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| 1 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 2 | Strontium and boron isotopic constraint on the marine origin of the Khammuane potash deposits in southeastern Laos显示文摘Since 2006,we have conducted a geological exploration of the Khammuane area in southeastern Laos.Several thick sequences of potash deposits containing sylvite and carnallite were discovered from drilling Paleocene strata of the Thangon Formation(E1tg).To constrain the origin of the brine that formed thick sequences of salt mineral deposits,we measured the strontium and boron isotope composition of some salt minerals in the potash deposit.Boron isotope composition of halite-and potash-associated minerals in the Khammuane potash deposit varied from 19.91%to 31.01‰,which differs significantly from continental evaporates(-6.83‰--5.79‰)but is very close to that of salts precipitated from evapo-concentrated seawater(10‰-36‰).The 87Sr/86Sr ratios(0.707542 to 0.709461)of salts were also close to the values of Paleocene seawater(0.70772 to 0.707830).The content of Br-(0.01%-0.25%)and Br×103/Cl ratios(0.10-0.52)of halite were>10 times higher than that of common continental salts.These characteristics indicate clearly that the Laos potash deposits were deposited from seawater.The small variation in boron and strontium isotopes in all salt sedimentary sequences(gypsum-halite-potash-halite)also suggests that the recharge source should be stable and the effects of other continental water mixing are negligible.Large-scale potash deposits are commonly precipitated from seawater.Hence,the results of recent regional drilling work and geochemical research suggest extensive potash resources could occur in the Thangon Formation of southeastern Laos. | TAN HongBing MA HaiZhou LI BinKai ZHANG XiYing XIAO YingKai | 2010 | Chinese Science Bulletin2010，55，27： | 37 |
| 3 | Crustal structure of northeastern margin of the Tibetan Plateau by receiver function inversion显示文摘Using seismic data of about one year recorded by 18 broadband stations of ASCENT project,we obtained 2547 receiver functions in the northeastern Tibetan Plateau.The Moho depths under 14 stations were calculated by applying the H-κ domain search algorithm.The Moho depths under the stations with lower signal-noise ratio(SNR) were estimated by the time delay of the PS conversion.Results show that the Moho depth varies in a range of ~40–60 km.The Moho near the Haiyuan fault is vague,and its depth is larger than those on its two sides.In the Qinling-Qilian Block,the Moho becomes shallower gradually from west to east.To the east of 105°E,the average depth of the Moho is 45 km,whereas the west is 50 km or even deeper.Combining our results with surface wave research,we suggest a boundary between the Qinling and the Qilian Mountains at around 105°E.S wave velocities beneath 15 stations have been obtained through a linear inversion by using Crust2.0 as an initial model,and the crustal thickness that was derived by H-κ domain search algorithm was also taken into account.The results are very similar to the results of previous active source studies.The resulting figure indicates that low velocity layers developed in the middle and lower crust beneath the transition zone of the Tibet Block and western Qinling,which may be related to regional faults and deep earth dynamics.The velocity of the middle and lower crust increases from the Songpan Block to the northeastern margin of Tibetan Plateau.Based on the velocity of the crust,the distribution of the low velocity zone and the composition of the curst(Poisson's ratio),we infer that the crust thickening results from the crust shortening along the direction of compression. | LIU QiMin ZHAO JunMeng LU Fang LIU HongBing | 2014 | Science China Earth Sciences2014，57，4： | 23 |
| 4 | Improving water-use efficiency by decreasing stomatal conductance and transpiration rate to maintain higher ear photosynthetic rate in drought-resistant wheat显示文摘In wheat, the ear is one of the main photosynthetic contributors to grain filling under drought stress conditions. In order to determine the relationship between stomatal characteristics and plant drought resistance, photosynthetic and stomatal characteristics and water use efficiency(WUE) were studied in two wheat cultivars: the drought-resistant cultivar ‘Changhan 58' and the drought-sensitive cultivar ‘Xinong 9871'. Plants of both cultivars were grown in pot conditions under well-watered(WW) and water-stressed(WS) conditions. In both water regimes,‘Changhan 58' showed a significantly higher ear photosynthetic rate with a lower rate of variation and a significantly higher percentage variation of transpiration compared to control plants at the heading stage under WS conditions than did ‘Xinong 9871' plants. Moreover,‘Changhan 58' showed lower stomatal density(SD) and higher stomatal area per unit organ area(A) under both water conditions. Water stress decreased SD, A, and stomatal width(SW), and increased stomatal length in flag leaves(upper and lower surfaces) and ear organs(awn, glume,lemma, and palea), with the changes more pronounced in ear organs than in flag leaves.Instantaneous WUE increased slightly, while integral WUE improved significantly in both cultivars. Integral WUE was higher in ‘Changhan 58', and increased by a greater amount, than in‘Xinong 9871'. These results suggest that drought resistance in ‘Changhan 58' is regulated by stomatal characteristics through a decrease in transpiration rate in order to improve integral WUE and photosynthetic performance, and through sustaining a higher ear photosynthetic rate, therefore enhancing overall drought-resistance. | Yuping Li Hongbing Li Yuanyuan Li Suiqi Zhang | 2017 | The Crop Journal2017，5，3： | 18 |
| 5 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 6 | Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway显示文摘Matrine 被使用了在反煽动性并且反癌症治疗很长时间。然而,在 colorectal 癌症(CRC ) 的反变形的效果和相关机制仍然是不清楚的。在这研究,我们调查了 matrine 的管理是否能经由调整表明小径的 p38 禁止人的 CRC 房间的增长,活动性,和侵略。结果证明 matrine 在 vitro 并且在 vivo 禁止了 CRC 房间的移植和侵略。在为 24 h 与 matrine 被对待以后,另外,表示在 CRC 房间矩阵 metalloproteinase-2 (MMP-2 ) 和 MMP-9 以及朊酶活动铺平以一种剂量依赖者方式被减少。而且, matrine 显然减少了 p38 的 phosphorylation 水平。有 p38 禁止者(SB203580 ) 和 matrine 的联合治疗在 CRC 房间导致了侵略以及 MMP-2/-9 表示的 synergistic 减小。matrine 在 vivo 禁止了 CRC 肿瘤的增长和转移,这也被发现。在结论, p38 发信号小径可以由减少 MMP-2/-9 的表示在 CRC 房间的移植和侵略上在 matrine 的禁止的效果包含,建议 matrine 可以是为 CRC 的一个潜在的治疗学的代理人。 | Hongtao Ren Shuqun Zhang Hongbing Ma Yali Wang Di Liu Xijing Wang Zhongwei Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 16 |
| 7 | Humification degrees of peat in Qinghai-Xizang Plateau and palaeoclimate change显示文摘In this article we report a new and sensitive palaeoclimate proxy indieator-humification degrees of peat. Based on the comparison of humification degrees with other climate proxy records, such as δ^13C time series of the C. mulieensis remains cellulose in the same peat profile, we suggest that humifieation degrees of peat in Qinghai-Xizang Plateau can served as a palaeoclimate proxy indicator. The higher the hnmification degrees of peat, the warmer-wetter the climate; on the contrary, the lower the humification degrees, the colder-drier the climate. Due to the simple method of deter-mination, humifieation degree of peat is worthy studying and applying further. | WANGHua HONGYetang ZHUYongxuan HONGBing LINQinghua XUHai LENGXuetian MAOXumei | 2004 | Chinese Science Bulletin2004，49，5： | 16 |
| 8 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis显示文摘Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young patients.The incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all stroke.To reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of CVST.Methods PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July 2019.Data were synthesised by evidence tables.Each recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow Committees.Levels of evidence grading algorithm of Chinese Stroke Association was used to grade each recommendation.results This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of CVST.CT/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected CVST.Anticoagulation therapy with low-molecular weight heparin should be initiated in patients with CVST immediately.After the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic events.Conclusions The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China. | Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan Jinsheng Zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，2： | 14 |
| 9 | Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China显示文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group(24.35±3.14 years,P = 0.000).The mean maternal body mass index(BMI) at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group(21.76±2.59 kg/m 2,P = 0.000).About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group(P = 0.000).Compared with women with normal weight(BMI:18.5-23.9 kg/m 2),women who were overweight(BMI:24-27.9 kg/m 2) or obese(BMI ≥ 28 kg/m 2),respectively,had a 1.69-fold(P = 0.000) and a 1.49-fold(P = 0.000) increased risks of having a neonate with macrosomia,while light weight(BMI<18.5 kg/m 2) women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years(P = 0.001 and P = 0.000).Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，4： | 14 |
| 10 | Insights into CYP2B6-mediated drug–drug interactions显示文摘Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed.The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the enzyme.The expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor(CAR) and pregnane X receptor(PXR) in the liver.In addition to CYP2B6,these receptors also mediate the inductive expression of CYP3A4,and a number of important phase II enzymes and drug transporters.CYP2B6 has been demonstrated to play a role in the metabolism of 2%–10% of clinically used drugs including widely used antineoplastic agents cyclophosphamide and ifosfamide,anesthetics propofol and ketamine,synthetic opioids pethidine and methadone,and the antiretrovirals nevirapine and efavirenz,among others.Significant inter-individual variability in the expression and function of the human CYP2B6 gene exists and can result in altered clinical outcomes in patients receiving treatment with CYP2B6-substrate drugs.These variances arise from a number of sources including genetic polymorphism,and xenobiotic intervention.In this review,we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions. | William D.Hedrich Hazem E.Hassan Hongbing Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 14 |
| 11 | Validation of an agricultural non-point source(AGNPS)pollution model for a catchment in the Jiulong River watershed,China显示文摘测试并且评估农业非点来源(AGNPS ) 的这研究为 Wuchuan 集水的模型,在 Jiulong 河分水岭的一个典型农业区域,福建省, China.The AGNPS 模型在十暴风雨上与观察数据为学习区域被校准并且验证。当二暴风雨上的数据被用于模型的确认时,在 2002 的八暴风雨上的数据被用于刻度。就在一个长期的系列上的水质数据的缺乏而言,一个新奇方法,把内部嵌套的集水与它的包围集水作比较,被用来补充不太长期的系列数据。AGNPS 模型的双刻度和确认被这比较获得。结果显示相关系数为流量是 0.99 和 0.98,分别地, 0.94 和 0.95 大集水和小集水为山峰流量评价并且 0.76 为小集水的沉积仅仅。每个相关系数为为二集水的一样的事件是同类的。与沉积收益和微粒磷的例外,山峰流量率和另外的营养素很好被预言。敏感分析证明土壤保持服务曲线数字和降雨数量是最敏感的参数,它导致了高产量 variations.Erosivity,另外的参数几乎没在水文学和优秀产量上有小影响。 | LIU Jianchang ZHANG Luoping ZHANG Yuzhen HONG Huasheng DENG Hongbing | 2008 | Journal of Environmental Sciences2008，20，5： | 13 |
| 12 | Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling显示文摘穿过种类障碍感染人的很少鸟的流行性感冒病毒,高度病原的流行性感冒 A (H5N1 ) 紧张夺走生活多于感染的病人的一半。与由 H5N1 感染的肺损害的大部分未知的机制,尖锐呼吸悲痛症候群(ARDS ) 是在牺牲品之中的死亡的主要原因。这里我们在场 H5N1 通过 mTOR 的抑制引起了 autophagic 房间死亡的事实发信号。由 autophagy 基因 Beclin1 的弄空或由 autophagy 禁止者 3-methyladenine (3 麻省) , autophagy 的抑制显著地减少了 H5N1 调停的房间死亡。我们建议 autophagic 房间死亡可以在 H5N1 流行性感冒病人贡献 ARDS 的发展, autophagy 的抑制能因此为 H5N1 感染的治疗成为新奇策略。 | Jianhui Ma Qian Sun Ruifang Mi Hongbing Zhang | 2011 | Journal of Genetics and Genomics2011，38，11： | 13 |
| 13 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 14 | mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3b/MMPs显示文摘Golgi membrane protein 1(GOLM1/GP73)is a serum marker of hepatocellular carcinoma(HCC).We have previously shown that mTOR promoted tumorigenesis of HCC through stimulating GOLM1 expression.In this study,we demonstrated that the mammalian target of rapamycin(mTOR)was a negative regulator of microRNA-145(miR-145)expression.miR-145 inhibited GOLM1 expression by targeting a coding sequence of GOLM1 gene.GOLM1 and miR-145 were inversely correlated in human HCC tissues.GOLM1-enriched exosomes activated the glycogen synthase kinase-3β/matrix metalloproteinases(GSK-3β/MMPs)signaling axis of recipient cells and accelerated cell proliferation and migration.In contrast,miR-145 suppressed tumorigenesis and metastasis.We suggest that mTOR/miR-145/GOLM1 signaling pathway should be targeted for HCC treatment. | Xiaochen Gai Bufu Tang Fangming Liu Yuting Wu Fang Wang Yanling Jing Fuqiang Huang Di Jin Ling Wang Hongbing Zhang | 2019 | Journal of Genetics and Genomics2019，46，5： | 13 |
| 15 | Composition and flux of nutrients transport to the Changjiang Estuary显示文摘Based on the results of water sample measurements of nutrient concentrations at th e Datong Station of the Changjiang River from 1998 to 1999, combined w ith historical data of water quality, seasonal variations of nutrient concentrations and nutrient transports are discussed.The following results have been obtained: (1) the fluxes of the nitrate nitrogen, ammonium nitrogen and nitrite nitrogen increased by time-series from 1962 to 1990 , even if runoff volume had a little variation; (2) the concentrations and fluxes of the dissolved inorganic nitrogen (DIN) and dissolved in organic phosphorus (DIP) increased notably with time, but those of the dissolved silicon (DSI) decreased pronouncedly; and (3) the concentration s and fluxes changed synchronously with time between the Datong Station a nd the Changjiang Estuary. | ZHANG Shen,JI Hongbing,YAN Weijin,DUAN Shuiwang(Inst. of Geographic Sciences and Natural Resources Research, Beijing 100101, China) | 2003 | Journal of Geographical Sciences2003，13，1： | 13 |
| 16 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 17 | Low-dose CT for lung cancer screening: opportunities and challenges显示文摘肺癌症在世界范围的最经常诊断的癌症和在男性和女性的癌症死亡的领先的原因之中。为肺癌症屏蔽结合了更早的干预长作为死亡减小的一条途径被学习了。然而,当低剂量的螺线计算了屏蔽的断层摄影术(LDCT ) 时,最小的进步直到最近被获得在使随机化的控制试用(RCT ) 从肺癌症在死亡表明了 20% 减小,屏蔽试用的国家的肺,从美国。根据这发现, LDCT 为由几个临床的指南在高风险的人口屏蔽的肺癌症被推荐了。然而,从在欧洲的下列独立 RCT 的结果没能显示出一致结论。另外,难处理的问题逐渐地与屏蔽的 LDCT 的进步出现了。这份报纸总结并且讨论为肺癌症屏蔽的 LDCT 的主要观察和挑战。在散布屏蔽的 LDCT 的实现前,质问,包括高假积极的率, overdiagnosis,庞大的费用,和放射风险,必须被探讨。互补 biomarkers 和技术改进在在不久的将来屏蔽的肺癌症的领域里被期望。 | Hongbing Shen | 2018 | Frontiers of Medicine2018，12，1： | 12 |
| 18 | Waste oyster shell as a kind of active filler to treat the combined wastewater at an estuary显示文摘Estuaries have been described as one of the most difcult environments on Earth. It is difcult to know how to treat the combined wastewater in tidal rivers at the estuary, where the situation is very diferent from ordinary fresh water rivers. Waste oyster shell was used as the active filler in this study in a bio-contact oxidation tank to treat the combined wastewater at the Fengtang Tidal River. With a middle-experimental scale of 360 m3/day, the average removal efciency of COD, BOD, NH3-N, TP and TSS was 80.05%, 85.02%,86.59%, 50.58% and 85.32%, respectively, in this bio-contact oxidation process. The living microbes in the biofilms on the waste oyster shell in this bio-contact oxidation tank, which were mainly composed of zoogloea, protozoa and micro-metazoa species, revealed that waste oyster shell as the filler was suitable material for combined wastewater degradation. This treatment method using waste oyster shell as active filler was then applied in a mangrove demonstration area for water quality improvement near the experiment area, with a treatment volume of 5 × 103m3/day. Another project was also successfully applied in a constructed wetland, with a wastewater treatment volume of 1 × 103m3/day. This technology is therefore feasible and can easily be applied on a larger scale. | Hongbing Luo Gu Huang Xiaoying Fu Xiaoling Liu Daocai Zheng Jian Peng Ke Zhang Bo Huang Liangqian Fan Fenghui Chen Xiubo Sun | 2013 | Journal of Environmental Sciences2013，25，10： | 11 |
| 19 | Typical Geochemical Elements in Loess Deposit in the Northeastern Tibetan Plateau and Its Paleoclimatic Implication显示文摘Widespread and thick loess deposit in the northeastern Tibetan Plateau records paleoclimatic changes over the Quaternary period. In this study, we investigate a loess section located in a high terrace of the Huangshui River in the Xining Basin, and collect samples at 20-cm intervals by digging a well of 16-m depth (including paleosol S1 and S0 and several loess interlayers over the last glacial-interglacial cycle and the Holocene). Concentration of some active elements (Sr and Ca) and inert elements (Rb, Zr, Ti) in these loess samples are measured. The results show that ratios of those elements (oxide), such as Rb/Sr, Ti/Sr, and Zr/CaO ratios, would indicate sensitively paleoclimatic changes, especially the history of precipitation over the last glacial-interglacial and the Holocene. Moreover, the curves of Rb/Sr, Ti/Sr, and Zr/CaO ratios had almost the same variable trends from the bottom to the top and also closely correlated with values of magnetic susceptibility and the global marine δ18O record. But compared with the curves of magnetic susceptibility, the changes of ratios of these elements (oxide) are clearer and easy to understand. Therefore, the ratios of these typical chemical elements in the loess deposit may be used as an excellent index to investigate the history of paleoclimate, particularly precipitation changes in the northeastern Tibetan Plateau. | TAN Hongbing MA Haizhou ZHANG Xiying LU Huayu WANG Jianguo | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 10 |
| 20 | Deep structure at northern margin of Tarim Basin显示文摘In this paper, a 2D velocity structure of the crust and the upper mantle of the northern margin of the Tarim Basin (TB) has been obtained by ray tracing and theoretical seismogram calculation under the condition of 2D lateral inhomogeneous medium using the data of seismic wide angle reflection/refraction profile from Baicheng to Da Qaidam crossing the Kuqa Depression (KD) and Tabei Uplift (TU). And along the Baicheng to Da Qaidam profile, 4 of the 10 shot points are located in the northern margin of the TB. The results show that the character of the crust is uniform on the whole between the KD and TU, but the depth of the layers, thickness of the crust and the velocity obviously vary along the profile. Thereinto, the variation of the crust thickness mainly occurs in the middle and lower crust. The Moho has an uplifting trend near the Baicheng shot point in KD and Luntai shot point in TU, and the thickness of the crust reduces to 42 km and 47 km in these two areas, respectively. The transition zone between the KD and TU has a thickest crust, up to 52 km. In this transition zone, there are high velocity anoma-lies in the upper crust, and low velocity anomalies in the lower crust, these velocity anomalies zone is near vertical, and the sediment above them is thicker than the other areas. According to the velocity distributions, the profile can be divided into three sections:KD, TU and transition zone between them. Each section has a special velocity structural feature, the form of the crystalline basement and the relationship between the deep structure and the shallow one. The differences of velocity and tectonic between eastern and western profile in the northern margin of the Tarim Basin (NMTB) may suggest different speed and intensity of the subduction from the Tarim basin to the Tianshan orogenic belt (TOB). | ZHAO JunMeng CHENG HongGang PEI ShunPing LIU HongBing ZHANG JianShi LIU BaoFeng | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
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