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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 3 | Endovascular management in abdominal visceral arterial aneurysms:A pictorial essay显示文摘Visceral artery aneurysms(VAAs) include aneurysms of the splanchnic circulation and those of the renal artery.Their diagnosis is clinically important because of the associated high mortality and potential complications.Splenic,superior mesenteric,gastroduodenal,hepatic and renal arteries are some of the common arteries affected by VAAs.Though surgical resection and anastomosis still remains the treatment of choice in some of the cases,especially cases involving the proximal arteries,increasingly endovascular treatment is being used for more distal vessels.We present a pictorial review of various intra-abdominal VAAs and their endovascular management. | Manisha Jana Shivanand Gamanagatti Amar Mukund Sujoy Paul Pankaj Gupta Pramod Garg Tushar K Chattopadhyay Peush Sahni | 2011 | World Journal of Radiology2011，3，7： | 5 |
| 4 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 5 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 6 | 临床试验数据共享声明国际医学期刊编辑委员会统一要求显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了1项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。迄今,应我们的反馈要求,ICMJE收到了很多来自个人和团体的意见。 | Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 7 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 8 | Endoscopic or Percutaneous Biliary Drainage for Gallbladder Cancer: A Randomized Trial and Quality of Life Assessment显示文摘 | Sundeep Singh Saluja Manpreet Gulati Pramod Kumar Garg Hemraj Pal Sujoy Pal Peush Sahni Tushar K. Chattopadhyay | 2008 | Clinical Gastroenterology and Hepatology2008，，： | 1 |
| 9 | Impact on outcome of the route of conduit transposition after transhiatal oesophage- ctomy:a randomized controlled trial 显示文摘 | Khiria LS Pal S Peush S | 2009 | Dig Liver Dis2009，40，10： | 1 |
| 10 | MR evaluation of biliary-enteric anastomotic stricture: Does contrast-enhanced T1W MRC provide additional information?显示文摘 | Devasenathipathy Kandasamy Raju Sharma Ashu Seith Bhalla Shivanand R. Gamanagatti Deep N. Srivastava Peush Sahni Rakesh Kumar | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，8： | 1 |
| 11 | Surgical management and outcomes of severe gastrointestinal injuries due to corrosive ingestion显示文摘AIM:To report our experience in the surgical management of severe injuries of the gastrointestinal tract due to corrosive ingestion.METHODS:A retrospective review of patients who underwent emergency surgery for severe gastrointestinal injuries following corrosive ingestion between 1983 and 2010 was carried out.Data was extracted from a prospectively maintained esophageal disease database.Severe corrosive injuries were defined as full thickness necrosis with perforation of the esophagus or the stomach(with or without involvement of the adjacent viscera) with resultant mediastinitis or peritonitis.RESULTS:Between 1983 and 2010,209 patients with corrosive injury of the esophagus were managed.Of these,13(6.2%) patients underwent emergency surgery for severe corrosive injury.The median age of the patients was 22 years and the median interval between ingestion of the corrosive substance and surgery was 24 h.The surgical procedures done included esophagogastrectomy alone(n = 6),esophagogastrectomy withduodenectomy(n = 4),esophagogastrectomy with pancreaticoduodenectomy(n = 1),esophagogastrectomy with splenectomy(n = 1) and distal gastrectomy with duodenectomy(n = 1).Two patients died in the postoperative period and one after discharge awaiting the second surgery.The factors significantly predictive of mortality following such an injury included renal failure at the time of initial presentation,presence of metabolic acidosis,delay of more than 24 h between corrosive ingestion and surgery,and corrosive induced adjacent organ injury(pancreatic)(P < 0.001,0.02,0.005 and 0.015 respectively).Ten patients underwent subsequent surgery for restoration of the alimentary tract continuity with a colonic pull-up(n = 8) and gastrojejunostomy(n = 1).In one patient,the attempted colon pull-up failed due to extensive scarring of the mesocolon.The median follow up(following restoration of continuity of the gastrointestinal tract) was 36.5 mo.One patient developed dysphagia due to a stricture at the anastomotic site,which was successfully managed by dilatation.Another patient developed severe aspiration,necessitating laryngeal inlet closure and permanent tracheostomy,and 3 patients complained of occasional regurgitation.CONCLUSION:Management of severe corrosive injury involves prompt resuscitation and urgent surgical debridement.Although the subsequent restoration of continuity may be complicated and may not always be possible,long term outcomes are acceptable in the majority. | Amit Javed Sujoy Pal Elan Kumaran Krishnan Peush Sahni Tushar Kanti Chattopadhyay | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 1 |
| 12 | Call for emergency action to limit global temperature increases, restore biodiversity and protect health显示文摘Wealthy nations must do much more,much faster.The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis.They will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,UK.Ahead of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5°C,halt the destruction of nature and protect health. | Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton Laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard Smith Nicholas J Talley Sue Turale Damián Vázquez | 2021 | General Psychiatry2021，34，5： | 1 |
| 13 | Impact on outcome of the route of conduit transposition after transhiatal oesophagectomy : A ran- domized controlled trial显示文摘 | Khiria LS Pal S Peush S | 2009 | Dig Liver Dis2009，41，10： | 1 |
| 14 | Call for emergency action to limit global temperature increases, restore biodiversity and protect health显示文摘Wealthy nations must do much more,much faster.The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis.They will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,UK.Ahead of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5℃,halt the destruction of nature and protect health. | Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton Laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard Smith Nicholas J Talley Sue Turale Damián Vázquez | 2021 | World Journal of Pediatric Surgery2021，4，4： | 0 |
| 15 | Call for emergency action to limit global temperature increases,restore biodiversity and protect health显示文摘Wealthy nations must do much more,much faster.The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis.They will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,UK.Ahead of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5℃,halt the destruction of nature and protect health. | Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton Laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick Nigel Praities Marcel GM Olde Rikkert Eric J Rubin Peush Sahni Richard Smith Nicholas J Talley Sue Turale Damián Vázquez | 2021 | Stroke & Vascular Neurology2021，6，3： | 0 |
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