pan troglodytes)显示文摘 | ELFRIEDE K CORNELIA F KARL C | 2008 | Developmental Psychobiology2008，50，8： | 1 |
| 15 | Incidence of and risk factors for sudden cardiac death in children with di- lated cardiomyopathy : a report from the pediatric cardiomyopa- thy registry显示文摘 | ELFRIEDE P LYNN A S CHARLES E C | 2012 | Journal of the American College of Cardiolo- gy2012，59，6： | 1 |
| 16 | Elevations of Troponin I after interventional cardiac catheterization显示文摘 | Prince J K David F W Elfriede P | 2001 | Cardiol Young2001，11，4： | 1 |
| 17 | 7-Glu- tamyltransferase as a risk factor for cardiovascular disease mortality: An epidemiologieal investigation in a cohort of 163 944 austrian adults显示文摘 | ELFRIEDE R LARRY J B HANS C | 2005 | Circulation2005，112，： | 1 |
| 18 | Roles of thymidylate synthase and dihydropyrimidine dehydrogenase expression in blood as predictors of response to multimodal therapy in esophageal cancer显示文摘 | Jan Brabender Ralf Metzger Daniel Vallb?hmer Frederike Ling Susanne Neiss Elfriede Bollschweiler Paul M. Schneider Arnulf H. H?lscher Peter P. Grimminger | 2012 | Surgery2012，，2： | 1 |
| 19 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 20 | The overexpression of c-met as a prognostic indicator for gastric carcinomacompared to p53 and p21 nuclear accumulation显示文摘 | Uta Drebber Stephan Baldus Britt Nolden Guido Grass Elfriede Bollschweiler Hans Dienes Arnulf H?lscher Stefan M?nig | 2008 | Oncology Reports2008，，6： | 1 |
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