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| 1 | MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。 | Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 7 |
| 2 | Experimental Study on Interaction Between Degrees of Freedom in a Wave Buoy显示文摘Increasing degrees of freedom(DOFs)is a useful way to raise the power capture efficiency of oscillating wave energy converters.Thus,this study proposes a buoy with three DOFs,which are surge,heave,and pitch.The hydrodynamic performance and power capture efficiency of the buoy is physically modeled.Amplitudes of unidirectional and coupled motions are compared to analyze the interaction effect between freedoms under conditions with and without power take-off damping.The capture width ratio and corresponding growth rates are also calculated.Results show that the buoy makes a periodic sinusoidal(or approximate)movement in every DOF.Coupling effect can cause an increase in the amplitude in one DOF and a decrease in the amplitudes of the others.This phenomenon shows that the kinematic energy of the buoy redistributes to all DOFs compared with the unidirectional conditions.Adding DOFs can improve the power absorption of the buoy in most cases,but the number of DOFs is not the more the better. | HUANG Shuting SHI Hongda CAO Feifei TAN Junzhe CHENG Haixun LI Demin LIU Shangze GONG Haoxiang TAO Ji | 2019 | Journal of Ocean University of China2019，18，6： | 5 |
| 3 | Microcavity top-emission perovskite light-emitting diodes显示文摘Light-emitting diodes(LEDs)based on perovskites show great potential in lighting and display applications.However,although perovskite films with high photoluminescence quantum efficiencies are commonly achieved,the efficiencies of perovskite LEDs are largely limited by the low light out-coupling efficiency.Here,we show that high-efficiency perovskite LEDs with a high external quantum efficiency of 20.2% and an ultrahigh radiant exitance up to 114.9mWcm^(−2) can be achieved by employing the microcavity effect to enhance light extraction.The enhanced microcavity effect and light outcoupling efficiency are confirmed by the study of angle-dependent emission profiles.Our results show that both the optical and electrical properties of the device need to be optimized to achieve high-performance perovskite LEDs. | Yanfeng Miao Lu Cheng Wei Zou Lianghui Gu Ju Zhang Qiang Guo Qiming Peng Mengmeng Xu Yarong He Shuting Zhang Yu Cao Renzhi Li Nana Wang Wei Huang Jianpu Wang | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 4 | A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish(Pelteobagrus fulvidraco)显示文摘The sex-determining genes are found to be variable among different fish species. Yellow catfish(Pelteobagrus fulvidraco) is an important aquaculture fish species in China with XX/XY sex-determining type. Recently, YY super-male yellow catfish has been successfully produced by combining hormonalinduced sex reversal method with sex chromosome-linked markers. Here, we identified a novel PDZ domain-containing gene in yellow catfish designated as pfpdz1, in whose intron the sex-linked marker was located. The coding sequence of pfpdz1 in Y chromosome was identical to that in X chromosome except a missense SNP(A/T) that changes an amino acid(E8V) in the N-terminal region. Pfpdz1 displayed male-specific expression during sex differentiation. Overexpression of pfpdz1 using additive transgenesis induces XX ovary to differentiate into testis-like tissue, while the targeted inactivation of pfpdz1 in Y chromosome using CRISPR/Cas9-mediated mutagenesis triggers ovarian differentiation. Furthermore,we demonstrated that pfpdz1 initiates testicular differentiation through upregulating expression of amh, dmrt1 and sox9a1, as well as downregulating expression of cyp19a1, foxl2 and wnt4. Our data provide functional evidence that pfpdz1 is significant for male differentiation and maintenance in yellow catfish. | Cheng Dan Qiaohong Lin Gaorui Gong Tianyi Yang Shuting Xiong Yang Xiong Peipei Huang Jian-Fang Gui Jie Mei | 2018 | Science Bulletin2018，63，21： | 4 |
| 5 | Prediction of nonlinear pilot-induced oscillation using an intelligent human pilot model显示文摘This paper proposes a method to predict nonlinear Pilot-Induced Oscillation(PIO)using an intelligent human pilot model.This method is based on a scalogram-based PIO metric,which uses wavelet transforms to analyze the nonlinear characteristics of a time-varying system.The intelligent human pilot model includes three modules:perception module,decision and adaptive module,and execution module.Intelligent and adaptive features,including a neural network receptor,fuzzy decision and adaptation,are also introduced into the human pilot model to describe the behavior of the human pilot accommodating the nonlinear events.Furthermore,an algorithm is proposed to describe the procedure of the PIO prediction method with nonlinear evaluation cases.The prediction results obtained by numerical simulation are compared with the assessments of flight test data to validate the utility of the method.The flight test data were generated in the evaluation of the Smart-Cue/Smart-Gain,which is capable of reducing the PIO tendencies considerably.The results show that the method can be applied to predict the nonlinear PIO events by human pilot model simulation. | Shuting XU Wenqian TAN Xiangju QU Cheng ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，12： | 3 |
| 6 | Construction of robust coupling interface between MoS2 and nitrogen doped graphene for high performance sodium ion batteries显示文摘As a layered inorganic material,MoS2 has recently attracted intensive attention as anode for sodium ion batteries(SIBs).However,this anode is plagued with low electronic conductivity,serious volume expansion and sluggish kinetics,resulting in capacity fading and poor rate performance.Herein,we develop an interface engineering strategy to substantially enhance the sodium storage performance of MoS2 by incorporating layered MoS2 into three dimensional N-doped graphene scaffold.The strong coupling-interface between MoS2 and N-doped graphene scaffold can not only stabilize the MoS2 structure during sodium insertion/extraction processes,but also provide plenty of anchor sites for additional surface sodium storage.The 3D MoS2@N-doped graphene composite as anode for SIBs performs an outstanding specific capacity of 667.3 mA h g^-1 at 0.2 A g^-1,a prolonged stability with a capacity retention of 94.4%after 140cycles and excellent rate capability of 445 mA h g^-1 even at a high rate of 10 A g^-1.We combined experiment and theoretical simulation to further disclose the interaction between MoS2 and N-doped graphene,adsorption and diffusion of sodium on the composite and the corresponding sodium storage mechanism.This study opens a new door to develop high performance SIBs by introducing the interface engineering technique. | Yun Qiao Jiawei Wu Xiaoguang Cheng Yudong Pang Zhansheng Lu Xiangdong Lou Qingling Li Jin Zhao Shuting Yang Yang Liu | 2020 | Journal of Energy Chemistry2020，29，9： | 3 |
| 7 | Historical Evolution of Mariculture in China During Past 40 Years and Its Impacts on Eco-environment显示文摘The rapid development of mariculture in China in recent decades has satisfied people's demand of seafood, and has made a great contribution to economic development. However, mariculture has also caused some negative impacts on the eco-environment. By statistically analyzing national data(as well as data for four main provinces) regarding the mariculture area and cultivation species in China since reform and opening up, the historical evolution of mariculture during the past 40 years was analyzed, the driving factors related to policy, market and technology innovation were discussed, and the potential impacts of mariculture on the coastal eco-environment were also illustrated. The statistical results indicated that the maricultural area increased radically during the past 40 years, from 1979(116.47 × 10~3 ha) to 2012(2205.65 × 10~3 ha), with an increase of nearly 20-fold. Shandong Province represented the fastest-growing region, with an increase of 31-fold. Moreover, the cultivated species had gradually become diversified. Initially, shellfish and algae were major species, and then it developed to various species including fish, and currently shellfish and crustaceans were the major species. The development of mariculture was driven by government policies, market economy and technology innovation. Rapid development of mariculture also caused significantly adverse impacts on the eco-environment of the coastal regions. For example, the sea reclamation for mariculture decreased the area and function of coastal wetlands and the contaminants originating from mariculture destroyed the coastal aquatic environment. Fortunately, the implementation of ‘13 th Five-Year Fisheries Planning' is expected to help both improve the seafood quality and reduce the contamination in coastal aquatic environment. This current study will provide reference for management and structure adjustment of mariculture in the future. | LIANG Yinxiu CHENG Xianwei ZHU Hui Brian SHUTES YAN Baixing ZHOU Qingwei YU Xiangfei | 2018 | Chinese Geographical Science2018，28，3： | 3 |
| 8 | Nutrient removal in a pilot and full scale constructed wetland, Putrajaya city, Malaysia显示文摘 | Cheng Hua Sim Mohd Kamil Yusoff Brian Shutes Sinn Chye Ho Mashhor Mansor | 2007 | Journal of Environmental Management2007，，2： | 1 |
| 9 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 10 | Microglial Exosome miR-7239-3p Promotes Glioma Progression by Regulating Circadian Genes显示文摘Glioma-associated microglial cells,a key component of the tumor microenvironment,play an important role in glioma progression.In this study,the mouse glioma cell line GL261 and the mouse microglia cell line BV2 were chosen.First,circadian gene expression in glioma cells co-cultured with either M1 or M2 microglia was assessed and the exosomes of M2-polarized and unpolarized BV-2 microglia were extracted.Subsequently,we labeled the exosomes with PKH67 and treated GL261 cells with them to investigate the exosome distribution.GL261 cell phenotypes and related protein expression were used to explore the role of M2 microglial exosomes in gliomas.Then a specific miR-7239-3p inhibitor was added to verify miR-7239-3p functions.Finally,the mouse subcutaneous tumorigenic model was used to verify the tumorigenic effect of M2 microglial exosomes in vivo.Our results showed that in gliomas co-cultured with M2 microglia,the expression of the BMAL1 protein was decreased(P<0.01),while the expression of the CLOCK protein was increased(P<0.05);opposite results were obtained in gliomas co-cultured with M1 microglia.After treatment with M2 microglial exosomes,the apoptosis of GL261 cells decreased(P<0.001),while the viability,proliferation,and migration of GL261 cells increased.Increased expression of N-cadherin and Vimentin,and decreased E-cadherin expression occurred upon treatment with M2 microglial exosomes.Addition of an miR-7239-3p inhibitor to M2 microglial exosomes reversed these results.In summary,we found that miR-7239-3p in the glioma microenvironment is recruited to glioma cells by exosomes and inhibits Bmal1 expression.M2 microglial exosomes promote the proliferation and migration of gliomas by regulating tumor-related protein expression and reducing apoptosis. | Xuepei Li Junwen Guan Zhou Jiang Shuting Cheng Wang Hou Junjie Yao Zhengrong Wang | 2021 | Neuroscience Bulletin2021，37，4： | 1 |
| 11 | Evaluation of antimicrobial and anticancer activities of three peptides identified from the skin secretion of Hylarana latouchii显示文摘The skins of frogs of the family Ranidae are particularly rich sources of biologically active peptides, among which antimicrobial peptides (AMPs) constitute the major portion. Some of these have attracted the interest of researchers because they possess both antimicrobial and anticancer activities. In this study, with ‘shotgun’ cloning & MS/MS fragmentation, three AMPs, homologues of family brevinin-1 (brevinin-1HL), & temporin (temporin-HLa and temporin-HLb), were discovered from the skin secretion of the broad-folded frog, Hylarana latouchii. They exhibited various degrees of antimicrobial & antibiofilm activities against test microorganisms & hemolysis on horse erythrocytes. It was found that they could induce bacteria death through disrupting cell membranes & binding to bacterial DNA. In addition, they also showed different potencies towards human cancer cell lines. The secondary structure & physicochemical properties of each peptide were investigated to preliminarily reveal their structure–activity relationships. Circular dichroism spectrometry showed that they all adopted a canonical α-helical conformation in membrane-mimetic solvents. Notably, the prepropeptide of brevinin-1HL from H. latouchii was highly identical to that of brevinin-1GHd from Hylarana guentheri, indicating a close relationship between these two species. Accordingly, this study provides candidates for the design of novel anti-infective & antineoplastic agents to fight multidrug-resistant bacteria & malignant tumors & also offers additional clues for the taxonomy of ranid frogs. | Yan Lin Tianxing Lin Ningna Cheng Shuting Wu Jiancai Huang Xiaoling Chen Tianbao Chen Mei Zhou Lei Wang Chris Shaw | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 12 | New Discovery of Upper Crustal High-and Low-Velocity Belts and High-Velocity Core in the Tarim Basin显示文摘The Tarim Basin is the biggest oil-and gas-bearing basin in China,which has undergone long-term and complicated evolutionary history.During each evolutional stage and in different sub-basins in the same stage,the Tarim Basin has different proto-types,and it is thus named a composite and superimposed basin.A study on the basement nature of such a complex but significant to the national oil and gas strategy basin is of great significance(Huang Chenjun et al.,2017).Based on earthquake data,detailed velocity structure of deep basin can be obtained in order to research the basement nature. | WANG Tengfei JIN Zhenkui YU Xiaoxia CHENG Rihui SONG Xue YANG Baoju LI Shuo SHI Shuting | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 0 |
| 13 | Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis显示文摘Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological processes.Therefore,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD treatment.Accordingly,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside XVII.Guided by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected region.This nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ phagocytosis.Resultantly,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic mice.Our research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy. | Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 14 | Vertical graphene-coated Cu wire for enhanced tolerance to high current density in power transmission显示文摘Cu wires(CuWs)are widely used as electric transmission lines.However,their limited thermal and chemical stabilities become challenges under the high-power and harsh environment.Graphene is regarded as an ideal protective barrier for CuW benefiting from its impermeability to all atoms and molecules.Particularly,the excellent hydrophobicity of vertical graphene(VG)will strengthen its protective capability as a corrosion and oxidation barrier.Herein,VG is directly synthesized on CuW by plasmaenhanced chemical vapor deposition method.The hydrophobic VG coating with a high water contact angle can effectively exclude the corrosive liquid and moisture from CuW surface and prevent their further penetration.Consequently,the electrochemical corrosion rate of VG-CuW is reduced by~13,8,and 2 times,compared with bare CuW,VG-CuW with hydrophilic treatment,and CuW coated with thick horizontal graphene layers,respectively.Negligible oxidation occurs on VGCuW after the long-time exposure to humid air at~200℃ along with the largely enhanced tolerance under high-current operating condition.This study reveals the impressive potentials of hydrophobic VG as a robust corrosion and oxidation barrier for metal wires used in high-power cables and electronic devices in harsh environment. | Kun Wang Shuting Cheng Qingmei Hu Feng Yu Yi Cheng Kewen Huang Hao Yuan Jun Jiang Wenjuan Li Junliang Li Shichen Xu Jianbo Yin Yue Qi Zhongfan Liu | 2022 | Nano Research2022，15，11： | 0 |
| 15 | Deformation behavior and fluid action of quartz veins in the Xuelongshan metamorphic complex,Western Yunnan显示文摘The Xuelongshan metamorphic complex underwent Cenozoic sinistral strike-slip shearing and exhumation from deep to shallow in the southeast margin of the Tibet Plateau.We studied the deformation behavior and fluid action of quartz veins in the metamorphic complex in depth based on macroscopic observation,electron backscatter diffraction fabric,and fluid inclusion analysis.The mylonitic samples are characterized by strongly elongated and orientated porphyroclasts and a finegrained matrix with a shear strain of 2.4.The ultramylonitic samples are characterized by a strongly fine-grained matrix with a shear strain of 5.8.The{m}glide controls the quartz deformation in the mylonites and ultramylonites.As the dominant recovery mechanism,subgrain rotation dynamic recrystallization reduces the grain size and promotes rheological weakening.The porphyroclasts restrict the crystal orientation of the recrystallized quartz matrix.The mylonitic quartz veins have abundant single-phase and two-phase fluid inclusions.However,the ultramylonitic quartz veins have a few fluid inclusions,most of which are small and irregular toward the grain boundaries.The temperature and pressure of fluid activity in quartz veins are 550–500℃and 391–218 MPa for ultramylonitic quartz veins,with a depth of 14.2–7.9 km and 450–400℃and 236–91 MPa for mylonitic quartz veins,with a depth of 8.6–3.3 km.The deformation process changes the shape of fluid inclusions from mylonitization to ultramylonitization and causes fluid leakage,an increase in local fluid pressure at the boundary,and hydrolysis weakening,promoting lattice dislocation glide and recrystallization,which is directly related to regional continuous shear deformation and exhumation. | Shuting WANG Shuyun CAO Lefan ZHAN Xuemei CHENG Yanlong DONG Xiaowen LI Wenyuan LI | 2023 | Science China Earth Sciences2023，66，9： | 0 |
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