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| 1 | Association of arterial stiffness with coronary flow reserve in revascularized coronary artery disease patients显示文摘AIM: To investigate the association of arterial wave reflection with coronary flow reserve(CFR) in coronary artery disease(CAD) patients after successful revascularization.METHODS: We assessed 70 patients with angiographically documented CAD who had undergone recent successful revascularization. We measured(1) reactive hyperemia index(RHI) using fingertip peripheral arterial tonometry(RH-PAT Endo-PAT);(2) carotid to femoral pulse wave velocity(PWVc-Complior);(3) augmentation index(AIx), the diastolic area(DAI%) and diastolic reflection area(DRA) of the central aortic pulse wave(Arteriograph);(4) CFR using Doppler echocardiography; and(5) blood levels of lipoprotein-phospholipase A2(LpPLA2).RESULTS: After adjustment for age, sex, blood pressure parameter, lipidemic, diabetic and smoking status, we found that coronary flow reserve was independently related to AIx(b =-0.38, r = 0.009), DAI(b = 0.36, P = 0.014), DRA(b = 0.39, P = 0.005) and RT(b =-0.29,P = 0.026). Additionally, patients with CFR < 2.5 had higher PWVc(11.6 ± 2.3 vs 10.2 ± 1.4 m/s, P = 0.019), SBPc(139.1 ± 17.8 vs 125.2 ± 19.1 mm Hg, P = 0.026), AIx(38.2% ± 14.8% vs 29.4% ± 15.1%, P = 0.011) and lower RHI(1.26 ± 0.28 vs 1.50 ± 0.46, P = 0.012), DAI(44.3% ± 7.9% vs 53.9% ± 6.7%, P = 0.008), DRA(42.2 ± 9.6 vs 51.6 ± 11.4, P = 0.012) and Lp PLA2(268.1 ± 91.9 vs 199.5 ± 78.4 ng/m L, P = 0.002) compared with those with CFR ≥ 2.5. Elevated Lp PLA2 was related with reduced CFR(r =-0.33, P = 0.001), RHI(r =-0.37, P < 0.001) and DRA(r =-0.35, P = 0.001) as well as increased PWVc(r = 0.34, P = 0.012) and AIx(r = 0.34, P = 0.001). CONCLUSION: Abnormal arterial wave reflections are related with impaired coronary flow reserve despite successful revascularization in CAD patients. There is a common inflammatory link between impaired aortic wall properties, endothelial dysfunction and coronary flow impairment in CAD. | Vlassis Tritakis Stavros Tzortzis Ignatios Ikonomidis Kleanthi Dima Georgios Pavlidis Paraskevi Trivilou Ioannis Paraskevaidis Giorgos Katsimaglis John Parissis John Lekakis | 2016 | World Journal of Cardiology2016，8，2： | 4 |
| 2 | Increased levels of circulating platelet-derived microparticles in psoriasis:Possible implications for the associated cardiovascular risk显示文摘AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascular disease,and 12 healthy controls were subjected to measurement of baseline platelet CD62 P, CD63 and CD42 b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes(PMC), platelet-neutrophil complexes(PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles(PMPs) using flow cytometry. Both larger-size(0.5-0.9 μm) and smallersize(< 0.5 μm) PMPs were determined. Serum interleukin(IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index(PASI).RESULTS PMP concentrations were significantly higher in psoriasis patients than controls [mean±standard error of mean(SEM): 22±5/μL vs 11±6/μL; P=0.018), for both smaller-size(10±2/μL vs 4±2/μL; P=0.033) and larger-size(12±3/μL vs 6±4/μL; P=0.014) PMPs. Platelet CD62 P, CD63 and CD42 b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls(mean±SEM: 16%±3% vs 23%±6%; P=0.047). Larger-size PMPs were related with IL-12 levels(P<0.001) and smaller-size PMPs with both IL-12 and IL-17 levels(P<0.001). Total PMPs also correlated with IL-12(P<0.001). CD63 expression was positively correlated with both IL-12 and IL-17(P<0.05). Increased PASI score was associated with increased levels of larger-size PMPs(r=0.45; P=0.011) and increased CD63 expression(r=0.47; P<0.01).CONCLUSION PMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients. | Evangelia Papadavid Konstantina Diamanti Aris Spathis Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos Petros Karakitsos John Lekakis Dimitrios Rigopoulos Ignatios Ikonomidis | 2016 | World Journal of Cardiology2016，8，11： | 2 |
| 3 | 阿利吉仑对2型糖尿病合并高血压患者循环内皮祖细胞和血管功能的影响显示文摘该研究旨在探讨阿利吉仑对2型糖尿病合并高血压患者循环内皮祖细胞(endothelial progenitor cells,EPC)和血管功能的影响。方法:研究纳入血糖控制稳定、首次诊断为轻度原发性高血压〉50岁的2型糖尿病患者。在A阶段(n=20),患者接受150-300mg/d阿利吉仑治疗3月。 | Raptis AE Markakis KP Mazioti MC Ikonomidis I Maratou EP Vlahakos DV Kotsifaki EE Voumvourakis AN Tsiro- gianni AG Lambadiari VA Lekakis JP Raptis SA Dimitria- dis GD 练桂丽 叶鹏 | 2015 | 中华高血压杂志2015，23，7： | 2 |
| 4 | Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease显示文摘 | Ignatios Ikonomidis Nikolaos N.P. Kadoglou Vlassis Tritakis Ioannis Paraskevaidis Kleanthi Dimas Paraskevi Trivilou Ioannis Papadakis Stavros Tzortzis Helen Triantafyllidi John Parissis Maria Anastasiou-Nana John Lekakis | 2014 | Atherosclerosis2014，，1： | 2 |
| 5 | Oral L-arginine improves endothelial dysfunction in patients with essential hypertension显示文摘 | Lekakis JP Papathanassiou S Papaioannou TG | 2002 | Int J Cardiol2002，86，23： | 1 |
| 6 | Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery disease 显示文摘 | Lekakis JP Protogerou A Papamichael C | 2005 | Cardiovasc Drugs Ther2005，19，4： | 1 |
| 7 | Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures显示文摘 | Theodoros G. Papaioannou Kalliopi Karatzi Emmanouil Karatzis Christos Papamichael John P. Lekakis | 2005 | American Journal of Hypertension2005，，1： | 1 |
| 8 | Cardiac hypertrophy in hypertension:relation to 24-h blood pressure Profile and arterial stiffness显示文摘 | Lekakis JP Zakopoulos NA Protogerou AD | 2004 | Int J Cardiol2004，97，1： | 1 |
| 9 | Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis显示文摘 | Lekakis JP Papamichael CM Cimponeriu AT | 2000 | Am J Cardiol2000，85，8： | 1 |
| 10 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with cor- onary artery disease显示文摘 | Papamichael CM Lekakis JP Stamatelopoulos KS | 2000 | Am J Cardiol2000，86，6： | 1 |
| 11 | Pulse pressure in normotensive: A marker of cardiovasvular disease显示文摘 | NIKON A JOHN P LEKAKIS CM | 2001 | Am J Hypertens2001，14，： | 1 |
| 12 | Ankle- brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patientswith coronary artery disease 显示文摘 | Papamichael CM Lekakis JP Stamatelopoulos KS | 2000 | AmJCardiol2000，86，6： | 1 |
| 13 | Pulse pressure in normotensive:A marker of cardiovascular disease显示文摘 | Lekakis CM Nikos A John P | 2001 | Am J Hypertens2001，14，： | 1 |
| 14 | Atheresclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis 显示文摘 | Lekakis JP Papamichael CM Cimponeriu AT | 2000 | Am J Cardio]2000，85，： | 1 |
| 15 | Flow-mediated, endotheli- urn-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin ( TSH ) values 显示文摘 | Lekakis J Papamichael C Alevizaki M | 1997 | Thyroid1997，7，3： | 1 |
| 16 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos MP Lekakis JP Stamtelopoulos KS | 2000 | Am J Cardiol2000，86，7： | 1 |
| 17 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Papamichael CM Lekakis JP Stamatelopoulos KS | 2000 | Am J Cardiol2000，86，： | 1 |
| 18 | An- kle-brachial index as a predictor of extent of coronary athero- sclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Papamicheal CM Lekakis JP Stamatelopoulos KS | 2000 | Azn J Cardiol2000，86，6： | 1 |
| 19 | Association of tar- get organ damage with three arterial stiffness indexes according to blood pressure dipping status in untreated hypertensive patients 显示文摘 | Triantafyllidi H Tzortzis S Lekakis J | 2010 | Am J Hypertens2010，23，12： | 1 |
| 20 | Pulse pressure in normotensives: a make of cardiovarscular disease 显示文摘 | Zakopoulos NA Lekakis JP Papamichael CM | 2011 | Am J Hypertens2011，14，3： | 1 |
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