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| 1 | Therapeutic management options for stage Ⅲ non-small cell lung cancer显示文摘Lung cancer is the leading cause of cancer death worldwide.Majority of newly diagnosed lung cancers are non-small cell lung cancer(NSCLC), of which up to half are considered locally advanced at the time of diagnosis.Patients with locally advanced stage Ⅲ NSCLC consists of a heterogeneous population, making management for these patients complex.Surgery has long been the preferred local treatment for patients with resectable disease.For select patients, multimodality therapy involving systemic and radiation therapies in addition to surgery improves treatment outcomes compared to surgery alone.For patients with unresectable disease, concurrent chemoradiation is the preferred treatment.More recently, research into different chemotherapy agents, targeted therapies, radiation fractionation schedules, intensity-modulated radiotherapy, and proton therapy have shown promise to improve treatment outcomes and quality of life.The array of treatment approaches for locally advanced NSCLC is large and constantly evolving.An updated review of past and current literature for the roles of surgery, chemotherapeutic agents, radiation therapy, and targeted therapy for stage Ⅲ NSCLC patients are presented. | Stephanie M Yoon Talha Shaikh Mark Hallman | 2017 | World Journal of Clinical Oncology2017，8，1： | 32 |
| 2 | 益气活血补肾法对腰椎间盘突出症术后恢复的影响显示文摘目的探讨益气活血补肾法对腰椎间盘突出症术后患者功能活动及生活质量的临床疗效。方法选择2010年1月~2012年5月在广州南方医科大学附属南方医院脊柱骨科住院行手术治疗,术前中医辨证为肝肾亏虚的腰椎间盘突出症患者120例,经患者同意参加试验。采用随机数字表法随机分为观察组60例,对照组60例。对照组术后给予单纯西医常规对症治疗,观察组在西医常规对症治疗基础上给予益气活血补肾方。分别在各个观察时点对疼痛的视觉模拟评分(VAS系统)、JOA下腰痛评分、WHOQOL-BREF评分、住院天数、不良事件进行观察。结果 120例腰椎间盘突出症患者全部得到随访,进入结果分析,没有脱失。术后2、4、8周观察组在VAS、JOA、WHOQOL-BREF评分要优于对照组,有统计学差异(P〈0.01)。术后半年及1年后随访,观察组和对照组在VAS、WHOQOL-BREF评分之间无统计学意义(P〉0.01)。但在JOA评分方面,观察组要优于对照组,差异有统计学意义(P〈0.01)。结论益气活血补肾法对腰椎间盘突出症患者术后恢复,改善术后主要症状体征及减少不良事件方面存在优势。 | 郑少伟 Shaikh Atik Badshah 王健 蒋晖 李敏 陈国奋 | 2015 | 南方医科大学学报2015，35，1： | 27 |
| 3 | Distributed cooperative control of autonomous multi-agent UAV systems using smooth control显示文摘This paper addresses the cooperative control problem of multiple unmanned aerial vehicles(multi-UAV)systems.First,a new distributed consensus algorithm for second-order nonlinear multi-agent systems(MAS)is formulated under the leader-following approach.The algorithm provides smooth input signals to the agents’control channels,which avoids the chattering effect generated by the conventional sliding mode-based control protocols.Second,a new formation control scheme is developed by integrating smooth distributed consensus control protocols into the geometric pattern model to achieve three-dimensional formation tracking.The Lyapunov theory is used to prove the stability and convergence of both distributed consensus and formation controllers.The effectiveness of the proposed algorithms is demonstrated through simulation results. | BELKACEM Kada MUNAWAR Khalid MUHAMMAD Shafique Shaikh | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 16 |
| 4 | 不同水肥条件对温室黄瓜生长及产量品质的影响显示文摘为寻找利于黄瓜高产优质的合理灌水施肥组合,在水肥一体化条件下探究不同灌水下限、施氮量、施钾量对黄瓜生长、产量和品质的影响,对于灌溉下限分别设置高水(W3:85%田持)、中水(W2:75%田持)、低水(W1:65%田持)三个水平;对于施肥量分别设置高氮(N3:468kg·hm-2)、中氮(N2:360kg·hm-2)、低氮(N1:252kg·hm-2)和高钾(K3:702kg·hm-2)、中钾(K2:540kg·hm-2)、低钾(K1:378kg·hm-2)各三个水平,为缩小试验规模,采用正交试验方法对三因素进行组合试验。试验结果表明:提高灌水下限,可以增加植株鲜重,W3灌溉水平下单株鲜重平均达到561.3g;大量施入氮肥虽不利于茎的生长但对于叶片生长有促进作用,N3处理叶片鲜重最大(225.6g);钾肥施入量对生长发育无显著影响。综合比较W3N2K2水肥组合最有利于植株生长。灌水下限、施氮量和施钾量均对黄瓜产量具有显著影响,随着灌水下限的提高黄瓜增产明显,W3处理产量平均达到131.6t·hm-2;随着氮肥钾肥施入量的增加黄瓜产量呈现先增加后减少的趋势;黄瓜全生育期耗水量与灌溉量呈正比关系,不同灌溉处理灌水量与耗水量关系曲线K值分别为1.53,1.04,0.79,随着灌溉量的增加耗水量逐渐趋于平稳;鲜果品质随着灌水下限的提高而降低但与钾肥施用量呈正相关关系,经评分法分析,W1N2K3水肥组合可以得到最优品质。通过模型精确预测,得出在灌水下限为田持的85%,施氮量381.3kg·hm-2,施钾量600.7kg·hm-2时可以得到最高产量,同时品质较为优质,预测产量为136.14t·hm-2,为最佳灌水下限与肥料施用量。 | 王丽学 李振华 姜熙 孟维忠 陈伟 SHAIKH Abdullah AI Mamun Hossain | 2019 | 沈阳农业大学学报2019，50，1： | 13 |
| 5 | A New Switching Sequences of SVPWM for Six-Phase Induction Motor with Features of Reduced Switching Losses显示文摘In this paper,new SVPWM switching sequences for six-phase asymmetrical induction motor drives are derived with the aim to reduce inverter’s switching losses.Total three switching sequences are introduced in this paper.These sequences are derived such that the phases get continuously clamped when a current of the phases is around its peak magnitude and hence reduced switching losses are recorded.The comparative performances of these modulation techniques are studied with two existing switching sequences.Simulation,analytical and experimental results are presented.Based on these results,it is found that new switching sequences reduce switching losses effectively in dual three phase inverters. | Shaikh Mohammed Suhel Rakesh Maurya | 2021 | CES Transactions on Electrical Machines and Systems2021，5，2： | 8 |
| 6 | Circulating extracellular RNAs,myocardial remodeling,and heart failure in patients with acute coronary syndrome显示文摘Background:Given high on-treatment mortality in heart failure(HF),identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues.Circulating extracellular RNAs(ex-RNAs)regulate important biological processes and are emerging as biomarkers of disease,but less is known about their role in the acute setting,particularly in the setting of HF.Methods:We examined the ex-RNA profiles of 296 acute coronary syndrome(ACS)survivors enrolled in the Transitions,Risks,and Actions in Coronary Events Center for Outcomes Research and Education Cohort.We measured 374 ex-RNAs selected a priori,based on previous findings from a large population study.We employed a two-step,mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes(left ventricular[LV]ejection fraction,LV mass,LV end-diastolic volume,left atrial[LA]dimension,and LA volume index)then tested relations of these ex-RNAs with prevalent HF(N=31,10.5%).We performed further bioinformatics analysis of microRNA(miRNAs)predicted targets’genes ontology categories and molecular pathways.Results:We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF.Of these 44 exRNAs,miR-29-3p,miR-584-5p,and miR-1247-5p were also associated with prevalent HF.The three microRNAs were implicated in the regulation p53 and transforming growth factor-βsignaling pathways and predicted to be involved in cardiac fibrosis and cell death;miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.Conclusions:Among ACS survivors,we observed that miR-29-3p,miR-584-5p,and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF.Relevance for Patients:miR-29c-3p,miR-584-5p,and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. | Khanh-Van Tran Kahraman Tanriverdi Gerard P.Aurigemma Darleen Lessard Mayank Sardana Matthew Parker Amir Shaikh Matthew Gottbrecht Zachary Milstone Selim Tanriverdi Olga Vitseva John F.Keaney Catarina I.Kiefe David D.McManus Jane E.Freedman | 2019 | Journal of Clinical & Translational Research2019，5，1： | 7 |
| 7 | Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi,Pakistan显示文摘AIM: To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases.METHODS: Medical records of patients who attended the Gastroenterology Department at Aga Khan University Hospital from 1999 to 2001 and had endoscopic diagnosis of duodenal ulcers were reviewed. Duodenal ulcer associated with H pylori was diagnosed on the basis of endoscopy,rapid urease test and histopathology whereas histories of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) related duodenal ulcers. Non-H pylori, non-NSAID duodenal ulcers were those without H pylori infection and history of NSAID intake. Co-morbid conditions associated were noted.RESULTS: Of 2 260 patients, 10% (217/2 260) had duodenal ulcer. Duodenal ulcer related to H pylori infectionaccounted for 53% (116/217), NSAID-related 10% (22/217),non-H pylori non-NSAID 29% (62/217), and 8% (17/217) had both Hpyloriinfection and histories of NSAID intake. Fifteen percent (18/116)_patients had past histories of peptic ulcer disease in Hpyloriinfection, while 8% (5/62) in non-Hpylorinon-NSAID ulcer. Co-morbid conditions in H pylori infection were seen in 23% (27/116) and 34%(21/62) in non-H pylori non-NSAID ulcer.CONCLUSION: Incidence of H pylori infection related with duodenal ulcer is common. In the presence of co-morbids, non-Hpyloriand non-NSAID duodenal ulcer is likely to be present. | Javed Yakoob Wasim Jafri Nadim Jafri Muhammad Islam Shahab Abid Saeed Hamid Hasnain AliShah Hizbullah Shaikh | 2005 | World Journal of Gastroenterology2005，11，23： | 6 |
| 8 | 基于温室番茄生长、产量和品质确定适宜滴灌灌水下限与氮肥、钾肥施用量显示文摘为寻找利于番茄高产高质的合理灌水施肥组合,在水肥一体化条件下,采用正交试验和模型预测探究不同灌水下限、施氮量、施钾量对番茄生长、产量和品质的影响。试验结果表明:提高灌水下限,可以增加茎粗和叶面积;大量施入氮肥不利于茎粗的增加,但对于增加番茄叶面积有促进作用;钾肥施入量对番茄茎粗、叶面积均无显著影响。在生育前期适当的增加灌水和减少氮肥施入量,有利于植株的生长。灌水下限、施氮量和施钾量均对番茄产量具有显著影响,且随灌水施肥量的增加,产量呈现先增加后减少的趋势。经评分法分析,W2N2K2水肥组合可以得到最优品质。通过模型精确预测,得出在灌水下限为76%,施氮量358.5 kg/hm2,施钾量607.5 kg/hm2时,产量最高、品质优,作物生长良好,预测产量为108.82 t/hm2。 | 李振华 姜熙 孟维忠 陈伟 王丽学 Shaikh Abdullah AI Mamun Hossain 戴皖宁 | 2018 | 中国农村水利水电2018，，2： | 6 |
| 9 | STIM1和Orai1在骨肉瘤细胞HOS增殖和凋亡中的作用显示文摘目的探讨钙库操纵的钙内流(SOCE)组成蛋白STIM1和Orai1蛋白在骨肉瘤细胞系HOS增殖和凋亡中的作用。方法用shRNA干扰技术抑制STIM1和Orai1蛋白的表达。Western blot测定STIM1和Orai1的蛋白表达;激光共聚焦检测细胞Ca2+内流变化;噻唑蓝(MTT)比色法检测HOS细胞的增殖能力;流式细胞技术检测HOS细胞的凋亡变化。结果与空白对照组和转染negative-shRNA的对照组相比,转染48 h后STIM1-shRNA组STIM1蛋白的表达均明显降低(P<0.01),Orai1-shRNA组Orai1蛋白的表达也明显降低。抑制STIM1和Orai1蛋白后,细胞Ca2+内流减少。转染24、48和72 h后,STIM1-shRNA组及Orai1-shRNA组HOS细胞的增殖能力明显下降(P<0.01)。流式细胞检测显示,与control组和negative-shRNA组相比,转染48 h后细胞的周期受到明显抑制,而凋亡水平明显升高(P<0.01)。结论 STIM1和Orai1在骨肉瘤细胞HOS增殖中有重要作用,抑制STIM1和Orai1蛋白表达可以抑制HOS细胞增殖、促进凋亡。 | 郑少伟 陈国奋 王健 李郅涵 Shaikh Atik Badshah 李敏 张洋 史占军 | 2014 | 中华关节外科杂志(电子版)2014，8，2： | 6 |
| 10 | 长骨节段性缺损修复重建的理论及应用进展显示文摘背景:长骨节段性骨缺损修复重建方法众多,各有优缺点,限制了其广泛应用,仍是一个未完美解决的骨科难题。目的:综述近年国内外长骨节段性缺损的修复重建进展研究。方法:第一作者应用计算机检索1990年1月至2012年12月PubMed数据库、中国期刊全文数据库、维普数据库有关长骨节段性缺损修复重建的文章,英文检索词'bone defect,long bone reconstruction,tissue engineering of bone,scaffolds,bone reconstruction,bone graft,bone tumor;tumor resection,musculoskeletal tumors,regeneration,autografts';中文检索词'大段,骨缺损,骨肿瘤,软组织肿瘤,瘤段切除,组织工程,骨移植'。共检索到104篇相关文献,纳入52篇文献进一步研究。结果与结论:传统长骨节段性骨缺损的修复方法包括自体骨移植、异体骨移植、骨延长、人工假体置换等。研制适用于儿童保肢需要,符合儿童生长发育特点的假体成为儿童保肢的一个挑战课题。为了解决这一问题,人们研制出可以不断延长的假体,用于儿童骨肿瘤的保肢重建。随着医疗技术的进步,各种人工骨,尤其是骨组织工程和基因治疗在骨缺损修复中的逐步应用将进一步提高骨缺损的修复效果,是未来的研究方向。 | 李敏 陈国奋 王健 史占军 Shaikh Atik Badshah 郑少伟 | 2013 | 中国组织工程研究2013，17，43： | 6 |
| 11 | 全膝关节置换术后低位髌骨的处理策略及文献回顾显示文摘目的探讨全膝关节置换术后低位髌骨的诊断与治疗。方法回顾分析1例全膝关节置换术后低位髌骨的临床资料,并进行文献回顾分析。结果 1例55岁女性患者,右膝关节置换术后1年,以膝前痛、膝关节屈曲受限收入院。经膝关节正侧位X线片确诊为右膝关节置换术后低位髌骨,入院后行右侧髌骨表面置换及髌韧带松解术,有效地解除膝前痛及膝关节屈曲活动受限的症状,术后随访HSS评分显示患者膝关节疼痛、功能、关节活动度明显改善。结论全膝关节置换术后低位髌骨并不常见,正确的诊断与治疗对改善患者术后生活质量尤为重要。 | 王健 郑少伟 陈国奋 李郅涵 Shaikh Atik Badshah 李敏 张洋 史占军 | 2014 | 中国临床解剖学杂志2014，32，6： | 6 |
| 12 | Path planning for moving target tracking by fixed-wing UAV显示文摘For the automatic tracking of unknown moving targets on the ground,most of the commonly used methods involve circling above the target.With such a tracking mode,there is a moving laser spot on the target,which will bring trouble for cooperative manned helicopters.In this paper,we propose a new way of tracking,where an unmanned aerial vehicle(UAV) circles on one side of the tracked target.A circular path algorithm is developed for monitoring the relative position between the UAV and the target considering the real-time range and the bearing angle.This can determine the center of the new circular path if the predicted range between the UAV and the target does not meet the monitoring requirements.A transition path algorithm is presented for planning the transition path between circular paths that constrain the turning radius of the UAV.The transition path algorithm can generate waypoints that meet the flight ability.In this paper,we analyze the entire method and detail the scope of applications.We formulate an observation angle as an evaluation index.A series of simulations and evaluation index comparisons verify the effectiveness of the proposed algorithms. | Song-lin Liao Rong-ming Zhu Nai-qi Wu Tauqeer Ahmed Shaikh Mohamed Sharaf Almetwally M.Mostafa | 2020 | Defence Technology(防务技术)2020，16，4： | 6 |
| 13 | Natural orifice translumenal surgery:Flexible platform review显示文摘Natural orifice translumenal surgery(NOTES) has garnished significant attention from surgeons and gastroenterologists,due to the fusion of flexible endoscopy and operative technique.Preliminary efforts suggest that NOTES holds potential for a less invasive approach with certain surgical conditions.Many of the hurdles encountered during the shift from open to laparoscopic surgery are now being revisited in the development of NOTES.Physician directed efforts,coupled with industry support,have brought about several NOTES specific devices and platforms to help address limitations with current instrumentation.This review addresses current flexible platforms and their attributes,advantages,disadvantages and limitations. | Sohail N Shaikh Christopher C Thompson | 2010 | World Journal of Gastrointestinal Surgery2010，2，6： | 5 |
| 14 | Novel therapy for non-cirrhotic hyperammonemia due to a spontaneous splenorenal shunt显示文摘Spontaneous splenorenal shunts in the absence of cirrhosis have rarely been reported as a cause hyperammonemia with encephalopathy. Several closure techniques of such lesions have been described. Here we report a case of a patient with no history of liver disease who developed significant confusion. After an extensive workup, he was found to have hyperammonemia and encephalopathy due to formation of a spontaneous splenorenal shunt. There was no evidence of cirrhosis on biopsy or imaging and no portal hypertension when directly measured. The shunt was 18 mm and too large for embolization so the segment of the splenic vein between the portal vein and the shunt was occluded using an Amplatzer plug. Thus, the superior mesenteric flow was directed entirely to the liver. After interventional radiology closure of the shunt using this technique there was complete resolution of symptoms.The case represents the first report of a successful closure of splenorenal shunt via percutaneous embolization of the splenic vein with an amplatzer plug using a common femoral vein approach. | Shari S Rogal Angela Hu Rupal Bi Obaid Shaikh | 2014 | World Journal of Gastroenterology2014，20，25： | 5 |
| 15 | Emergency laparotomy in octogenarians: A 5-year study of morbidity and mortality显示文摘AIM: To determine the morbidity and mortality associated with emergency laparotomy for a clinically acute abdomen in patients aged ≥ 80 years. METHODS: In this retrospective audit, octogenarians undergoing emergency laparotomy between 1st January 2005 and 1 st January 2010 were identified using the Galaxy Theatre System. Patients undergoing abdominal surgery through groin crease incisions or Lanz or Gridiron incisions were excluded. Also simple appendectomies were excluded. All patients were aged 80 years or more at the time of their surgery. Data were obtained using casenote review with a standardised proforma to determine patient age, American Society of Anesthesiologists (ASA) grade, indications for surgery, early (within 30 d) and late (after 30 d) complications, mortality and length of stay. Data were inserted into a Microsoft Excel spreadsheet and analysed. RESULTS: One hundred patients were identified from the database (Galaxy) as having undergone emergency laparotomy. Of those, 55 underwent the procedure for intestinal procedures and 37 for secondary peritonitis.There was a 2:1 female predominance; average age 85 and ASA grade 3. Bowel resection was required in 51 out of the 100 patients and 22 (43%) died. Other procedures included appendicectomy, adhesiolysis, repair of AAA graft leak and colostomies for the pathological process resulting in an acute abdomen. Twelve of 100 patients (12%) suffered intra-operative complications, including splenic and bowel-serosal tears. Seventy patients (70%) had postoperative complications including myocardial infarction, wound infection, haematoma and sepsis. Overall mortality was 45/100 patients (45%). The major causes of death were sepsis (19/45 patients, 42%), underlying cancer (13/45 patients, 29%); with others including bowel obstruction (2/45 patients, 4%), myocardial and intestinal ischaemia and dementia. CONCLUSION: Emergency laparotomy in octogenarians carries a significant morbidity and mortality. In particular, surgery requiring bowel resection has higher mortality than without resection. | Gemma Green Irshad Shaikh Roland Fernandes Henk Wegstapel | 2013 | World Journal of Gastrointestinal Surgery2013，5，7： | 4 |
| 16 | Characterisation of mechanical and thermal properties in flax fabric reinforced geopolymer composites显示文摘This paper presents the mechanical and thermal properties of flax fabric reinforced fly ash based geopolymer composites.Geopolymer composites reinforced with 2.4,3.0 and 4.1 wt%woven flax fabric in various layers were fabricated using a hand lay-up technique and tested for mechanical properties such as flexural strength,flexural modulus,compressive strength,hardness,and fracture toughness.All mechanical properties were improved by increasing the flax fibre contents,and showed superior mechanical properties over a pure geopolymer matrix.Fourier transform infrared spectroscopy(FTIR)and scanning electron microscopy(SEM)studies were carried out to evaluate the composition and fracture surfaces of geopolymer and geopolymer/flax composites.The thermal behaviour of composites was studied by thermogravimetric analysis(TGA)and the results showed significant degradation of flax fibres at 300℃. | Hasan ASSAEDI Thamer ALOMAYRI Faiz U.A SHAIKH It-Meng LOW | 2015 | Journal of Advanced Ceramics2015，4，4： | 4 |
| 17 | 全球聚氨酯市场显示文摘全球对聚氨酯(PU)的需求日益扩大。2019年,市场总规模估计超过2 200万t,市值为630亿欧元。PU涂料占总量的16%。2017–2020年全球聚氨酯市场的产量和产值见表1。如今,人们发现,各种聚氨酯产品,如泡沫、胶黏剂、涂料、弹性体、薄膜和片材、纤维等在建筑、汽车、鞋类、包装、绝缘和消费类产品中都有使用。仅在欧盟,该行业就为近15 000人提供了直接就业机会,而在整个价值链中创造了近80万个就业机会。 | Toheed Shaikh | 2020 | 中国涂料2020，35，4： | 4 |
| 18 | Transjugular intrahepatic porto 全身的分流在老: 为门高血压的复杂并发症的减轻显示文摘 AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population group.METHODS:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and 2010.Twentyfive patients were referred for TIPS.We deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver disease.Of the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing TIPS.Sixteen of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 mo.Ascites and/or hydrothorax was controlled following technically successful procedures in 12 of 13 patients.Bleeding was controlled following technically successful procedures in 10 out of 11 patients.CONCLUSION:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients. | Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh Uzma Waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell | 2012 | World Journal of Hepatology2012，4，2： | 4 |
| 19 | 聚乳酸/羟基磷灰石纳米复合物对MC3T3-E1细胞增殖活性的影响显示文摘背景:研究表明聚乳酸/羟基磷灰石复合材料与自然骨结构和性能相似,具有骨传导性和良好的生物相容性。目的:观察聚乳酸/羟基磷灰石纳米复合物与成骨细胞株MC3T3-E1的生物相容性。方法:分别采用普通完全培养基(对照组)与聚乳酸/羟基磷灰石纳米复合物浸提液(实验组)培养第3代成骨细胞株MC3T3-E1,培养3,5,7 d,采用CCK-8法检测细胞的吸光度值;在培养第7,14天检测细胞碱性磷酸酶、骨钙素、Ⅰ型胶原、核心结合因子α1/成骨特异性转录因子表达。将聚乳酸/羟基磷灰石纳米复合物与第3代成骨细胞株MC3T3-E1共培养,培养7,14 d细胞骨架染色及扫描电镜观察细胞在支架材料上的形态。结果与结论:随着时间的延长,成骨细胞株MC3T3-E1的吸光度值明显增加,两组细胞吸光度值比较差异无显著性意义。实验组培养第7天细胞碱性磷酸酶活性高于对照组(P<0.05),培养第14天细胞碱性磷酸酶、Ⅰ型胶原、核心结合因子α1/成骨特异性转录因子表达高于对照组(P<0.05)。种植7 d后细胞在材料上贴附生长,细胞呈多角形;种植14 d后细胞较7 d前数目明显增多,且完全伸展,呈多角形和梭形。表明聚乳酸/羟基磷灰石纳米复合物对成骨细胞有良好的生物相容性,无细胞毒性。 | 李敏 唐元 atik badshah shaikh 史占军 王健 | 2014 | 中国组织工程研究2014，18，43： | 4 |
| 20 | Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation显示文摘Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
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