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| 1 | New Family of RPR-Equivalent Parallel Mechanisms:Design and Application显示文摘Parallel mechanisms(PMs)have been used as skeletons or end-effectors in various advanced manufacturing equipment.Compared with their serial counterparts,PMs offer high rigidity,good dynamic response,and large payload capability.Three-degrees-of-freedom(DOFs)parallel mechanisms with two rotational and one translational(2R1T)motion are particularly useful,such as | Qinchuan LI Lingmin XU Qiaohong CHEN Wei YE | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 12 |
| 2 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 3 | Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese显示文摘Apoptosis plays a key role in inhibiting tumor growth, progression and resistance to anti-tumor therapy. We hypothesized that genetic variants in apoptotic genes may affect the prognosis of lung cancer. To test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (SNPs) from 12 genes (BAX, BCL2, BID, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, FAS, FASLG and MCL1) involved in apoptosis to assess their prognostic significance in lung cancer in a Chinese case cohort with 568 non-small cell lung cancer (NSCLC) patients. Thirty-five SNPs passing quality control underwent association analyses, 11 of which were shown to be significantly associated with NSCLC survival (P<0.05). After Cox stepwise regression analyses, 3 SNPs were independently associated with the outcome of NSCLC (BID rs8190315: P=0.003; CASP9 rs4645981: P=0.007 and FAS rs1800682: P=0.016). A favorable survival of NSCLC was significantly associated with the genotypes of BID rs8190315 AG/GG (adjusted HR=0.65, 95% CI: 0.49-0.88), CASP9 rs4645981 AA (HR=0.22, 95% CI: 0.07-0.69) and FAS rs1800682 GG (adjusted HR=0.67, 95% CI: 0.46-0.97). Time-dependent receptor operation curve (ROC) analysis revealed that the area under curve (AUC) at year 5 was significantly increased from 0.762 to 0.819 after adding the risk score of these 3 SNPs to the clinical risk score. The remaining 32 SNPs were not significantly associated with NSCLC prognosis after adjustment for these 3 SNPs. These findings indicate that BID rs8190315, CASP9 rs4645981 and FAS rs1800682 polymorphisms in the apoptotic pathway may be involved in the prognosis of NSCLC in the Chinese population. | Songyu Cao Cheng Wang Xinen Huang Juncheng Dai Lingmin Hu Yao Liu Jiaping Chen Hongxia Ma Guangfu Jin Zhibin Hu Lin Xu Hongbing Shen | 2013 | The Journal of Biomedical Research2013，27，3： | 6 |
| 4 | Aminosaccharide-gold nanoparticle assemblies as narrow-spectrum antibiotics against methicillin-resistant Staphylococcus aureus显示文摘Bacterial infection has continued to be a leading cause of death or disability worldwide because of antibiotic resistance.Antibiotic agents specific to certain taxa of bacteria,i.e.,narrow-spectrum antibiotics,have become useful because they can kill bacteria without resulting in broad-spectrum drug resistance.In this study,we describe a series of antibiotics based on combining gold nanoparticles (AuNPs) with aminosaccharides,even though these AuNPs or aminosaccharides by themselves are ineffective against any bacteria.The AuNP-based multivalent aminosaccharides can effectively and selectively inhibit the growth of Gram-positive bacteria (including drug-resistant superbacteria).In particular,aminosaccharidemodified AuNPs are effective against methicillin-resistant Staphylococcus aureus (MRSA),a particularly hard-to-treat strain.This report carves out a way to explore antibiotics by combining AuNPs and an aminosaccharide as multivalent nanostructures,neither of which by itself is effective as an antibiotic. | Xinglong Yang Lingmin Zhang Xingyu Jiang | 2018 | Nano Research2018，11，12： | 5 |
| 5 | Rotation-based finite elements:reference-configuration geometry and motion description显示文摘Infinitesimal-rotation finite elements allow creating a linear problem that can be exploited to systematically reduce the number of coordinates and obtain efficient solutions for a wide range of applications,including those governed by nonlinear equations.This paper discusses the limitations of conventional infinitesimal-rotation finite elements(FE)in capturing correctly the initial stress-free reference-configuration geometry,and explains the effect of these limitations on the definition of the inertia used in the motion description.An alternative to conventional infinitesimal-rotation finite elements is a new class of elements that allow developing inertia expressions written explicitly in terms of constant coefficients that define accurately the reference-configuration geometry.It is shown that using a geometrically inconsistent(GI)approach that introduces the infinitesimal-rotation coordinates from the outset to replace the interpolation-polynomial coefficients is the main source of the failure to capture correctly the reference-configuration geometry.On the other hand,by using a geometrically consistent(GC)approach that employs the position gradients of the absolute nodal coordinate formulation(ANCF)to define the infinitesimal-rotation coordinates,the reference-configuration geometry can be preserved.Two simple examples of straight and tapered beams are used to demonstrate the basic differences between the two fundamentally different approaches used to introduce the infinitesimal-rotation coordinates.The analysis presented in this study sheds light on the differences between the incremental co-rotational solution procedure,widely used in computational structural mechanics,and the non-incremental floating frame of reference formulation(FFR),widely used in multibody system(MBS)dynamics. | Ahmed A.Shabana Lingmin Xu | 2021 | Acta Mechanica Sinica2021，37，1： | 4 |
| 6 | Bioinformatics analysis for structure and function of CPR of Plasmodium falciparum显示文摘Objective:To analyse the structure and function of NADPH-cytochrome p450 reductase(CYPOR or CPR) from Plasmodium falciparum(Pf),and to predict its’ drug target and vaccine target. Methods:The structure,function,drug target and vaccine target of CPR from Plasmodium falciparum were analyzed and predicted by bioinformatics methods.Results:PfCPR,which was older CPR,had close relationship with the CPR from other Plasmodium species,but it was distant from its hosts,such as Homo sapiens and Anopheles.PfCPR was located in the cellular nucleus of Plasmodium falciparum.335aa-352aa and 591aa - 608aa were inserted the interior side of the nuclear membrane,while 151aa-265aa was located in the nucleolus organizer regions.PfCPR had 40 function sites and 44 protein-protein binding sites in amino acid sequence.The teriary structure of laa-700aa was forcep-shaped with wings.15 segments of PfCPR had no homology with Homo sapien CPR and most were exposed on the surface of the protein.These segments had 25 protein-protein binding sites.While 13 other segments all possessed function sites. Conclusions:The evolution or genesis of Plasmodium falciparum is earlier than those of Homo sapiens.PfCPR is a possible resistance site of antimalarial drug and may involve immune evasion, which is associated with parasite of sporozoite in hepatocytes.PfCPR is unsuitable as vaccine target,but it has at least 13 ideal drug targets. | Zhigang Fan Lingmin Zhang Guogang Yan Qiang Wu Xiufeng Gan Saifeng Zhong Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 3 |
| 7 | Controlled synthesis of Zeolite adsorbent from lowgrade diatomite:A case study of self-assembled sodalite microspheres显示文摘Highly efficient and sustainable conversion technologies to generate uniform sodalite(Na8(AlSiO4)6(OH)2)zeolite micro spheres with low-grade waste natural diatomite as raw materials via a solution-mediated crystallization route were developed in the present study.The synthesis process can be considered as an in-situ zeolitization of diatomite precursor without involving any me so scale template and any post-synthetic modification.The mass ratios of diatomite and AlCl3·6 H2 O have remarkable effect on the morphology,crystal structure and porosity of sodalite zeolite product.The preferred sodalite microspheres with uniform mesoporous of size 3.5-5.5 nm and large surface area of 162.5 m2/g exhibit well removal performance for heavy metal ions(Pb(II),Cd(II),Zn(II),and Cu(II)),with the highest adsorption abilities for Pb(II)ions of 365 mg/g.In addition,the effect of contact time,initial ion concentration,competitive adsorption and solution pH were evaluated.The removal performance results from synergistic effects of dominating cation-exchange and additional surface chemisorption.The study may broadly help unveil chemical control reactions of the zeolitization processes of diatomite,and thus facilitates the development of promising zeolite materials for the use in natural and engineered aquatic environments by recvcling waste diatomite resources. | Lingmin Sun Junshu Wu Jinshu Wang Gong Yu Jingchao Liu Yucheng Du Yongli Li Hongyi Li | 2020 | Journal of Environmental Sciences2020，32，5： | 3 |
| 8 | Prediction of stable BC_(3)N_(2)monolayer from first-principles calculations:Stoichiometry,crystal structure,electronic and adsorption properties显示文摘In this paper,a novel BC_(3)N_(2)monolayer has been found with a graphene-like structure using the developed particle swarm optimization algorithm in combination with ab initio calculations.The predicted structure meets the thermodynamical,dynamical,and mechanical stability requirements.Interestingly,the BC_(3)N_(2)plane shows a metallic character.Importantly,BC_(3)N_(2)has an in-plane stiffness comparable to that of graphene.We have also investigated the adsorption characteristics of CO_(2)on pristine monolayer and Mo functionalized monolayer using density functional theory.Subsequently,electronic structures of the interacting systems(CO_(2)molecule and substrates)have been preliminarily explored.The results show that Mo/BC_(3)N_(2)has a stronger adsorption capacity towards CO_(2)comparing with the pristine one,which can provide a reference for the further study of the CO_(2)reduction mechanism on the transition metal-functionalized surface as well as the new catalyst’s design. | Jiahui Yu Chaozheng He Chunying Pu Ling Fu Dawei Zhou Kun Xie Jinrong Huo Chenxu Zhao Lingmin Yu | 2021 | Chinese Chemical Letters2021，32，10： | 2 |
| 9 | Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women显示文摘Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility. | Meiqun Jia Lulu Ren Lingmin Hu Hongxia Ma Guangfu Jin Dake Li Ni Li Zhibin Hu Dong Hang | 2019 | The Journal of Biomedical Research2019，33，5： | 2 |
| 10 | Femtosecond laser-assisted cataract surgery显示文摘 | Lingmin He Katrina Sheehy William Culbertson | 2011 | Current Opinion in Ophthalmology2011，，1： | 2 |
| 11 | 为从变形体 berghei 的氮的氧化物 synthase 和类似的蛋白质的结构和功能的生物信息学分析和预言显示文摘 <正>Objective:To search and analyze nitric oxide synthase(NOS) and similar proteins from Plasmodium berghei(Pb).Methods:The structure and function of nitric oxide synthase and similar proteins from Plasmodium berghei were analyzed and predicted by bioinformatics. Results:P6NOS were not available,but nicotinamide adenine dinucleotide 2’-phosphate reduced tetrasodium(NADPH)-cytochrome p450 reductase(CPR) were gained.PiCPR was in the nucleus of Plasmodium berghei,while 134aa-229aa domain was localize in nucleolar organizer. The amino acids sequence of P6CPR had the closest genetic relationship with Plasmodium vivax showing a 73%homology.The tertiary structure of PbCPR displayed the forcep-shape with wings,but no wings existed in the tertiary structure of its’ host,Mus musculus(Mm).137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of P6CPR showed no homology with MmCPRs’,and all domains were exposed on the surface of the protein.Conclusions:NOS can’t be found in Plasmodium berghei and other Plasmodium species.PbCPR may be a possible resistance site of antimalarial drug,and the targets of antimalarial drug and vaccine.It may be also one of the mechanisms of immune evasion.This study on Plasmodium berghei may be more suitable to Plasmodium vivax.And137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of PbCPR are more ideal targets of antimalarial drug and vaccine. | Zhigang Fan Gang Lv Lingmin Zhang Xiufeng Gan Qiang Wu Saifeng Zhong Guogang Yan Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 2 |
| 12 | A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata显示文摘 | Lingmin Tian Yan Zhao Chao Guo Xingbin Yang | 2010 | Carbohydrate Polymers2010，，2： | 2 |
| 13 | A splice variant of PGRP-LC required for expression of antimicrobial peptides in Anopheles gambiae显示文摘peptidoglycan 识别蛋白质(PGRP ) 的成员在在昆虫的免疫反应的不同表明的家庭戏必需品角色。PGRP-LC,在疟疾向量疟蚊属 gambiae 的这个家庭的七个成员之一生产了几拼接的变体。这里,我们显示出那 PGRP-LC,并且不 PGRP 家庭的另外的成员也不 Gram-negativebinding 蛋白质家庭的六个成员,在 A 在 Imd-Rel2 小径的控制下面为抗菌剂肽基因(如此的 asCEC1 和 GAM1 ) 的表示被要求。gambiae 房间线, 4a3A。PGRP-LCproduces 许多拼接能被分类进三亚群(LC1, LC2 和 LC3 ) 的变体,基于 carboxyl 终端序列。对一 LC1 亚群的 RNA 干扰导致了 CEC1 和 GAM1 的戏剧的减小。LC1a 并且到更小的程度 LC3a 的在表示上(theLC1 和 LC3 亚群的一个成员,分别地) 在房间线提高的 4a3A, CEC1 和 GAM1.These 的表示导致证明 LC1 亚群拼接变体在 A 为表示 ofCEC1 和 GAM1 是必要的。gambiae 房间排队。 | HUI LIN LINGMIN ZHANG CORALIA LUNA NGO T. HOA LIANGBIAO ZHENG | 2007 | Insect Science2007，14，3： | 2 |
| 14 | A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata显示文摘 | Lingmin Tian Yan Zhao Chao Guo Xingbin Yang | 2010 | Carbohydrate Polymers2010，，2： | 2 |
| 15 | Recent progress of efficient utilization of titanium-bearing blast furnace slag显示文摘Titanium-bearing blast furnace slag(BFS)has valuable compositions and potential environmental hazardousness.Thus,developing efficient and green approaches to utilize BFS is highly desired for resource economization and environmental protection.In the past decades,many attempts have been adopted to reuse BFS efficiently,and significant advances in understanding the fundamental features and the development of efficient approaches have been achieved.This review provides a comprehensive overview of the latest progress on the efficient utilization of BFS and discusses the mechanism and characteristics of various approaches,along with their application prospects.In particular,the extraction and enrichment of titanium-bearing phases from BFS are highlighted because of the high availability of titanium resources.This systemic and comprehensive review may benefit the design of new and green utilization routes with high efficiency and low cost. | Yongfeng Cai Ningning Song Yunfei Yang Lingmin Sun Peng Hu Jinshu Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 2 |
| 16 | The construction of drug-resistant cancer cell lines by CRISPR/Cas9 system for drug screening显示文摘Cancer therapy is often hampered by the rapid emergence of drug resistance. Drug-resistant cellular models are essential for understanding the drug resistance and developing new therapeutics. The low efficiency and long time required in creating these models are major obstacles hindering drug resistance research and drug screening. Herein, we report an approach that can accelerate(shortening the time from years to 3 weeks) the establishment of cancer cell line-based, inheritable drug resistance models by specific knockout of MED12 gene using CRISPR/Cas9 system. The resultant MED12^(KO) A375(melanoma)cell line was resistant to inhibitors of B-Raf proto-oncogene, serine/threonine kinase(BRAF), whereas the resultant MED12^(KO) PC9(non-small cell lung cancer) cell line was resistant to inhibitors of epidermal growth factor receptor(EGFR). Evaluation of anti-cancer drugs and their combinations shows that certain combinations of BRAF inhibitors and TGF-β receptor(TGF-βR) inhibitors are active in suppressing the growth of MED12^(KO) A375 cells, and a few combinations of EGFR inhibitors and TGF-βR inhibitors were active in suppressing the growth of MED12^(KO) PC9 cells. The drug-resistant models will be useful in screening novel drugs and drug combinations for multi-drug-resistant cancer therapy. | Lingmin Zhang Ying Li Qinghua Chen Yong Xia Wenfu Zheng Xingyu Jiang | 2018 | Science Bulletin2018，63，21： | 2 |
| 17 | Qualitative and quantitative phase analyses of Pingguo bauxite mineral using X-ray powder diffraction and the Rietveld method显示文摘 | Yang Xiying Zeng Lingmin | 2007 | Powder Diffr2007，22，4： | 1 |
| 18 | Investigation of 1- Phenyl-3-Methyl-5-Pyrazolone as a corrosion inhib- itor for mild steel in 1M hydrochloric acid 显示文摘 | Cao Kun Li Weihua Yu Lingmin | 2012 | Inter- national Journal of Electrochemical Science2012，7，1： | 1 |
| 19 | Surface photo-dis- coloration and degradation of dyed wood veneer exposed to different wavelength of artificial light 显示文摘 | LIU Yi SHAO Lingmin GAO Jianmin | 2015 | Applied Surface Science2015，311，： | 1 |
| 20 | A comparative stud-y on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata显示文摘 | Lingmin Tian Yan Zhao Guo Chao | 2011 | Carbohydrate Polymers2011，83，： | 1 |
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