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| 1 | Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population显示文摘我们与早泄(PE ) 在病人评估了血清素 transporter 基因(5-HTT ) 的遗传型在 PE 并且可能的 etiopathogenesis 决定基因因素的角色识别耐心的亚群。70 个 PE 病人和 70 控制的一个总数在这研究被包括。所有人是异性爱的,没有另外的混乱并且是结婚的任何一个或在一种稳定的关系中。PE 被定义为射精发生在阴道插入的 1 min 以内。从病人和控制的 Genomic DNA 用血清素 transporter 基因(5-HTTLPR ) 的倡导者区域的聚合酶链反应,和突变而产生之遗传的变化被分析被决定。5-HTTLPR (血清素 transporter 倡导者基因) 在 PE 病人对控制的遗传型如下被散布:L/L 16% 对 17% , L/S 30% 对 53% 并且 S/S 54% 对 28% 。我们为 5-HTTLPR 基因的三多型性检验了 haplotype 分析:LL, LS 和 SS。在 5-HTTLPR 基因的等位基因频率的适当被 Hardy-Weinberg 平衡用 2 测试分析。5-HTTLPR 基因的短(S) 等位基因是显著地在 PE 病人更经常比在控制(P < 0.05 ) 。我们建议 5-HTTLPR 基因在所有主要 PE 盒子的 pathophysiology 起一个作用。进一步的研究被需要评估在 5-HTTLPR 基因多型性和耐心的亚群之间的关系(例如主要、第二等的 PE ) 对选择血清素举起禁止者以及种族差别的回答。 | Emin Ozbek Ali I. Tasci Volkan Tugcu Yusuf O. Ilbey Abdulmuttalip Simsek Levent Ozcan Emre C. Polat Vedat Koksal | 2009 | Asian Journal of Andrology2009，11，3： | 19 |
| 2 | Hepatic osteodystrophy and liver cirrhosis显示文摘AIM: To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS: Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X-ray absorptiometry. All the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca 2+ were measured as bone destruction markers, while alkaline phosphatase (ALP), osteocalcin and insulin-like growth factor-1 (IGF-1) were measured as bone formation markers. Furthermore, interleukin-1 (IL-1), IL-6, tumor necrosis factor α (TNF-α), vitamin D3, direct bilirubin, albumin, cortisol and parathyroid hormone (PTH) levels were measured. The independent Student t test and χ 2 test were employed in comparing both groups, and the Pearson correlation test was used to determine associations. RESULTS: Comparing cirrhosis and control groups, lumbar total T-score (-1.6 ± 1.2 g/cm 2 vs -0.25 ± 1.3 g/cm 2 , P < 0.001), lumbar total Z-score (-1.2 ± 1.23 g/cm 2 vs -0.6 ± 1.3 g/cm 2 , P < 0.001), total femur T-score (-0.05 ± 1 g/cm 2 vs -0.6 ± 0.9 g/cm 2 , P = 0.003) and total femur Z-score (-0.08 ± 1.5 g/cm 2 vs 0.7 ± 0.9 g/cm 2 , P =0.003) showed significantly lower values in the cirrhosis group. Blood ALP level (109.2 ± 57 U/Lvs 62.6 ± 32.5 U/L, P < 0.001), IL-6 level (27.9 ± 51.6 pg/mL vs 3.3 ± 3.1 pg/mL, P = 0.01), TNF-α level (42.6 ± 33.2 pg/mL vs 25.3 ± 12.3 pg/mL, P = 0.007) and direct bilirubin level (0.9 ± 0.7 mg/dL vs 0.3 ± 0.2 mg/dL, P < 0.001) were significantly higher in the cirrhosis group. IGF-1 level (47.7 ± 26.2 ng/mL vs 143.4 ± 53.2 ng/mL, P < 0.001), osteocalcin level (1.05 ± 2.5 ng/mL vs 7.0 ± 13 ng/mL, P = 0.002) and 24 h urinary Ca 2+ (169.6 ± 227.2 mg/dL vs 287 ± 168.6 mg/dL, P = 0.003) were significantly lower in the cirrhosis group. Urinary deoxypyridinoline/creatinine (9.4 ± 9.9 pmol/μmol vs 8.1 ± 5.3 pmol/μmol, P = 0.51), urinary pyridinoline/creatinine (51.3 ± 66.6 pmol/μmol vs 29 ± 25.8 pmol/μmol, P = 0.08), blood IL-1 level (3.4 ± 8.8 pg/mL vs 1.6 ± 3.5 pg/mL, P = 0.29), vitamin D3 level (18.6 ± 13.3 μg/L vs 18.4 ± 8.9 μg/L, P = 0.95), cortisol level (11.1 ± 4.8 μg/dL vs 12.6 ± 4.3 μg/dL, P = 0.15) and PTH level (42.7 ± 38 μg/dL vs 34.8 ± 10.9 μg/dL,P = 0.27) were not significantly different. CONCLUSION: Hepatic osteodystrophy is an important complication encountered in patients with liver cirrhosis and all patients should be monitored for hepatic osteodystrophy. | Vedat Goral Mehmet Simsek Nuriye Mete | 2010 | World Journal of Gastroenterology2010，16，13： | 11 |
| 3 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 4 | Is there an association between Helicobacter pylori in the inlet patch and globus sensation?显示文摘AIM:To determine the association between Helicobacter pylori(H.pylori)and globus sensation(GS)in the patients with cervical inlet patch. METHODS:Sixty-eight patients with esophageal inlet patches were identified from 6760 consecutive patients undergoing upper gastrointestinal endoscopy prospectively.In these 68 patients with cervical inlet patches, symptoms of globus sensation(lump in the throat), hoarseness,sore throat,frequent clearing of the throat,cough,dysphagia,odynophagia of at least 3 mo duration was questioned prior to endoscopy. RESULTS:Cervical heterotopic gastric mucosa(CHGM) was found in 68 of 6760 patients.The endoscopic prevalence of CHGM was determined to be 1%.H.pylori was identified in 16(23.5%)of 68 patients with inlet patch.53 patients were classified as CHGMⅡ.This group included 48 patients with globus sensation,4 patients with chronic cough and 1 patient with hoarseness.All the patients who were H.pylori(+)in cervical inlet patches had globus sensation.CONCLUSION:Often patients with CHGM have a long history of troublesome throat symptoms.We speculate that disturbances in globus sensation are like non-ulcer dyspepsia. | Hakan Alagozlu Zahide Simsek Selahattin Unal Mehmet Cindoruk Sukru Dumlu Ayse Dursun | 2010 | World Journal of Gastroenterology2010，16，1： | 8 |
| 5 | Hepatocellular Carcinoma and the Role of Liver Transplantation:A Review显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer deaths worldwide and liver transplantation(LT)is the only potentially curative treatment.Over the years,Milan criteria has been used for patient selection.There is ongoing research in this field with introduction of new biomarkers for HCC that can help guide future treatment.Furthermore,newer therapies for downstaging of the tumor are being implemented to prevent dropout from the transplant list.In addition,combination therapies for better outcome are under investigation.Interestingly,the concept of living-donor LT and possible use of hepatitis C virus-positive donors has been implemented as an attempt to expand the organ pool.However,there is a conflict of opinion between different centers regarding its efficacy and data is scarce.The aim of this review article is to outline the various selection criteria for LT,discuss the outcomes of LT in HCC patients,and explore future directions of LT for HCC.Therefore,a comprehensive PubMed/MEDLINE review was conducted.To expand our search,references of the retrieved articles were also screened for additional data.After selecting the studies,the authors independently reviewed them to identify the relevant studies.After careful evaluation 120 studies relevant to out topic are cited in the manuscript.Three tables and two figures are also included.In conclusion LT for HCC has evolved over the years.With the introduction of several expanded criteria beyond Milan,the introduction of bridging therapies,such as transcatheter arterial chemoembolization and radiofrequency ablation,and the approval of newer systemic therapies,it is evident that there will be more LT recipients in the future.It is promising to see ongoing trials and the continuous evolution of protocols.Prospective studies are needed to guide the development of a pre-LT criteria that can ensure low HCC recurrence risk and is not overly stringent,clarify the role of LDLT,and determine the optimal bridging therapies to LT. | Haris Muhammad Aniqa Tehreem Peng-Sheng Ting Merve Gurakar Sean Young Li Cem Simsek Saleh A.Alqahtani Amy K.Kim Ruhail Kohli Ahmet Gurakar | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 7 |
| 6 | Short-term effects of intravitreal triamcinolone acetonide injection on ocular blood flow evaluated with color Doppler ultrasonography显示文摘AIM:To evaluate the changes in ocular blood flow with color Doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) injection.METHODS:A total of 46 patients who underwent IVTA(4 mg/0.1 mL) injection for diabetic macular edema(DME)(n =22), central retinal vein occlusion(CRVO)(n =12) and choroidal neovascular membrane(CNVM)(n =12) were included in the study. Peak systolic velocity(PSV), end diastolic velocity(EDV) and resistivity index(RI) were measured from the ophthalmic artery(OA), the central retinal artery(CRA) and the posterior ciliary artery(PCA)of each patient with CDU before, at the end of the first week and at the end of the first month following IVTA injection.RESULTS:In the DME group, PSV of OA at the first of the first month(mean ±SD)(37.48 ±10.87 cm/s) increased compared to pre-injection value(31.39 ±10.84 cm/s)(P =0.048). There was a statistically significant decrease(P =0.049) in PSV of CRA at the end of the first month(7.97±2.67 cm/s) compared to the pre-injection(9.47±3.37 cm/s).There was not any statistically significant difference onthe other parameters in the DME group. Also, there was not any statistically significant difference on the ocular blood flow values in the CRVO and CNVM groups.CONCLUSION:We observed that 4 mg/0.1 mL IVTA increased PSV of OA and decreased PSV of CRA in DME patients and did not have any effect on ocular blood flow values of CRVO and CNVM patients. | Mustafa Alpaslan Anayol Yasin Toklu Elif Asik Kamberoglu Sabri Raza Hasan Basri Arifoglu Huseyin Simavli Ayse Gul Kocak Altintas Saban Simsek | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 4 |
| 7 | Effectivity of intraoperative adjustable suture technique in horizontal strabismus显示文摘AIM:To compare the long-term effectivity of intraoperative adjustable suture technique with traditional non-adjustable strabismus surgery.·METHODS:Two hundred and thirty-three patients,who underwent strabismus surgery either with traditional procedures or one-stage intraoperative adjustable suture technique,were included in our long-term follow-up study.One hundred and eighteen patients were evaluated in traditional surgery group(TSG) and 115 who underwent adjustable suture were in the one-stage intraoperative adjustable surgery group(ASG).In this group 9 patients had paralytic strabismus and 16 had reoperations,2 patients had restrictive strabismus related to thyroid eye disease.The mean follow up in the TSG was 26.2 months and it was 24.8 months in the ASG group.·RESULTS:In patients with exotropia(XT) the mean correction of deviation for near fixation in ASG(32.4 ±13.2PD) and in TSG(26.4±8.2PD) were similar(P =0.112).The correction for distant fixation in ASG(33.2±11.4PD)and TSG(30.9±7.2PD) were not significantly different(P =0.321).In patients with esotropia(ET) even the mean correction of deviation for both near(31 ±12PD) and distant(30.6±12.8PD) fixations were higher in ASG thanin TSG,for both near(28.27±14.2PD) and distant(28.9±12.9PD) fixations,the differences were not significant(P =0.346,0.824 respectively).The overall success rate of XT patient was 78.9% in TSG and 78.78% in ASG,the difference was not significant(P =0.629).The success rates were 78.75% in TSG and 75.51% in ASG in ET patient,which was also not significantly different(P =0.821).·CONCLUSION:Although patients in ASG had more complex deviation such as paralysis,reoperations and restrictive strabismus,success rates of this tecnique was as high as TSG which did not contain complicated deviation.One-stage intraoperative adjustable suture technique is a safe and effective method for cooperative patient who has complex deviation. | Ayse Gul Kocak Altintas Hasan Basri Arifoglu Inci Kocak Midillioglu Elif Damar Gungor Saban Simsek | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 3 |
| 8 | 优势眼测量法的研究(英文)显示文摘目的:为了检查一项新的性能测试,对同以受试者用两种不同的方法进行检测和再测试,并比较和讨论这些检测方法的可靠性。方法:共179个大学生(平均年龄±标准差为19.37±1.62)a自愿参加这项由110名女性(61.5%)和69名男性(38.5%)组成的调查。优势眼由两种不同的方法检测,一个为McManus方法,一个为Gndo■an方法。利用SPSS的重测信度的可靠性分析保证该项调查的可靠性。结果:McManus方法检测128名(71.5%)参加者右眼为优势眼,无性别差异。同样利用Gndogˇan方法再检测发现110名(61.5%)参加者右眼为优势眼。两种方法的检测结果由Fisher确切概率法分析发现呈显著性相关(P<0.01),一致性数值为为κ=0.256,P<0.001。利用Mc-Manus法发现女性参加者中74名(67.3%)右眼为优势眼,36名(32.7%)左眼为优势眼。利用Gndog■an法再检测发现62名女(56.4%)右眼为优势眼,48名女(43.6%)左眼为优势眼。通过Fisher确切概率法分析发现McMa-nus和Gndo■an两种方法在女性优势眼检测方面呈显著性相关(P<0.05),一致性数值为κ=0.239,P<0.01。在男性参与者中,通过McManus法检测右眼优势眼为54眼(78.3%),左眼优势眼为15眼(21.7%),利用Gndo■an法再检测右眼优势眼为48眼(69.6%),左眼优势眼为21眼(30.4%)。利用χ2检验和Fisher确切概率法分析数据。利用Kappa一致性检验分析不同方法的一致性。比例的比较由z检验完成,P值小于0.05为差异显著。结论:通过检测观察到女性和男性均以右眼优势眼为主,没有性别差异。右眼优势这种功能性偏侧化现象可能是由于大脑左半球的主导作用造成的。这对于将来在一侧面偏重方面的研究很重要,也许会成为一个重要的模式系统。 | Nimet Unay Gundogan Ayse Canan Yazici Ayten Simsek | 2008 | 国际眼科杂志2008，8，10： | 3 |
| 9 | 雷珠单抗治疗新生血管性年龄相关性黄斑变性的长期疗效(英文)显示文摘目的:研究就诊于我院新生血管性年龄相关性黄斑变性(NV-AMD)患者使用雷珠单抗治疗后3年的疗效。方法:回顾性研究。共纳入73例(101眼)患者。根据入组时视力情况(ETDRS chart),患者被分为3组。第1组:视力≤35;第2组:视力36~54;第3组:视力≥55字母。患者接受3次,每次0.5 mg的雷珠单抗负荷剂量,之后根据病情决定是否再次注射。对患者每月进行一次随访,进行视力、详细的眼前节及眼底的生物显微镜,以及光学相干断层扫描(OCT)检查。对最接近12、24、36mo的视力检查结果进行分析。结果:纳入的101眼中,男性57眼,女性44眼。患者平均年龄75.1岁。治疗24mo和36mo时,三组患者之间视力变化情况差异均有统计学意义(P=0.002,0.0001)。治疗36mo后,第2组视力较入组时显著改善(P=0.001),第3组患者视力改善不显著。随访12、24、36mo时,第1组视力无明显变化的患者人数最多。所有患者平均注射雷珠单抗7.3次,随访次数23.9次。结论:入组时视力情况尚可的患者视力改善最明显。视力较差和视力较好的患者视力改变不明显。最终视力与注射次数无明显关系。 | Burak Simsek Aylin Ardagil Akcakaya Isilay Ozsoy Koyun Sevil Ari Yaylali | 2018 | 国际眼科杂志2018，18，3： | 3 |
| 10 | Overcoming scarring in the urethra: Challenges for tissue engineering显示文摘Urethral stricture disease is increasingly common occurring in about 1%of males over the age of 55.The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis.An increase in collagen is associated with the loss of the normal vasculature of the normal urethra.The actual incidence differs based on worldwide populations,geography,and income.The stricture aetiology,location,length and patient’s age and comorbidity are important in deciding the course of treatment.In this review we aim to summarise the existing knowledge of the aetiology of urethral strictures,review current treatment regimens,and present the challenges of using tissue-engineered buccal mucosa(TEBM)to repair scarring of the urethra.In asking this question we are also mindful that recurrent fibrosis occurs in other tissuesdhow can we learn from these other pathologies? | Abdulmuttalip Simsek Reem Aldamanhori Christopher RChapple Sheila MacNeil | 2018 | Asian Journal of Urology2018，5，2： | 3 |
| 11 | Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline:an overview显示文摘Purpose The purpose of this study is to review the urine products of bone breakdown as markers of bone resorption and usefulness of urinary hydroxyproline. Data Related researches published in 1985 -2000 were systematically reviewed. Results Bone markers could be used for early diagnosis of bone metabolic diseases. Biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism. Assessment of bone resorption can be achieved with measurement of urinary hydroxylysine glycosides, urinary excretion of the collagen pyridinium cross-links, urinary excretion of type I collagen telopeptide breakdown products (cross-linked telopeptides) and urinary hydroxyproline. Conclusion Urinary hydroxyproline has been in use as a marker of bone resorption, but it lacks sensitivity and specificity. It is a modified aminoacid that is a metabolic product of collagen breakdown.Hydroxyproline may be released either free or with fragments of the collagen molecule attached during bone resorption, and it is also liberated by the breakdown of complement and nonskeletal collagen. | Baris Simsek zgülKaracaer inci Karaca | 2004 | Chinese Medical Journal2004，17，2： | 3 |
| 12 | Evaluation of success rates of immediate and delayed implants after tooth extraction显示文摘Objective To evaluate the success rates of immediate and delayed placement of implants with respect to the causes of tooth extraction and implant positions.Methods A total of 310 dental implants (immediate implants∶delayed implants=76∶234) were inserted into 80 patients. The types,sizes and positions of the implants and the causes of tooth extraction were recorded. We then investigated the relationship of implant loss with the causes of tooth extraction and placement methods. Results A higher failure rate was found for the implants in the posterior region of the maxilla,and when periodontitis was cited as a reason for tooth extraction. The overall success rates were 93.4% and 95.7% in the immediate and delayed implant placement groups,respectively,after a 2-year follow-up. No obvious relationship of success rate was observed with the implant placement method,cause of tooth extaction,and implants’ position. Conclusion The immediate placement of implants into fresh extraction sockets could offer advantages over the delayed implant placement. It seems to be a safe and predictable method for patients. | Baris Simsek Sebnem Simsek | 2003 | Chinese Medical Journal2003，，8： | 2 |
| 13 | Why more research needs to be done on echinococcosis in Pakistan显示文摘Background:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent.Due to the frequent outbreaks in different parts of Pakistan in the recent past,echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic diseases in the country.In endemic regions,predominantly settings with limited resources,there are high numbers of echinococcosis patients,as these communities do not have access to appropriate treatment.In Pakistan,there are limited reports on echinococcosis.The disease is prevalent in human and livestock,but this has not been sufficiently explored yet.Pakistan is an agricultural country and due to the disease’s zoonotic mode of transmission,there is a dire need of future research on it.The present paper is an effort to highlight the importance of echinococcosis in Pakistan.Discussion:There is a dire need for future research on echinococcosis in Pakistan as very few investigations had been carried out on this topic thus far.The prevalence of the disease in neighbouring countries highlights that Pakistan might be at severe risk of this zoonotic infection and further supports the need for more research.In Pakistan,the majority of the population lives in rural areas with limited acess to proper hygienic/sanitary facilities.These conditions favour the outbreak of diseases such as echinococcosis.The limited available data could result in higher outbreaks in the future,and thus cause the already weak healthcare system to overburden.The country has a meagre annual budget for health,which is being spent on known infections such as polio,dengue fever and hepatic viral infections.A proper surveillance system for echinococcosis is required across the country as treatment is usually expensive,complicated and may require extensive surgery and/or prolonged drug therapy.Development of new/novel drugs and other treatment modalities receives very little,if any,attention.Prognostic awareness programmes against this infection involve deworming of the infected animals,improved food inspection and slaughterhouse hygiene,and public education campaigns.Conclusion:Future research on echinococcosis is anticipated to demonstrate whether the epidemiology,diagnosis and recombinant vaccines/antibodies relating to echinococcosis can meet the quality standards(purity,potency,safety and efficacy)defined by the World Health Organization.Research work should be carried out on the epidemiology and serodiagnosis of echinocossis in the different areas of Pakistan,which will be useful for the proper eradication of echinococcosis in this region.The health department should implement awareness-raising campaigns for the general public in order to reduce the burden of disease. | Haroon Ahmed Shahzad Ali Muhammad Sohail Afzal Abid Ali Khan Hamid Raza Zaheer Hussain Shah Sami Simsek | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 14 | 恩替卡韦治疗中重度肝纤维化慢性乙型肝炎患者48周的疗效分析显示文摘目的III期临床研究结果显示恩替卡韦(ETV)治疗48周,在组织学改善、ALT复常和HBVDNA抑制方面均优于拉米夫定(LMV);肝纤维化的改善在核苷类似物初治患者中2个治疗组相似,在拉米夫定失效患者中,ETV明显优于LMV。对基线时表现为中重度肝纤维化/硬化患者(Ishak评分:4-6)进行亚组分析,评估ETV或LMV治疗48周的疗效。方法纤维化评分是由1位病理学家对基线和48周时标本进行评估,治疗组及标本先后顺序均对他设盲。结果对HBeAg(+)核苷类似物初治的患者,48周时肝纤维化发生改善的患者比例ETV组为57%,LMV组为49%;肝纤维化没变化的患者比例ETV组35%,LMV组为28%;肝纤维化恶化的患者比例ETV组为0,LMV组为6%;对HBeAg(-)核苷类似物初治的患者,48周时肝纤维化发生改善的患者比例ETV组为59%,LMV组为53%;肝纤维化没变化的患者比例ETV组为31%,LMV组为18%;肝纤维化恶化的患者比例ETV组为2%,LMV组为5%;对HBeAg(+)LMV失效的患者,48周时肝纤维化发生改善的患者比例ETV组为43%,LMV组为33%;肝纤维化没变化的患者比例ETV组为35%,LMV组为29%;肝纤维化恶化的患者比例ETV组为0,LMV组为19%。结论接受ETV治疗的中重度肝纤维化/硬化患者比接受LMV治疗更可能获得纤维化改善或不变,这些数据与其他治疗终点(全组人群的病毒学、生化学和Knodell评价的组织学改善情况)结果一致,均为ETV优于LMV。 | Simsek H Schiff E Goodman Z Brett-Smith H Klesczewski K Kreter B 王蔚 | 2006 | 传染病信息2006，19，5： | 2 |
| 15 | 富炭硬沥青基WO3/TiO2催化剂提升染料和药物降解的光催化行为研究显示文摘采用溶剂热法制备出富炭硬沥青基WO3/TiO2催化剂。通过光电子能谱议(XPS)、红外光谱仪(FTIR)、拉曼光谱仪(Raman)、扫描电镜(SEM)和UV-Vis漫反射光谱仪(DRS)等手段表征催化剂的形貌、结构、光学和物理性质。SEM观察到硬沥青表面完全被WO3/TiO2颗粒覆盖。Raman和XPS分析表明,富炭硬沥青与WO3,TiO2复合良好。DRS结果显示在带隙较低时(2.83 eV),富炭硬沥青基WO3/TiO2催化剂对可见光的吸收性能得到提高。在UV-A辐照下,通过降解橙色Ⅱ染料和药物来探讨所制催化剂的光催化性能。橙色Ⅱ染料降解度随着硬沥青添加比例增加而增加,这归因于吸附和光催化的协同效应,即光吸收的增加和光产生的空穴和电子在W/Ti界面容易转移。而且,为了对比硬沥青原料与所制催化剂的吸附性能,在不同pH值下进行了批量吸附实验,并采用等温线和动力吸附模型探讨了温度和吸附值。本研究提供了富炭硬沥青作为自然碳源应用于碳基光催化材料制备思路。 | Zeynep Balta Esra Bilgin Simsek | 2020 | 新型炭材料2020，35，4： | 2 |
| 16 | 国际教育技术学家对教育技术学的认识与看法显示文摘对绝大多数人而言,教育技术似乎是一个令人迷惑,甚至难以理解的概念。教育技术学家的理解可以为教育技术领域的从业人员认识教育技术提供一个多维的视角。本研究采用问卷调查法,对6个国家12所大学的71位教育技术学家做了调查,旨在揭示专家对教育技术学的理解以及不同国家的专家对教育技术应用的认识有何不同。研究结果表明教育技术学的作用大多与教/学过程和学习资源有关,教育技术的相关问题在不同国家并无显著差异。 | Nurettin Simsek 秦炜炜 | 2007 | 现代教育技术2007，17，10： | 2 |
| 17 | 白内障超声乳化术后前房膜形成的危险因素(英文)显示文摘目的:探讨白内障超声乳化术后前房膜形成的危险因素。方法:对1356例行白内障超声乳化+单片式PMMA人工晶体植入术患者进行前瞻性研究。假性囊膜剥脱综合症,核硬度,瞳孔大小,超声时间,实际超声时间,系统性疾病,术中并发症(囊膜撕裂,悬韧带断裂,后囊破裂伴玻璃体丢失),IOL植入位置和术后并发症(眼内压变化,粘连形成)作为膜形成的危险因素分析。结果:观察到111例患者(8.1%)术后出现伴有膜形成的纤维素性前葡萄膜炎。膜形成平均时间是术后第2d(术后第1~7d),膜存在持续时间平均为5.2d(1~48d)。在膜形成病例中,+4级核病例占45%,而在无膜形成病例中仅为13.5%,差异具有显著统计学意义(P<0.05)。在膜形成组,平均超声时间为2.4min,平均实际超声时间为32.8s,而无膜形成组分别为1.8min和22.1s。这两项参数在膜形成组均明显较长(P<0.05)。在膜形成组中,出现后囊破裂伴玻璃体丢失和IOL睫状沟植入者占33%,而无膜形成组为11%(P<0.05)。其他危险因素在膜形成组和无膜形成组中的比较无统计学意义。在术后第1d和第7d,平均最佳矫正视力(Snellen视力表)在膜形成组分别为0.2和0.4,无膜形成组为0.4和0.6(P<0.05)。但术后3mo,平均最佳矫正视力在膜形成组和无膜形成组中结果相似(分别为0.8和0.9)。结论:晶状体核硬度较高,较长超声时间和实际超声时间,术中后囊破裂是术后前房纤维膜形成的明显相关性危险因素。 | Ayse Gul Kocak Altintas M. Alpaslan Anayol Saban Simsek | 2006 | 国际眼科杂志2006，6，6： | 2 |
| 18 | Usher syndrome associa-ted with a variant of Dandy-Walker malformation显示文摘 | Simsek T Ozdamar Y Simsek E | 2009 | J Pediatr Ophthalmol Strabismus2009，10，1： | 1 |
| 19 | Transformational lea- dership's role in promotion corporate entrepreneurship: Exa- mining the CEO-TMT interface显示文摘 | Yan L Simsek Z Lubatkin H | 2008 | Academy of Managem- ent Journal2008，51，3： | 1 |
| 20 | The effect of environmental pollution on the heavy metal content of raw milk 显示文摘 | Simsek O Gultekin R Oksuz | 2000 | Nahrung-Food2000，5，44： | 1 |
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