|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 氯离子对9Cr马氏体钢静态腐蚀和应力腐蚀行为的影响显示文摘目的研究9Cr马氏体钢在非服役条件下的腐蚀行为。方法运用传统电化学测试和微区扫描振动电极(SVET)技术研究材料的静态腐蚀行为,采用慢应变速率动态拉伸腐蚀试验与传统电化学测试技术相结合的方法研究材料的应力腐蚀行为。结果获得常温下氯离子对马氏体钢静态腐蚀行为的影响规律,以及慢拉伸过程中材料表面钝化膜生成和破裂过程。结论马氏体钢在氯化钠溶液中的腐蚀为阳极溶解型,且随着氯离子浓度的上升,局部腐蚀电流密度增大。常温下材料在含氯离子环境中发生弹性变形时,表面生成的钝化膜使材料的抗腐蚀性能升高。当材料进入塑性变形阶段后,由于金属表面缺陷的增多、颈缩区体积的收缩,以及钝化膜与基体金属塑性变形能力的差异,钝化膜逐渐溶解并发生破裂。 | 张振 胡正飞 Preet M.Singh | 2019 | 表面技术2019，48，12： | 9 |
| 2 | 1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells显示文摘AIM:To study the mechanism of 5-fluorouracil(5-FU)resistance in colon cancer cells and to develop strategies for overcoming such resistance by combination treatment.METHODS:We established and characterized a 5-FU resistance(5-FU-R)cell line derived from continuous exposure(25μmol/L)to 5-FU for 20 wk in 5-FU sensitive HCT-116 cells.The proliferation and expression of different representative apoptosis and anti-apoptosis markers in 5-FU sensitive and 5-FU resistance cells were measured by the MTT assay and by Western blotting,respectively,after treatment with Resveratrol(Res)and/or 1,3-Bis(2-chloroethyl)-1-nitrosourea(BCNU).Apoptosis and cell cycle arrest was measured by 4',6'-diamidino-2-phenylindole hydrochloride staining and fluorescence-activated cell sorting analysis,respectively.The extent of DNA damage was measured by the Comet assay.We measured the visible changes in the DNA damage/repair cascade by Western blotting.RESULTS:The widely used chemotherapeutic agents BCNU and Res decreased the growth of 5-FU sensitive HCT-116 cells in a dose dependent manner.Combined application of BCNU and Res caused more apoptosis in5-FU sensitive cells in comparison to individual treatment.In addition,the combined application of BCNU and Res caused a significant decrease of major DNA base excision repair components in 5-FU sensitive cells.We established a 5-FU resistance cell line(5-FU-R)from 5-FU-sensitive HCT-116(mismatch repair deficient)cells that was not resistant to other chemotherapeutic agents(e.g.,BCNU,Res)except 5-FU.The 5-FU resistance of 5-FU-R cells was assessed by exposure to increasing concentrations of 5-FU followed by the MTT assay.There was no significant cell death noted in5-FU-R cells in comparison to 5-FU sensitive cells after5-FU treatment.This resistant cell line overexpressed anti-apoptotic[e.g.,AKT,nuclear factorκB,FLICE-like inhibitory protein),DNA repair(e.g.,DNA polymerase beta(POL-β),DNA polymerase eta(POLH),protein Flap endonuclease 1(FEN1),DNA damage-binding protein 2(DDB2)]and 5-FU-resistance proteins(thymidylate synthase)but under expressed pro-apoptotic proteins(e.g.,DAB2,CK1)in comparison to the parental cells.Increased genotoxicity and apoptosis were observed in resistant cells after combined application of BCNU and Res in comparison to untreated or parental cells.BCNU increased the sensitivity to Res of 5-FU resistant cells compared with parental cells.Fifty percent cell death were noted in parental cells when 18μmol/L of Res was associated with fixed concentration(20μmol/L)of BCNU,but a much lower concentration of Res(8μmol/L)was needed to achieve the same effect in 5-FU resistant cells.Interestingly,increased levels of adenomatous polyposis coli and decreased levels POL-β,POLH,FEN1 and DDB2 were noted after the same combined treatment in resistant cells.CONCLUSION:BCNU combined with Res exerts a synergistic effect that may prove useful for the treatment of colon cancer and to overcome drug resistance. | Dipon Das Ranjan Preet Purusottam Mohapatra Shakti Ranjan Satapathy Chanakya Nath Kundu | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 3 | 有机转化过程中的二氧化硅负载Br?nsted酸催化剂(英文)显示文摘Br?nsted acid catalysts have been used in a number of organic transformations. To overcome limi-tations, such as toxicity, volatility, high price and hazardous nature of the conventional methods, the catalysts are adsorbed on silica gel to give the benefits and advantages of ready availability, simple work-up procedure, long catalytic life, environment-friendliness, good to excellent yields and recy-clability. The uses of such catalysts have gained importance worldwide. This article describes some of the important silicated catalysts, namely, heteropolyacids, polyphosphoric acid, perchloric acid, fluoroboric acid, and silicated sulphuric acid. These catalysts have been used in a number of organic reactions to yield compounds that are important in the chemical and pharmaceutical industries. We summarize the beneficial effects of these catalysts and the reports that have been published on them in the past several years. In the present review, the description of the catalysts are introduced followed by a recent research history, and a comparison between the silica supported catalysts and other(polymer) supported catalysts. The article ends up giving the advantages of these catalytic systems over the conventional catalyst. | Manpreet Kaur Sahil Sharma Preet M.S.Bedi | 2015 | 催化学报2015，36，4： | 4 |
| 4 | Statins Are Associated With a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-analysis显示文摘 | Siddharth Singh Preet Paul Singh Abha Goyal Singh Mohammad Hassan Murad William Sanchez | 2013 | Gastroenterology2013，，： | 3 |
| 5 | Impact of sepsis and non-communicable diseases on prognostic models to predict the outcome of hospitalized chronic liver disease patients显示文摘AIM To evaluate the impact of sepsis and non-communicable diseases(NCDs) on the outcome of decompensated chronic liver disease(CLD) patients.METHODSIn this cross-sectional study, medical records of patients with CLD admitted to the Gastroenterology unit at the Aga Khan University Hospital were reviewed.Patients older than 18 years with decompensation of CLD(i.e., jaundice, ascites,encephalopathy, and/or upper gastrointestinal bleed) as the primary reason for admission were included, while those who were admitted for reasons other than decompensation of CLD were excluded. Each patient was followed for 6 wk after index admission to assess mortality, prolonged hospital stay(> 5 d), and early readmission(within 7 d).RESULTS A total of 399 patients were enrolled. The mean age was 54.3 ± 11.7 years and64.6%(n = 258) were male. Six-week mortality was 13%(n = 52). Prolonged hospital stay and readmission were present in 18%(n = 72) and 7%(n = 28) of patients, respectively. NCDs were found in 47.4%(n = 189) of patients. Acute kidney injury, sepsis, and non-ST elevation myocardial infarction were found in41%(n = 165), 17.5%(n = 70), and 1.75%(n = 7) of patients, respectively. Upon multivariate analysis, acute kidney injury, non-ST elevation myocardial infarction, sepsis, and coagulopathy were found to be statistically significant predictors of mortality. While chronic kidney disease(CKD), low albumin, and high Model for End-Stage Liver Disease(MELD)-Na score were found to be statistically significant predictors of morbidity. Addition of sepsis in conventionalMELD score predicted mortality even better than MELD-Na(area under receiver operating characteristic: 0.735 vs 0.686; P < 0.001). Among NCDs, CKD was found to increase morbidity independently.CONCLUSION Addition of sepsis improved the predictability of MELD score as a prognostic marker for mortality in patients with CLD. Presence of CKD increases the morbidity of patients with CLD. | Fakhar Ali Qazi Arisar Shahab Abid Preet Ayoub Shaikh Safia Awan | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 6 | Muhinationality and Firm Performance:The Moderating Role of R&'D and Marketing Capabilities 显示文摘 | Masaaki Kotabe&Preet S | 2002 | Joumal of International Business Studies2002，，23： | 1 |
| 7 | Acceleration of the pechmann reaction by microwave irradiation: Application to the preparation of coumarins显示文摘 | Jasvindar S Preet K | 1997 | J CHEN KES(S)1997，，2： | 1 |
| 8 | Midterm results using a medial pivot total knee replacement compared with the Australian National Joint Replacement Registry data显示文摘 | Justus - Martijn Brinkman Preet Singh Bubra Peter Walker | 2014 | ANZ Journal of Surgery2014，84，3： | 1 |
| 9 | Assessment to hospital and police ascertainment of automobile versus childhood pedestrian and bicyclist collisions显示文摘 | Preet K D Amy S L Corinne P A | 2001 | Accident Analysis and Prevention2001，33，4： | 1 |
| 10 | Tissue and serum microRNAs in the Kras(G12D)transgenic animal model and in patients with pancreatic cancer显示文摘 | La Conti JJ Shivapurkar N Preet A | 2011 | PLo S One2011，6，20： | 1 |
| 11 | Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer显示文摘 | QAMRI Z PREET A NASSER M W | 2009 | Molec Canc Therap2009，8，11： | 1 |
| 12 | Rhabdomyolysis: not a textbook case显示文摘 | Sunit- Preet Chaudhry Kavita Krishnasamy | 2012 | Am J Medicine2012，125，2： | 1 |
| 13 | Margaret Atwood' s Oryx and Crake : An Ecocritical Approach 显示文摘 | Bhalla Ambika Jap Preet Kaur Bhangu & Manmohan Singh | 2014 | International Journal of Research2014，10，1： | 1 |
| 14 | Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs显示文摘 | Preet MC Igor BR | | 0，，： | 1 |
| 15 | Acceleration of the Pechmann reaction by microwave irradiation:application to the preparationof coumarins显示文摘 | Vasundhara S Jasvindar S Preet KK | 1997 | J Chem Res(S)1997，，2： | 1 |
| 16 | Effects of heat treatment and re inforcement size on reinforcement fracture during tension testing of a SiC discontinuously reinforced aluminum alloy 显示文摘 | Lewandowski J J | 1993 | Metal lurgical Transaction A1993，24，11： | 1 |
| 17 | Role of residual stresses induced by industrial fabrication on stress corrosion cracking susceptibility of austenitic stainless steel显示文摘 | Swati Ghosh Vishav Preet Singh Rana Vivekanand Kain Vivek Mittal S.K. Baveja | 2011 | Materials and Design2011，，7： | 1 |
| 18 | The Influence of Complementarity, Compatibility, and Relationship Capital on Alliance Performance 显示文摘 | MB SARKAR RAJ ECHAMBADI TAMER CAVUSGIL PREET S AULAKH | 2001 | Journal of the A- cademy of Marketing Science2001，，29： | 1 |
| 19 | Statin a day keeps cancer at bay显示文摘In addition to cholesterol reduction,statins,currently the most commonly prescribed drug in the world,have been shown to have anti-neoplastic and immunomodulatory effects.Several observational studies and meta-analyses have shown reduction in risk of multiple cancers.More recently there has been an increasing interest in the potential role of statins as adjuvant therapy after cancer diagnosis and in modifying cancer mortality.Although post-hoc analyses of randomized controlled trials of statins for cardiovascular outcomes have not shown reduction in the risk of cancer mortality with statin use,these studies lack sufficient power to detect a significant difference in cancer outcomes.Recently,in a Danish nationwide population-based cohort study,Nielsen et al showed a 15%reduction in all-cause and cancer-specific mortality in statin users as compared to non-users.Improved survival with statin exposure was seen in 13/27 cancer subtypes,including the 4 most common cancers-lung,prostate,colorectal and breast.In this commentary,we examine this important study,review its implications and limitations,and briefly discuss impact of other drugs like metformin and aspirin that also exhibit anti-neoplastic effects. | Siddharth Singh Preet Paul Singh | 2013 | World Journal of Clinical Oncology2013，4，2： | 1 |
| 20 | Trust and performance in cross-border marketing partnerships: A behavioral approach 显示文摘 | Preet S Aulakh Masaaki Kotabe Arvind Sahay | 1996 | Journal of International Business Studies1996，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员