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| 1 | 氮肥用量及其后效对棉花产量和生物质累积动态的影响显示文摘【目的】长江流域棉花适宜氮肥用量为300 kg·hm^(-2),在迟播高密度下可减少为225 kg·hm^(-2),而不影响产量。本研究旨在探讨迟播高密度下于见花期一次性施用氮肥,氮肥用量进一步减少的可行性、氮肥后效及其对棉花产量形成规律的影响。【方法】采用盆栽试验,2014年设5个氮肥水平(120、150、180、210、240 kg·hm^(-2)),2015年设置相同氮肥用量(180 kg·hm^(-2)),研究棉花生育进程、产量及其构成以及生物质累积动态。【结果】氮肥用量显著影响棉花生物质累积和产量而不影响生育进程,氮肥后效不明显。施氮量为180 kg·hm^(-2)时籽棉产量(30.5 g·plant^(-1))和铃重(3.8 g)最高,生物质累积量较大,且生物质快速累积期生殖器官生物量所占比例最大,为64.4%。【结论】在中等肥力棉田氮肥用量减为180 kg·hm^(-2)是可行的,因为其快速累积期生殖器官生物质累积强度增加。 | 宋兴虎 Tufail Ahmed Wagan Biangkham Souliyanonh Saif Ali 黄颖 袁源 杨国正 | 2018 | 棉花学报2018，30，2： | 34 |
| 2 | Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-nave patients显示文摘AIM: To determine whether adding vitamin D, a potent immunomodulator, improves the hepatitis C virus (HCV) response to antiviral therapy. METHODS: Seventy-two consecutive patients with chronic HCV genotype 1 were randomized into two groups: the treatment group (n = 36, 50% male, mean age 47 ± 11 years) received Peg-α-2b interferon (1.5 μg/kg per week) plus ribavirin (1000-1200 mg/d) together with vitamin D3 (2000 IU/d, target serum level > 32 ng/mL), and the control group (n = 36, 60% male, mean age 49 ± 7 years) received identical therapy without vitamin D. HCV-RNA was assessed by realtime polymerase chain reaction (sensitivity, 10 IU/mL). The sustained virologic response (SVR) was defined as undetectable HCV-RNA at 24 wk post-treatment. RESULTS: Clinical characteristics were similar in both groups. The treatment group had a higher mean bodymass index (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P < 0.01), viral load (50% vs 42%, P < 0.01), and fibrosis score (> F2: 42% vs 19%, P < 0.001) than the controls. At week 4, 16 (44%) treated patients and 6 (17%) controls were HCV-RNA negative (P < 0.001). At week 12, 34 (94%) treated patients and 17 (48%) controls were HCV-RNA negative (P < 0.001). At 24 wk post-treatment (SVR), 31 (86%) treated patients and 15 (42%) controls were HCV-RNA negative (P < 0.001). Viral load, advanced fibrosis and vitamin D supplementation were strongly and independently associated with SVR (multivariate analysis). Adverse events were mild and typical of Peg-α-2b/ribavirin. CONCLUSION: Adding vitamin D to conventional Peg-α-2b/ribavirin therapy for treatment-na■ve patients with chronic HCV genotype 1 infection significantly improves the viral response. | Saif Abu-Mouch Zvi Fireman Jacob Jarchovsky Abdel-Rauf Zeina Nimer Assy Liver Unit | 2011 | World Journal of Gastroenterology2011，17，47： | 29 |
| 3 | Giant cavernous liver hemangiomas: is it the time to change the size categories?显示文摘BACKGROUND: Four different sizes(4, 5, 8 and 10 cm in diameter) can be found in the literature to categorize a liver hemangioma as giant. The present review aims to clarify the appropriateness of the size category 'giant' for liver hemangioma.DATA SOURCES: We reviewed the reports on the categorization of hemangioma published between 1970 and 2014. The number of hemangiomas, size criteria, mean and range of hemangioma sizes, and number of asymptomatic and symptomatic patients were investigated in patients aged over 18 years. Liver hemangiomas were divided into four groups: <5.0 cm, 5.0-9.9 cm, 10.0-14.9 cm and ≥15.0 cm in diameter. Inclusion criteria were noted in 34 articles involving 1972(43.0%) hemangiomas(>4.0 cm).RESULTS: The patients were divided into the following groups: 154 patients(30.0%) with hemangiomas less than 5.0 cm in diameter(small), 182(35.5%) between 5.0 cm and 9.9 cm(large), 75(14.6%) between 10.0 and 14.9 cm(giant), and 102(19.9%) more than 15.0 cm(enormous). There were 786(39.9%) asymptomatic patients and 791(40.1%) symptomatic patients. Indications for surgery related to symptoms were reported in only 75(3.8%) patients. Operations including 137 non-anatomical resection(12.9%) and 469 enucleation(44.1%) were unclearly related to size and symptoms.CONCLUSIONS: The term 'giant' seems to be justified for liver hemangiomas with a diameter of 10 cm. Hemangiomas categorized as 'giant' are not indicated for surgery. Surgery should be performed only when other symptoms are apparent. | isidoro di carlo renol koshy saif al mudares annalisa ardiri gaetano bertino adriana toro | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 22 |
| 4 | MicroRNAs and Type 2 Diabetes/Obesity显示文摘MicroRNAs 属于广泛地在调整象类型 2 糖尿病(T2D ) 和肥胖的致病那样的许多生理的过程被含有的小非编码的 RNA 的一个最新识别的班。Microarray 研究在糖尿病、肥胖的模型在胰岛素目标纸巾加亮 miRNA 表示的改变的侧面。新兴的证据建议 miRNAs 在胰岛素生产,分泌物和行动,以及在葡萄糖动态平衡和 adipocyte 区别的多样的方面起重要作用。织物特定的 miRNAs 的鉴定在 T2D 和肥胖含有可能为为早诊断和肥胖相关的医药复杂并发症的治疗学的干预的有效策略的未来发展有用。 | Mustafa Abdo Saif Dehwah Aimin Xu Qingyang Huang | 2012 | Journal of Genetics and Genomics2012，39，1： | 20 |
| 5 | Estrogen receptors in gastric cancer:Advances and perspectives显示文摘Worldwide, gastric cancer is one of the most common malignancies with high mortality. Various aspects of thedevelopment and progression of gastric cancer continue to be extensively investigated in order to further our understanding and provide more effective means for the prevention, diagnosis, and treatment of the disease. Estrogen receptors(ERs) are steroid hormone receptors that regulate cellular activities in many physiological and pathological processes in different tissues. There are two distinct forms of ERs, namely ERα and ERβ, with several alternative-splicing isoforms for each. They show distinct tissue distribution patterns and exert different biological functions. Dysregulation of ERs has been found to be associated closely with many diseases, including cancer. A number of studies have been conducted to investigate the role of ERs in gastric cancer, the possible mechanisms underlying these roles, and the clinical relevance of deregulated ERs in gastric cancer patients. To date, inconsistent associations of different ERs with gastric cancer have been reported. These inconsistencies may be caused by variations in in vitro cell models and clinical samples, including assay conditions and protocols with regard to different forms of ERs. Given the potential of the deregulated ERs as diagnostic/prognostic markers or therapeutic targets for gastric cancer, it will be important to identify/confirm the association of each ER isoform with gastric cancer, to determine the specific roles and interactions that these individual ER isoforms play under specific conditions in the development and/or progression of gastric cancer, and to elucidate precisely these mechanisms. In this review, we summarize the achievements from early ER studies in gastric cancer to the most up-to-date discoveries, with an effort to provide a comprehensive understanding of the role of ERs roles in gastric cancer and its possible mechanisms. Furthermore, we propose directions for future investigations. | Muhammad Saif Ur Rahman Jiang Cao | 2016 | World Journal of Gastroenterology2016，22，8： | 11 |
| 6 | Genetic alterations in pancreatic cancer显示文摘The diagnosis of pancreatic cancer is devastating for patients and their relatives as the incidence rate is approximately the same as mortality rate. Only a small percentage, which ranges from 0.4% to 4% of patients who have been given this diagnosis, will be alive at five years. At the time of diagnosis, 80% of pancreatic cancer patients have unresectable or metastatic disease. Moreover, the therapeutic alternatives offered by chemotherapy or radiotherapy are few, if not zero. For all these reasons, there is an imperative need of analyzing and understanding the primitive lesions that lead to invasive pancreatic adenocarcinoma. Molecular pathology of these lesions is the key of our understanding of the mechanisms underlying the development of this cancer and will probably help us in earlier diagnosis and better therapeutic results. This review focuses on medical research on pancreatic cancer models and the underlying genetic alterations. | Muhammad Wasif Saif Lena Karapanagiotou Kostas Syrigos | 2007 | World Journal of Gastroenterology2007，13，33： | 10 |
| 7 | 基于概率潮流的光伏电站中储能系统的优化配置方法显示文摘高比例光伏发电接入会对电力系统的稳定性等造成不利影响,而储能则被认为是消除这些影响的有效手段之一。本文从电力系统潮流的角度,分析了光伏发电对电力系统的影响,进而分析了储能对抑制这种影响的作用。首先,介绍了电力系统中元件的概率分布模型和储能模型,以及拉丁超立方采样法及Gram-Schmidt序列正交化方法;其次,建立了多目标优化模型,模型考虑了储能系统的成本、支路潮流的越限概率和电网的网络损耗,并用遗传算法求取目标函数的最优解;最后,在IEEE24节点测试系统中进行了仿真,分析了光伏不同接入容量和接入位置对电力系统的影响,储能对电力系统的作用,得出了对应不同光伏容量的储能最优配置。 | 张德隆 MUBAARAK Saif 蒋思宇 王龙泽 刘金鑫 陈永聪 李美成 | 2021 | 储能科学与技术2021，10，6： | 9 |
| 8 | Incidence and management of ZIv-aflibercept related toxicities in colorectal cancer显示文摘Ziv-afilbercept(Zaltrap, Ziv) is a humanized fusion protein constructed by joining the vascular endothelial growth factor(VEGF) binding portions of human VEGF receptors 1 and 2 to the Fc portion of human immunoglobulin IgG 1. Recently, a randomized, open-label, phase Ⅲ study compared 5-fluorouracil, leucovorin, irinotecan(FOLFIRI)/Ziv with FOLFIRI/placebo in patients who had been previously treated with oxaliplatin based chemotherapy for metastatic colon cancer(mC RC). Patients who had received prior bevacizumab therapy were also eligible. This study showed that the addition of Ziv improved overall survival with median survival time of 13.5 mo vs 12.06 mo in ziv vs placebo arm. Ziv also improved progression free survival from 4.67 mo to 6.9 mo with a response rate of 19.8% in the Ziv/FOLFIRI group vs 11.1% in FOLFIRI alone group. This led to the approval of Ziv in combination with FOLFIRI in metastatic colon cancer patients treated with prior oxaliplatin regimens. The mostcommon side effects were diarrhea, stomatitis, fatigue, hypertension, weight loss, loss of appetite, abdominal pain, and headache. As the use of Ziv has become more widespread in oncology practices, familiarity with the toxicity profile of the drug and the use of practice guidelines for their treatment has become increasing important. This review will address the toxicities noted in trials using Ziv for the treatment of mC RC, and will provide recommendations for toxicity management. | Muhammad Wasif Saif Valerie Relias Kostas Syrigos Krishna S Gunturu | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 9 | Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis显示文摘Periodontitis 是 periodontium 的煽动性的疾病。在 neutrophils 和织物禁止者分泌的矩阵 metalloproteinases (MMP ) 之间的任何不平衡在口香糖织物开始骨胶原的破坏,导致长期的 periodontitis。这研究瞄准了 MMP-8 的唾液的层次和长期的 periodontitis 的牙齿周围的参数到相互关联为长期的 periodontitis 的早诊断作为一个 noninvasive 标记建立 MMP-8。学习包含了访问扎乌丁·阿赫马德博士的 periodontic OPD 的 40 个题目牙齿的学院和医院,在 Aligarh 定位了, U.P,印度,从 2011 ~ 2012。这些题目被划分成二个组:组当组 II 与长期的 periodontitis 由 20 个病人组成了时,我由 20 个牙齿周围地健康的题目(控制) 组成了。长期的 periodontitis 根据几个牙齿周围的参数被估计,包括探查深度(PPD ) 的衣袋,临床的附件水平(CAL ) ,齿龈的索引(官方补给) ,并且匾索引(PI ) 。为由用 Quantikine 人总数 MMP-8 免疫分析工具包的 ELISA 的 MMP-8 评价在 unstimulated 和整个吐的口水的 3ml 附近是镇定的。数据用 STATISTICA (Windows 版本 6 ) 软件被分析。组的唾液的 MMP-8 层次我和 II 是 190.91?? | Namita Gupta N.D. Gupta Akash Gupta Saif Khan Neha Bansa | 2015 | Frontiers of Medicine2015，9，1： | 5 |
| 10 | 内镜全层切除术与外科手术切除胃巨大间质瘤的对照性分析(含视频)显示文摘目的评价内镜全层切除术治疗长径5~7 cm胃巨大间质瘤的安全性和有效性。方法回顾性分析2017年1月—2018年10月,于郑州大学第一附属医院接受内镜全层切除术或外科手术(包括腹腔镜及开腹手术)治疗,长径5~7 cm且经术后病理确诊为胃间质瘤的36例病例,按照手术方式分为内镜组9例和外科组27例,对比分析2组围术期指标和并发症总体发生率。结果围术期指标方面,内镜组中位手术时间明显长于外科组(4.0 h比2.0 h,P<0.01),术后禁食时间明显短于外科组[(4.55±0.88)d比(6.22±2.24)d,t=-2.15,P=0.03],术后住院时间明显短于外科组[(6.88±1.26)d比(10.03±2.90)d,t=-3.13,P<0.01],术后第1天腹痛视觉模拟评分中位评分明显低于外科组(3分比6分,P<0.01),术后第3天腹痛视觉模拟评分中位评分亦明显低于外科组(1分比3分,P<0.01),住院费用明显少于外科组[(5.5±1.47)万元比(7.3±2.43)万元,t=-2.11,P=0.04]。总体并发症发生率方面,内镜组为11.1%(1/9),高于外科手术组的7.4%(2/27),但差异无统计学意义(P=1.00)。结论内镜全层切除术治疗长径5~7 cm胃巨大间质瘤是安全和有效的,且具有创伤小、术后恢复快、住院费用低等优势,但如何缩短手术时间是亟待解决的问题。 | 卢英姿 郑庆芬 刘丹 杨荟玉 孔令建 李德亮 赵丽霞 Saif Ullah 刘冰熔 | 2021 | 中华消化内镜杂志2021，38，7： | 5 |
| 11 | Achieving timely percutaneous reperfusion for rural ST-elevation myocardial infarction patients by direct transport to an urban PCI-hospital显示文摘圣举起心肌的梗塞(STEMI ) 指南由主要经皮的冠的干预(一种总线标准) 推荐灌注从第一医药接触(FMC ) 的时间的 90 min。这策略在缺乏一所附近一种总线标准有能力的医院的农村区域是挑战性的。推荐灌注时间能为在一所附近一种总线标准有能力的医院外面,由医疗服务(他们) STEMI 地 triage protocol.MethodsSixty STEMI 病人直接从三个农村县由他们搬运了的协议驱动的紧急情况的使用由地面交通在农村区域介绍给一所中央一种总线标准有能力的医院的 STEMI 病人被完成(拿骚,卡姆登和 Charlton 县)在佛罗里达的大学的50英里的半径以内,到 12/31/2013 的从 01/01/2009 的 Health-Jacksonville ( UFHJ )是 iden STEMI 地 triage 协议合并了三个元素:(1 ) 在每农村紧急情况之间的一个合作协议医疗服务(他们) 机构和 UFHJ;(2 ) 医院前 ECG 到的性能便于 STEMI 鉴定和实验室激活;并且(3 ) 直接由地面交通转到 UFHJ 心脏的 catheterization 实验室。 FMC-to-device ( FMC2D ), door-to-device ( D2D ),和运输时间,星期的日子,白天的时间,和他们转移时间被记录,并且机会比率(或)完成 FMC2D 时间 calculated.ResultsFMC2D 时间是更短的为安置 STEMI ( 81 牡楤污椠普牡瑣潩????敍桴摯?琠瑯污漠???挠湯敳畣楴敶??瀠瑡敩瑮?摡業瑴摥琠?敐楫杮唠楮敶獲瑩?敐灯敬?潈灳瑩污映潲?慊畮牡???琠?敄散扭牥㈠?‵敷敲爠'填船摀?桔楥?汣湩捩污挠慨慲瑣牥獩楴獣眠牥?敲牴獯数瑣癩汥?潣灭牡摥戠瑥敷湥瀠瑡敩瑮?楷桴漠?楷桴畯??敲畣牲湥???吠敨?畭瑬癩牡慩? | Charles-Lwanga K Bennin Saif Ibrahim Farah Al-Saffar Lyndon C Box Joel A Strom | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 12 | Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction显示文摘Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomiting, burning sensations, dizziness, and edema. We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. A 57-year-old female with T3N2M0 rectal adenocarcinoma received modified FOLFOX-6. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9th and 10th infusions, she developed fever to a maximum of 38.3℃ with stable hemodynamic status despite medications. During 11th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever. On examination, she was pale, cyanotic, with a temperature of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min and O2 saturation of 88%-91%. She was hospitalized for management and recovered in 24 h. Fever alone is not a usual symptom of oxaliplatin HSR. It may be indicative that the patient may develop serious reactions subsequently, as did our patient who developed hypotension with the third challenge. Treatment and prevention consists of slowing the infusion rate, use of steroids and antagonists of Type 1 and 2 histamine receptor antagonists, whereas desensitization could help to provide the small number of patients who experience severe HSR with the ability to further receive an effective therapy for their colorectal cancer. | M Wasif Saif Shailja Roy Leslie Ledbetter Jennifer Madison Kostas Syrigos | 2007 | World Journal of Gastroenterology2007，13，39： | 4 |
| 13 | 羊膜移植治疗睑球黏连的临床观察(英文)显示文摘目的:评估羊膜移植(AMT)在治疗睑球黏连中的应用效果。方法:这项无对照干预性病例研究于2013/01~2015/12,包括连续就诊的12名患者共14眼。患者均接受永久性羊膜移植,以治疗睑球黏连,使用冷冻保存或冷冻干燥的羊膜(AM)。这12例(14眼)患者,年龄在26~62岁,平均43.38±11.25岁,其中8例(4名男性,4名女性)10眼为翼状胬肉切除术后继发,4例患者(1名男性,3名女性)斜视手术后继发。所有患者距上次手术至少6mo。术后以恢复深度稳定的穹窿为手术成功,无瘢痕或炎症发生,6mo的随访期间无眼球运动的限制。结果:随访期平均为7±4.2mo(6-9mo)。在所有14只眼中,手术后3wk均观察到AM完全上皮化,手术部位无炎症表现。总共14眼中有8眼(成功率57%)显示穹窿重建成功,穹窿深,无复发。有4眼(29%)表现出部分成功,中度深度的穹窿和中度瘢痕。有2眼(14%)显示重建失败,穹窿完全闭合。有7眼手术后视力改善,7眼视力保持稳定。AMT术后并发症少,14眼中1眼(7%)发生严重的结膜反应和眼球运动受限。而在术后前3mo中,14眼中有2眼发生化脓性肉芽肿(14%),予以手术切除,局部糖皮质激素注射。结论:单用AMT是一种治疗睑球黏连安全有效的方法。考虑到与角膜缘切除有关的潜在不良反应,AMT也是一种有效的重建穹窿以修复各种眼表疾病所致睑球黏连的方法。 | Ahmed Tamer Sayed Saif Passant Sayed Saif Amr El Deeb | 2017 | 国际眼科杂志2017，17，5： | 4 |
| 14 | Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis显示文摘Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow. However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare. A 57-year-old female presented with abdominal pain and matted lymph nodes in her axilla. She was admitted with a diagnosis of acute pancreatitis. Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy. Biopsy of the axillary mass revealed a large B-cell lymphoma. The patient was classified as stage Ⅳ, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index. She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). Within a week after chemotherapy, the patient’s abdominal pain resolved. Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy. A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis. However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published. Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy. | M Wasif Saif Sapna Khubchandani Marek Walczak | 2007 | World Journal of Gastroenterology2007，13，36： | 4 |
| 15 | Hydrodynamic Characteristics of Three Rows of Vertical Slotted Wall Breakwaters显示文摘In this study, we examine the hydrodynamic characteristics of three rows of vertical slotted wall breakwaters in which the front and middle walls are permeable and partially immersed in a water channel of constant depth, whereas the third wall is impermeable. The wave–structure interaction and flow behavior of this type of breakwater arrangement are complicated and must be analyzed before breakwaters can be appropriately designed. To study the hydrodynamic breakwater performance, we developed a mathematical model based on the eigenfunction expansion method and a least squares technique for predicting wave interaction with three rows of vertical slotted wall breakwaters. We theoretically examined the wave transmission, reflection, energy loss, wave runup, and wave force under normal regular waves. Comparisons with experimental measurements show that the mathematical model results adequately reproduce most of the important features. The results of this investigation provide a better understanding of the hydrodynamic performance of triple-row vertical slotted wall breakwaters. | Majed O. Alsaydalani Mohammed A. N. Saif Medhat M. Helal | 2017 | Journal of Marine Science and Application2017，16，3： | 4 |
| 16 | Mechanical properties and microstructure of rolled and electrodeposited thin copper foil显示文摘Commercial grade rolled and electrodeposited copper foils from Japan and China were selected, and their mechanical properties and microstructure were investigated.It was observed that there are notable differences in fracture strength, elongation at break and hydrophilicity between rolled and electrodeposited copper foils. The rolled copper foils have higher tensile strength, lower ductility and larger static contact angle than electrodeposited copper foils. The rolled copper foils contain a b-fiber texture, and the electrodeposited copper foils have random crystalline orientations. It was also observed that the rolled foils have packed grains, and electrodeposited foils have equiaxial grains. The uniform fine grain size and a few substructures of Japanese electrodeposited foils are major reasons for their higher elongation. | Xiang-Qian Yin Li-Jun Peng Saif Kayani Lei Cheng Jian-Wei Wang Wei Xiao Li-Gen Wang Guo-Jie Huang | 2016 | Rare Metals2016，35，12： | 4 |
| 17 | The N-terminal Pro-BNP Investigation of Dyspnea in the Emergency department (PRIDE) study显示文摘 | James L. Januzzi Carlos A. Camargo Saif Anwaruddin Aaron L. Baggish Annabel A. Chen Daniel G. Krauser Roderick Tung Renee Cameron J. Tobias Nagurney Claudia U. Chae Donald M. Lloyd-Jones David F. Brown Stacy Foran-Melanson Patrick M. Sluss Elizabeth Lee-L | 2005 | The American Journal of Cardiology2005，，8： | 3 |
| 18 | Quantitative analysis of cefixime via complexation with palladium(Ⅱ) in pharmaceutical formulations by spectrophotometry显示文摘An optimized and validated spectrophotometric method has been developed for the determination of cefixime in pharmaceutical formulations. The method is based on the complexation reaction between cefixime and palladium ion in the presence of acidic buffer solution (pH 3) in ethanol-distilled water medium at room temperature. The complex absorbed maximally at 352 nm. Beer's law is obeyed in the working concentration range of 2.5-35 μg/mL with apparent molar absorptivity of 1.015×104L/mol cm and Sandell's sensitivity of 0.001 μg/cm2 /0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.175 and 0.583 μg/mL, respectively. The effect of common excipients used as additives has been studied in the determination of cefixime. The proposed method has been successfully applied for the determination of cefixime in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t and F values and found no significant difference between the two methods. | Syed Najmul Hejaz Azmi Bashir Iqbal Nada Said Hassan Al-Humaimi Iman Rashid Saif Al-Salmani Noora Ali Saad Al-Ghafri Nafisur Rahman | 2013 | Journal of Pharmaceutical Analysis2013，3，4： | 3 |
| 19 | 乳汁免疫和猪流行性腹泻病毒病疫苗:历史和现状(译文)显示文摘由于肠道病毒感染导致仔猪在发病率、死亡率和生产能力丧失方面的影响,每年给养猪者带来数百万美元的损失。2013—2014年间,猪流行性腹泻病毒(PEDV)病的暴发给美国养猪业带来了9亿~18亿美元的经济损失。被动乳汁免疫被认为是保护新生哺乳仔猪免受PED等肠道疾病危害的最有希望和有效的方法。通过乳汁免疫被动保护哺乳仔猪的效果依赖于病原特异性IgA浆细胞转运至乳腺的数量和乳汁中分泌型IgA的积累程度,这种免疫途径被定义为'肠-乳腺-sIgA轴'。由于胎盘的不可穿透性,新生仔猪处于无免疫球蛋白的状态,对很多的传染性病原体极易感。它们仅依靠来源于母源的初乳和乳汁抗体获得被动保护。先前开发的关于猪传染性胃肠炎病毒(TGEV)病的活疫苗和灭活疫苗,提供了对母源性免疫和仔猪被动保护机制的理解。在这篇文章中,综述了猪传染性胃肠炎病毒诱导乳汁免疫的研究进展,并指出对当前养猪业正努力控制的猪流行性腹泻病毒感染和相关疫苗的研究方向。同时研究和鉴别出影响乳汁免疫和'肠-乳腺-sIgA轴'的各种因素,有助于改善妊娠母猪预防猪流行性腹泻病毒感染以及改进其它肠道病原用疫苗方案,从而达到提升整个猪群的免疫力、猪群健康和企业生产力的目的。 | Langel Stephanie N Paim Francine Chimelo Lager Kelly M Vlasova Anastasia N Saif Linda J 吕茂杰 | 2017 | 养猪2017，，1： | 3 |
| 20 | Elevated CO2 differentially affects tobacco and rice defense against lepidopteran larvae via the jasmonic acid signaling pathway显示文摘Atmospheric CO_2 levels are rapidly increasing due to human activities. However, the effects of elevated CO_2(ECO_2) on plant defense against insects and the underlying mechanisms remain poorly understood. Here we show that ECO_2 increased the photosynthetic rates and the biomass of tobacco and rice plants, and the chewing lepidopteran insects Spodoptera litura and Mythimna separata gained less and more mass on tobacco and rice plants, respectively. Consistently, under ECO_2, the levels of jasmonic acid(JA), the main phytohormone controlling plant defense against these lepidopteran insects, as well as the main defense-related metabolites, were increased and decreased in insectdamaged tobacco and rice plants. Importantly, bioassaysand quantification of defense-related metabolites in tobacco and rice silenced in JA biosynthesis and perception indicate that ECO_2 changes plant resistance mainly by affecting the JA pathway. We further demonstrate that the defensive metabolites, but not total N or protein, are the main factors contributing to the altered defense levels under ECO_2. This study illustrates that ECO_2 changes the interplay between plants and insects, and we propose that crops should be studied for their resistance to the major pests under ECO_2 to predict the impact of ECO_2 on future agroecosystems. | Chengkai Lu Jinfeng qi Christian Hettenhausen Yunting Lei Jingxiong Zhang Mou Zhang Cuiping Zhang Juan Song Jing Li Guoyan Cao Saif ul Malook Jianqiang Wu | 2018 | Journal of Integrative Plant Biology2018，60，5： | 3 |
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