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| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | Nipple sparing mastectomy: Can we predict the factors predisposing to necrosis?显示文摘 | Z.K. Algaithy J.Y. Petit V. Lohsiriwat P. Maisonneuve P.C. Rey N. Baros H. Lai P. Mulas D.M. Barbalho P. Veronesi M. Rietjens | 2011 | European Journal of Surgical Oncology2011，，2： | 3 |
| 3 | Mechanical properties and electrical conductivity of Cu–Cr and Cu–Cr–4% SiC nanocomposites for thermo-electric applications显示文摘 | Suhrit Mula Pankajini Sahani S.K. Pratihar Siddhartha Mal Carl C. Koch | 2011 | Materials Science & Engineering A2011，，13： | 2 |
| 4 | Plant diversity and community structure of Brazilian Páramos显示文摘In Eastern South America, high altitude grasslands represent a mountain system that has a high number of endemic species. However, studies on the ecology of plant communities in these environments remain scarce. We aimed to evaluate the patterns of biodiversity and structure of plant communities from rocky outcrops in high altitude grasslands of three areas at the Caparaó National Park, southeastern Brazil, by sampling 300 randomly distributed plots. Then, we compared the floristic composition, relative abundance, and biological and vegetation spectra among areas. We classified species as endemic and non-endemic and verified the occurrence of endangered species. Species richness was evaluated by rarefaction analysis on the sampling units. The importance value and species abundance distribution(SAD) models were assessed. We also performed an indicator species analysis. We sampled 58 species belonging to 49 genera and 32 families. The number of species decreased with increasing altitude, with significant differences being observed among areas regarding richness, abundance, and cover. Of the total number of species, 10 are endemic to the Caparaó National Park and 17 are listed on the Brazilian Red List of endangered species. The dominant families on all peaks were Asteraceae and Poaceae. The SAD models showed lognormal and geometric distributions, corroborating the fact that 10 species that were common to all three areas were also the most dominant ones in the communities and showed the highest importance values, which ranged between 35% and 60%. Indicator species analysis revealed that 28 species(48.27%) were indicators. Of these, 42.85% had maximum specificity, meaning that they occurred only in one area. Thus, the number of species per life form ratio was similar among areas, yet vegetation spectra differed, especially for hemicryptophytes. The altimetric difference among the areas showed to be a very important driver in the community assembly, influencing the evaluated variables, however, other drivers as soil depth, slope and water could also influence the community structure on a smaller and local spatial scale. | prímula viana campos pedro manuel villa jaquelina alves nunes carlos e.g.r.schaefer stefan porembski andreza viana neri | 2018 | Journal of Mountain Science2018，15，6： | 2 |
| 5 | A structural model for panel zones in nonlinear seismic ananlysis of steel moment-resisting frames显示文摘 | MULAS M G | 2004 | Engineering Structures2004，26，2： | 1 |
| 6 | The global burden and stigma of epilepsy显示文摘 | de Boer HM Mula M SanderJW | 2008 | Epilepsy Behav2008，12，4： | 1 |
| 7 | The Reverse Logistic Process of an Automobile Supply Chain Network Supported by a Collaborative Decision-making Model显示文摘 | JORGE E POLER H R MULA J | 2011 | Group Decis Negot2011，20，6： | 1 |
| 8 | Oncogene HER 2 in canine mammary gland carcinomas An immunohistochemical and chromogenic in situ hybridization study 显示文摘 | Martin delas Mulas Ordas J Millan Y etal | 2003 | Breast Cancer Research and Treatment2003，80，： | 1 |
| 9 | Antioxidant activity of Piper betel leaf extract and its constituents 显示文摘 | Rathee J S Patro B S Mula S | 2006 | J Agric Food Chem2006，54，24： | 1 |
| 10 | Fuzzy estimations and system dynamics for improving supply chains显示文摘 | Francisco Campuzano Josefa Mula David Peidro | 2009 | Fuzzy Sets and Systems2009，，11： | 1 |
| 11 | Fuzzy goal programming for material requirements planning under uncertainty and integrity conditions显示文摘 | DIAZ M M MULA J JIMENEZ M | 2014 | International Journal of Production Research2014，52，23： | 1 |
| 12 | Negative effects of antiepileptic drugs on mood in patients with epilepsy显示文摘 | Mula M Sander JW | 2007 | Drug Saf2007，30，7： | 1 |
| 13 | The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy显示文摘 | Mula M Trimble MR Sander JW | 2003 | Epilepsia2003，44，2： | 1 |
| 14 | On structure and mechanical properties of ultrasonically cast A1-2% A1203 nanocomposite 显示文摘 | Mula S Padhi P Panigrahi S C | 2009 | Materials Research Bulletin2009，44，5： | 1 |
| 15 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 16 | Mechanical alloying processes and reactive milling显示文摘 | COCCO G MULAS G SCHIFFINI L | 1995 | Journal of Metals1995，47，3： | 1 |
| 17 | Factors associated with a rapid normalization of HbA1c in newly diagnosed type 2 diabetes patients seen in a specialist setting显示文摘 | Giorda CB Mulas MF Manicardi V | | 0，，： | 1 |
| 18 | On structure and mechanical properties of ultrasonically cast A1 - 2% AlxOa nanocomposite 显示文摘 | Mula S Padhi P Panigrahi S C | 2009 | Materials Research Bulletin2009，44，5： | 1 |
| 19 | Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM study显示文摘 | Labate A Cerasa A Mula M | 2012 | Epilepsia2012，53，2： | 1 |
| 20 | Cognitive evoked potentials and executive functions in children with attention deficit hyperactivity disorder显示文摘 | Roca P Mulas F Presentación-Herrero MJ | 2012 | Rev Neurol2012，541，： | 1 |
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