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| 1 | Revisiting the origin of modern humans in China and its implications for global human evolution显示文摘The debates over the origin of modern humans have long been centered on two competing theories:the 'Out-of-Africa'(single-place origin) theory and the 'Multi-regional Evolution' theory.China is an extremely important region where many ancient human fossils were collected along with numerous associated faunal remains and artefacts.These cultural remains,unearthed from different areas in the country and covering a long time span,will help clarify the controversy.The study of cultural materials in China is expected to shed important light on biological evolutionary patterns and social and technical developments of those early humans as well as their environmental conditions.Based on the analysis of Chinese fossils and associated materials,in conjunction with some genetic studies,this paper aims at evaluating each of the two theories in order to stimulate more discussions.Our study suggests that the evolutionary model of 'Continuity with Hybridization' is most relevant in reflecting the current understanding of human evolutionary history in China.Furthermore,we propose that the concept of regional diversity of evolutionary models should be seriously considered to illustrate different evolutionary modes applied to different parts of the world. | GAO Xing1,2*,ZHANG XiaoLing1,2,3,YANG DongYa2,4,SHEN Chen2,5 & WU XinZhi1,2 1 Institute of Vertebrate Paleontology and Paleoanthropology,Chinese Academy of Sciences,Beijing 100044,China 2 Laboratory of Human Evolution,Chinese Academy of Sciences,Beijing 100044,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 4 Department of Archaeology,Simon Fraser University,Vancouver V5A 1S6,Canada 5 The Royal Ontario Museum,Toronto M5S 2C6,Canada | 2010 | Science China Earth Sciences2010，53，12： | 11 |
| 2 | Why 90%of clinical drug development fails and how to improve it?显示文摘Ninety percent of clinical drug development fails despite implementation of many successful strategies,which raised the question whether certain aspects in target validation and drug optimization are overlooked?Current drug optimization overly emphasizes potency/specificity using structure-activityrelationship(SAR)but overlooks tissue exposure/selectivity in disease/normal tissues using structure-tissue exposure/selectivity—relationship(STR),which may mislead the drug candidate selection and impact the balance of clinical dose/efficacy/toxicity.We propose structure-tissue exposure/selectivity—activity relationship(STAR)to improve drug optimization,which classifies drug candidates based on drug’s potency/selectivity,tissue exposure/selectivity,and required dose for balancing clinical efficacy/toxicity.ClassⅠdrugs have high specificity/potency and high tissue exposure/selectivity,which needs low dose to achieve superior clinical efficacy/safety with high success rate.ClassⅡdrugs have high specificity/potency and low tissue exposure/selectivity,which requires high dose to achieve clinical efficacy with high toxicity and needs to be cautiously evaluated.ClassⅢdrugs have relatively low(adequate)specificity/potency but high tissue exposure/selectivity,which requires low dose to achieve clinical efficacy with manageable toxicity but are often overlooked.ClassⅣdrugs have low specificity/potency and low tissue exposure/selectivity,which achieves inadequate efficacy/safety,and should be terminated early.STAR may improve drug optimization and clinical studies for the success of clinical drug development. | Duxin Sun Wei Gao Hongxiang Hu Simon Zhou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
| 3 | Decomposition Methods for Manufacturing System Scheduling:A Survey显示文摘Manufacturing is the application of labor, tools,machines, chemical and biological processing, to an original raw material by changing its physical and geometrical characteristics, in order to make finished products. Since the first industrial revolution, to accommodate the large-scale production,tremendous changes have happened to manufacturing through the innovations of technology, organization, management, transportation and communication. This work first reviews the highvolume low-mix process by focusing on the quantity production,transfer line and single model assembly line. Then, it reviews the high-volume high-mix process. For such a process type,mixed/multi model assembly line is usually adopted. Hence,two main decisions on them, i.e., balancing and, sequencing are reviewed. Thereafter, it discusses the low-volume high-mix process in detail. Then, technology gap and future work is discussed, and at last, conclusions are given. | Fajun Yang Kaizhou Gao Ian Ware Simon Yuting Zhu Rong Su | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 3 |
| 4 | Geochronology of the Mesozoic volcanic rocks in the Great Xing’an Range, northeastern China: Implications for subduction-induced delamination显示文摘 | Ji-Heng Zhang Shan Gao Wen-Chun Ge Fu-Yuan Wu Jin-Hui Yang Simon A. Wilde Ming Li | 2010 | Chemical Geology2010，，3： | 2 |
| 5 | DNA repair and synthetic lethality显示文摘Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach, which may lead to new therapeutic strategies. It is well known that poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitors show the synthetically lethal effect in tumors defective in BRCA1 or BRCA2 genes encoded proteins that are required for efficient HR. In this review, we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells. | Gong-she Guo Feng-mei Zhang Rui-jie Gao Robert Delsite Zhi-hui Feng Simon N. Powell | 2011 | International Journal of Oral Science2011，3，4： | 2 |
| 6 | Molecular screening for GS2lipase regula-tors:inhibition of keratinocyte retinylester hydrolysis by TIP47显示文摘 | Gao J G Simon M | 2006 | J Invest Dermatol2006，126，9： | 1 |
| 7 | The reaction kinetics of cyclopentadiene dimerization using differential scanning calorimetry: Experiments and modelling显示文摘 | Siyang Gao Sindee L. Simon | 2014 | Thermochimica Acta2014，，： | 1 |
| 8 | Increased delivery of TAT across an endothelial monolayer following ischemic injury 显示文摘 | Simon M J Kang WH Gao S | 2010 | Neurosei Lett2010，486，： | 1 |
| 9 | The Determinants of the Demand for Life Insurance in An Emerging Economy-the Case of China 显示文摘 | Hwang Tienyu Gao Simon | 2003 | Managerial Fi- nance2003，，29： | 1 |
| 10 | Prospective study of statin use and risk of Parkinson disease显示文摘 | GAO X SIMON KC SCHWARZSCHILD MA | 2012 | Arch Neu- rol2012，69，3： | 1 |
| 11 | Up-regulation of TNF-producing T cells in the bone marrow:s key mechanism by which estfigen deficiency induces bone loss in vivo显示文摘 | Cristiana Roggia Yuhao Gao Simone Cenci | | 0，，： | 1 |
| 12 | A plasmid display platform for the selection of peptides exhibiting a functional cell-penetrat- ing phenotype 显示文摘 | Gao S Simon M J Morrison B | 2010 | Biotechnol Prog2010，26，6： | 1 |
| 13 | Antioxidants maintain Ecadherin levels to limit Drosophila prohemocyte differentiation 显示文摘 | Gao H Wu X Simon L | 2014 | PLoSOne2014，16，10： | 1 |
| 14 | An unusual cell penetrat- ing peptide identified using a plasmid display-based functional selection platform显示文摘 | GAO S SIMON MJ HUE CD | 2011 | ACS Chem Biol2011，6，5： | 1 |
| 15 | CD39/ENTPD1 Expression by CD4 + Foxp3 + Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice显示文摘 | Xiaofeng Sun Yan Wu Wenda Gao Keiichi Enjyoji Eva Csizmadia Christa E. Müller Takashi Murakami Simon C. Robson | 2010 | Gastroenterology2010，，3： | 1 |
| 16 | Yanhusuo extract inhibits metastasis of breast cancer cells by modulatingmitogen-activated protein kinase signaling pathways显示文摘 | Jian-Li Gao Jun-Min Shi Kai He Qing-Wen Zhang Shao-Ping Li Simon Lee Yi-Tao Wang | 2008 | Oncology Reports2008，，4： | 1 |
| 17 | Two Characteristic Regimes in Frequency-Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates显示文摘 | Simon Jungbauer Huajian Gao Joachim P. Spatz Ralf Kemkemer | 2008 | Biophysical Journal2008，，： | 1 |
| 18 | Prospective study ofstatin use and risk of Parkinson disease 显示文摘 | Gao X Simon KC Schwarzschild MA | 2012 | Arch Neurol2012，693，： | 1 |
| 19 | Tribological Characteristicsand Surface Interaction Between Piston ring Coatings and a Bend of Energy-conserving Oils and Ethanol Fu- els显示文摘 | Simon C Tung Hong Gao | 2003 | Wear2003，255，： | 1 |
| 20 | Registration of 3D trans-esophageal echocardiography to X-ray fluoroscopy using image-based probe tracking显示文摘 | Gang Gao Graeme Penney Yingliang Ma Nicolas Gogin Pascal Cathier Aruna Arujuna Geraint Morton Dennis Caulfield Jaswinder Gill C. Aldo Rinaldi Jane Hancock Simon Redwood Martyn Thomas Reza Razavi Geert Gijsbers Kawal Rhode | 2011 | Medical Image Analysis2011，，1： | 1 |
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