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| 1 | Bmi-1:At the crossroads of physiological and pathological biology显示文摘Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.Despite three decades of research that have elucidated the transcriptional regulation,post-translational modifications and functions of Bmi-1 in regulating the DNA damage response,cellular bioenergetics,and pathologies,the entire potential of a protein with such varied functions remains to be realized.This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer.Additionally,since cancer stem cells are emerging as a new paradigm for therapy resistance,the role of Bmi-1 in this perspective is also highlighted.The wide spectrum of malignancies that implicate Bmi-1 as a signature for stemness and oncogenesis also make it a suitable candidate for therapy.Nonetheless,new approaches are vitally needed to further characterize physiological roles of Bmi-1 with the long-term goal of using Bmi-1 as a prognostic marker and a therapeutic target. | Resham Bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi | 2015 | Genes & Diseases2015，2，3： | 15 |
| 2 | Biomedical Perspective of Electrochemical Nanobiosensor显示文摘Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed. | Priti Singh Shailendra Kumar Pandey Jyoti Singh Sameer Srivastava Sadhana Sachan Sunil Kumar Singh | 2016 | Nano-Micro Letters2016，8，3： | 5 |
| 3 | Treatment of wheat straw using tannase and white-rot fungus to improve feed utilization by ruminants显示文摘Background: Current research to enrich cattle feed has primarily focused on treatment using white rot fungi, while there are scarce reports using the enzyme tannase, which is discussed only in reviews or in the form of a hypothesis. In this context, the aim of the present study was to evaluate the effect of tannase on wheat straw(WS)and also the effect of lyophilized tannase at concentrations of 0.1%, 0.2%, and 0.3%(w/w) on WS followed by fermentation with Ganoderma sp. for 10 d and compared in relation to biochemical parameters, crude protein(CP)content, and nutritional value by calculating the C/N ratio in order to improve the nutritional value of cattle feed.Results: Penicillium chorlesii, a tannase-producing microorganism, produced 61.4 lU/mL of tannase in 54 h when 2%(w/v) tannic acid(TA) was initially used as a substrate in medium containing(% w/v) sucrose(1.0), NaN03(1.0), and MgS〇4(0.08 pH, 5.0) in a 300-L fermentor(working volume 220 L), and concomitantly fed with 1.0%(w/v) TA after24 h. The yield of partially purified and lyophilized tannase was 5.8 lU/mg. The tannin-free myco-straw at 0.1%(w/w) tannase showed 37.8%(w/w) lignin degradation with only a 20.4%(w/w) decrease in cellulose content and the in vitro feed digestibility was 32.2%. An increase in CP content(up to 1.28-fold) along with a lower C/N ratio of25.0%, as compared to myco-straw, was obtained.Conclusions: The use of tannin-free myco-straw has potential to improve the nutritional content of cattle feed.This biological treatment process was safe, eco-friendly, easy to perform, and was less expensive as compared to other treatment methods. | Shailendra Raghuwanshi Swati Misra Rajendra Kumar Saxena | 2014 | Journal of Animal Science and Biotechnology2014，5，2： | 5 |
| 4 | A review on emerging smart technological innovations in healthcare sector for increasing patient's medication adherence显示文摘In this paper,we reviewed the various advanced technologies and methods that could help patients for measuring ad herence of patients.There exist intelligent technologies that are available for measuring medication adherence,including medication event monitoring system(MEMS@),smart blister packs,radio frequency identifcation(RFID)embedded smart drawers,and wisely aware RFID dosage(WARD)system,Utilization of these advanced technologies and systems have aided in enhancing the adherence to a greater extent.For example,MEMS@refers to the electronic cap that counts the number of bottles opened,but it can be employed only with bottles.Smart blisters are pharmaceutical packagings that possess the capability of monitoring when a pill or tablet is taken out of its packing.All those intelligent technologies can help in active monitoring of patients regarding adherence and capable of eradicating various medication errors due to which adherence is affected. | Pankaj Pal Sharda Sambhakar Vivek Dave Shailendra Kumar Paliwal Sarvesh Paliwal Monika Sharma Aadesh Kumare Nidhi Dhama | 2021 | Global Health Journal2021，5，4： | 2 |
| 5 | 生物可吸收支架进展及前景显示文摘已有系列临床研究证实生物可吸收支架(BVS)的安全性和有效性。与药物洗脱支架相比,BVS的优点是主要不良心脏事件及支架内再狭窄率较低,但在减少支架内血栓方面并无优势,可能与不充分的抗血小板治疗、支架厚度及支架扩张不全有关。该文主要介绍BVS中应用经验较多的Absorb支架。 | 陆寒新 Shailendra Kumar Karn 车文良 徐亚伟 | 2016 | 国际心血管病杂志2016，43，2： | 2 |
| 6 | Synthesis,isolation,identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC,LC/ESI-MS and NMR显示文摘One unknown impurity(Imp-Ⅱ) during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-1,2-diol(Imp-Ⅱ) using the liquid chromatography–mass spectrophotometry(LC–MS) analysis. Imp-Ⅱ was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as ~1H,^(13)C, DEPT(1D NMR), HSQC(2D NMR)and infrared spectroscopy(IR), and retention time and purity with HPLC followed by the chemical synthesis.Due to less removable nature of Imp-Ⅱ during the purification, the synthetic process was optimized proficiently to control the formation of Imp-Ⅱ below to the limit < 0.12% in the course of reaction. The new chemical route was developed for the preparation of this impurity in required quantity with purity to use as reference standard.The most probable mechanism for the formation of Imp-Ⅱ was discussed in details. | Neeraj Kumar Subba Rao Devineni Prasad Reddy Gajjala Shailendra Kumar Dubey Pramod Kumar | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 2 |
| 7 | GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation显示文摘Bone metastases occur in patients with advanced-stage prostate cancer(PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15(GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis. | Jawed Akhtar Siddiqui Parthasarathy Seshacharyulu Sakthivel Muniyan Ramesh Pothuraju Parvez Khan Raghupathy Vengoji Sanjib Chaudhary Shailendra Kumar Maurya Subodh Mukund Lele Maneesh Jain Kaustubh Datta Mohd Wasim Nasser Surinder Kumar Batra | 2022 | Bone Research2022，10，1： | 2 |
| 8 | Mergers and acquisitions: making brand equity a key factor in M&A decision-making 显示文摘 | Shailendra Kumar Kristiane Hansted Blomqvist | 2004 | Strategy Leadership2004，32，2： | 1 |
| 9 | Surgical dislocation of the hip for reduction of acetabular fracture and evaluation of chondral damage显示文摘 | Maini Lalit Batra Sahil Arora Sumit Singh Shailendra Kumar Santosh Gautam V K | 2014 | Journal of Orthopaedic Surgery2014，22，1： | 1 |
| 10 | Charge generation and photovoltaic properties of hybrid solar cells based on ZnO and copper phthalocyanine(CuPc) 显示文摘 | SHARMA G D KUMAR R SHAILENDRA S K | 2006 | Sol Energy Mater Sol Cells2006，90，78： | 1 |
| 11 | Size-effect of fracture parameters for crack propagation in concrete : a comparative study 显示文摘 | Shailendra Kumar S V Barai | 2012 | Computers &Concrete2012，9，1： | 1 |
| 12 | Determining double-K fracture parameters of concrete for compact tension and wedge splitting tests using weight function 显示文摘 | Kumar Shailendra Barai S V | 2009 | Engineering Fracture Mechanics2009，76，： | 1 |
| 13 | Mergers and Acquisitions: Making Brand Equity a Key Factor in M&A Decision-Making显示文摘 | Shailendra Kumar and Kristiane Hansted Blomqvist | 2004 | Strategy & Leadership2004，32，2： | 1 |
| 14 | Experimental investigation of control of NOx emissions in biodiesel-fueled compression ignition engine显示文摘 | Deepak Agarwal Shailendra Sinha Avinash Kumar Agarwal | 2006 | Renewable Energy2006，31，： | 1 |
| 15 | Biodiesel development from rice bran oil: Transesterification process optimization and fuel characterization显示文摘 | Shailendra Sinha Avinash Kumar Agarwal Sanjeev Garg | 2008 | Energy Conversion and Management2008，49，： | 1 |
| 16 | A multilevel Voltage Source Inverter (VSI) to maximize the number of levels in output waveform显示文摘 | Krishna Kumar Gupta Shailendra Jain | 2013 | International Journal of Electrical Power and Energy Systems2013，，1： | 1 |
| 17 | Impact of Bloom Filter on Infection Rate in Epidemic Forwarding for ICNs 显示文摘 | Shailendra Shukla Nishant Kumar Rajiv Misra | 2014 | Wireless Per- sonal Communications2014，75，4： | 1 |
| 18 | Swallowing of Casson fluid in oesophagus under the influence of peristaltic waves of varying amplitude显示文摘 | Sanjay Kumar Pandey Shailendra Kumar Tiwarit | 2017 | International Journal of Biomathematics2017，10，2： | 1 |
| 19 | Entrepreneurship and economic development in adeveloping country:A case study of India显示文摘 | Sierdjan Koster Shailendra Kumar Rai | 2008 | Journal of entrepreneurship2008，，17： | 1 |
| 20 | Influence of specimen geometry and size-effect on the KR-curve based on the cohesive stress in concrete显示文摘 | Shailendra Kumar Barai S V | 2008 | International Journal of Fracture2008，152，： | 1 |
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