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137篇 您的检索式:作者名="SIMON MJ"
    题名 作者 年代 出处 被引量
1使用cDNA微阵列和组织微阵列对三种上皮性卵巢肿瘤基因表达的分析显示文摘背景与目的卵巢癌是在妇科恶性肿瘤中死亡率最高的肿瘤,主要原因是由于缺乏有效的早期诊断方法。为了发现新的、特异性癌基因和进一步探索上皮性卵巢癌的临床意义,本文探索出一种新方法,通过结合cDNA微阵列和RNA原位杂交冰冻组织微阵列的方法寻找特异性卵巢癌基因。方法利用cDNA微阵列筛选在3种不同卵巢癌中(卵巢浆液性交界性肿瘤、卵巢浆液性腺癌和卵巢子宫内膜样腺癌)显示有意义表达的基因,并由RNA原位杂交冰冻组织微阵列证实其结果。结果40个基因和ESTs显示出在卵巢浆液性交界性肿瘤、浆液性和子宫内膜样卵巢癌3种类型之间基因表达有明显的差异;EPHB6、PTPRF、GFER、ERG25、PLRP1,FLJ22060和WISP2被进一步用于RNA原位杂交冰冻组织微阵列研究,其结果与cDNA微阵列研究结果相符合。结论cDNA微阵列和RNA原位杂交冰冻组织微阵列相结合是一种理想的寻找癌相关基因的方法,EPHB6,PTPRF,GFER,ERG25,PLRP1,FLJ22060和WISP2有可能成为新的上皮性卵巢癌候选基因。郑敏 Simon R Kononen J Sauter G Mihatsch MJ Moch H 2004癌症2004,23,7:8
2Levamisole and lymphocyte responsiveness 显示文摘Chan SH Simons MJ 1975Lancet1975,1,:1
3Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL 2010Hepatology2010,52,2:1
4Assess mentof left ventricular funcition by the midwall frational short-ening/end systolic stress relation in human hypertension显示文摘De simone G Deverex RB Roman MJ 1994JACC1994,23,:1
5Preliminary indication of sur- vival benefit from ERCC1 and RRM1 - tailored chemotherapy in pa- tients with advanced nonsmall cell lung cancer: Evidence from an in- dividual patient analysis显示文摘Simon GR Schell MJ Begum M 2012cancer2012,118,9:1
6Cardiac markers of pre- clinical disease in adolescents with the metabolic syndrome: the strong heart study显示文摘Chinali M de Simone G Roman MJ 2008JACC2008,52,11:1
7Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass 显示文摘Palmieri V de Simone G Roman MJ 1999Hypertension1999,34,5:1
8Status epilepticus:Causes,clinical features and consequences in 98 patients显示文摘Aminoff MJ Simon RP 1980Am J Med1980,69,:1
9A randomised controlled trial comparing three analgesia regimens following total knee joint replacement:continuous femoral nerve block,intrathecal morphine or both显示文摘Olive DJ Barrington MJ Simone SA 2015Anaesth Intensive Care2015,43,4:1
10Cardiovascular and metabolic predictors of progression of prehypertension into hypertension:the Strong Heart Study显示文摘De Marco M de Simone G Roman MJ 2009Hypertension2009,54,:1
11Hypothermic blood substitution enables resuscitation after hemorrhagic shock and 2 hours of cardiac arrest显示文摘Simon D Taylox MJ Elrifai AM 1995ASAIO J1995,41,3:1
12Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention显示文摘Simon KW Roberts PC Vespremi MJ 2009Mol Nutr Food Res2009,53,3:1
13Assessment of leftventricular function by the midwall fractional shortening/end -systolic stress relation in human hypertension显示文摘de Simone G* Devereux RB Roman MJ 1994J Am Coll Car-diol1994,23,:1
14Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels 显示文摘Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL 2010Hepatology2010,52,2:1
15Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation显示文摘MODI NB DRESSER MJ SIMON M 2006J Clin Pharmacol2006,46,3:1
16Method for quantifying the fate of petroleum in the environment显示文摘Mills MA McDonald MJ Bonner JS Simon MA Autenrieth RL 1999Chemosphere1999,39,14:1
17Gitelman variant ofBartter's syndrome,inherited hypokalaemic alkalosis,is caused by mutations in the thiazide-sensitive Na-Cl cotransporter显示文摘Simon DB Nelson WC Bia MJ 1996Nat Genet1996,12,1:1
18Assessment of feft ventricular function by the midwall fractional shortening/end- systolic sress relation in human hypertension显示文摘de Simone G Devereux RB Roman MJ 1994J Am Coll Cardiol1994,23,6:1
19Cardiovascular and metabolic predictors of pro- gression of prehypertension into hypertension: the Strong Heart Study 显示文摘De Marco M de Simone G Roman MJ 2009Hypertension2009,54,5:1
20Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder显示文摘Simon NM Pollack MH Ostacher MJ 2007Journal of Affective Disorders2007,97,13:1
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