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| 1 | Deficit irrigation of sunflower (Helianthus annuus L.) in a sub-humid climate显示文摘 | Ali Osman Demir Abdurrahim Tanju G?ksoy Hakan Büyükcangaz Zeki Metin Turan Eyüp Selim K?ksal | 2006 | Irrigation Science2006，，4： | 1 |
| 2 | Co-infection with hepatitis B does not alter treatment response in chronic hepatitis C显示文摘 | Ahmet Uyanikoglu Filiz Akyuz Bulent Baran Binnur Pinarbasi Simsek Fatih Ermis Kadir Demir Mine Gulluoglu Selim Badur Sabahattin Kaymakoglu | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 1 |
| 3 | Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells显示文摘Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine.Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P. vulgaris flower extract on human cervical cancer(HeLa)cells. The cytotoxic effect of the extract on HeLa cells was revealed using the MTT assay. Mechanisms involved in the extract's cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P. vulgaris flower extract exhibited selective cytotoxic effects against HeLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect of P. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms. | Selim Demir Ibrahim Turan Rezzan Aliyazicioglu Serap Ozer Yaman Yuksel Aliyazicioglu | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 1 |
| 4 | Intrahepatic and peripheral T-cell responses in genotype 1b hepatitis C virus-infected patients with persistently normal and elevated aminotransferase levels显示文摘AIM: To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels. METHODS: Thirty-three (16 with normal ALT level as group 1 and 17 with elevated ALT level as group 2) patients infected with genotype 1b hepatitis C virus (HCV) were examined. Liver infiltrating lymphomononuclear cells (LILMCs) were isolated from liver biopsy by collagenase type 1 and stimulated with phytohemagglutinin and interleukin 2 (IL-2). IL-10, IL-12, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were determined in serum and LILMCs by ELISA. RESULTS: Serum cytokine levels were similar in both groups (P>0.05). Stimulated IFN-γ and TNF-α levels in LILMCs were increased in both groups. IL-12 and IL-10 levels stimulated with IL-2 were higher in group 1 than in group 2 (P = 0.023). Histological activity index (HAI) and stage had a negative correlation with TNF-α and IFN-γ levels in group 2. CONCLUSION: Increased T-helper type 2 (Th2) cytokine response may regress inflammatory and biochemical activity. Progression of histological abnormalities in persons with elevated ALT probably depends on insufficient Th2 cytokine response, which does not balance Th1 cytokine response. | Filiz Akyüz Nuray Polat Sabahattin Kaymakoglu Nevzat Aksoy Kadir Demir Fatih Besisik Selim Badur Yilmaz Cakaloglu Atilla (O|¨)kten | 2005 | World Journal of Gastroenterology2005，11，45： | 1 |
| 5 | Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group显示文摘AIM: To compare two different anti-vascular endothelial growth factor(anti-VEGF) treatment regimens'-a priori pro re nata(PRN) and PRN regimen following^(th)e loading phaseanatomical and functional results in neovascular agerelated macular degeneration(n AMD) patients. METHODS: Totally 544 n AMD patients followed and treated with aflibercept(n=135) and ranibizumab(n=409)at 9 different centers between 2013 and 2015 were enrolled into^(th)is retrospective multicenter study. Patients with initial best corrected visual acuity(BCVA) interval of 1.3-0.3(log MAR) and a minimum follow-up of 12 mo were included. Patients under two different regimens-a priori pro re nata(1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen(3+PRN)-were compared in BCVA at 3^(th), 6^(th) and 12^(th) months, and in central macular^(th)ickness(CMT) at 6^(th) and 12^(th) months. The total study group, intravitreal ranibizumab(IVR) and intravitreal aflibercept(IVA) groups were evaluated separately. RESULTS: The mean CMT decreased in^(th)e 1+PRN(n=101) regimen from 407 to 358 and 340 μm and in^(th)e 3+PRN(n=443) group from 398 to 318 and finally to 310 μm at months 6 and 12, respectively. Anatomically,^(th)e CMT reduction at 6^(th) month(48.5 vs 76.4;P<0.05) was statistically significant in favor of 3+PRN group. BCVA changed in 1+PRN group from 0.77 to 0.78, 0.75 and 0.75;in 3+PRN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PRN group at 3^(th) month(-0.01 vs 0.12;P<0.001). In IVR group, CMT reduction was in greater in 3+PRN at 6^(th)(44 vs 72) and 12^(th) month(61 vs 84), but statistically insignificant. The 3+PRN group revealed statistically better visual results at 3^(th) month(-0.02 vs 0.11, P<0.05). In IVA group, although statistically insignificant, CMT reduction(61 vs 89, 6^(th) month;85 vs 97, 12^(th) month) and visual gain(0.02 vs 0.16;0.02 vs 0.14;0.05 vs 0.11) was found in favor of 3+PRN group at all visits.CONCLUSION: The loading dose of anti-VEGF treatments in n AMD leads to significantly better anatomical and functional results, regardless of the agent, specially in early follow-up interval. | Burak Erden Selim Bolükbasi Abdullah Ozkaya Levent Karabas Cengiz Alagoz Zeynep Alkin Ozgür Artunay Sadik Etka Bayramoglu Gokhan Demir Mehmet Demir Ali Demircan Gürkan Erdogan Mehmet Erdogan Erdem Eris Havva Kaldirim Ismail Umut Onur Ozen Ayranci Osmanbasoglu Sezin Ozdogan Erkul Mine Oztürk Irfan Perente Kübra Sarici Nihat Sayin Dilek Yasa Ihsan Yilmaz Zeynep Yilmazabdurrahmanoglu 无 | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 1 |
| 6 | Retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in children with obesity显示文摘AIM:To evaluate retinal nerve fiber layer(RNFL)thickness analysis of peripapillary optic nerve head(PONH) and macula as well as ganglion cell-inner plexiform layer(GCIPL) thickness in obese children.· METHODS:Eighty-five children with obesity and 30 controls were included in the study.The thicknesses of the PONH and macula of each subject's right eye were measured by high-resolution spectral-domain optic coherence tomography(OCT).· RESULTS:The RNFL thicknesses of central macular and PONH were similar between the groups(all P >0.05).The GCIPL thickness was also similar between the groups.However,the RNFL thickness of temporal outer macula were 261.7±13.7 and 268.9±14.3 μm for the obesity and the control group,respectively(P =0.034).· CONCLUSION:Obesity may cause a reduction in temporal outer macular RNFL thickness. | Selim Demir Samet ozer Sait Alim Alper Günes Hüseyin Ortak Resul Yilmaz | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 1 |
| 7 | CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation显示文摘 | Semra S?kücü Ay?e Tülin ?zden ?zlem Durmaz Süo?lu Berna Elkabes Fikri Demir U?ur ?evikba? Selim G?k?e Günay Saner | 2006 | Journal of Gastroenterology2006，，6： | 1 |
| 8 | Low Concentration of CO Gas Sensor by Atomic Layer Deposition显示文摘 | Mehmet Demir Ozlem Barin Irmak Karaduman Dilber Esra Yildiz Selim Acar | 2014 | Journal of Physical Science and Application2014，4，8： | 0 |
| 9 | Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression显示文摘Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R.canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer(WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential(MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent. | Ibrahim Turan Selim Demir Kagan Kilinc Serap Ozer Yaman Sema Misir Hanife Kara Berna Genc Ahmet Mentese Yuksel Aliyazicioglu Orhan Deger | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 0 |
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