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13篇 您的检索式：作者名="Stanislas G"

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		题名	作者	年代	出处	被引量
	1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
	2	Vaccination of chronic hepatitis B virus carriers with preS2/S envelope protein is not associated with the emergence of envelope escape mutants显示文摘	PATRICK S STANISLAS P FLORIANNE G	2001	J Gen Virol2001，82，：	1
	3	Control of a decelerating boundary layer: Part 1 optimization of passive vortex generators显示文摘	Godard G Stanislas M	2006	Aerospace Science and Technology2006，10，3：	1
	4	Control of a decelerating boundary layer:Part 2 optimization of slotted jets vortex generators显示文摘	Godard G Foucaut J M Stanislas M	2006	Aerospace Science and Technology2006，10，6：	1
	5	Control of a decelerating boundary layer:Part 3 optimization of round jets vortex generators显示文摘	Godard G Stanislas M	2006	Aerospace Science and Technology2006，10，6：	1
	6	Determination of rimonabant in human plasma and hair by liquid chromatography-mass spectrometry 显示文摘	STANISLAS G D EMURI A PHILIPPE D	2008	Chromatography2008，872，：	1
	7	Diagnosis of aneuploidy in archival, paraffin-embedded pregnancy-loss tissues by comparative genomic hybridization显示文摘	Karen A Bell Peter G Van Deerlin Ronald F Feinberg Stanislas du Manoir Bassem R Haddad	2001	Fertility and Sterility2001，，2：	1
	8	Efficacy of the Protease Inhibitor BI 201335, Polymerase Inhibitor BI 207127, and Ribavirin in Patients With Chronic HCV Infection显示文摘	Stefan Zeuzem Tarik Asselah Peter Angus Jean–Pierre Zarski Dominique Larrey Beat Müllhaupt Ed Gane Marcus Schuchmann Ansgar Lohse Stanislas Pol Jean–Pierre Bronowicki Stuart Roberts Keikawus Arasteh Fabien Zoulim Markus Heim Jerry O. Stern George Kukolj G	2011	Gastroenterology2011，，6：	1
	9	A microanalytic study of particles transport across the alveoli:role of blood platelets显示文摘	Berry JP Arnoux B Stanislas G Galle P Chretien J	1977	Biomedicine1977，27，910：	1
	10	A microanalytic study of particles transport across the alveoli :role of blood platelets 显示文摘	BERRY J P ARNOUX B STANISLAS G	1977	Biomedicine1977，27，：	1
	11	A microanalytic study of particles transport cross the alveoli:role of blood plateles显示文摘	Berry J P Arnoux B Stanislas G	1977	Biomedicine1977，27，：	1
	12	IL -23 up- regulates IL- 10 and induces IL- 17 synthesis by polyclonally activated ha'i've T cells in human 显示文摘	Serge V E Stanislas G Dominique D W	2005	Europe- an Journal of Immunology2005，35，2：	1
	13	A microanalytic study of particles transport across the alveoli: role of blood platelets 显示文摘	Berry JP Arnoux B Stanislas G	1977	Biomedicine/[ publiee pour 1'' AAICIG ]1977，27，910：	1

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