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| 1 | Increasing terrestrial vegetation activity in China, 1982—1999显示文摘Variations in vegetation activity during the past 18 years in China were investigated using the normalized difference vegetation index (NDVI) derived from the 3rd generation time series dataset of NOAA-AVHRR from 1982 to 1999. In order to eliminate the effects of non-vegetation factors, we characterized areas with NDVI < 0.1 as sparsely vegetated areas and areas with NDVI ≥ 0.1 as vegetated areas. The results showed that increasing NDVI trends were evident, to varying extents, in almost all regions in China in the 18 years, indicating that vegetation activity has been rising in recent years in these regions. Compared to the early 1980s, the vegetated area increased by 3.5% by the late 1990s, while the sparsely vegetated area declined by 18.1% in the same period. The national total mean annual NDVI increased by 7.4% during the study period. Extended growing seasons and increased plant growth rates ac-counted for the bulk of these increases, while increases in temperature and summer rainfall, and strengthening agricultural activity were also likely important factors. NDVI changes in China ex-hibited relatively large spatial heterogeneity; the eastern coastal regions experienced declining or indiscernibly rising trends, while agricultural regions and western China experienced marked increases. Such a pattern was due primarily to urbanization, agricultural activity, regional climate characteristics, and different vegetation responses to regional climate changes. | FANG Jingyun PIAO Shilong HE Jinsheng MA Wenhong | 2004 | Science China(Life Sciences)2004，47，3： | 109 |
| 2 | Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province显示文摘Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of viral pneumonia on chest imaging.Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis. | Kui Liu Yuan-Yuan Fang Yan Deng Wei Liu Mei-Fang Wang Jing-Ping Ma Wei Xiao Ying-Nan Wang Min-Hua Zhong Cheng-Hong Li Guang-Cai Li Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，9： | 100 |
| 3 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 4 | Hydrogen Sulfide Promotes Root Organogenesis in Ipomoea batatas, Salix matsudana and Glycine max显示文摘In this report, we demonstrate that sodium hydrosulfide (NaHS), a hydrogen sulfide (H2S) donor, promoted adventitious root formation mediated by auxin and nitric oxide (NO). Application of the H2S donor to seedling cuttings of sweet potato (Ipomoea batatas L.) promoted the number and length of adventitious roots in a dose-dependent manner. It was also verified that H2S or HS- rather than other sulfur-containing components derived from NaHS could be attributed to the stimulation of adventitious root formation. A rapid increase in endogenous H2S, indole acetic acid (IAA) and NO were sequentially observed in shoot tips of sweet potato seedlings treated with HaHS. Further investigation showed that H2S-mediated root formation was alleviated by N-1-naphthylphthalamic acid (NPA), an IAA transport inhibitor, and 2-(4-carboxyphenyl)- 4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), an NO scavenger. Similar phenomena in H2S donor-dependent root organogenesis were observed in both excised willow (Salix matsudana var. tortuosa Vilm) shoots and soybean (Glycine max L.) seedlings. These results indicated that the process of H2S-induced adventitious root formation was likely mediated by IAA and NO, and that H2S acts upstream of IAA and NO signal transduction pathways. | Hua Zhang Jun Tang Xiao-Ping Liu Yun Wang Wei Yu Wei-Yan Peng Fang Fang Dai-Fu Ma Zhao-Jun Wei Lan-Ying Hu | 2009 | Journal of Integrative Plant Biology2009，51，12： | 58 |
| 5 | Change of Inflammatory Factors in Patients with Acute Coronary Syndrome显示文摘 | Cai-Yun Ma Zhen-Ye Xu Shao-Ping Wang Hong-Yu Peng Fang Liu Jing-Hua Liu Feng-Xue Ren | 2018 | Chinese Medical Journal2018，，12： | 47 |
| 6 | Spatial differences and multi-mechanism of carbon footprint based on GWR model in provincial China显示文摘全球温暖是在世界后面的主要担心之一高速度的经济生长。怎么实现碳脚印和经济的协调发展将是世界的核心问题经济、社会的开发,以及在最近的年里的家和国外的研究的激烈的争论。基于精力消费,与自顶向下的生命周期途径和地理上加权的回归(GWR ) 综合模型,这篇论文在 2010 在省的中国分析了碳脚印的空间差别和多机制。第一,这研究用自顶向下的生命周期途径计算了每个省的碳脚印的数量并且发现在省的中国有碳脚印和人均的碳脚印的重要差别。有更高的碳脚印的省,主要在北中国定位了,有大经济规模;有更高人均的碳脚印的省主要在象北京,上海和充满精力的区域和重化学的底那样的中央城市里被散布。在 GIS 和空间分析模型(GWR 模型) 的帮助下,第二,这篇论文展开了经济规模的扩大是碳脚印的快速的生长的主要司机。人口和都市化的生长也充当了为碳脚印的增加支持因素。精力结构没为碳脚印的增加有可观的支持效果。改进精力效率是最重要的因素禁止成长的碳脚印。第三,开发低碳的经济和低碳的工业,以及倡导低碳的城市建设和改善的碳效率将是主要途径禁止碳脚印的快速的生长。中等控制经济规模和人口尺寸将也被要求减轻碳脚印。同时,低碳的城市的环境保护和建设将在都市化的过程唤起广泛的注意。 | WANG Shaojian FANG Chuanglin MA Haitao WANG Yang QIN Jing | 2014 | Journal of Geographical Sciences2014，24，4： | 40 |
| 7 | The vegetation and climate change during Neocene and Early Quaternary in Jiuxi Basin, China显示文摘Sporopollen record in the Laojunmiao Section at Yumen in the Hexi Corridor foreland depression at the northern margin of the Tibetan Plateau revealed that during the period of 13.0―11.15 Ma the ecological environment of the Jiuxi Basin is characterized by steppe vegetation and a semi-moist climate. During 11.16―8.60 Ma prevailed forests of cypress and a still warmer, moister climate; steppe vegetation and dry climate began probably at about 8.6 Ma. Although aridification had been relaxed time and again during 8.40―6.93 Ma (forest-steppe, warm-semi-moist), 6.64―5.67 Ma (open-forest and steppe, warmer-semi-moist) and 5.42―4.96 Ma (steppe, semi-arid), the climate in the region became drier and drier in response to the fre- quent occurrence of aridity during 6.93―6.64 Ma (steppe, semi-arid), 5.67―5.42 Ma (de- sert-steppe, arid), 3.66―3.30 Ma (desert-steppe, arid) and 2.56―2.21 Ma (desert, arid). Perhaps the important findings of our study are the notable expansion of drought-enduring plants during 3.66―3.30 Ma and about 2.56 Ma and the replacement of vegetation by vast arid desert. | MA Yuzhen 1 , FANG Xiaomin 1,2 , LI Jijun 1 , WU Fuli 1 & ZHANG Jun 1 1. Key Laboratory of Western China’s Environmental Systems and College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 2. State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China | 2005 | Science China Earth Sciences2005，48，5： | 31 |
| 8 | ShRNA-mediated gene silencing of β-catenin inhibits growth of human colon cancer cells显示文摘AIM: To observe the gene silencing mediated by the specific shRNA targeted against β-catenin and its effect on cell proliferation and cycle distribution in the human colon cancer cell line Colo205. METHODS: Two shRNA plasmid vectors against β-catenin were constructed and transfected into Colo205 cells with LipofectamineTM2000. The down-regulations of β-catenin, c-myc and cyclinD1 expressions were detected by RT-PCR and western blot analysis. The cell proliferation inhibitions were determined by MTT assay and soft agar colony formation assay. The effect of these two β-catenin shRNAs on cell cycle distribution and apoptosis was examined by flow cytometry. RESULTS: These two shRNA vectors targeted against β-catenin efficiently suppressed the expression of β-catenin and its down stream genes, c-myc and cyclinD1. The expression inhibition rates were around 40%-50% either at the mRNA or at the protein level. The shRNA-mediated gene silencing of β-catenin resulted in significant inhibition of cell growth both on the culture plates and in the soft agar. Moreover, the cancer cells showed significant G0/G1 arrest and increased apoptosis at 72 h post transfection due to gene silencing. CONCLUSION: These specific shRNAs targeted against β-catenin could have a gene silencing effect and block the WNT signaling pathway. They could inhibit cell growth, increase apoptosis, and induce cell cycle arrest in Colo205 cells. ShRNA interference against β-catenin is of potential value in gene therapy of colon cancer. | Wen-Sheng Huang Jian-Ping Wang Ting Wang Jie-Yu Fang Ping Lan Jin-Ping Ma | 2007 | World Journal of Gastroenterology2007，13，48： | 33 |
| 9 | Above-and belowground biomass in relation to envi- ronmental factors in temperate grasslands, Inner Mongolia显示文摘Above- and belowground biomasses of grasslands are important parameters for characterizing re- gional and global carbon cycles in grassland ecosystems. Compared with the relatively detailed in- formation for aboveground biomass (AGB), belowground biomass (BGB) is poorly reported at the re- gional scales. The present study, based on a total of 113 sampling sites in temperate grassland of the Inner Mongolia, investigated regional distribution patterns of AGB, BGB, vertical distribution of roots, and their relationships with environmental factors. AGB and BGB increased from the southwest to the northeast of the study region. The largest biomass occurred in meadow steppe, with mean AGB and BGB of 196.7 and 1385.2 g/m2, respectively; while the lowest biomass occurred in desert steppe, with an AGB of 56.6 g/m2 and a BGB of 301.0 g/m2. In addition, about 47% of root biomass was distributed in the top 10 cm soil. Further statistical analysis indicated that precipitation was the primary determinant factor in shaping these distribution patterns. Vertical distribution of roots was significantly affected by precipitation, while the effects of soil texture and grassland types were weak. | MA WenHong1,2, YANG YuanHe1, HE JinSheng1, ZENG Hui1,2 & FANG JingYun1 1 Department of Ecology, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China 2 School of Environment & Urban Study, Peking University Shenzhen Graduate School, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，3： | 34 |
| 10 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 11 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 12 | Zircon U-Pb SHRIMP ages of the Taiping (calc-alkaline)-Huangshan (alkaline) composite intrusion:Constraints on Mesozoic lithospheric thinning of the southeastern Yangtze Craton,China显示文摘The Taiping-Huangshan composite intrusion is a unique complex with characteristics changing from calc-alkaline (Taiping intrusion) to alkaline (Huangshan intrusion). Huangshan intrusion samples show a spectacular tetrad effect in their REE distribution patterns as well as non-CHARAC (charge-and radius-controlled) trace element behavior, indicating a highly evolved late-stage magma component. This composite intrusion provides a rare opportunity to investigate the variance of tectonic setting and lithospheric thinning of the southeastern Yangtze Craton in late Mesozoic era. Zircon SHRIMP U-Pb analyses yield an emplacement age of 140.6±1.2 Ma for the Taiping intrusion, and ages of 127.7±1.3, 125.7±1.4, 125.1±1.5, and 125.2±5.5 Ma for four samples from the Huangshan intrusion respectively. The ages for four different phases of the Huangshan intrusion agree within their small analytical errors, indicating that the emplacement was in a short time. The Taiping and Huangshan intrusions are intimately associated, but there is about 15 Ma interval between their intrusion, and the magma characters change from calc-alkaline to alkaline without transition. This probably corresponds to lithospheric thinning of the southeastern Yangtze Craton. This event possibly happened from about 141 Ma (the emplacement age of the Taiping intrusion), to 128 Ma (start of emplacement of the Huangshan intrusion). The thinning mechanism is dominantly delamination. | XUE HuaiMin WANG YingGeng MA Fang WANG Cheng WAN DeEn ZUO YanLong | 2009 | Science China Earth Sciences2009，52，11： | 28 |
| 13 | Structure of Chinese City Network as Driven by Technological Knowledge Flows显示文摘Based on patent cooperation data,this study used a range of city network analysis approaches in order to explore the structure of the Chinese city network which is driven by technological knowledge flows.The results revealed the spatial structure,composition structure,hierarchical structure,group structure,and control structure of Chinese city network,as well as its dynamic factors.The major findings are:1) the spatial pattern presents a diamond structure,in which Wuhan is the central city;2) although the invention patent knowledge network is the main part of the broader inter-city innovative cooperation network,it is weaker than the utility model patent;3) as the senior level cities,Beijing,Shanghai and the cities in the Zhujiang(Pearl) River Delta Region show a strong capability of both spreading and controlling technological knowledge;4) whilst a national technology alliance has preliminarily formed,regional alliances have not been adequately established;5) even though the cooperation level amongst weak connection cities is not high,such cities still play an important role in the network as a result of their location within ′structural holes′ in the network;and 6) the major driving forces facilitating inter-city technological cooperation are geographical proximity,hierarchical proximity and technological proximity. | MA Haitao FANG Chuanglin PANG Bo WANG Shaojian | 2015 | Chinese Geographical Science2015，25，4： | 28 |
| 14 | Storage,Patterns and Controls of Soil Nitrogen in China显示文摘Soil holds the largest nitrogen(N)pool in terrestrial ecosystems,but estimates of soil N stock remain controversial. Storage and spatial distribution of soil N in China were estimated and the relationships between soil N density and environmental factors were explored using data from China's Second National Soil Survey and field investigation in northwest China and the Tibetan Plateau.China's soil N storage at a depth of one meter was estimated at 7.4 Pg,with an average density of 0.84 kg m^(-2).Soil N density appeared to be high in southwest and northeast China and low in the middle areas of the country.Soil N density increased from the arid to semi-arid zone in northern China,and decreased from cold-temperate to tropical zone in the eastern part of the country.An analysis of general linear model suggested that climate and vegetation determined the spatial pattern of soil N density for natural vegetation,which explained 75.4% of the total variance. | YANG Yuan-He MA Wen-Hong A. MOHAMMAT FANG Jing-Yun | 2007 | Pedosphere2007，17，6： | 26 |
| 15 | Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents显示文摘Objectives To explore the optimal threshold values of waist circumference(WC)for detecting cardiovascular(CV)risk factors among Chinese children and adolescents.Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China.CV risk factors in this study included hypertension(blood pressure above 95 percentile levels),dyslipidemia(with one or more of the following three indexes:TG≥1.7 mmol/L,TC≥5.18 mmol/L,and HDL-C≤1.04 mmol/L)and elevated glucose level(fasting plasma glucose ≥5.6 mmol/L).Receive-operating characteristic analysis(ROC)and logistic regression were employed to derive optimal age-and sex-specific waist circumference references for predicting CV risk factors.Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population,while a remarkable increasing trend occurred from the 90th percentile.The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls,which was at the 90th percentiles for detecting at least two of the above three CV risk factors.In comparison with children with waist circumference below the 75th percentile,the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile,and increased by 6 times among children with waist circumference above the 90th percentile.The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category.Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents,respectively. | GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI R1TA YT SLING FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG | 2010 | Biomedical and Environmental Sciences2010，23，1： | 25 |
| 16 | Prediction of recurrence and prognosis in patients with hepatocellular carcinoma after resection by use of CLIP score显示文摘AIM: The survival time of patients with hepatocellular carcinoma (HCC) after resection is hard to predict. Both residual liver function and tumor extension factors should be considered. A new scoring system has recently been proposed by the Cancer of the Liver Italian Program (CLIP).CUP score was confirmed to be one of the best ways to stage patients with HCC. To our knowledge, however, the literature concerning the correlation between CLIP score and prognosis for patients with HCC after resection was not pubhshed. The aim of this study is to evaluate the recurrence and prognostic value of CLIP score for the patients with HCC after resection.METHODS: A retrospective survey was carried out in 174patients undergoing resection of HCC from January 1986 toJune 1998. Six patients who died in the hospital afteroperation and 11 patients with the recurrence of the diseasewere excluded at 1 month after hepatectomy. By the end ofJune 2001, 4 patients were lost and 153 patients with curativeresection have been followed up for at least three years.Among 153 patients, 115 developed intrahepatic recurrenceand 10 developed extrahepatic recurrence, whereas the other28 remained free of recurrence. Recurrences were classifiedinto early ( < / = 3 year) and late ( > 3 year) recurrence. TheCLIP score included the parameters involved in the Child-Pugh stage (0-2), plus macroscopic tumor morphology (0-2), AFP levels (0-1), and the presence or absence of portalthrombosis (0-1)o By contrast, portal vein thrombosis wasdefined as the presence of tumor emboli within vascularchannel analyzed by microscopic examination in this study.Risk factors for recurrence and prognostic factors forsurvival in each group were analyzed by the chi-square test,the Kaplan-Meier estimation and the COX proportionalhazards model respectively.RESULTS: The 1-, 3-, 5-, 7-, andl0-year disease-free survivalrates after curative resection of HCC were 57.2 %、 28.3 %、23.5 %、 18.8 % and 17.8 %, respectively. Median survivaltime was 28,16,10,4,and 5 mo for CLIP score 0,1,2,3, and 4to 5, respectively. Early and late recurrence developed in109 patients and 16 patients respectively. By the chi-squaretest, tumor size, micrusatsllite, venous invasion, tumortype (uninodular, muitinodular, massive), tumor extension( < / = or > 50 % of liver parenchyna replaced by tumor),TNM stage,CLIP score,and resection margin were the risk factors for early recurrence,whereas CLIP score and Child-Pugh stage were significant risk factors for late recurrence. in univariate survival analysis,Child-Pugh stages,resection margin,tumor size,microsatellite,venous invasion,tumor type,tumor extension,TNM stages,and CLIP score were associated with prognosis.The multivariale analysis by COX proportional hazards modes showed that the independent predictive factors of survival were resection margins and TNM stages. CONCLUSION:CLIP score has displayed a unique superiority in predictin the tumor early and late recurrence and prognosis in the patients with HCC after resection. | Wen He Zhao Zhi-Min Ma Xing-Ren Zhou Yi-Zheng Feng Bao-Shan Fang,Department of Oncosurgery,the First Affiliated Hospital,Zhejiang University,Medical College,Hangzhou 310003,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 26 |
| 17 | Dust storms and loess accumulation on the Tibetan Plateau: A case study of dust event on 4 March 2003 in Lhasa显示文摘Whether the Tibetan Plateau is a significant dust source area is of great importance, because this is re-lated to the understanding of sources, accumulation and environmental effects of dusts on the Tibetan Plateau and in the Far East-Pacific Ocean regions as well as to the evolution of coupling of the Tibetan Plateau and atmosphere-ocean- continent exchange. Synoptic dynamics and remote sensing tracing of a dust storm on 3 to 5 March, 2003 in Lhasa on South Tibet demonstrate that the Tibetan Plateau possesses all factors and conditions of generating dust storms. Accom-panied with this dust storm is a strong ascending stream on the Plateau which has raised various sizes of dust particles into different levels. The lifted coarse particles were largely fallen down and accumulated as loess on the eastern Tibetan Plateau, and the fine particles were translated by the west-erly jet and subsided in the northern Pacific Ocean. The spa-tial-temporal distribution of dust-storms between years 1961 and 2000 on the Plateau shows that dust-storms mainly occur in winter and early spring with high frequency, and the path of dust storm moves gradually from south to north, which is closely coupled with the northward moving of the westerly jet from winter to spring over the Tibetan Plateau. Com-pared with other twelve dust source areas in China, the Ti-betan Plateau is one of the key dust source areas for the long-distance transport because its high occurring frequency and elevation cause fine particles easily to be lifted into the zone of the westerly jet. | FANG Xiaomin HAN Yongxiang MA Jinghui SONG Lianchun YANG Shengli ZHANG Xiaoye | 2004 | Chinese Science Bulletin2004，49，9： | 25 |
| 18 | The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. | Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma | 2021 | Cancer Communications2021，41，11： | 22 |
| 19 | Left posterior fascicular block: a new endpoint of ablation for verapamil-sensitive idiopathic ventricular tachycardia显示文摘Background Verapamil-sensitive, idiopathic left ventricular tachycardia (ILVT) with right bundle branch block configuration and left-axis deviation is known to be due to re-entry mechanism but the exact nature of reentrant circuit in ILVT is not fully elucidated. Radiofrequency (RF) ablation was applied during ventricular tachycardia (VT) and termination of the VT or abolishing the inducibility of the tachycardia was used as an endpoint for successful RF. In this study, the left posterior fascicular block in surface electrocardiogram (ECG) was used as a new endpoint of ablation to cure ILVT. Methods Electrophysiological studies and radiofrequency ablation were performed in 39 consecutive patients [30 men, 9 women; age ranging from 10 to 64 years, mean (29±16) years] with verapamil-sensitive ILVT and structurally normal hearts. VT could be terminated by the intravenous administration of verapamil in all patients. The target site was the midseptum of LV where the earliest Purkinje potentials were recorded during VT. RF current was applied to the target site with or without late diastolic potential (LDP) during sinus rhythm in 37 patients and during VT in 2 patients to meet the ablation endpoint: the left posterior fascicular block in the surface ECG. Results Thirty-seven patients with ILVT had been treated by RF ablation during sinus rhythm and two had been treated during VT. All of them met the endpoint of the left posterior fascicular block. Thirty-eight cases were symptom-free without medications during the follow-up period (range from 3 to 95 months, median 17 months). One patient developed a clinical recurrence and the left posterior fascicular block in surface ECG disappeared. The patient received another treatment. The endpoint was met and the procedure was successful. Conclusions The left posterior fascicular block in surface ECG used as an endpoint of RF ablation to treat ILVT is effective. It is important especially in those patients whose VT can not be induced or the inducible condition is unstable. The effective endpoint implied that the left posterior fascicle might be a critical part of the re-entrant circuit. | MA Fu-sheng MA Jian TANG Kai HAN Hao JIAYu-he FANG Pi-hua CHU Jian-min PU Jie-lin ZHANG Shu | 2006 | Chinese Medical Journal2006，，5： | 21 |
| 20 | Aquaporins as potential drug targets显示文摘aquaporins (AQP ) 是有选择地搬运水的不可分的膜蛋白质的一个家庭并且在一些情况中,小中立溶质象甘油和脲那样。13 哺乳动物的 AQP 分子地被识别了并且对局部性各种各样上皮,内皮和另外的纸巾。 AQP 大美人的转基因的老鼠模型,的显型研究变化,并且在有 AQP 的一些情况人,变化在哺乳动物的生理学和病理生理学为 AQP 表明了必要角色包括尿专注的功能,外分泌腺的液体分泌物,大脑浮肿形成,颅内的规定和 intraocular 压力,皮肤水和,脂肪代谢,肿瘤血管生成和细胞移行。这些研究建议 AQP 可以为大脑浮肿,煽动性的疾病,绿内障,肥胖,和癌症的新奇治疗是为为病理学的水保留,而且目标的各种各样的形式的不仅新利尿的试剂的潜在的药目标。然而,为在活体内申请的有势力 AQP 调节的人尚待被发现。 | Fang WANG Xue-chao FENG Yong-ming LI Hong YANG Tong-hui MA | 2006 | Acta Pharmacologica Sinica2006，27，4： | 21 |
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