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| 1 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 2 | Progress in neural plasticity显示文摘One of the properties of the nervous system is the use-dependent plasticity of neural circuits.The structure and function of neural circuits are susceptible to changes induced by prior neuronal activity,as reflected by short-and long-term modifications of synaptic efficacy and neuronal excitability.Regarded as the most attractive cellular mechanism underlying higher cognitive functions such as learning and memory,activity-dependent synaptic plasticity has been in the spotlight of modern neuroscience since 1973 when activity-induced long-term potentiation(LTP) of hippocampal synapses was first discovered.Over the last 10 years,Chinese neuroscientists have made notable contributions to the study of the cellular and molecular mechanisms of synaptic plasticity,as well as of the plasticity beyond synapses,including activity-dependent changes in intrinsic neuronal excitability,dendritic integration functions,neuron-glia signaling,and neural network activity.This work highlight some of these significant findings. | POO Mu-Ming | 2010 | Science China(Life Sciences)2010，53，3： | 21 |
| 3 | rK39免疫层析试条在新疆黑热病诊断和流行病学调查中的应用显示文摘目的观察rK39免疫层析试条对新疆不同类型黑热病的诊断及流行病学调查中的应用价值。方法用rK39试条检查不同地区确诊的黑热病患者;用rK39-ELISA和rK39免疫层析试条检查不同流行地区居民血清标本与利什曼素皮内反应结果进行比较分析。结果对来自新疆不同地区的黑热病患者共1204例,用rK39试条检测抗体阳性者1169例,阳性率97.09%。其中人源型黑热病患者1052例中1031例阳性,阳性率98.0%;荒漠型黑热病患者158例中阳性143例,阳性率90.5%。二者之间差异显著(P<0.001),荒漠型患者阳性率较低。人源型黑热病流行区居民中rK39抗体阳性率在既往有黑热病史者中为42.7%~59.3%,在无既往史的居民中仅为2.2%~5.8%。在随访的rK39阳性,皮内反应阴性的18人中有4人在4和6个月后出现症状,确诊为黑热病。在黑热病治愈后2年内94.6%的患者rK39抗体仍为阳性。9年后仍有82.5%保持阳性。结论rK39层析试条对新疆黑热病患者有很高的诊断价值。其保存、携带方便,操作简单适于在基层现场使用。由于其可在潜伏期中发现黑热病患者。故可用于在流行地区皮内反应阴性的居民中进行免疫学检测,早期发现病人。由于黑热病患者治愈后血清中rK39抗体长期存在,故不适用于预后判定和疗效评价。 | 左新平 伊马木 开赛尔 张松 焦伟 瞿靖琦 Kwang Poo Chang 柴君杰 | 2007 | 热带病与寄生虫学2007，5，1： | 15 |
| 4 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 5 | Whereto the mega brain projects?显示文摘The mega brain projects announced by the US President and European Commission in2013 ofer new initiatives for developing innovative neurotechnology,but the prospect of efective therapies for brain disease remains uncertain.In his 2013 State of the Union address President Obama of the United States shook the global neuroscience community by announcing a 10-year,3 billion dollar project,the‘Brain Activity Map’,that aims to‘image every | Mu-ming Poo | 2014 | National Science Review2014，1，1： | 9 |
| 6 | Towards brain-inspired artificial intelligence显示文摘A wave of artificial intelligence (AI) has swept across the globe.The World Artificial Intelligence Conference 2018, held in Shanghai this September, drew thousands of participants from 40 countries and regions. | Mu-ming Poo | 2018 | National Science Review2018，5，6： | 5 |
| 7 | Neuroscience in China 2000-2009:Introduction显示文摘The year 2009 marks the tenth anniversary of the founding of Institute of Neuroscience (ION) in the Shanghai campus of Chinese Academy of Sciences. | POO Mu-Ming | 2010 | Science China(Life Sciences)2010，53，3： | 5 |
| 8 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 9 | Moral imperative for immediate release of 2019-nCoV sequence data显示文摘Only two weeks ago,when the COVID-19 outbreak caused by the novel coronavirus,SARS-CoV-2(previously named 2019-nCoV),started to look dangerous nationwide,we published an editorial in this space urging the instant posting of the population genomic data of the viruses[1].Because these data are of grave signifcance to global human health,such an urgent call is justifed and has been repeated elsewhere[2].To our disappointment,the rate of releasing such data seems to have slowed down,when the need for them has become more acute. | Chung-I Wu Mu-ming Poo | 2020 | National Science Review2020，7，4： | 4 |
| 10 | Mars exploration on the move显示文摘While the world is still struggling to overcome the COVID-19 pandemic,a new round of Mars exploration proceeded as planned,catching the July-August 2020 window of Earth-Mars close proximity that occurs once every 26 months.The excitement began with United Arab Emirates'launch of the Hope orbiter on 19 July,followed by China's launch of the Tianwen l(天问一号)explorer on 23 July,and NASA's launch of the Perseverance rover on 30 July. | Mu-ming Poo | 2020 | National Science Review2020，7，9： | 3 |
| 11 | Lai Guolong,Excavating the Afterlife: The Archaeology of Early Chinese Religion.Seattle: University of Washington Press,2015显示文摘Lai Guolong’s book is a new attempt at understanding early Chinese religion by integrating archaeological, art historical, anthropological, philological, and historical methods. Lai has successfully demonstrated that careful rereading of artifacts and texts from excavations, as well as received texts, supported by balanced use of comparative materials from other cultures and anthropological and religious theories. | Mu-chou Poo | 2018 | 浙江大学艺术与考古研究2018，，1： | 2 |
| 12 | New light on the horizon of Alzheimer’s disease显示文摘The beginning of the year 2020 is marked by a groundbreaking event in drug development in China.A first-in-class drug for Alzheimer’s disease(AD),GV-971,received conditional approval by the China Food and Drug Administration for the Chinese market.China now has at least 10 million patients with diagnosed AD;afflicting almost one-third of the population aged 90-94 years.There is increasing demand for new AD drugs,as the societal burden caused by this devastating disease is becoming a major healthcare issue in all aging societies.This urgency is reflected by the conditional approval of the drug,a widely used method by drug regulatory agencies in advanced countries to expedite promising new medicines to the market and facilitate early patient access,before long-term assessment of the treatment is available. | Mu-ming Poo | 2020 | National Science Review2020，7，5： | 2 |
| 13 | Evaluation of Simple Performance Measures for Tuning SVM Hyperparameters 显示文摘 | Duan K Keerthi S S Poo A N | 2003 | Neurocomputing (S0925-2312)2003，51，1： | 1 |
| 14 | Postsynaptie target specificity of neurotrophin-induced presynaptic potentiation 显示文摘 | Schinder AF Beminger B Poo MM | 2000 | Neuron2000，25，1： | 1 |
| 15 | Adaptive iso-planar tool path generation for machining of free- form surfaces 显示文摘 | DING S MANNAN M A POO A N | 2003 | Computer-Aided Design2003，35，2： | 1 |
| 16 | Error Compensation in Machine Tools-A Review Part I: Geometric, Cutting-force Induced and Fixture-dependent Errors显示文摘 | Ramesh R Mannan M A Poo A N | 2000 | International Journal of Machine Tools & Manufacture2000，40，： | 1 |
| 17 | Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice显示文摘 | Lee J S Poo H Han D P | 2006 | J Virol2006，80，8： | 1 |
| 18 | FLAIR: flux line-segment model for advection and interface reconstruction显示文摘 | ASHGRIZ N POO J Y | 1991 | Journal of Computational Physics1991，93，2： | 1 |
| 19 | Calcium signalling in the guidance of nerve growth by netrin-1 显示文摘 | Hong K Nishiyama M Poo MM | 2000 | Nature2000，403，： | 1 |
| 20 | Error compensation in machine tools-a review: Part I: geometric, cutting-force induced and fixture-dependent errors 显示文摘 | Ramesh R Mannan M A Poo A N | 2000 | International Journal of Machine Tools and Manufacture2000，40，9： | 1 |
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