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| 1 | MicroRNAs and Type 2 Diabetes/Obesity显示文摘MicroRNAs 属于广泛地在调整象类型 2 糖尿病(T2D ) 和肥胖的致病那样的许多生理的过程被含有的小非编码的 RNA 的一个最新识别的班。Microarray 研究在糖尿病、肥胖的模型在胰岛素目标纸巾加亮 miRNA 表示的改变的侧面。新兴的证据建议 miRNAs 在胰岛素生产,分泌物和行动,以及在葡萄糖动态平衡和 adipocyte 区别的多样的方面起重要作用。织物特定的 miRNAs 的鉴定在 T2D 和肥胖含有可能为为早诊断和肥胖相关的医药复杂并发症的治疗学的干预的有效策略的未来发展有用。 | Mustafa Abdo Saif Dehwah Aimin Xu Qingyang Huang | 2012 | Journal of Genetics and Genomics2012，39，1： | 20 |
| 2 | Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes显示文摘Patients with inflammatory bowel disease(IBD)have an increased risk of 10%-15%developing colorectal cancer(CRC)that is a common disease of high economic costs in developed countries.The CRC has been increasing in recent years and its mortality rates are very high.Multiple biological and biochemical factors are responsible for the onset and progression of this pathology.Moreover,it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health.The gut microflora,or microbiota,has an extensive diversity both quantitatively and qualitatively.In utero,the intestine of the mammalian fetus is sterile.At birth,the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms,ultimately developing into a stable community,with marked variations in microbial composition between individuals.The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora(dysbiosis).The healthy human gut harbours about10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract.The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC.In healthy subjects,the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature,competition between different bacterial strains,peristalsis and drugs can influence the intestinal microenvironment.The microbiota exerts diverse physiological functions to include:growth inhibition of pathogenic microorganisms,synthesis of compounds useful for the trophism of colonic mucosa,regulation of intestinal lymphoid tissue and synthesis of amino acids.Furthermore,mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity.Changes in the microbiota composition are mainly influenced by diet and age,as well as genetic factors.Increasing evidence indicates that dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis and induces dysregulation of the immune response whichpromotes and sustains inflammation in IBD leading to carcinogenesis.A disequilibrium in gut microflora composition leads to the specific activation of gut associated lymphoid tissue.The associated chronic inflammatory process associated increases the risk of developing CRC.Ulcerative colitis and Crohn’s disease are the two major IBDs characterized by an early onset and extraintestinal manifestations,such as rheumatoid arthritis.The pathogenesis of both diseases is complex and not yet fully known.However,it is widely accepted that an inappropriate immune response to microbial flora can play a pivotal role in IBD pathogenesis. | Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 3 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 4 | The past, current and future trends in DNA vaccine immunisations显示文摘This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation. | Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 7 |
| 5 | 血液恶性肿瘤患者肠道菌群分析显示文摘目的将血液恶性肿瘤患者肠道菌群与健康个体进行比较,观察血液肿瘤患者肠道菌群结构的变化,探讨肠道菌群与血液恶性肿瘤发生发展的联系。方法收集血液恶性肿瘤患者与健康志愿者粪便样品,提取样品中菌群总DNA,然后通过变性凝胶梯度电泳(DGGE)技术分析肠道菌群多样性和差异性。结果血液恶性肿瘤组与健康组肠道菌群的DGGE指纹图谱有明显差异。与正常组相比,患者组肠道大肠埃希菌呈现过度增长趋势,有益菌柔嫩梭菌减少或缺失,某些患者肠道内一些细菌呈现特异性增长,如粪肠球菌、硫磺肠球菌、约氏不动杆菌等。结论与健康对照组相比,血液恶性肿瘤患者肠道菌群结构与多样性发生改变,这可能为血液恶性肿瘤早期抗感染提供实验依据。 | 杨显 温建勋 Abdo Meyiah 王秀娟 肖伟利 张翠丽 曹雪娇 辛毅 | 2017 | 中国微生态学杂志2017，29，10： | 7 |
| 6 | 采用海泡石纳米颗粒控制膨润土基钻井液性能显示文摘提出在膨润土基钻井液中添加海泡石纳米颗粒来控制其性能,并通过实验研究了不同温度压力条件下海泡石纳米颗粒对膨润土基钻井液流变性、滤失性等性能的影响。测量了添加海泡石纳米颗粒前后膨润土基钻井液在不同温度压力条件下的塑性黏度、动切力和滤失量,并在储集层温度压力条件下对添加海泡石纳米颗粒前后的膨润土基钻井液进行了岩心驱替实验,对比了钻井液的滤失量及对地层的伤害程度。结果表明:添加海泡石纳米颗粒可以提高清水和盐水膨润土基钻井液的塑性黏度和动切力;海泡石纳米颗粒可以在较大的温度和压力范围内特别是高温高压条件下保持钻井液流变性的稳定;储集层温度压力条件下,海泡石纳米颗粒降低了钻井液的滤失量,抑制了砂岩岩心渗透率降低。海泡石纳米颗粒是一种理想的膨润土基钻井液添加剂。 | AL-MALKI Needaa POURAFSHARY Peyman AL-HADRAMI Hamoud ABDO Jamil | 2016 | 石油勘探与开发2016，43，4： | 7 |
| 7 | Causes of rockfalls in Al-Huwayshah area,Yemen显示文摘According to topography of Yemen,most areas and villages are located at obligated crest,toe of mountain and under cliffs.Therefore Al-Huwayshah consisting of Tawilah sandstone group is characterized by steep slope reach to 90° in some areas.This area is affected by strong tectonic movements and faults that occurred during the geological epochs.This effect enhances to find out fractures and joints as well as the rocks become brittle and ready to slide depending on the position of area.And there are some fractures and joints on the surface of the areas due to tectonic movement associated with opening the Red Sea and Gulf of Aden.The rainfalls,fractures,joints,earthquakes,gravity,vegetations,temperatures and human activities play a big role in the processes of rockfalls and landslides in this area.All those factors are considered as the basic causes and catalyzed factors for occurrence of rockfall in the studide area.In addition,the authors carried out laboratory test for many rock samples to get the physical properties of the rocks. | Aref M. O. AL-JABALI NIE Lei Abdo S. AL-MAQTARY Hussein AL-AKHALI Mohammed HAZAEA Fadel AL-AGHBARI | 2009 | Global Geology2009，12，1： | 6 |
| 8 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 9 | Toxicity of cadmium and lead on tropical midge larvae,Chironomus kiiensis Tokunaga and Chironomus javanus Kieffer(Diptera:Chironomidae)显示文摘Objective:To investigate the acute toxicity of cadmium and lead on larvae of two tropical Chironomid species,Chironomus kiiensis(C.kiiensis) Tokunaga and Chironomus javanus(C. javanus) Kieffer.Methods:Different larval instars(first-fourth) were exposed using a sialic non-replacement testing procedures to various concentrations of cadmium and lead.Results: In general,younger larvae(first and second instars) of both species were more sensitive to both metals than older larvae(third and forth instars).The toxic effects of the metals on C.kiiensis and C. javanus were influenced by the age of the larvae(first to fourth instars),types of metals(cadmium or lead) and duration of larval exposure(24,48,72 and 96 h) to the metals.Conclusions:Cadmium was more toxic to the chironomids than lead and C.javanus was significantly more sensitive to both metals than C.kiiensis(P<0.05). | Warrin Ebau Che Salmah Md Rawi Zubir Din Salman Abdo Al-Shami | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 5 |
| 10 | Novel yellow colored flame compositions with superior spectral performance显示文摘The production of colored flames is the primary purpose of military signaling, projectile tracing, and illuminating devices. Certain elements and compounds when heated to high temperature have the unique property of emitting lines or narrow bands in the visible region(380-780 nm). This study, reports on the development of novel yellow colored flame compositions with enhanced spectral performance in terms of luminous intensity, and color quality to standard Russian yellow tracer. The light intensity and the imprint spectra of developed yellow flares were measured using digital luxmeter and UV e Vis. spectrometer respectively. The main giving of this study is that the light intensity, and color quality of Russian yellow tracer were improved by 287%, and 170% respectively. This was accomplished by means of optimizing the ratio of novel binder to color source using aluminum metal fuel. Aluminumbased formulations were found to maximize the formation of yellow reactive emitting specimens, and to eliminate any interfering incandescent emission resulted from Mg O. Quantification of yellow color emitting specimens in the combustion gaseous products was achieved using chemical equilibrium thermodynamic code named ICT(Institute of Chemical Technology in Germany, Virgin 2008); in an attempt to judge the light quality. This improvement in yellow flare performance established the rule that the emission intensity increases as the reaction temperature increases. In the meantime upper limit of temperature was avoided to maximize the color quality. | Ramy Sadek Mohamed Kassem Mohamed Abdo Sherif Elbasuney | 2017 | Defence Technology(防务技术)2017，13，1： | 4 |
| 11 | Spectrally adapted red flare tracers with superior spectral performance显示文摘The production of bright light, with vivid color, is the primary purpose of signaling, illuminating devices,and fire control purposes. This study, reports on the development of red flame compositions with enhanced performance in terms of luminous intensity, and color quality. The light intensity and the imprint spectra of developed red flame compositions to standard NATO red tracer(R-284 NATO) were measured using digital luxmeter, and UV-Vis. spectrometer. The main giving of this study is that the light intensity of standard NATO red tracer was increased by 72%, the color quality was also improved by60%(over the red band from 650 to 780 nm). This enhanced spectral performance was achieved by means of deriving the combustion process to maximize the formation of red color emitting species in the combustion flame. Thanks to the optimum ratio of color source to color intensifier using aluminum metal fuel; this approach offered the highest intensity and color quality. Upon combustion, aluminum was found to maximize the formation SrCL(the main reactive red color emitting species) and to minimize the interfering incandescent emission resulted from MgO and SrO. Quantification of active red color emitting species in the combustion flame was conducted using chemical equilibrium thermodynamic code named ICT. The improvement in red flare performance, established the rule that the color intensifier should be in the range from 10 to 15 Wt % of the total composition. | Ramy Sadek Mohamed Kassem Mohamed Abdo Sherif Elbasuney | 2017 | Defence Technology(防务技术)2017，13，6： | 3 |
| 12 | Mortality and rebleeding following variceal haemorrhage in liver cirrhosis and periportal fibrosis显示文摘AIM To investigate mortality and rebleeding rate and identify associated risk factors at 6 wk and 5 d following acute variceal haemorrhage in patients with liver cirrhosis and schistosomal periportal fibrosis.METHODS This is a prospective study conducted during the period from March to December 2014. Patients with portal hypertension presenting with acute variceal haemorrhage secondary to either liver cirrhosis(group A) or schistosomal periportal fibroses(group B) presenting within 24 h of the onset of the bleeding were enrolled in the study and followed for a period of 6 wk. Analysis of data was done by Microsoft Excel and comparison between groups was done by Statistical Package of Social Sciences version 20 to calculate means and find the levels of statistical differences and define the mortality rates, the P value of < 0.05 was considered to be significant. RESULTS A total of 94 patients were enrolled in the study. Thirtytwo patients(34%) had liver cirrhosis(group A) and62(66%) patients had periportal fibrosis(group B).Mortality: The 6-wk and 5-d mortality were 53% and16% respectively in group A compared to 10% and 0%in group B(P value < 0.000 and < 0.004). In group A;a Child-Turcotte-Pugh class C and rebleeding within 5 d were significantly associated with 5-d mortality(P value< 0.029 and < 0.049 respectively) and Child- TurcottePugh class C was also a significant risk factor for 6-wk mortality(P value < 0.018). In group B; mortality was significantly associated with rebleeding within the 6-wk follow-up period and requirement for blood transfusion on admission(P value < 0.005 and < 0.049). Rebleeding:The 6-wk and 5-d rebleeding rate in group A were 56%and 25% respectively compared to 32% and 3% in group B(P value < 0.015 and < 0.002). Clinical presentation with encephalopathy was a significant risk factor for 5 d rebleeding in group A(P value < 0.005) while grade Ⅲperiportal fibrosis and requirement for blood transfusion on admission were significant risk factors for 6-wk rebleeding in group B(P value < 0.004 and < 0.02).CONCLUSION The 6-wk and 5-d mortality and rebleeding rate were significantly higher in patients with liver cirrhosis compared to patients with schistosomal periportal fibrosis. | Sara Elfadil Abbas Mohammed Abdelmunem Eltayeb Abdo Hatim Mohamed Yousif Mudawi | 2016 | World Journal of Hepatology2016，8，31： | 3 |
| 13 | Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years显示文摘AIM: To determine the seroprevalence of Hepatitis A (HAV) amongst Saudi children and compare it with previously reported prevalence data from the same population. METHODS: A total of 1357 students were randomly selected between the ages of 16 and 18 years (689 males and 668 females) from three different regions of Saudi Arabia (Madinah, Al-Qaseem, and Aseer) and tested for anti-HAV-IgG. RESULTS: The overall prevalence of anti-HAV-IgG among the study population was 18.6%. There was no difference between males and females but there was a significant difference in the seroprevalence (P = 0.0001) between the three different regions, with Ma- dinah region showing the highest prevalence (27.4%). When classified according to socioeconomic status, lower class students had a prevalence of 36.6%, lower middle class 16.6%, upper middle class 9.6%, and up- per class 5.9% (P = 0.0001). Comparing the current study results with those of previous studies in 1989 and 1997 involving the same population, there was a marked reduction in the overall prevalence of HAV from 52% in 1989, to 25% in 1997, to 18.6% in 2008 (P < 0.0001). CONCLUSION: Over the last 18 years, there has been a marked decline in the prevalence of HAV in Saudi children and adolescents. The current low prevalence rates call for strict adherence to vaccination policies in high-risk patients and raises the question of a univer- sal HAV vaccination program. | Faleh Al Faleh Suliman Al Shehri Saleh Al Ansari Mohammed Al Jeffri Yaqoub Al Mazrou Ahmad Shaffi Ayman A Abdo | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 14 | Assessment of Alpha-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma in Middle Eastern Patients显示文摘 | Faisal M. Sanai Samia Sobki Khalid I. Bzeizi Shaffi A. Shaikh Khalid Alswat Waleed Al-Hamoudi Majid Almadi Faisal Al Saif Ayman A. Abdo | 2010 | Digestive Diseases and Sciences2010，，12： | 2 |
| 15 | Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells显示文摘Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against different doses of A. vera and C. comosum. Viability of the cells was assessed by MTT assay. Evaluation of apoptosis and DNA damage in HepG 2 cells were performed using annexin V apoptosis detection kit. The expression of p53 and anti-apoptotic(Bcl-2) were tested by real time-PCR and flow cytometer analyser. Hematoxylin and eosin stained sections from untreated and treated HepG 2 cells were observed using light microscopy.Results: The IC50 values of A. vera and C. comosum extracts were(10.45 ± 0.31) and(9.60 ± 0.01) μg/mL respectively. The extracts separately increased cytotoxicity against HepG 2 cells in a time and dose dependent manners. Also, it apparently induced apoptosis through increase P53 and decrease Bcl-2 genes expressions.Conclusions: The results indicated that the extracts could have anti-hepatocarcinogenic effect, at least in part, through modulation of apoptosis. | Maram Shalabi Kh.Khilo Mahmoud M.Zakaria Mahmoud G.Elsebaei Walied Abdo Walaa Awadin | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 2 |
| 16 | Routine rectal retroflexion during colonoscopy has a low yield for neoplasia显示文摘AIM: To investigate the value of retroflexion in detecting neoplasia in the distal rectum. METHODS: This was a prospective observational study performed in an academic endoscopy unit. Consecutive patients undergoing colonoscopy had careful forward viewing of the distal rectum by retroflexion. Of 1502 procedures, 1076 (72%) procedures were performed with a 140° angle of view colonoscope and 426 (28%) were performed with a 170° angle of view colonoscope. The outcome measurement was the yield of neoplasia in the distal rectum detected by forward viewing vs retroflexion. RESULTS: A total of 1502 patients, including 767 (51%) females and 735 (49%) males, with mean age of 58.8 ± 12.5 years were enrolled. Retroflexion was successful in 1411 (93.9%) patients, unsuccessful or not performed because the rectum appeared narrow in 91 (6.1%). Forty patients had a polyp detected in the distal rectal mucosa. Thirty-three were visible in both the forward and retroflexed view (25 hyperplastic, 8 adenomatous). Seven polyps were visualized only by retroflexion (6 hyperplastic sessile polyps, one 4 mm sessile tubular adenoma). There was no significant difference in information added by retroflexion with 140° vs 170° angle of view instrument. CONCLUSION: To our knowledge, this is the largest reported evaluation of retroflexion in the rectum. Routine rectal retroflexion did not detect clinically important neoplasia after a careful forward examination of the rectum to the dentate line. Since retroflexion has risks and may cause discomfort, theuse of routine retroflexion should be at the discretion of the endoscopist. | Abdo Saad Douglas Kevin Rex | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 17 | 高度近视合并青光眼患者黄斑区脉络膜厚度的多元回归分析(英文)显示文摘目的:探讨高度近视合并原发性开角型青光眼(POAG)患者的黄斑区脉络膜厚度分布特征及影响黄斑区脉络膜厚度的相关因素。方法:研究共纳入高度近视合并POAG患者18例32眼,POAG患者20例36眼,以及高度近视患者21例33眼。采用频域OCT增强深度扫描测定中心凹下(SFCT)、距中心凹1mm和3mm处上、下、鼻、颞四个方位的脉络膜厚度(S1CT、S3CT、I1CT、I3CT、N1CT、N3CT、T1CT、T3CT)。比较三组间黄斑区脉络膜厚度的差异,并利用多元回归分析对POAG患者的诊断、屈光度、年龄、眼压、角膜厚度、视野缺损等对黄斑区脉络膜厚度的影响进行分析。结果:高度近视合并POAG患者的黄斑区脉络膜厚度较POAG患者在各测量位置均明显变薄(均P<0.05),但与高度近视患者在各测量点的脉络膜厚度差异均无统计学意义(均P>0.05)。屈光度是POAG患者黄斑区各测量点脉络膜厚度的主要影响因素,颞侧距中心凹3mm处的脉络膜厚度(S3CT)受年龄的影响,而诊断、视野缺损、眼压及角膜厚度不是脉络膜厚度的影响因素。结论:高度近视合并POAG患者黄斑区脉络膜厚度比单纯POAG患者薄,但与高度近视患者无统计学差异,黄斑区脉络膜厚度与青光眼性视神经损伤程度无明显关联。 | 栗改云 陈威 Samer abdo Al-wesabi 王莉 张虹 | 2016 | 国际眼科杂志2016，16，8： | 2 |
| 18 | 64-Slice CT for Diagnosis of Coronary Artery Disease: A Systematic Review显示文摘 | Paul D. Stein Abdo Y. Yaekoub Fadi Matta H. Dirk Sostman | 2008 | The American Journal of Medicine2008，，8： | 2 |
| 19 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 20 | Pancreatic duct disruption and nonoperative management: the SEALANTS approach显示文摘Pancreatic-duct disruption (PDD) can be difficult to manage, with diverse etiologies and sequelae in a heterogeneous population. Common etiologies include pancreatitis, iatrogenic injury, and trauma. Sequelae of PDD include pseudocyst, pancreatic ascites, | Alain Abdo Niraj Jani Steven C Cunningham | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 2 |
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