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| 1 | Improvement of gastric emptying by enhanced recovery after pancreaticoduodenectomy显示文摘BACKGROUND: Enhanced recovery after surgery(ERAS) has improved postoperative outcomes particularly in colorectal surgery. This study aimed to assess compliance with an ERAS protocol and evaluate its effect on postoperative outcomes in patients undergoing pancreaticoduodenectomy. METHODS: Fifty patients who had received conventional peri operative management from 2005 to 2009(conventional group)were compared with 75 patients who had received perioperative care with an ERAS protocol(fast-track group) from 2010 to2014. Mortality, complications, readmissions and length of hospital stay were evaluated and compared in the groups.RESULTS: Compliance with each element of the ERAS pro tocol ranged from 74.7% to 100%. Uneventful patients had a significant higher adherence to the ERAS protocol(87.5% vs40.7%; P<0.001). There were no significant differences in de mographics and perioperative characteristics between the two groups. Patients in the fast-track group had a shorter time to remove the nasogastric tube, start liquid diet and solid food pass flatus and stools, and remove drains. No difference was found in mortality, relaparotomy, readmission rates and over all morbidity. However, delayed gastric emptying and length of hospital stay were significantly reduced in the fast-track group. The independent effect of the ERAS protocol in reduc ing delayed gastric emptying and length of hospital stay was confirmed by multivariate analysis.CONCLUSION: ERAS pathway was feasible and safe in improving gastric emptying, yielding an earlier postoperative recovery, and reducing the length of hospital stay. | Efstratios Zouros Theodoros Liakakos Anastasios Machairas Paulos Patapis Christos Agalianos Christos Dervenis | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 16 |
| 2 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 3 | Current evidence for histone deacetylase inhibitors in pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive human cancers,with more than 200 000 deaths worldwide every year.Despite recent efforts,conventional treatment approaches,such as surgery and classic chemotherapy,have only slightly improved patient outcomes.More effective and well-tolerated therapies are required to reverse the current poor prognosis of this type of neoplasm.Among new agents,histone deacetylase inhibitors (HDACIs) are now being tested.HDACIs have multiple biological effects related to acetylation of histones and many non-histone proteins that are involved in regulation of gene expression,apoptosis,cell cycle progression and angiogenesis.HDACIs induce cell cycle arrest and can activate the extrinsic and intrinsic pathways of apoptosis in different cancer cell lines.In the present review,the main mechanisms by which HDACIs act in pancreatic cancer cells in vitro,as well as their antiproliferative effects in animal models are presented.HDACIs constitute a promising treatment for pancreatic cancer with encouraging anti-tumor ef-fects,at well-tolerated doses. | Ioannis Koutsounas Constantinos Giaginis Efstratios Patsouris Stamatios Theocharis | 2013 | World Journal of Gastroenterology2013，19，6： | 9 |
| 4 | Effects of Helicobacterpyloriinfection on gastric emptying rate in patients with non-ulcer dyspepsia显示文摘AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear. We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacterpylori(Hpylori) infection and whether it was affected by eradication of the infection. METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=-17). Hpylori status was assessed by serology and biopsy urease test. Hpylori-positive NUD patients (n=-23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated. RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (Cmax/BM) was 0.173 and 0.224 mg/L.kg respectively (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM) was 18.42 and 24.39 mg.min/L.kg respectively (P=-0.01). Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The mean Cmax/BM was 0.172 and 0.177 mg/Ukg respectively (P=-0.58), the mean AUC/BM was 18.43 and 18.38 rag.min/L.kg respectively (P=0.91). Among 14 NUD patients who were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate. The mean Cmax/BM was 0.171 and 0.160 mg/Ukg before and after Hp eradication, respectively (P=0.64), the mean AUC/BM was 17.41 and 18.02 mg.min/Ukg before and after eradication, respectively (P=-0.93). CONCLUSION: Although gastric emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection. | Grigoris I Leontiadis George I Minopoulos Efstratios Maltezos Stamatia Kotsiou Konstantinos I Manolas Konstantinos Simopoulos Dimitrios Hatseras | 2004 | World Journal of Gastroenterology2004，10，12： | 9 |
| 5 | Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis显示文摘AIM:To investigate the adipokine levels of leptin,adiponectin,resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,males:35(87.5%),Child-Pugh(CP)score:median 7(5-12),CP A/B/C:18/10/12,Model for End-stage Liver Disease(MELD):median 10(6-25),follow-up:median 32.5 mo(10-43)]were prospectively included.The serum adipokine levels were estimated in duplicate by ELISA.Somatometric characteristics were assessed with tetrapolar bioelectrical impedance analysis.Pearson’s rank correlation coefficient was used to assess possible associations with adipokine levels.Univariate and multivariate Cox regression analysis was used to determine independent predictors for overallsurvival.RESULTS:Body mass index:median 25.9(range:20.1-39.3),fat:23.4%(7.6-42.1),fat mass:17.8(5.49-45.4),free fat mass:56.1(39.6-74.4),total body water(TBW):40.6(29.8-58.8).Leptin and visfatin levels were positively associated with fat mass(P<0.001/P=0.027,respectively)and RBP4 with TBW(P=0.025).Median adiponectin levels were significantly higher in CPC compared to CPA(CPA:7.99±14.07,CPB:7.66±3.48,CPC:25.73±26.8,P=0.04),whereas median RBP4 and apelin levels decreased across the spectrum of disease severity(P=0.006/P=0.034,respectively).Following adjustment for fat mass,visfatin and adiponectin levels were significantly increased from CPA to CPC(both P<0.001),whereas an inverse correlation was observed for both RBP4 and apelin(both P<0.001).In the multivariate Cox regression analysis,only MELD had an independent association with overall survival(HR=1.53,95%CI:1.05-2.32;P=0.029).CONCLUSION:Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis. | Maria Kalafateli Christos Triantos Emmanuel Tsochatzis Marina Michalaki Efstratios Koutroumpakis Konstantinos Thomopoulos Venetsanea Kyriazopoulou Eleni Jelastopulu Andrew Burroughs Chryssoula Lambropoulou-Karatza Vasiliki Nikolopoulou | 2015 | World Journal of Gastroenterology2015，21，10： | 8 |
| 6 | Serum levels of vaspin and visfatin in patients with coronary artery disease—Kozani study显示文摘 | Nikolaos P.E. Kadoglou Argirios Gkontopoulos Alkistis Kapelouzou Grigorios Fotiadis Efstratios K. Theofilogiannakos George Kottas Stilianos Lampropoulos | 2010 | Clinica Chimica Acta2010，，1： | 3 |
| 7 | Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss显示文摘 | Dimitrios Papazoglou Georgios Galazios Konstantinos Papatheodorou Vasilios Liberis Nikolaos Papanas Efstratios Maltezos Georgios B. Maroulis | 2005 | Fertility and Sterility2005，，： | 2 |
| 8 | Three-dimensional representation software as image enhancement tool in small-bowel capsule endoscopy: A feasibility study显示文摘 | Anastasios Koulaouzidis Alexandros Karargyris Emanuele Rondonotti Colin L. Noble Sarah Douglas Efstratios Alexandridis Ali M. Zahid Andrew J. Bathgate Ken C. Trimble John N. Plevris | 2013 | Digestive and Liver Disease2013，，： | 2 |
| 9 | Rec- net Advances in Optimization - Based Simultaneous Process and Control Design 显示文摘 | Vassilis Sakizlis John D Perkins Efstratios N Pistikopoulos | 2004 | Computers and Chemical Engineering2004，28，10： | 1 |
| 10 | Three-dimensional representation software as image enhancement tool in small-bowel capsule endoscopy: A feasibility study显示文摘 | Anastasios Koulaouzidis Alexandros Karargyris Emanuele Rondonotti Colin L. Noble Sarah Douglas Efstratios Alexandridis Ali M. Zahid Andrew J. Bathgate Ken C. Trimble John N. Plevris | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 11 | Modified natural cycle for IVF does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels,as a last resort prior to ooeyte danation 显示文摘 | Efstratios Kolibianakis Kostantinos Zikopoulos Michel Camus | 2004 | Hum Reprod2004，19，： | 1 |
| 12 | 40-Gb/s All-Optical Processing Systems Using Hybrid Photonic Integration Technology显示文摘 | Efstratios Kehayas Dimitris Tsiokos Graeme Maxwell | 2006 | J Lightwave Technol2006，24，12： | 1 |
| 13 | Risk of Venous Thromboembolism in Patients with Inflammatory Bowel Disease显示文摘 | Efstratios Koutroumpakis Georgia Tsiolakidou Ioannis Koutroubakis | 2013 | Semin Thromb Hemost2013，，： | 1 |
| 14 | A flexible and adaptable planning and control system for an MTO supply chain system 显示文摘 | Mustafa Ozbayraka Theopisti C Papadopouloub Efstratios Samaras | 2006 | Robotics and Computer-Integrated Manufacturing2006，，22： | 1 |
| 15 | Therapeutic modalities for pancoast tumors显示文摘 | Nikolaos P Vasilios L Efstratios K | 2014 | Journal of Thoracic Disease2014，6，： | 1 |
| 16 | Value of volume measurements in evaluating abdominal aortic aneurysms growth rate and need for surgical treatment显示文摘 | Nikolaos Kontopodis Eleni Metaxa Yannis Papaharilaou Efstratios Georgakarakos Dimitris Tsetis Christos V. Ioannou | 2014 | European Journal of Radiology2014，，： | 1 |
| 17 | Toxicity of Methyl Ketones from Tomato Trichomes to Tetranychus urticae Koch显示文摘 | EFSTRATIOS A CHATZIVASILEIADIS MAURICE W S | 1997 | Experimental & Applied Acarology1997，21，： | 1 |
| 18 | Growth differentiation factor 15:A novel risk marker adjunct to the Euro SCORE for risk stratification in cardiac surgery patients显示文摘 | Matthias H Efstratios IC Nicola G | 2013 | J Cardiol2013，61，6： | 1 |
| 19 | Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease显示文摘 | Ioannis Koutsounas Stamatios Theocharis Efstratios Patsouris Constantinos Giaginis | 2013 | Current Drug Metabolism2013，，3： | 1 |
| 20 | Therapeutic mo- dalities for pancoast tumors 显示文摘 | Nikolaos P Vasilios L Efstratios K | 2014 | J Thorac Dis2014，6，1： | 1 |
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