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| 1 | Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic(type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease显示文摘AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease(NAFLD) in patients with and without type 2 diabetes mellitus(T2DM) using updated nonalcoholic steatohepatitis clinical research network(NASH-CRN) grading system.METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2 DM.This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author.The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison.The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist.The updated criteria for type 2 diabetes have been utilized for analysis.Background data of patients with NASH and NAFLD has been included.The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis.RESULTS: Patients with NAFLD and T2 DM were significantly older(49.9 vs 43.0,P < 0.01),predominantly female(71.4 vs 56.3,P < 0.02),had higher rate of metabolic syndrome(88.7 vs 36.4,P < 0.01),had significantly higher aspartate transaminase(AST)/alanine transaminase(ALT) ratio(0.94 vs 0.78,P < 0.01) and Fib-4 index(1.65 vs 1.06,P < 0.01) as markers of NASH,showed higher mean NAFLD activity score(3.5 vs 3.0,P = 0.03) and higher mean fibrosis score(1.2 vs 0.52,P < 0.01) compared to patients with NAFLD without T2 DM.Furthermore,advanced fibrosis(32.5 vs 12.0,P < 0.01) and ballooning(27.3 vs 13.3,P < 0.01) was significantly higher among patients with NAFLD and T2 DM compared to patients with NAFLD without T2 DM.On multivariate analysis,T2 DM was independently associated with NASH(OR = 3.27,95%CI: 1.43-7.50,P < 0.01) and advanced fibrosis(OR = 3.45,95%CI: 1.53-7.77,P < 0.01) in all patients with NAFLD.There was a higher rate of T2DM(38.1 vs 19.4,P < 0.01) and cirrhosis(8.3 vs 0.0,P = 0.01) along with significantly higher mean Bilirubin(0.71 vs 0.56,P = 0.01) and AST(54.2 vs 38.3,P < 0.01) and ALT(78.7 vs 57.0,P = 0.01) level among patients with NASH when compared to patients with steatosis alone.The mean platelet count(247 vs 283,P < 0.01) and high-density lipoprotein cholesterol level(42.7 vs 48.1,P = 0.01) was lower among patients with NASH compared to patients with steatosis.CONCLUSION: Patients with NAFLD and T2 DM tend to have more advanced stages of NAFLD,particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2 DM. | Bharat K Puchakayala Siddharth Verma Pushpjeet Kanwar John Hart Raghavendra R Sanivarapu Smruti R Mohanty | 2015 | World Journal of Hepatology2015，7，25： | 10 |
| 2 | Predictive value of ALT levels for non‐alcoholic steatohepatitis ( NASH ) and advanced fibrosis in non‐alcoholic fatty liver disease ( NAFLD )显示文摘 | Siddharth Verma Donald Jensen John Hart Smruti R. Mohanty | 2013 | Liver Int2013，，9： | 5 |
| 3 | Overtreatment and Undertreatment of Hyperlipidemia in the Outpatient Setting显示文摘 | Ashish Verma Paul Visintainer Mohamed Elarabi Siddharth Wartak Michael B. Rothberg | 2012 | Southern Medical Journal2012，，7： | 1 |
| 4 | Prevalence of Helicobacter pylori infection in bariatric patients: a histologic assessment显示文摘 | Siddharth Verma Desh Sharma Pushpjeet Kanwar Won Sohn Smruti R. Mohanty Anthony J. Tortolani Piotr Gorecki | 2012 | Surgery for Obesity and Related Diseases2012，，： | 1 |
| 5 | Molecular typing of fecal eukaryotic microbiota of human infants and their respective mothers显示文摘 | Pandey PK Siddharth J Verma P | 2012 | J Biosci2012，37，2： | 1 |
| 6 | A comprehensive review of the influence of physicochemical properties of biodiesel on combustion characteristics,engine performance and emissions显示文摘Energy is a basic requirement for development in the world.The continuously rising demand for energy resources and the fast depletion of fossil fuel is raises researcher's concern to focus on alternative sources of energy that can replace the shortage of fossil fuels soon.Biodiesel is recognized as one of the potential alternative renewable energy fuels that can be easily available in a wide range in every part of the world.This paper reviews biodiesel's prospect and focuses on the different fuel properties(physicochemical)of 100 biodiesels from first-,second-and third-generation followed by the evaluation of CI engine characteristics.It has been observed that the fuel properties of first-,second-and third-generation biodiesel are compatible with the ASTM standards.The present paper discussed the potential of various generations of biodiesel feedstocks from production perspectives.This paper also examined many aspects of these feedstocks which include different biodiesel feedstock sources,biodiesel conversion technology,and second-generation biodiesel performance and emission characteristics.Most of the studies showed that biodiesel derived from plant feedstock is costly than diesel.Thus,more influence is to be given to non-edible sources.However,the engine characteristics are shown promising behavior with biodiesel and a slight increase in NOX is also reported on using various biodiesel. | Tikendra Nath Verma Pankaj Shrivastava Upendra Rajak Gaurav Dwivedi Siddharth Jain Ali Zare Anoop Kumar Shukla Puneet Verma | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，4： | 1 |
| 7 | On Design and Implementation of an Embedded Automatic SpeechRecognition System显示文摘 | Sujay Phadke Rhishikesh Limaye Siddharth Verma | 2004 | IEEE Transactions on VLSI Design2004，21，3： | 1 |
| 8 | On Design and Implementation of an Embedded Automatic Speech Recognition System显示文摘 | Sujay Phadke Rhishikesh Limaye Siddharth Verma | 2004 | IEEE Transactions on VLSI Design2004，21，3： | 1 |
| 9 | Gut microbiota interactions with anti-diabetic medications and pathogenesis of type 2 diabetes mellitus显示文摘Microorganisms including bacteria,viruses,protozoa,and fungi living in the gastrointestinal tract are collectively known as the gut microbiota.Dysbiosis is the imbalance in microbial composition on or inside the body relative to healthy state.Altered Firmicutes to Bacteroidetes ratio and decreased abundance of Akkermansia muciniphila are the predominant gut dysbiosis associated with the pathogenesis of type 2 diabetes mellitus(T2DM)and metabolic syndrome.Pathophysiological mechanisms linking gut dysbiosis,and metabolic diseases and their complications include altered metabolism of short-chain fatty acids and bile acids,interaction with gut hormones,increased gut microbial metabolite trimethylamine-N-oxide,bacterial translocation/Leaky gut syndrome,and endotoxin production such as lipopolysaccharides.The association between the gut microbiota and glycemic agents,however,is much less understood and is the growing focus of research and conversation.Recent studies suggest that the gut microbiota and anti-diabetic medications are interdependent on each other,meaning that while anti-diabetic medications alter the gut microbiota,the gut microbiota also alters the efficacy of anti-diabetic medications.With increasing evidence regarding the significance of gut microbiota,it is imperative to review the role of gut microbiota in the pathogenesis of T2DM.This review also discusses the interaction between gut microbiota and the various medications used in the treatment of T2DM. | Ravi Kant Lakshya Chandra Vipin Verma Priyanshu Nain Diego Bello Siddharth Patel Subash Ala Rashmi Chandra Mc Anto Antony | 2022 | World Journal of Methodology2022，12，4： | 1 |
| 10 | Chronic methadone use,poor bowel visualization and failed colonoscopy:A preliminary study显示文摘AIM:To examine effects of chronic methadone usage on bowel visualization,preparation,and repeat colonoscopy.METHODS:In-patient colonoscopy reports from October,2004 to May,2009 for methadone dependent(MD) patients were retrospectively evaluated and compared to matched opioid naive controls(C).Strict criteria were applied to exclude patients with risk factors known to cause constipation or gastric dysmotility.Colonoscopy reports of all eligible patients were analyzed for degree of bowel visualization,assessment of bowel preparation(good,fair,or poor),and whether a repeat colonoscopy was required.Bowel visualization was scored on a 4 point scale based on multiple prior studies:excellent = 1,good = 2,fair = 3,or poor = 4.Analysis of variance(ANOVA) and Pearson χ 2 test were used for data analyses.Subgroup analysis included correlation between methadone dose and colonoscopy outcomes.All variables significantly differing between MD and C groups were included in both univariate and multivariate logistic regression analyses.P values were two sided,and < 0.05 were considered statistically significant.RESULTS:After applying exclusionary criteria,a total of 178 MD patients and 115 C patients underwent a colonoscopy during the designated study period.A total of 67 colonoscopy reports for MD patients and 72 for C were included for data analysis.Age and gender matched controls were randomly selected from this population to serve as controls in a numerically comparable group.The average age for MD patients was 52.2 ± 9.2 years(range:32-72 years) years compared to 54.6 ± 15.5 years(range:20-81 years) for C(P = 0.27).Sixty nine percent of patients in MD and 65% in C group were males(P = 0.67).When evaluating colonoscopy reports for bowel visualization,MD patients had significantly greater percentage of solid stool(i.e.,poor visualization) compared to C(40.3% vs 6.9%,P < 0.001).Poor bowel preparation(35.8% vs 9.7%,P < 0.001) and need for repeat colonoscopy(32.8% vs 12.5%,P = 0.004) were significantly higher in MD group compared to C,respectively.Under univariate analysis,factors significantly associated with MD group were presence of fecal particulate [odds ratio(OR),3.89,95% CI:1.33-11.36,P = 0.01] and solid stool(OR,13.5,95% CI:4.21-43.31,P < 0.001).Fair(OR,3.82,95% CI:1.63-8.96,P = 0.002) and poor(OR,8.10,95% CI:3.05-21.56,P < 0.001) assessment of bowel preparation were more likely to be associated with MD patients.Requirement for repeat colonoscopy was also significant higher in MD group(OR,3.42,95% CI:1.44-8.13,P = 0.01).In the multivariate analyses,the only variable independently associated with MD group was presence of solid stool(OR,7.77,95% CI:1.66-36.47,P = 0.01).Subgroup analysis demonstrated a general trend towards poorer bowel visualization with higher methadone dosage.ANOVA analysis demonstrated that mean methadone dose associated with presence of solid stool(poor visualization) was significantly higher compared to mean dosage for clean colon(excellent visualization,P = 0.02) or for those with liquid stool only(good visualization,P = 0.01).CONCLUSION:Methadone dependence is a risk factor for poor bowel visualization and leads to more repeat colonoscopies.More aggressive bowel preparation may be needed in MD patients. | Siddharth Verma Joshua Fogel David J Beyda Brett Bernstein Vincent Notar-Francesco Smruti R Mohanty | 2012 | World Journal of Gastroenterology2012，18，32： | 0 |
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