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| 1 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 2 | Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis显示文摘AIM: Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis, hypothesizing that DAB2 promoter hypermethylation-mediated gene silencing may account for loss of the protein. METHODS: DAB2 expression was analyzed by immunohistochemistry in 50 primary esophageal squamous cell carcinomas (ESCCs), 30 distinct hyperplasia, 15 dysplasia and 10 non-malignant esophageal tissues. To determine whether promoter hypermethylation contributes to loss of DAB2 expression in ESCCs, methylation status of DAB2 promoter was analyzed in DAB2 immuno-negative tumors using methylation-specifi c PCR. RESULTS: Loss of DAB2 protein was observed in 5/30 (17%) hyperplasia, 10/15 (67%) dysplasia and 34/50 (68%) ESCCs. Significant loss of DAB2 protein was observed from esophageal normal mucosa to hyperplasia, dysplasia and invasive cancer (Ptrend < 0.001). Promoter hypermethylation of DAB2 was observed in 2 of 10 (20%) DAB2 immuno-negative ESCCs. CONCLUSION: Loss of DAB2 protein expression occurs in early pre-neoplastic stages of development of esophageal cancer and is sustained down the tumorigenic pathway. Infrequent DAB2 promoter methylation in ESCCs suggests that epigenetic genesilencing is only one of the mechanisms causing loss of DAB2 expression in ESCCs. | Kumar Anupam Chatopadhyay Tusharkant Siddhartha Datta Gupta Ralhan Ranju | 2006 | World Journal of Gastroenterology2006，12，37： | 11 |
| 3 | Mineralogy and carbothermal reduction behaviour of vanadium-bearing titaniferous magnetite ore in Eastern India显示文摘Vanadium-bearing titaniferous magnetite bands hosted by Precambrian gabbro-norite-anorthositic rocks or their metamorphic equivalents were discovered in some parts of Eastern Indian Shield,containing 48%-49%Fe(total),10%-25%TiO2,and 0.3%-2.20%V2O5by mass.Mineralogical and petrological study,composition,and characterization of the vanadium-bearing titaniferous magnetite ore were carried out by scanning electron microscopy-energy dispersive X-ray(SEM-EDX),wave length X-ray florescence(WDXRF),inductively coupled plasma-atomic emission spectroscopy(ICP-AES),X-ray difraction(XRD),etc.Chemical beneficiation for valuable metals,such as Fe,Ti,and V,was performed by reduction roasting.The direct and indirect reduction were investigated by mixing the lump ore with solid activated charcoal in a closed reactor and purging the reducing gas mixture in standard reducibility index apparatus at diferent temperatures and time intervals.The reduction roasting parameters were optimized.Finally,the reduced samples were crushed and upgraded by magnetic separation.The results show that,the maximum mass fractions of magnetic and nonmagnetic parts achieved are 69.36%and 30.64%,respectively,which contain 10.6%TiO2and 0.84%V2O5in the magnetic part and 36.5%TiO2and 0.22%V2O5in the nonmagnetic part. | Saikat Samanta Manik Chandra Goswami Tapan Kumar Baidya Siddhartha Mukherjee Rajib Dey | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，10： | 9 |
| 4 | Differentiation of Crohn’s disease from intestinal tuberculosis in India in 2010显示文摘Differentiating intestinal tuberculosis from Crohn’s disease (CD) is an important clinical challenge of considerable therapeutic significance. The problem is of greatest magnitude in countries where tuberculosis continues to be highly prevalent, and where the incidence of CD is increasing. The final clinical diagnosis is based on a combination of the clinical history with endoscopic studies, culture and polymerase chain reaction for Mycobacterium tuberculosis, biopsy pathology, radiological investigations and response to therapy. In a subset of patients, surgery is required and intraoperative findings with pathological study of the resected bowel provide a definitive diagnosis. Awareness of the parameters useful in distinguishing these two disorders in each of the different diagnostic modalities is crucial to accurate decision making. Newer techniques, such as capsule endoscopy, small bowel enteroscopy and immunological assays for Mycobacterium tuberculosis, have a role to play in the differentiation of intestinal tuberculosis and CD. This review presents currently available evidence regarding the usefulness and limitations of all these different modalities available for the evaluation of these two disorders. | Anna Benjamin Pulimood Deepak Narayan Amarapurkar Ujjala Ghoshal Mathew Phillip Cannanore Ganesh Pai Duvvur Nageshwar Reddy Birender Nagi Balakrishna Siddhartha Ramakrishna | 2011 | World Journal of Gastroenterology2011，17，4： | 8 |
| 5 | Optimization by Estimation of Distribution with DEUM Framework Based on Markov Random Fields显示文摘这篇论文论述一个 Markov 随机的领域(MRF ) 估计和采样的途径在答案的人口的概率分发。途径被用来用 Markov 随机的领域(DEUM ) 在一般标题分发评价下面定义算法的一个班。因为一张未受指导的图和一个解决方案的联合概率作为分发从图的结构导出的吉布斯是 factorized, DEUM 是在解决方案变量之间的相互作用被代表的分发算法(EDA ) 的评价的一个子类。这篇论文的焦点将在描述 DEUM 框架的三个主要特征上,它把它与传统的 EDA 区分开来。他们是:1 ) MRF 模型,的使用 2 ) 估计模型的参数的健康建模途径并且 3 ) 从模型的采样的蒙特卡罗途径。分发算法的关键词评价 - 进化 algorthms - 健康建模 - Markov 随机的地 - 吉布斯分发 Siddhartha K。Shakya 从 Vladimir 州立大学在计算机工程收到了他的 B.E 和 M.E 度。俄国,在 1998 和 1999 分别地,并且 M.Sc。在来自萨西克斯郡的大学的聪明的系统的度。在 2002 的英国。他从罗伯特·格登大学在计算机科学收到了他的博士学位,阿伯丁,在 2006 的英国。当前,他是在在 BT 研究以内的聪明的系统研究中心的一个研究家伙。Ipswich,英国。在加入 BT 以前,他是在罗伯特·格登大学的计算的学校里的一个研究助手。特别地,他的研究兴趣包括优化算法的理论、实际的方面分发算法,概率的图形的模型和 Markov 随机领域,绘画图的算法,机器学习技术,生物信息学和运作的研究的进化算法和评价技术,例如收入管理和动态定价。他在计算智力是 IEEE 和 ACM 协会的一个成员。约翰·麦卡尔在阿伯丁的大学学习了纯数学,在他在 1991 在谎言组的稳定的 Homotopy 上完成了一个博士的地方。从那以后,他的研究兴趣通过当模特儿和优化到进化算法并且最近地演变, EDA 的强壮的焦点。他特别地对 Markov 随机的领域模型和他们的潜力感兴趣由从评估答案的样品为健康建模改进启发式的搜索。他也在进化算法的应用有强烈、忍受的兴趣到医疗优化,特别地癌症化疗,并且在这个区域广泛地出版了。另外的兴趣包括粒子群,蚂蚁殖民地和人工的免疫系统。McCall 当前是在在他领导计算智力研究组的罗伯特·格登大学的计算的一个高级讲师。 | Siddhartha Shakya John McCall | 2007 | International Journal of Automation and computing2007，4，3： | 5 |
| 6 | Label-free colorimetric estimation of proteins using nanoparticles of silver显示文摘Metallic nanoparticles have received considerable attention in bioassays and diagnostics due to their unique surface plasmon resonance(SPR) properties.Gold nanoparticles have been employed for the development of SPR-based colorimetric bioassays.In the present report we have described a sensitive colorimetric approach for estimation of proteins,within a detection limit of 10?80 μg/m L,using unmodified silver nanoparticles.Besides the common advantages of colorimetric assay such as simplicity,high sensitivity,and low cost,our method has a label-free design and provides an important and attractive alternative to classical sensing probes and systems.The present work will contribute to the development of nanotechnology-based diagnostic tools. | Siddhartha Shrivastava Debabrata Dash | 2010 | Nano-Micro Letters2010，2，3： | 5 |
| 7 | Intestinal barrier function and metabolic/liver diseases显示文摘Dietary,environmental or genetic changes contribute to the development of several metabolic and neurological diseases.Extensive research efforts have been directed towards examining how these fac-tors modulate gut bacterial composition.However,the mechanisms by which changes in gut bacterial diversity affect host function are not completely defined.Intestinal barrier dysfunction is being increasingly recognized as an early or initiating step in communicating bacterial diversity-dependent changes to the host.Here,we review the functional composition of the intestinal barrier and describe the consequences of the breach of this barrier.The functional layers of the intestinal barrier provide an initial defense and prevent the infiltration of bacteria or bacterial products from the gut lumen to the underlying lamina propria.Mesenteric lymph nodes subsequently act as the first firewall where dendritic cells from the lamina propria transport the infiltrated bacteria or bacterial products during the early stages of barrier dysfunction.When overwhelmed,the liver functions as the second firewall to detoxify bacterial endotoxins,such as lipopolysaccharide(LPS),and limit systemic involvement.Continuous translocation of LPS from the leaky gut to the liver results in liver damage or dysfunction that leads to the development of type 2 diabetes,atherosclerosis,heart disease,heart failure and also neurological dis-eases,such as Alzheimer’s and Parkinson’s disease.Thus,targeted restoration of intestinal barrier function represents a novel strategy for the attenuation of multiple diseases. | Siddhartha S.Ghosh Jing Wang Paul J.Yannie Shobha Ghosh | 2020 | Liver Research2020，4，2： | 4 |
| 8 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 9 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 10 | Effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair显示文摘Reconstituted type I collagen fibres have received considerable interest as tendon implant materials due to their chemical and structural similarity to the native tissue.Fibres produced through a semi-continuous extrusion process were cross-linked with different concentrations of the zerolength cross-linker 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC)in combination with N-hydroxysuccinimide(NHS).Tensile properties of the fibres were considered,along with imaging of both surface structure and fibrillar alignment.Resistance of the fibres to bacterial collagenase was investigated and fibre sections seeded with human tendon cells for biological characterization,including cell adhesion and proliferation.The work clearly demonstrated that whilst the concentration of EDC and NHS had no significant effect on the mechanics,a higher concentration was associated with higher collagenase resistance,but also provided a less attractive surface for cell adhesion and proliferation.A lower cross-linking concentration offered a more biocompatible material without reduction in mechanics and with a potentially more optimal degradability. | Zafar Ahmad Jennifer H.Shepherd David V.Shepherd Siddhartha Ghose Simon J.Kew Ruth E.Cameron Serena M.Best Roger A.Brooks John Wardale Neil Rushton | 2015 | Regenerative Biomaterials2015，2，2： | 2 |
| 11 | Mechanical properties and electrical conductivity of Cu–Cr and Cu–Cr–4% SiC nanocomposites for thermo-electric applications显示文摘 | Suhrit Mula Pankajini Sahani S.K. Pratihar Siddhartha Mal Carl C. Koch | 2011 | Materials Science & Engineering A2011，，13： | 2 |
| 12 | Advances in reduction of NO_x and N_2O emission formation in an oxy-fired fluidized bed boiler显示文摘Fossil fuel combustion is one of the major means to meet the mounting global energy demand. However, the increasing NO_x and N_2 O emissions arising from fossil fuel combustion process have hazardous effects. Thus, mitigating these gases is vital to attain a sustainable environment. Interestingly, oxy-fuel combustion in fluidized bed for carbon capture and minimized NO_x emissions is strongly sustainable compare to the other approaches. It was assessed that NO_x formation and fuel-N conversion have significant limitation under oxy-fluidized bed compared to air mode and the mechanism of NO_x formation is still deficient and requires further development. In addition, this review paper discussed the potential of primary measure as low emission process with others supplementary techniques for feasible NO_x reduction. The influences of combustion mode, operating parameters, and reduction techniques such as flue gas recirculation, oxygen staging, biomass co-firing, catalyst, influence of fluidized bed design and structure, decoupling combustion and their merges are respectively evaluated. Findings show that significant minimization of NO_x emission can be achieved through combination of primary and secondary reduction techniques. | Khalid El Sheikh Mohammad Jakir Hossain Khan Mahar Diana Hamid Siddhartha Shrestha Brahim Si Ali G.A.Ryabov Lya A.Dolgushin Mohd Azlan Hussain Tatiana V.Bukharkina Elena A.Gorelova | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 13 | CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis显示文摘 | Siddhartha Jaiswal Catriona H.M. Jamieson Wendy W. Pang Christopher Y. Park Mark P. Chao Ravindra Majeti David Traver Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 14 | CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells显示文摘 | Ravindra Majeti Mark P. Chao Ash A. Alizadeh Wendy W. Pang Siddhartha Jaiswal Kenneth D. Gibbs Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 15 | VO(acac)_2 catalyzed condensation of o-phenylenediamine with aromatic carboxylic acids/aldehydes under microwave radiation affording benzimidazoles显示文摘Vanadyl acetylacetonate, VO (acac ) 2,被发现了是为在没有溶剂的状况下面的许多 benzimidazoles 的合成的很有效的催化剂。没有任何溶剂或支持的代理人的使用,方法论包含 o-phenylenediamine 和选择芳香的羧基的酸 / 醛的混合物的暴露到微波放射。benzimidazoles 与高收益在快时间被获得。 | Madhudeepa Dey Krishnajyoti Deb Siddhartha Sankar Dhar | 2011 | Chinese Chemical Letters2011，22，3： | 2 |
| 16 | PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports显示文摘 | Neelima Verma Shaloo Kapoor Deepa Rao Siddhartha Sharma Anita Arora | 2014 | Indian Journal of Clinical Biochemistry2014，，1： | 2 |
| 17 | Diesel oxidation catalyst and particulate filter modeling in active -flow configurations 显示文摘 | Ming Zheng Siddhartha Banerjee | 2009 | Ap- plied Thermal Engineering2009，29，1415： | 1 |
| 18 | Influence of lower current densities on the residual stress and structure of thick nickel electrodeposits 显示文摘 | Siddhartha Pathak Marion Guinard Martine G C | 2011 | Surface & Coatings Technology2011，205，： | 1 |
| 19 | Performance of drain- age water management systems in Illinois, Unitde Steates 显示文摘 | Richard Cooke and Siddhartha Verma | 2012 | Journal of Soil and Water Conservation2012，67，6： | 1 |
| 20 | Stochastic techniques used for optimization in solarsystems: A review 显示文摘 | Naveen SharmasVarun Siddhartha | 2012 | Renewable and Sustain- able Energy Reviews2012，，16： | 1 |
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