|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis显示文摘 | Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge | 2017 | Molecular Plant2017，10，10： | 15 |
| 3 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 4 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 12 |
| 5 | 英国国家免疫细胞化学外部质量评估方案及其乳腺病理应用模式显示文摘免疫细胞化学的外部质量评估方案是1985年由Mount Veron医院的Gerry Reynolds提出并建立.其目的不仅在于独立地评估免疫组织化学染色质量,同时也帮助实验室发展和改进免疫细胞化学技术. | 魏兵 步宏 Anthony Rhodes 张红英 | 2004 | 中华病理学杂志2004，33，4： | 10 |
| 6 | Is there a role for serum endothelin in predicting the severity of acute pancreatitis?显示文摘BACKGROUND: Acute pancreatitis remains a common presentation to acute surgical units and carries significant morbidity and mortality. The progression of the disease to necrotizing pancreatitis and multi-organ dysfunction syndrome (MODS) is associated with a very poor clinical outcome, and persistendy high mortality. Increases in serum endothelin (ET) have been seen in animal models of acute pancreatitis and this study aims to investigate whether there is a change in serum ET-1 in patients with acute pancreatitis and whether any such change is linked to disease severity. METHODS: All patients admitted with acute pancreatitis were prospectively recruited from die emergency admissions at the Norfolk and Norwich University Hospital. Serum ET levels were determined on admission, at 24 hours and 5 days post admission. Healthy adult controls were recruited from dermatology outpatients. RESULTS: A total of 21 patients joined the trial after giving informed consent. There were 3 men and 18 women with a median age of 65 years (range 26-87 years). Serum ET levels were significantly higher in acute pancreatitis patients than in normal controls (P <0. 05). An association was seen between persistendy raised serum ET levels and progression to MODS. CONCLUSIONS: The study does demonstrate a correlation between the circulating levels of ET and acute pancreatitis in humans, although it does not elicit its involvement in the pathogenesis of the disease. The observation that a persistendy high level of circulating ET-1 is associated with progression to MODS may indicate a role for ET in the monitoring of acute pancreatitis patients for recovery or progression to MODS. | John Bennett David Cooper Anita Balakrishnan Michael Rhodes Michael Lewis | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 8 |
| 7 | 一种毁灭性的西瓜新病害——细菌性果实腐斑病显示文摘1989年夏季在美国东南沿海各州的许多商品西瓜生产田均发生了细菌性果实腐斑病(Bacteril Fruit Blotch),成百公顷的瓜田里完好的商品瓜寥寥无几,造成毁灭性的危害。最近在澳大利亚和马利亚纳群岛也报道有这种病害的发生。 | 张兴平 Billy B. Rhodes | 1990 | 中国西瓜甜瓜1990，，2： | 8 |
| 8 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012显示文摘 | R. P. Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek | 2013 | Intensive Care Medicine2013，，2： | 7 |
| 9 | Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction显示文摘AIM To comprehensively evaluate mitochondrial(dys) function in preclinical models of nonalcoholic steatohepatitis(NASH).METHODS We utilized two readily available mouse models of nonalcoholic fatty liver disease(NAFLD) with or without progressive fibrosis: Lep^(ob)/Lep^(ob)(ob/ob) and FATZO mice on high trans-fat, high fructose and high cholesterol(AMLN) diet. Presence of NASH was assessed using immunohistochemical and pathological techniques, and gene expression profiling. Morphological features of mitochondria were assessed via transmission electron microscopy and immunofluorescence, and function was assessed by measuring oxidative capacity in primary hepatocytes, and respiratory control and proton leak in isolated mitochondria. Oxidative stress was measured by assessing activity and/or expression levels of Nrf1, Sod1, Sod2, catalase and 8-OHdG. RESULTS When challenged with AMLN diet for 12 wk, ob/ob and FATZO mice developed steatohepatitis in the presence of obesity and hyperinsulinemia. NASH development was associated with hepatic mitochondrial abnormalities, similar to those previously observed in humans, including mitochondrial accumulation and increased proton leak. AMLN diet also resulted in increased numbers of fragmented mitochondria in both strains of mice. Despite similar mitochondrial phenotypes, we found that ob/ob mice developed more advanced hepatic fibrosis. Activity of superoxide dismutase(SOD) was increased in ob/ob AMLN mice, whereas FATZO mice displayed increased catalase activity, irrespective of diet. Furthermore, 8-OHd G, a marker of oxidative DNA damage, was significantly increased in ob/ob AMLN mice compared to FATZO AMLN mice. Therefore, antioxidant capacity reflected as the ratio of catalase:SOD activity was similar between FATZO and C57 BL6 J control mice, but significantly perturbed in ob/ob mice. CONCLUSION Oxidative stress, and/or the capacity to compensate for increased oxidative stress, in the setting of mitochondrial dysfunction, is a key factor for development of hepatic injury and fibrosis in these mouse models. | Michelle L Boland Stephanie Oldham Brandon B Boland Sarah Will Jean-Martin Lapointe Silvia Guionaud Christopher J Rhodes James L Trevaskis | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 10 | 用于褐煤锅炉沾污控制的积灰监测系统显示文摘 | Rhodes,E 王学军 | 1991 | 热力发电译丛1991，，5： | 6 |
| 11 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 12 | 差示扫描量热法用于不同类型药物的纯度分析显示文摘本文应用差示扫描量热法对11种不同类型药物的纯度进行了分析测定。着重探讨了实验条件的选择及的限制等技术关键点。 | 张伟 赵明 Myron Rhodes | 1993 | 中国药学杂志1993，28，10： | 5 |
| 13 | 创伤后2-氧-4-羧噻唑烷增强谷胱甘肽浓度的研究显示文摘目的探讨创伤时给予外源性左旋 - 2 -氧 - 4-羧噻唑烷 (OTZ)以增加机体谷胱甘肽 (GSH)合成的可能性 ,同时利用OTZ检测GSH的水平。 方法 7只实验兔创伤前后测定机体静息能耗 (REE) ;经颈静脉导管注入稳定同位素标记的13 C -OTZ后 ,在 12 0min内采集多个时段的血及呼出气体标本以测定血OTZ浓度及13 CO2 呼出速度 ;根据13 CO2 呼出速度曲线 ,计算出13 CO2 呼出的总量。 结果创伤前后REE分别为 2 0 5 99± 2 6 5 8J·kg-1·d-1,2 6 0 46± 45 98J·kg-1·d-1,创伤后明显增加 ;创伤后血13 C -OTZ浓度持续下降 ,尤以创伤后 30min内下降更为显著 ;创伤后 12 0min内13 CO2 呼出总量为 2 5 986 86 μmol/kg ,创伤前为 2 115 9 5 5 μmol/kg ,创伤后明显增多。 结论创伤时机体对半胱氨酸需求明显增加 ;外源性OTZ可能是创伤后补充半胱氨酸的一个重要来源 ;稳定同位素标记的13 C -OTZ可作为创伤前后GSH水平评估的检测手段。 | 费哲为 Andrew Rhodes 尤永明 | 2002 | 上海第二医科大学学报2002，22，1： | 4 |
| 14 | Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)显示文摘 | B. Habermalz S. Sauerland G. Decker B. Delaitre J.-F. Gigot E. Leandros K. Lechner M. Rhodes G. Silecchia A. Szold E. Targarona P. Torelli E. Neugebauer | 2008 | Surgical Endoscopy2008，，4： | 3 |
| 15 | Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure: Prognostic Value of Heart Rate Variability Measured by an Implanted Cardiac Resynchronization Device显示文摘 | Philip B. Adamson Andrew L. Smith William T. Abraham Karen J. Kleckner Robert W. Stadler Alex Shih Melissa M. Rhodes | 2004 | Circulation2004，，16： | 3 |
| 16 | Robotic Intra-Operative Ultrasound:Virtual Environments and Parallel Systems显示文摘Robotic intra-operative ultrasound has the potential to improve the conventional practice of diagnosis and procedure guidance that are currently performed manually.Working towards automatic or semi-automatic ultrasound,being able to define ultrasound views and the corresponding probe poses via intelligent approaches become crucial.Based on the concept of parallel system which incorporates the ingredients of artificial systems,computational experiments,and parallel execution,this paper utilized a recent developed robotic trans-esophageal ultrasound system as the study object to explore the method for developing the corresponding virtual environments and present the potential applications of such systems.The proposed virtual system includes the use of 3 D slicer as the main workspace and graphic user interface(GUI),Matlab engine to provide robotic control algorithms and customized functions,and PLUS(Public software Library for Ultra Sound imaging research)toolkit to generate simulated ultrasound images.Detailed implementation methods were presented and the proposed features of the system were explained.Based on this virtual system,example uses and case studies were presented to demonstrate its capabilities when used together with the physical TEE robot.This includes standard view definition and customized view optimization for pre-planning and navigation,as well as robotic control algorithm evaluations to facilitate real-time automatic probe pose adjustments.To conclude,the proposed virtual system would be a powerful tool to facilitate the further developments and clinical uses of the robotic intra-operative ultrasound systems. | Shuangyi Wang James Housden Tianxiang Bai Hongbin Liu Junghwan Back Davinder Singh Kawal Rhode Zeng-Guang Hou Fei-Yue Wang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，5： | 3 |
| 17 | Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants显示文摘The 1,4-naphthoquinones(1,4-NQs)are a diverse group of natural products found in every kingdom of life.Plants,including many horticultural species,collectively synthesize hundreds of specialized 1,4-NQs with ecological roles in plant–plant(allelopathy),plant–insect and plant–microbe interactions.Numerous horticultural plants producing 1,4-NQs have also served as sources of traditional medicines for hundreds of years.As a result,horticultural species have been at the forefront of many basic studies conducted to understand the metabolism and function of specialized plant 1,4-NQs.Several 1,4-NQ natural products derived from horticultural plants have also emerged as promising scaffolds for developing new drugs.In this review,the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.An overview on the biochemical mechanisms of action,both from an ecological and pharmacological perspective,of 1,4-NQs derived from horticultural plants is also provided.In addition,future directions for improving basic knowledge about plant 1,4-NQ metabolism are discussed. | Joshua R Widhalm David Rhodes | 2016 | Horticulture Research2016，3，1： | 3 |
| 18 | The mechanism of enzyme in the collagen extracting 显示文摘 | MILLER E J RHODES R K | 1982 | Methods in enzymology1982，82，： | 2 |
| 19 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 20 | 印度洋-太平洋海洋生态系统的占有:活礁鱼食品贸易的实例研究显示文摘我们对珊瑚礁渔业,特别是活礁鱼食品贸易(FT)的生态足迹的分析表明,许多国家目前的消费量超过了估计的可持续的人均全球、地区及地方珊瑚礁生产水平。香港通过其FT需求占有了东南亚年礁鱼生产量135260~286560t的25%,超过地区生物生产力8.3倍;礁鱼渔业需求超过印度洋-太平洋和东南亚地区可持续产量2.5~6倍。相比之下,大多数太平洋岛屿靠本身的礁渔业手段维持生计,当地的需求小于大洋洲整个能力的20%。FT每年需要多达40%东南亚的估计礁鱼产量以及几乎所有其估计的鮨科鱼产量。我们的研究分析结果强调了FT的不可持续性以及对印度洋-太平洋珊瑚礁渔业加以区域管理和保护的迫切必要性。 | KimberleyWarren—Rhodes YvonneSadovy HermanCesar 林宝法 胡恩和 | 2003 | AMBIO-人类环境杂志2003，32，7： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员