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| 1 | Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the fifth most common cancer, and hepatitis C virus(HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(COX-2) and peroxisome proliferator-activated receptor α(PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC. | Shahab Mahmoudvand Somayeh Shokri Reza Taherkhani Fatemeh Farshadpour | 2019 | World Journal of Gastroenterology2019，25，1： | 8 |
| 2 | Immunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell lineImmunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell line显示文摘OBJECTIVE:To investigate immunomodulatory effects of Astragalus polysaccharides(APS)on the co-culture of peripheral blood mononuclear cells(PBMCs)with He La cervical cancer cell line.METHODS:To assess the proliferation of PBMCs,carboxyfluorescein succinimidyl ester(CFSE)-labeled PBMCs were co-cultured with He La cells and treated with different concentrations of APS.Supernatants of cell culture were collected for cytokines assay via enzyme-linked immunosorbent assay(ELISA).The impact of APS on the proliferation of PBMCs,induction of regulatory T cells(Tregs),and myeloid-derived suppressor cells(MDSCs)was carried out by flow cytometry.RESULTS:It was observed that APS could increase the proliferation of PBMCs co-cultured with He La cells(P<0.05).However,APS had no significant effects on the induction of Tregs and MDSCs in the co-culture assay(P>0.05).Furthermore,ELISA results demonstrated that APS could decrease IL-10 and TGF-βconcentration(P<0.05).CONCLUSION:The above-mentioned characteristics showed that APS might be able to modulate immune responses and improve anti-tumor effects through increasing the proliferation of PBMCs and decreasing inhibitory cytokines secretion as critical mediators of immune suppression in the tumor microenvironment. | Elham Shokati Mohammad-Reza Shokri Kobra Entezami Samaneh Khorrami Mona Amani Morteza Motallebnezhad Elahe Safari | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 5 |
| 3 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 4 | Cattle toxoplasmosis in Iran:a systematic review and meta-analysis显示文摘Objective:To analyze and review the overall seroprevalence rate of Toxoplasma gondii(T.gondii) infection in cattle from Iran.Methods:In the current study,data collection(published and unpublished papers,abstracts of national scientific congresses and dissertations) using particular terms was carried out systematically on the following electronic databases like PubMed,Google Scholar,Ebsco,Science Direct,Scopus,Magiran,Irandoc,IranMedex and SID(Scientific Information Database).Results:A total of 22 studies since 1983 to 2012 reporting the seroprevalence of toxoplasmosis in cattle from different regions of Iran met our eligibility criteria.The pooled proportion of toxoplasmosis,using random effect model,among cattle in Iran from over the 30-year period was estimated 18.1%(95%CI:9.9%to 28.2%).Conclusions:This study firstly establishes a crude seroprevalence rate of Toxoplasma infection in cattle which can lead us to understand the condition of eattle toxoplasmosis,which have to take into accounted fur an appropriate and effective prevention and controls.Secondly,it compares and discusses elaborately the role of risk factors including sex,age and breed in the epidemiology of the disease.Thus,it determines gaps and drawbacks in the prior studies which are greatly useful to design more accurate investigations in the future. | Shahabeddin Sarvi Ahmad Daryani Mohammad Taghi Rahimi Mohsen Aarabi Azar Shokri Ehsan Ahmadpour Azadeh Mizani Mahdi Sharif | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，2： | 4 |
| 5 | Bilateral same-session intravitreal injections of antivascular endothelial growth factors显示文摘AIM: To document the indications, safety and possible complications of bilateral same-session intravitreal antivascular endothelial growth factor(VEGF) injections performed in the ophthalmic operating room.METHODS: A retrospective case series study.Consecutive records of seventy four patients receiving simultaneous bilateral intravitreal injections of either ranibizumab or bevacizumab, between September 2010 and September 2013, were reviewed and the outcomes were assessed. Data collected included number of injections, indications for injections, pre-injection and post-injection visual acuity(VA), pre-injection and postinjection intraocular pressure and ocular and systemic complications/complaints after each injection.RESULTS: A total of 342 injections were administered to 74 patients, with a mean of 4.62 injections per patient.Seventy-three patients received bevacizumab(Avastin;Genentech Inc., South San Francisco, California, USA)alone, and only one patient received both bevacizumab and ranibizumab(Lucentis; Genentech Inc.) distributed between the injections. Pre- and post-injection VA follow-up measurements were available for 65 patients.Mean follow up period was 22 mo. The indications for initiating therapy were choroidal neovascular membrane from age-related macular degeneration(3 patients) and diabetic macular edema(71 patients). The mean Snellen VA before each injection was 6/22. The next post-injection follow-up mean Snellen VA was 6/20. One patient had a painful, culture-positive endophthalmitis in one eye 3d after bilateral bevacizumab. Another patient had a painless subconjunctival hemorrhage in one eye.No other ocular or systemic adverse side effects/complaints have been registered in this study group.CONCLUSION: Bilateral same-session intravitreal injections using a separate povidone-iodine preparation,speculum, needle, and syringe for each eye are well-tolerated. None of the subjects in this study requested to switch to alternating unilateral injections. Proper patient counseling as to the risk of complications with this procedure is necessary. | Nakhleh E.Abu-Yaghi Ahmed N Shokry Rami H Abu-Sbeit | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 3 |
| 6 | The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration显示文摘 | Hany Abdel-Aleem José Villar A Metin Gülmezoglu Sayed A Mostafa Alaa A Youssef Mahmoud Shokry Bernhard Watzer | 2002 | European Journal of Obstetrics and Gynecology2002，，1： | 2 |
| 7 | Improvement of the prediction performance of a soft sensor model based on support vector regression for production of ultra-low sulfur diesel显示文摘A novel data-driven, soft sensor based on support vector regression(SVR) integrated with a data compression technique was developed to predict the product quality for the hydrodesulfurization(HDS) process. A wide range of experimental data was taken from a HDS setup to train and test the SVR model. Hyper-parameter tuning is one of the main challenges to improve predictive accuracy of the SVR model.Therefore, a hybrid approach using a combination of genetic algorithm(GA) and sequential quadratic programming(SQP)methods(GA–SQP) was developed. Performance of different optimization algorithms including GA–SQP, GA, pattern search(PS), and grid search(GS) indicated that the best average absolute relative error(AARE), squared correlation coefficient(R2), and computation time(CT)(AARE = 0.0745, R2= 0.997 and CT = 56 s) was accomplished by the hybrid algorithm. Moreover, to reduce the CT and improve the accuracy of the SVR model, the vector quantization(VQ) technique was used. The results also showed that the VQ technique can decrease the training time and improve prediction performance of the SVR model. The proposed method can provide a robust, soft sensor in a wide range of sulfur contents with good accuracy. | Saeid Shokri Mohammad Taghi Sadeghi Mahdi Ahmadi Marvast Shankar Narasimhan | 2015 | Petroleum Science2015，12，1： | 2 |
| 8 | Soft sensor design for hydrodesulfurization process using support vector regression based on WT and PCA显示文摘A novel method for developing a reliable data driven soft sensor to improve the prediction accuracy of sulfur content in hydrodesulfurization(HDS) process was proposed. Therefore, an integrated approach using support vector regression(SVR) based on wavelet transform(WT) and principal component analysis(PCA) was used. Experimental data from the HDS setup were employed to validate the proposed model. The results reveal that the integrated WT-PCA with SVR model was able to increase the prediction accuracy of SVR model. Implementation of the proposed model delivers the best satisfactory predicting performance(EAARE=0.058 and R2=0.97) in comparison with SVR. The obtained results indicate that the proposed model is more reliable and more precise than the multiple linear regression(MLR), SVR and PCA-SVR. | Saeid Shokri Mohammad Taghi Sadeghi Mahdi Ahmadi Marvast Shankar Narasimhan | 2015 | Journal of Central South University2015，22，2： | 2 |
| 9 | Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis显示文摘 | Ahmad Daryani Shahabeddin Sarvi Mohsen Aarabi Azadeh Mizani Ehsan Ahmadpour Azar Shokri Mohammad-Taghi Rahimi Mehdi Sharif | 2014 | Acta Tropica2014，，： | 2 |
| 10 | Robust sensor fault detection based on nonlinear unknown input observer显示文摘 | Jafar Zarei Ehsan Shokri | 2014 | Measurement2014，8，1： | 1 |
| 11 | Assessment of growth-in- hibiting effect of some plant essential oils on different Fusarium solates显示文摘 | Naeini A Ziglari T Shokri H | 2010 | J Med Mycol2010，20，3： | 1 |
| 12 | Characterization of copper oxide nanolayers deposited by direct current magnetron sputtering显示文摘 | RASTKAR A R NIKNAM A R SHOKRI B | 2009 | Thin Solid Films2009，517，18： | 1 |
| 13 | Evaluation of the mandibu- lar canal visibility on cone-beam computed tomography images of the mandible显示文摘 | Shokri A 1 Shakibaei Z Langaroodi AJ | 2014 | J Craniofac Surg2014，25，3： | 1 |
| 14 | Hiding in the Mobile Crowd:Location Privacy Through Collaboration显示文摘 | Shokri R Theodorakopoulos G Papadimitratos P | 2014 | IEEE Transactions on Dependable and Secure Computing2014，11，3： | 1 |
| 15 | DNA overstretching in the presence of glyoxal: Structural evidence of force-induced DNA melting 显示文摘 | SHOKRI L MCCAULEY M J ROUZINA I | 2008 | Biophys J2008，95，： | 1 |
| 16 | Radiation from large pool fires显示文摘 | Shokri M Beyler C L | 1989 | Journal of Fire Protection Engineering1989，1，4： | 1 |
| 17 | Kinetics of murinedecidual dendritic cells显示文摘 | Zarnani AH Moazzeni SM Shokri F | 2007 | Reproduction2007，133，1： | 1 |
| 18 | Production and characterization of mouse monoelonal antibodies recognizing human pan-IgG specific eonformational or linear epitopes 显示文摘 | Hajighasemi F Khoshnoodi J Shokri F | 2012 | Avicenna J Med Biotechnol2012，4，4： | 1 |
| 19 | Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic diffuse axonal injury显示文摘 | Marquez de la Plata CD Garces J Shokri Kojori E | 2011 | Arch Neurol2011，68，1： | 1 |
| 20 | Diagnosis of simulated condylar bone defects using panoramic radiography,spiral tomography and cone-beam computed tomography:A comparison study显示文摘 | Salemi F Shokri A Mortazavi H | 2015 | J Clin Exp Dent2015，7，1： | 1 |
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