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| 1 | Capacity-need gap in hospital resources for varying mitigation and containment strategies in India in the face of COVID-19 pandemic显示文摘Background:Due to uncertainties encompassing the transmission dynamics of COVID-19,mathematical models informing the trajectory of disease are being proposed throughout the world.Current pandemic is also characterized by surge in hospitalizations which has overwhelmed even the most resilient health systems.Therefore,it is imperative to assess health system preparedness in tandem with need projections for comprehensive outlook.Objective:We attempted this study to forecast the need for hospital resources for one year period and correspondingly assessed capacity and tipping points of Indian health system to absorb surges in need due to COVID-19.Methods:We employed age-structured deterministic SEIR model and modified it to allow for testing and isolation capacity to forecast the need under varying scenarios.Projections for documented cases were made for varying degree of containment and mitigation strategies.Correspondingly,data on health resources was collated from various government records.Further,we computed daily turnover of each of these resources which was then adjusted for proportion of cases requiring mild,severe and critical care to arrive at maximum number of COVID-19 cases manageable by health care system of India.Findings:Our results revealed pervasive deficits in the capacity of public health system to absorb surge in need during peak of epidemic.Also,model suggests that continuing strict lockdown measures in India after mid-May 2020 would have been ineffective in suppressing total infections significantly.Augmenting testing to 1,500,000 tests per day during projected peak(mid-September)under social-distancing measures and current test to positive rate of 9.7%would lead to more documented cases(60,000,000 to 90,000,000)culminating to surge in demand for hospital resources.A minimum allocation of 13x,70x and 37x times more beds for mild cases,ICU beds and mechanical ventilators respectively would be required to commensurate with need under that scenario.However,if testing capacity is limited to 9,000,000 tests per day(current situation as of 19th August 2020)under continued social-distancing measures,documented cases would plummet significantly,still requiring 5x,31x and 16x times the current allocated resources(beds for mild cases,ICU beds and mechanical ventilators respectively)to meet unmet need for COVID-19 treatment in India. | Veenapani Rajeev Verma Anuraag Saini Sumirtha Gandhi Umakant Dash Shaffi Fazaludeen Koya | 2020 | Infectious Disease Modelling2020，5，1： | 3 |
| 2 | Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years显示文摘AIM: To determine the seroprevalence of Hepatitis A (HAV) amongst Saudi children and compare it with previously reported prevalence data from the same population. METHODS: A total of 1357 students were randomly selected between the ages of 16 and 18 years (689 males and 668 females) from three different regions of Saudi Arabia (Madinah, Al-Qaseem, and Aseer) and tested for anti-HAV-IgG. RESULTS: The overall prevalence of anti-HAV-IgG among the study population was 18.6%. There was no difference between males and females but there was a significant difference in the seroprevalence (P = 0.0001) between the three different regions, with Ma- dinah region showing the highest prevalence (27.4%). When classified according to socioeconomic status, lower class students had a prevalence of 36.6%, lower middle class 16.6%, upper middle class 9.6%, and up- per class 5.9% (P = 0.0001). Comparing the current study results with those of previous studies in 1989 and 1997 involving the same population, there was a marked reduction in the overall prevalence of HAV from 52% in 1989, to 25% in 1997, to 18.6% in 2008 (P < 0.0001). CONCLUSION: Over the last 18 years, there has been a marked decline in the prevalence of HAV in Saudi children and adolescents. The current low prevalence rates call for strict adherence to vaccination policies in high-risk patients and raises the question of a univer- sal HAV vaccination program. | Faleh Al Faleh Suliman Al Shehri Saleh Al Ansari Mohammed Al Jeffri Yaqoub Al Mazrou Ahmad Shaffi Ayman A Abdo | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 3 | Assessment of Alpha-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma in Middle Eastern Patients显示文摘 | Faisal M. Sanai Samia Sobki Khalid I. Bzeizi Shaffi A. Shaikh Khalid Alswat Waleed Al-Hamoudi Majid Almadi Faisal Al Saif Ayman A. Abdo | 2010 | Digestive Diseases and Sciences2010，，12： | 2 |
| 4 | Bougainvillea spectabilis flowers extract protects against the rotenone-induced toxicity显示文摘Objective:To investigate the effect of two extracts of Bougainvillea spectabilis(B. spectabilis) flowers with yellow and pink/purple on brain oxidative stress and neuronal damage caused in rats by systemic rotenone injection. Methods:Rotenone 1.5 mg/kg was given three times per week alone or in combination with B. spectabilis flowers extracts(25 mg or 50 mg) via the subcutaneous route for 2 weeks. Brain concentrations of the lipid peroxidation marker malondialdehyde(MDA),reduced glutathione,nitric oxide(nitrite),the pro-inflammatory cytokine interleukin-1beta(Il-1β) as well as butyrylcholinesterase,and paraoxonase-1(PON-1) activities,were determined. Histopathology and caspase-3 immunohistochemistry were also performed. Results:Rotenone resulted in significant increases of brain MDA(the product of lipid peroxidation),and nitric oxide content along with decreased brain reduced glutathione. There were also marked and significant inhibition of brain PON-1 and BCh E activities and increased Il-1β in brain of rotenone-treated rats. B. spectabilis flowers extract itself resulted in brain oxidative stress increasing both lipid peroxidation and nitrite content whilst inhibiting PON-1 activity. The yellow flowers extract inhibited BCh E activity and increased brain Il-1β. When given to rotenone-treated rats,B. spectabilis extracts,however,decreased lipid peroxidation while their low administered doses increased brain GSH. Brain nitrite decreased by the pink extract but showed further increase by the yellow extract. Either extract,however,caused further inhibition of PON-1 activity while the yellow extract resulted in further inhibition of BChE activity. Histopathological studies indicated that both extracts protected against brain,liver and kidney damage caused by the toxicant. Conclusions:These data indicate that B. spectabilis flowers extracts exert protective effect against the toxic effects of rotenone on brain,liver and kidney. B. spectabilis flowers extracts decreased brain lipid peroxidation and prevented neuronal death due to rotenone and might thus prove the value in treatment of Parkinson's disease. | Omar M.E.Abdel-Salam Eman R.Youness Nadia A.Ahmed Sayed A.El-Toumy Ahmed M.A.Souleman Nermeen Shaffie Dalia M.Abouelfadl | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，5： | 2 |
| 5 | Ammonia toxicity:Metabolic disorder in nine freshwater teleosts显示文摘 | Shaffi SA | 1980 | Toxicology Letters1980，6，6： | 1 |
| 6 | Low 25-hydroxy vitamin D lev- els and cognitive impairment in hemodialysis patients显示文摘 | Shaffi K Tighiouart H Scott T | 2013 | Clin J Am Soc Nephrol2013，8，6： | 1 |
| 7 | Cryptosporidiosis in patients with HIV/AIDS显示文摘 | Roberta M O?Connor Rehaan Shaffie Gagandeep Kang Honorine D Ward | 2011 | AIDS2011，，5： | 1 |
| 8 | Cryptosporidiosis inpatients with HIV/AIDS显示文摘 | O'connor RM Shaffie R Kang G | 2011 | AIDS2011，25，5： | 1 |
| 9 | Chipping performance of three processing potato cultivars during long term storage at two temperature regimes显示文摘 | Herman T J Love S L Shaffi B | 1996 | American Potato Journal1996，，73： | 1 |
| 10 | Comparison of the sublethal effect of mercury and lead on visceral dehydrogenate system in three inland teleosts显示文摘 | Shaffi S A | 1993 | Phy siol Res1993，42，1： | 1 |
| 11 | The activity of acid and alkaline phosphatases in the eggs of some freshwater teleosts显示文摘 | Shaffi S A Jafri A K | 1974 | Indian J Fish1974，21，1： | 1 |
| 12 | Towards flame retardant cotton fabrics by atmospheric pressure plasma - induced graft polymerization : synthesis and application of novel phosphoramidate monomers 显示文摘 | Edwards B EL - Shaffi A Hauser P | 2012 | Surface and Coatings Technology2012，，209： | 1 |
| 13 | Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes显示文摘 | Assim A. Alfadda Afshan Masood Shaffi Ahamed Shaik Hafedh Dekhil Michael Goran Mario Maggi | 2013 | International Journal of Endocrinology2013，，： | 1 |
| 14 | CYP1A1 polymorphisms and risk of lung cancer in the ethnic Kashmiri population显示文摘 | Shaffi SM Shah MA Bhat IA | 2009 | Asian Pac J Cancer Prev2009，10，4： | 1 |
| 15 | Effect of starvation on tissue and serum gluconeo-genic enzymes,alkaline phosphatase and tissue glycogen in thefreshwater catfish,Heteropneustes fossilis显示文摘 | Shaffi S A | 1979 | Acta PhysiolAcad Sci1979，53，4： | 1 |
| 16 | Effect of starvation on tissue and serum gluconeogenic enzymes, alkaline phosphatase and tissue glycogen in the freshwater catfish, Heteropneustes fossilis 显示文摘 | SHAFFI S A | 1979 | Acta Physiol Acad Sci Hung1979，53，4： | 1 |
| 17 | Estimating glomerular filtration rate using the chronic kidney disease-epidemiology collaboration creatinine equation: better risk predictions 显示文摘 | Inker LA Shaffi K Levey AS | 2012 | Circ Heart Fail2012，5，3： | 1 |
| 18 | A digital signature scheme secure against adaptive chosen-message attacks 显示文摘 | Shaffi Goldwasser Silvio Micali Ron L Rivest | 1988 | SIAM Journal on Computing1988，17，2： | 1 |
| 19 | ]'racing VAT-2008 program participants'self-development: Effect of social work program undergraduates intervention strategies显示文摘 | FUZ1AH SHAFFIE RUZLAN MD-ALI | 2015 | Social and Behavioral Sciences2015，171，： | 1 |
| 20 | The coagulopathy of liver disease: does vitamin K help?显示文摘 | Maha F. Saja Ayman A. Abdo Faisal M. Sanai Shaffi A. Shaikh Abdel Galil M. Abdel Gader | 2013 | Blood Coagulation & Fibrinolysis2013，，1： | 1 |
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