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| 1 | Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation显示文摘 | Jie Li Shenyang Zhang Mengru Lu Zhibin Chen Cong Chen Lijuan Han Meijuan Zhang Yun Xu | 2013 | Neuroscience Letters2013，，： | 2 |
| 2 | Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance显示文摘Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice. | Shiyang Shen Li Zhang Mengru Li Zhizi Feng Huixia Li Xiao Xu Shiqi Lin Ping Li Can Zhang Xiaojun Xu Ran Mo | 2020 | Nano Research2020，13，11： | 2 |
| 3 | Dual-metal single-atomic catalyst:The challenge in synthesis,characterization,and mechanistic investigation for electrocatalysis显示文摘Dual-metal single-atom catalysts(DACs),featuring high atomic utilization efficiency,excellent selectivity,and stability originating from the atomically dispersed nature,have emerged as a new frontier in heterogeneous electrocatalysis due to the synergistic effect between diversified metal active sites in promoting their catalytic activity.In this review,the recent progress and development on the syntheses,characterizations,theoretical uniqueness,and applications for various catalytic reactions and devices(oxygen reduction reaction,oxygen evolution reaction,hydrogen evolution reaction,CO_(2) reduction reaction,N2 reduction reaction,proton exchange membrane fuel cells)are summarized and reviewed.Specifically,the synergistic effect between the two metal centers and electronic structures of catalysts is systematically discussed.Moreover,the future challenges and prospects in developing practical DACs are proposed as a possible direction for further investigation. | Changli Chen Mengru Sun Kaixuan Wang Yujing Li | 2022 | SmartMat2022，3，4： | 2 |
| 4 | Some trace formulas for the eigenvalue problem of Schrodinger system显示文摘 | Wu Yongtang Li Mengru | 1999 | Phys Soc Jpn1999，68，： | 1 |
| 5 | Surface defect-rich ceria quantum dots anchored on sulfur-doped carbon nitride nanotubes with enhanced charge separation for solar hydrogen production显示文摘Designing defect-engineered semiconductor heterojunctions can effectively promote the charge carrier separation.Herein,novel ceria(CeO2) quantum dots(QDs) decorated sulfur-doped carbon nitride nanotubes(SCN NTs) were synthesized via a thermal polycondensation coupled in situ depositionprecipitation method without use of template or surfactant.The structure and morphology studies indicate that ultrafine CeO2 QDs are well distributed inside and outside of SCN NTs offering highly dispersed active sites and a large contact interface between two components.This leads to the promoted formation of rich Ce^(3+) ion and oxygen vacancies as confirmed by XPS.The photocatalytic performance can be facilely modulated by the content of CeO2 QDs introduced in SCN matrix while bare CeO2 does not show activity of hydrogen production.The optimal catalyst with 10% of CeO2 loading yields a hydrogen evolution rate of 2923.8 μmol h-1 g-1 under visible light,remarkably higher than that of bare SCN and their physical mixtures.Further studies reveal that the abundant surface defects and the created 0 D/1 D junctions play a critical role in improving the separation and transfer of charge carriers,leading to superior solar hydrogen production and good stability. | Mengru Li Changfeng Chen Liping Xu Yushuai Jia Yan Liu Xin Liu | 2021 | Journal of Energy Chemistry2021，30，1： | 1 |
| 6 | Organoeatalyzed anion elay leading to functionalized 2,3-dihydrofurans 显示文摘 | Li Mengru Lin Shaoxia Dong Zhiyong | 2013 | Org Lett2013，15，15： | 1 |
| 7 | Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation显示文摘 | Li Jie Zhang Shenyang Lu Mengru | 2013 | Neuroscience Letters2013，535，22： | 1 |
| 8 | Some trace formulas for the eigenvalue problem of Schrodinger system显示文摘 | Li Mengru | 1999 | Journal of the Physical society of Japan1999，8，4： | 1 |
| 9 | Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives显示文摘Employing the intermediate derivatization method(IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by1 H NMR,13 C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight(RSB) and sorghum anthracnose(SA) were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB(EC_(50)= 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively),higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA(EC_(50)= 1.03 mg/L), equal to commercial pyraclostrobin(EC_(50)= 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development. | Fuqiang Yu Aiying Guan Mengru Li Lan Hu Xiaowu Li | 2018 | Chinese Chemical Letters2018，29，6： | 1 |
| 10 | The Trace Formula of a Matrix Differential Operator with Application of Integrable System显示文摘 | Wu Yongtang Li Mengru | 2001 | Physics letter A2001，288，4： | 1 |
| 11 | Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation显示文摘 | Jie Li Shenyang Zhang Mengru Lu Zhibin Chen Cong Chen Lijuan Han Meijuan Zhang Yun Xu | 2013 | Neuroscience Letters2013，，： | 1 |
| 12 | Improved Prediction and Understanding of Glass-Forming Ability Based on Random Forest Algorithm显示文摘As an ideal material,bulk metallic glass(MG)has a wide range of applications because of its unique properties such as structural,functional and biomedical materials.However,it is difficult to predict the glass-forming ability(GFA)even given the criteria in theory and this problem greatly limits the application of bulk MG in industrial field.In this work,the proposed model uses the random forest classification method which is one of machine learning methods to solve the GFA prediction for binary metallic alloys.Compared with the previous SVM algorithm models of all features combinations,this new model is successfully constructed based on the random forest classification method with a new combination of features and it obtains better prediction results.Simultaneously,it further shows the degree of feature parameters influence on GFA.Finally,a normalized evaluation indicator of binary alloy for machine learning model performance is put forward for the first time.The result shows that the application of machine learning in MGs is valuable. | Chenjing Su Xiaoyu Li Mengru Li Qinsheng Zhu Hao Fu Shan Yang | 2021 | Journal of Quantum Computing2021，3，2： | 1 |
| 13 | Rational design of Fe-N-C electrocatalysts for oxygen reduction reaction:From nanoparticles to single atoms显示文摘As an alternative energy,hydrogen can be converted into electrical energy via direct electrochemical conversion in fuel cells.One important drawback of full cells is the sluggish oxygen reduction reaction(ORR)promoted by the high-loading of platinum-group-metal(PGM)electrocatalysts.Fe-N-C family has been received extensive attention because of its low cost,long service life and high oxygen reduction reaction activity in recent years.In order to further enhance the ORR activity,the synthesis method,morphology regulation and catalytic mechanism of the active sites in Fe-N-C catalysts are investigated.This paper reviews the research progress of Fe-N-C from nanoparticles to single atoms.The structure-activity relationship and catalytic mechanism of the catalyst are studied and discussed,which provide a guidance for rational design of the catalyst,so as to promote the more reasonable design of Fe-N-C materials. | Mengru Sun Changli Chen Menghao Wu Danni Zhou Zhiyi Sun Jianling Fan Wenxing Chen Yujing Li | 2022 | Nano Research2022，15，3： | 0 |
| 14 | Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway显示文摘OBJECTIVE: To determine whether Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction(HFp EF) by regulating the cyclic guanosine monophosphatedependent protein kinase(c GMP-PKG) signaling pathway. METHODS: Except for control group 8 and sham surgery group 8, the remaining 32 male Sprague-Dawlay rats were developed into HFp EF rat models using the abdominal aorta constriction method. These rats in the HFp EF model were randomly divided into the model group, the Shunxin high-dose group, the Shunxin lowdose group, and the Qiliqiangxin capsule group. The three groups received high-dose Shunxin decoction, lowdose Shunxin decoction, and Qiliqiangxin capsule by gavage, respectively, for 14 d. After the intervention, the diastolic function of each rat was evaluated by testing E/A, heart index, hematoxylin-eosin staining, Masson, myocardial ultrastructure, and N-terminal pro-brain natriuretic peptide(NT-pro BNP). The Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) software was used to predict targets for which Shunxin decoction acts on the c GMP-PKG pathway. Natriuretic peptide receptor A(NPRA) and guanylate cyclase(GC) were detected by immunohistochemistry, and e NOS, phosphodiesterase 5A(PDE5A), and c GMP-dependent protein kinase 1(PKG I) were determined by Western blotting. RESULTS: Compared to the model group, the thickness of the interventricular septum at the end of diastole(IVSd) and the thickness of the posterior wall at the end of diastole(PWd) of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group were all significantly reduced(P < 0.01). Furthermore, Shunxin decoction high-dose group E/A value was decreased(P < 0.01). Compared to the model group, the expression of NPRA and GC increased in the Shunxin decoction low-dose group and the Qiliqiangxin capsule group(P < 0.01). Compared to the model group, the expressions of e NOS and PKG I increased(P < 0.05) in the Shunxin decoction high-dose group. The expression of PDE5A expression decreased in the myocardium of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group compared to the model group(P < 0.01). CONCLUSIONS: Shunxin decoction can improve diastolic function in rats with HFp EF. It increases the expression of NPRA, GC, and e NOS in the myocardial cell c GMP-PKG signaling pathway, upregulates c GMP expression, decreases PDE5A expression to reduce the c GMP degradation. Thus, the c GMP continually stimulates PKG I, reversing myocardial hypertrophy and improving myocardial compliance in HFp EF rats. | ZHANG Jiaying WEI Xiangxiang LI Xuefeng YUAN Yang DOU Yinghuan SHI Yanbin XIE Ping ZHOU Mengru ZHAO Junnan LI Miao ZHANG Shuwen ZHU Rui TIAN Ying TAN Hao TIAN Feifei | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 15 | Next‑Generation Sequencing‑Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel DNAH5 Copy Number Variations显示文摘Primary ciliary dyskinesia(PCD)is a rare disorder characterized by extensive genetic heterogeneity.However,in the genetic pathogenesis of PCD,copy number variation(CNV)has not received sufcient attention and has rarely been reported,especially in China.Next-generation sequencing(NGS)followed by targeted CNV analysis was used in patients highly suspected to have PCD with negative results in routine whole-exome sequencing(WES)analysis.Quantitative real-time polymerase chain reaction(qPCR)and Sanger sequencing were used to confrm these CNVs.To further characterize the ciliary phenotypes,high-speed video microscopy analysis(HSVA),transmission electron microscopy(TEM),and immunofuorescence(IF)analysis were used.Patient 1(F1:II-1),a 0.6-year-old girl,came from a nonconsanguineous family-I.She presented with situs inversus totalis,neonatal respiratory distress,and sinusitis.The nasal nitric oxide level was markedly reduced.The respiratory cilia beat with reduced amplitude.TEM revealed shortened outer dynein arms(ODA)of cilia.chr5:13717907-13722661del spanning exons 71–72 was identifed by NGS-based CNV analysis.Patient 2(F2:IV-4),a 37-year-old man,and his eldest brother Patient 3(F2:IV-2)came from a consanguineous family-II.Both had sinusitis,bronchiectasis and situs inversus totalis.The respiratory cilia of Patient 2 and Patient 3 were found to be uniformly immotile,with ODA defects.Two novel homozygous deletions chr5:13720087_13733030delinsGTTTTC and chr5:13649539_13707643del,spanning exons 69–71 and exons 77–79 were identifed by NGS-based CNV analysis.Abnormalities in DNA copy number were confrmed by qPCR amplifcation.IF showed that the respiratory cilia of Patient 1 and Patient 2 were defcient in dynein axonemal heavy chain 5(DNAH5)protein expression.This report identifed three novel DNAH5 disease-associated variants by WES-based CNV analysis.Our study expands the genetic spectrum of PCD with DNAH5 in the Chinese population. | Weicheng Chen Zhuoyao Guo Mengru Li Wei Sheng Guoying Huang | 2024 | Phenomics2024，4，1： | 0 |
| 16 | Research and application of leek roots in medicinal field显示文摘Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical medicine of food and medicine continuum.It has a long history of medicinal applications and edible food in China.In this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were introduced.We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products. | Huaijian Wang Ying Tian Hao Tan Mengru Zhou Miao Li Yuchen Zhi Yanbin Shi Xuefeng Li | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 17 | RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration显示文摘Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported to play a crucial role in axonal regeneration.Howeve r,the role of the IncRNA-microRNAmessenger RNA(mRNA)-competitive endogenous RNA(ceRNA)network in exosome-mediated axonal regeneration remains unclear.In this study,we performed RNA transcriptome sequencing analysis to assess mRNA expression patterns in exosomes produced by cultured fibroblasts(FC-EXOs)and Schwann cells(SCEXOs).Diffe rential gene expression analysis,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and protein-protein intera ction network analysis were used to explo re the functions and related pathways of RNAs isolated from FC-EXOs and SC-EXOs.We found that the ribosome-related central gene Rps5 was enriched in FC-EXOs and SC-EXOs,which suggests that it may promote axonal regeneration.In addition,using the miRWalk and Starbase prediction databases,we constructed a regulatory network of ceRNAs targeting Rps5,including 27 microRNAs and five IncRNAs.The ceRNA regulatory network,which included Ftx and Miat,revealed that exsosome-derived Rps5 inhibits scar formation and promotes axonal regeneration and functional recovery after nerve injury.Our findings suggest that exosomes derived from fibro blast and Schwann cells could be used to treat injuries of peripheral nervous system. | Xinyang Zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 18 | Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case显示文摘The chemical complexity of traditional Chinese medicines(TCMs) makes the active and functional annotation of natural compounds challenging. Herein, we developed the TCMs-Compounds Functional Annotation platform(TCMs-CFA) for large-scale predicting active compounds with potential mechanisms from TCM complex system, without isolating and activity testing every single compound one by one. The platform was established based on the integration of TCMs knowledge base, chemome profiling, and high-content imaging. It mainly included:(1) selection of herbal drugs of target based on TCMs knowledge base;(2) chemome profiling of TCMs extract library by LC-MS;(3) cytological profiling of TCMs extract library by high-content cell-based imaging;(4) active compounds discovery by combining each mass signal and multi-parametric cell phenotypes;(5) construction of functional annotation map for predicting the potential mechanisms of lead compounds. In this stud TCMs with myocardial protection were applied as a case study, and validated for the feasibility and utility of the platform. Seven frequently used herbal drugs(Ginseng, etc.) were screened from 100,000 TCMs formulas for myocardial protection and subsequently prepared as a library of 700 extracts. By using TCMs-CFA platform, 81 lead compounds, including 10 novel bioactive ones, were quickly identified by correlating 8089mass signals with 170,100 cytological parameters from an extract library. The TCMs-CFA platform described a new evidence-led tool for the rapid discovery process by data mining strategies, which is valuable for novel lead compounds from TCMs. All computations are done through Python and are publicly available on GitHub. | Xudong Xing Mengru Sun Zifan Guo Yongjuan Zhao Yuru Cai Ping Zhou Huiying Wang Wen Gao Ping Li Hua Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 19 | Surface Molecular Encapsulation with Cyclodextrin in Promoting the Activity and Stability of Fe Single-Atom Catalyst for Oxygen Reduction Reaction显示文摘Fe single-atom catalysts(Fe-SACs)have been extensively studied as a highly efficient electrocatalyst toward the oxygen reduction reaction(ORR).Nonetheless,they suffer from stability issue induced by dissolution of Fe metal center and the OH^(−)blocking.Herein,a surface molecular engineering strategy is developed by usingβ-cyclodextrins(CDs)as a localized molecular encapsulation.The CD-modified Fe-SAC(Fe-SNC-β-CD)shows obviously improved activity toward the ORR with 0.90 V,4.10 and 4.09 mA cm^(-2)for E_(1/2),J_(0)and Jk0.9,respectively.Meanwhile,the Fe-SNC-β-CD shows the excellent long-term stability against aggressive stress and the poisoning.It is confirmed through electrochemical investigation that modification ofβ-CD can,on one hand,regulate the atomic Fe coordination chemistry through the interaction between the CD and FeN_(x) moiety,while on the other mitigate the strong adsorption of OH^(−)and function as protective barrier against the poisoning molecules leading to enhanced ORR activity and stability for the Fe-SACs.The molecular encapsulation strategy demonstrates the uniqueness of post-pyrolysis surface molecular engineering for the design of single-atom catalyst. | Changli Chen Haijing Li Jingzhao Chen Dong Li Wenxing Chen Juncai Dong Mengru Sun Yujing Li | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 20 | Identification of long non-coding RNAs in response to downy mildew stress in grape显示文摘The importance of long non-coding RNA in plants has been reported more frequently in recent years,but there has been few specific reports on lncRNAs in grape,especially in terms of disease resistance.We performed RNA-seq on grape leaves of two species(Vitis piasezkii accession Liuba-8,Vitis vinifera cultivar Pinot Noir)sampled at six time points after inoculation,and 4011 possible lncRNAs were identified.The characteristics of grape lncRNAs were analyzed,and it was found that lncRNAs showed relatively consistent characteristics with the reported lncRNAs in model plants.3,643 lncRNAs were predicted that have cis-regulatory effects on 6,622 protein-coding genes and 91 DElncRNAs were revealed to be coexpressed with its trans-regulated coding genes.One hundred and seventeen grape microRNAs were predicted to potentially target 184 lncRNAs and six lncRNAs were predicted to be endogenous targeting mimics of 15 microRNAs,among which some miRNAs have been reported in grape disease resistance.At six time points,LncRNAs showed different expression levels and different expression patterns in two species,suggesting that lncRNAs may have a certain regulatory effect on resistance to downy mildew in grape.Finally,a lncRNA MSTRG.12742.1 which may play a positive role in grape downy mildew resistance was verified by transient transformation.Its potential target gene,VIT_204s0008g02671.1,encodes cryptochrome DASH which may regulate stomatal opening and closing of plant leaves.In this study,we provided the systematic identification of lncRNAs in the course of downy mildew of grape,laying a foundation for further studies on downy mildew and lncRNAs of grape in the future. | Meijie Li Mengru Dou Ruiqi Liu Yuntong Jiao Zhiqiang Hao Yan Xu | 2022 | Fruit Research2022，2，1： | 0 |
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