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| 1 | Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma显示文摘AIM:To determine the efficacy of external beam radiotherapy(EBRT),with or without intraluminal brachytherapy(ILBT),in patients with non-resected locally advanced hilar cholangiocarcinoma.METHODS:We analyzed 64 patients with locally advanced hilar cholangiocarcinoma,including 25 who underwent resection(17 curative and 8 non-curative),28 treated with radiotherapy,and 11 who received best supportive care(BSC).The radiotherapy group received EBRT(50 Gy,30 fractions),with 11 receiving an additional 24 Gy(4 fractions) ILBT by iridium-192 with remote after loading.ILBT was performed using percutaneous transhepatic biliary drainage(PTBD) route.Uncovered metallic stents(UMS) were inserted into nonresected patients with obstructive jaundice,with the exception of four patients who received percutaneous transhepatic biliary drainage only.UMS were placed endoscopically or percutaneously,depending on the initial drainage procedure.The primary endpoints were patient death or stent occlusion.Survival time of patients in the radiotherapy group was compared with that of patients in the resection and BSC groups.Stent patency was compared in the radiotherapy and BSC groups.RESULTS:No statistically significant differences in patient characteristics were found among the resection,radiotherapy,and BSC groups.Three patients in the radiotherapy group and one in the BSC group did not receive UMS insertion but received PTBD alone;cholangitis occurred after endoscopic stenting,and patients were treated with PTBD.A total of 16 patients were administered additional systemic chemotherapy(5-fluorouracil-based regimen in 9,S-1 in 6,and gemcitabine in 1).Overall survival varied significantly among groups,with median survival times of 48.7 mo in the surgery group,22.1 mo in the radiotherapy group,and 5.7 mo in the BSC group.Patients who underwent curative resection survived significantly longer than those who were not candidates for surgery(P = 0.0076).Cumulative survival in the radiotherapy group was significantly longer than in the BSC group(P = 0.0031),but did not differ significantly from those in the non-resection group.Furthermore,the median survival time of patients in the radiotherapy group who were considered for possible resection(excluding the seven patients who were not candidates for surgery due to comorbid disease or age) was 25.9 mo.Stent patency was evaluated only in the 24 patients who received a metallic stent.Stent patency was significantly longer in the radiotherapy than in the BSC group(P = 0.0165).Biliary drainage was not eliminated in any patient.To determine the efficacy of ILBT,we compared survival time and stent patency in the EBRT alone and EBRT plus ILBT groups.However,we found no significant difference in survival time between groups or for stent patencies.Hemorrhagic gastroduodenal ulcers were observed in 5 patients(17.9%),three in the EBRT plus ILBT group and two in the EBRT alone group.Ulcers occurred 5 mo,7 mo,8 mo,16 mo,and 29 mo following radiotherapy.All patients required hospitalization,but blood transfusions were unnecessary.All 5 patients recovered following the administration of anti-ulcer medication.CONCLUSION:Radiotherapy improved patient prognosis and the patency of uncovered metallic stents in patients with locally advanced hilar cholangiocarcinoma,but ILBT provided no additional benefits. | Hiroyuki Isayama Takeshi Tsujino Yousuke Nakai Takashi Sasaki Keiichi Nakagawa Hideomi Yamashita Taku Aoki Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，19： | 24 |
| 2 | Radiation pneumonitis after stereotactic radiation therapy for lung cancer显示文摘Stereotactic body radiation therapy(SBRT)has a locacontrol rate of 95%at 2 years for non-small cell lungcancer(NSCLC)and should improve the prognosis oinoperable patients,elderly patients,and patients withsignificant comorbidities who have early-stage NSCLCThe safety of SBRT is being confirmed in internationalmulti-institutional PhaseⅡtrials for peripheral lungcancer in both inoperable and operable patients,bureports so far have found that SBRT is a safe and effective treatment for early-stage NSCLC and early metastatic lung cancer.Radiation pneumonitis(RP)is oneof the most common toxicities of SBRT.Although mospost-treatment RP is Grade 1 or 2 and either asymptomatic or manageable,a few cases are severe,symptomatic,and there is a risk for mortality.The reportedrates of symptomatic RP after SBRT range from 9%to28%.Being able to predict the risk of RP after SBRT isextremely useful in treatment planning.A dose-effecrelationship has been demonstrated,but suggesteddose-volume factors like mean lung dose,lung V20and/or lung V2.5 differed among the reports.We foundthat patients who present with an interstitial pneumo-nitis shadow on computed tomography scan and high levels of serum Krebs von den Lungen-6 and surfactant protein D have a high rate of severe radiation pneumo-nitis after SBRT.At our institution,lung cancer patients with these risk factors have not received SBRT since 2006,and our rate of severe RP after SBRT has de-creased significantly since then. | Hideomi Yamashita Wataru Takahashi Akihiro Haga Keiichi Nakagawa | 2014 | World Journal of Radiology2014，6，9： | 22 |
| 3 | Radiation therapy for portal venous invasion by hepatocellular carcinoma显示文摘AIM: To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment.METHODS: Fifty-two patients with HCC received PVI-targeted radiation therapy from January 1995 through December 2003. Portal venous invasion (PVI) was found in the second or lower order branches of the portal vein in 6 patients, in the first branch in 24 patients and in the main trunk in 22 patients. Child classifications of liver function before radiation therapy were A, B, and C for 19, 24 and 2 patients, respectively. All patients received three-dimensional conformal radiotherapy with a total dose ranging from 39 to 60 Gy (57.0 Gy in average).RESULTS: Overall survival rates at 1, 2, 3, 4, and 5 years were 45.1%, 25.3%, 15.2%, 10.1%, and 5.1%, respectively. Univariate analysis revealed that Child status, the number of tumor foci, tumor type,transcatheter arterial embolization (TAE) after radiation therapy were statistically significant prognostic factors.Multivariate analysis showed that the number of tumor foci and TAE after radiation therapy were statistically significant.CONCLUSION: The results of this study strongly suggest the efficacy of 3-D CRT as treatment for PVI in HCC. 3-D CRT is recommended in combination with postradiation TAE for PVI of HCC with 5 tumor foci or less in the liver and with Child A liver function. | Keiichi Nakagawa Hideomi Yamashita Kenshiro Shiraishi Naoki Nakamura Masao Tago Hiroshi Igaki Yoshio Hosoi Shuichiro Shiina Masao Omata Masatoshi Makuuchi Kuni Ohtomo | 2005 | World Journal of Gastroenterology2005，11，46： | 14 |
| 4 | Therapeutic outcomes of endoscopic resection for superficial non‐ampullary duodenal tumor显示文摘 | Yorimasa Yamamoto Natsuko Yoshizawa Hideomi Tomida Junko Fujisaki Masahiro Igarashi | 2014 | Digestive Endoscopy2014，，： | 2 |
| 5 | Extended cancer-free survival after palliative chemoradiation for metastatic esophageal cancer显示文摘We report on a patient who remained cancer-free for an extended time after palliative radiotherapy(RT) and chemotherapy(nedaplatin plus 5-fluorouracil) treatment for stage Ⅳ(cT3N3M1) esophageal squamous cell carcinoma. Although multiple lymph nodes outside the RT field recurred, the local primary tumor within the RT field did not recur, even 17 mo after palliative RT of 30 Gy in 10 fractions. In this case, acute toxicity, such as myelosuppression or esophagitis, was not enhanced by increasing the fraction dose from 1.8-2.0 Gy to 3.0 Gy. Because 30 Gy in 10 fractions can be completed within a shorter time and is less expensive than 50.4 Gy in 28 fractions, we think that 30 Gy without oblique beams is a more favorable RT method for patients. | Hideomi Yamashita Kae Okuma Akihiro Nomoto Mami Yamashita Hiroshi Igaki Keiichi Nakagawa | 2014 | World Journal of Gastrointestinal Oncology2014，6，2： | 2 |
| 6 | Efficacy of lafutidine, a histamine H2-receptor antagonist, for taxane-induced peripheral neuropathy in patients with gynecological malignancies显示文摘 | Hiroaki Nagano Hideomi Sanai Mitsue Muraoka Koichiro Takagi | 2012 | Gynecologic Oncology2012，，1： | 1 |
| 7 | Application of diamond films from CO-H2 plasma to tool blade coating显示文摘 | Yukio Saito Kouji Sato Shinpei Matuda Hideomi Koinuma | 1991 | Journal of Materials Science1991，，11： | 1 |
| 8 | Interesting response to concurrent chemoradiation in metastatic eccrine porocarcinoma显示文摘 | Hideomi YAMASHITA Takafumi KADONO Keiichi NAKAGAWA | 2008 | Journal of Dermatology2008，35，9： | 1 |
| 9 | Influence of angiotensin-converting enzyme gene polymorphism on development of athlete's heart显示文摘 | JUNZO N HARUKI M HIDEOMI T | 2000 | Clin Cardiol2000，23，： | 1 |
| 10 | Effects of aigamo ducks herding on weeding and pest control of duck free ranged in paddy fields显示文摘 | MANDA MASAHARA UCHIDA HIDEOMI | 1993 | Jpn Poult Sci1993，30，： | 1 |
| 11 | Use of an inactivated varicella vaccine in recipients of hematopoietie-cell transplants显示文摘 | Atsuko H Hideomi A Mary R | 2002 | N Engl J Med2002，347，： | 1 |
| 12 | Radiotherapy for 41 patients with stages I and II MALT lymphoma: A retrospective study显示文摘 | Hideomi Yamashita Keiichi Nakagawa Takao Asari Naoya Murakami Hiroshi Igaki Kuni Ohtomo | 2008 | Radiotherapy and Oncology2008，，3： | 1 |
| 13 | 显示文摘 | Takeshi Terajima Hideomi Koinuma | 2004 | Appried Surface Science2004，223，： | 1 |
| 14 | Preoperative Radiation Response Evaluated by 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Survival in Locally Advanced Rectal Cancer显示文摘 | Keiichi Nakagawa M.D. Hideomi Yamashita M.D. Naoki Nakamura M.D. Hiroshi Igaki M.D. Masao Tago M.D. Yoshio Hosoi M.D. Toshimitsu Momose M.D. Kuni Ohtomo M.D. Tetsuichiro Muto M.D. Hirokazu Nagawa M.D | 2008 | Diseases of the Colon & Rectum2008，，7： | 1 |
| 15 | Piezochromic behaviour of regioregular poly(3-hexylthiophene-2,5-diyl)and poly(5,8-dihexadecyloxy-anthraquinone-1,4-diyl)显示文摘 | Yukiko Muramatsu Takakaza Yamamoto Masashi Hasegawa Takehiko Yagi Hideomi Koinuma | 2001 | Polymer2001，42，： | 1 |
| 16 | A study of the secondary electron yield y of insulator cathodes for plasma display panels显示文摘 | YASUSHI M HIDEOMI M HIROSHI M | 2001 | IEEE Trans Electron Device2001，48，： | 1 |
| 17 | A study of the secondary electron yield γ of insulator cathodes for plasma display panels显示文摘 | YASUSHI M HIDEOMI M HIROSHI M | 2001 | IEEE Transactions on Electron Devices2001，48，8： | 1 |
| 18 | Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer显示文摘 | Hideomi Yamashita Keiichi Nakagawa Naoki Nakamura Keiko Abe Takahiro Asakage Makoto Ohmoto Shinji Okada Ichiro Matsumoto Yoshio Hosoi Nakashi Sasano Sen Yamakawa Kuni Ohtomo | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，5： | 1 |
| 19 | 查看详情显示文摘 | Inoue Shohei Koinuma Hideomi Tsuruta Teiji | | 0，，： | 1 |
| 20 | Effects of Aigamo ducks herding on weeding and pest control of duck free ranged in paddy fields显示文摘 | Masahara MANDA Hideomi UCHIDA | 1993 | Jpn Poult Sci1993，30，： | 1 |
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