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| 1 | Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice显示文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice. | Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang Wendong Huang Li Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 2 | Bile acid signaling and bariatric surgery显示文摘The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications.Bariatric surgical procedures,such as Roux-en-Y gastric bypass(RYGB)and vertical sleeve gastrectomy(VSG),currently provide the most effective treatment for obesity and type 2 diabetes(T2D),as well as for non-alcoholic steatohepatitis(NASH).However,the underlying mechanisms of the beneficial effects of bariatric surgery remain elusive.Recent studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric surgery.This review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor(FXR)and G protein-coupled bile acid receptor 5(TGR5)in bariatric surgery.We also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications. | Jingyan Tian Silvia Huang Siming Sun Lili Ding Eryun Zhang Yanjun Liu Wendong Huang | 2017 | Liver Research2017，1，4： | 2 |
| 3 | Precipitation study of CO2-loaded glycinate solution with the introduction of ethanol as an antisolvent显示文摘Focused beam reflectance measurement(FBRM)and 13C nuclear magnetic resonance(13C NMR)analysis were used to study the precipitation process of CO2-loaded potassium glycinate(KGLY)solutions at different CO2 loadings,during the addition of ethanol as an antisolvent at a rate of 10 mL·min−1.The volume ratio of ethanol added to the KGLY solution(3.0 mol·L−1,340 mL)ranged from 0 to 3.0.Three solid-liquid-liquid phases were formed during the precipitation process.The FBRM results showed that the number of particles formed increased with CO2 loading and ethanol addition for CO2-unsaturated KGLY solutions,whilst for CO2-saturated KGLY solution it first increased then decreased to a stable value with ethanol addition.13C NMR spectroscopic analysis showed that the crystals precipitated from the CO2-unsaturated KGLY solutions consisted of glycine only,and the quantity crystallised increased with CO2 loading and ethanol addition.However,a complex mixture containing glycine,carbamate and potassium bicarbonate was precipitated from CO2-saturated KGLY solution with the maximum precipitation percentages of 94.3%,31.4%and 89.6%,respectively,at the ethanol volume fractions of 1.6,2.5 and 2.3. | Siming Chen Yue Wu Geoffrey WStevens Guoping Hu Wenshou Sun Kathryn AMumford | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 1 |
| 4 | Chimeric anti-IL-17 full-length monoclonal antibody is a novel potentialcandidate for the treatment of rheumatoid arthritis显示文摘 | Fuliang Bai Hui Tian Zeshan Niu Mingyao Liu Guiping Ren Yinhang Yu Tian Sun Siming Li Deshan Li | 2014 | International Journal of Molecular Medicine2014，，3： | 1 |
| 5 | Effects and mechanism of modified starches on the gel properties of myofibrillar protein from grass carp显示文摘 | Fengyuan Sun Qilin Huang Ting Hu Shanbai Xiong Siming Zhao | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 6 | Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis显示文摘 | Wen Cai Zhang Ng Shyh-Chang He Yang Amit Rai Shivshankar Umashankar Siming Ma Boon Seng Soh Li Li Sun Bee Choo Tai Min En Nga Kishore Kumar Bhakoo Senthil Raja Jayapal Massimo Nichane Qiang Yu Dokeu A. Ahmed Christie Tan Wong Poo Sing John Tam Agasthian T | 2012 | Cell2012，，1： | 1 |
| 7 | Status and Progress on an HTS Strand with Quasi-isotropic Critical Current显示文摘The coated conductors(CCs),also known as the second-generation high-temperature superconducting(2G HTS)tape,has attractive potential applications in transmissions at low magnetic field/liquid nitrogen temperatures and high-field applications at low temperatures due to their excellent critical current density and mechanical performance.Its critical current density has strong anisotropy,particularly at 77 K.Because the single tape has limited capacity of carrying current,the cable or strand making of multi-tapes,stacked in parallel,is necessary.Within recent years,several cables,such as the Roebel cable,CORC cable,TSTC cable,TS cable,and the HTSCroCo cable,were proposed.This paper presents a status and progress on a type of HTS strand made from REBCO tapes.Its quasi-isotropic critical current is experimentally confirmed for liquid nitrogen temperature,mechanical characteristics,AC losses,thermal stability,and quench characterizations are also researched.Finally,the feasible process for the production of practical length of such strand is described by processing 10 m long sample,which is promising for applications of high fields or power transmission. | Jian Du Jianlong Sun Yang Nie Siming Mo Yuan Cai Huijuan Chen Wen Yuan Yinshun Wang | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 0 |
| 8 | A learning-based approach for efficient visualization construction显示文摘We propose an approach to underpin interactive visual exploration of large data volumes by training Learned Visualization Index(LVI).Knowing in advance the data,the aggregation functions that are used for visualization,the visual encoding,and available interactive operations for data selection,LVI allows to avoid time-consuming data retrieval and processing of raw data in response to user’s interactions.Instead,LVI directly predicts aggregates of interest for the user’s data selection.We demonstrate the efficiency of the proposed approach in application to two use cases of spatio-temporal data at different scales. | Yongjian Sun Jie Li Siming Chen Gennady Andrienko Natalia Andrienko Kang Zhang | 2022 | Visual Informatics2022，6，1： | 0 |
| 9 | Room-temperature continuous-wave topological Dirac-vortex microcavity lasers on silicon显示文摘Robust laser sources are a fundamental building block for contemporary information technologies.Originating from condensed-matter physics,the concept of topology has recently entered the realm of optics,offering fundamentally new design principles for lasers with enhanced robustness.In analogy to the well-known Majorana fermions in topological superconductors,Dirac-vortex states have recently been investigated in passive photonic systems and are now considered as a promising candidate for robust lasers.Here,we experimentally realize the topological Diracvortex microcavity lasers in InAs/InGaAs quantum-dot materials monolithically grown on a silicon substrate.We observe room-temperature continuous-wave linearly polarized vertical laser emission at a telecom wavelength.We confirm that the wavelength of the Dirac-vortex laser is topologically robust against variations in the cavity size,and its free spectral range defies the universal inverse scaling law with the cavity size.These lasers will play an important role in CMOS-compatible photonic and optoelectronic systems on a chip. | Jingwen Ma Taojie Zhou Mingchu Tang Haochuan Li Zhan Zhang Xiang Xi Mickael Martin Thierry Baron Huiyun Liu Zhaoyu Zhang Siming Chen Xiankai Sun | 2023 | Light(Science & Applications)2023，12，11： | 0 |
| 10 | Solid Pseudopapillary Tumor of the Pancreas:a Case Report显示文摘Case Report Solid pseudopapillary tumors(SPT)of the pancreas are considered to be a rare low-grade malignancy that mainly appears in young women.It accounts for less than 1%of all pancreatic neoplasms and is pathologically distinctive from other types of pancreatic cancers.Curative resection is the optimal choice for SPT and the 5-year survival rate of SPT is about 95%.Here we report a case of a young girl who presented with this rare pancreatic tumor. | Hongqun Zheng Qifan Zhang Beiqiu Han Lingyu Sun Siming Wang Yan Liu Ming Liu | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 0 |
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