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| 1 | Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning?显示文摘Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. Many clinical studies have tried numerous drugs and alternative medicine, however, investigators have failed to identify a safe and effective therapy for patients with NASH. As summarized, the heterogeneity of pathogenic pathways in individual patients with NASH may warrant the development of an individualized treatment according to the underlying pathogenic pathway. The differentiation of pathogenetic targets may require the development of diagnostic and prognostic biomarkers, and the identification of genetic susceptibilities. At present, evidence-based medicine provides only a few options including life-style modifications targeting weight loss, pioglitazone and vitamin E in non-diabetic patients with biopsy-proven NASH. | Bülent Baran Filiz Akyüz | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice显示文摘AIM:To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics(ketamine,propofol,thiopental,and fentanyl)in rats with obstructive jaundice.METHODS:There is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice.Thirty-two Wistar-albino rats were randomly divided into four equal groups.Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0.After 7 d,laparotomy was again performed using ketamine,propofol,thiopental,or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice.After 2 h,the rats were sacrificed.Renal tissue specimens were analyzed for catalase,superoxide dismutase and malondialdehyde enzymes activities.All values are expressed as the mean±SD.P values less than 0.05 were considered statistically significant.RESULTS:All animals survived without complications until the end of the study.Enlargement in the bile duct and obstructive jaundice were observed in all rats.Catalase was found to be significantly lower in the fentanyl group than in the ketamine(P=0.039),propofol(P=0.012),and thiopental(P=0.001)groups.Superoxide dismutase activities were similar in all groups(P>0.05).Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol(P=0.028),thiopental(P=0.002)and fentanyl(P=0.005)groups.Malondialdehyde was also lower in the fentanyl group than in the thiopental group(P=0.001).The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.CONCLUSION:Among the agents tested,ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation.The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure. | Sinan Hatipoglu Huseyin Yildiz Ertan Bulbuloglu Ismail Coskuner Ergul Belge Kurutas Filiz Hatipoglu Harun Ciralik Mehmet Sait Berhuni | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 3 | Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type显示文摘AIM: To investigate the correlation between ezrin expression and types of gastric carcinoma and clinicopathological variables. METHODS: We examined ezrin protein expression in 75 gastric carcinoma (53 intestinal types of adenocarcinoma, 22 diffuse types of carcinoma) tissues by immunohistochemistry. The results were compared with clinicopathological parameters such as tumor type, grade of tumor, clinical stage, presence of metastatic lymph node, and depth of invasion. RESULTS: Ezrin immunostaining was positive in 43 cases (81.1%) of intestinal type and in 9 (40.9%) cases of diffuse type adenocarcinomas (P < 0.001). In gastric carcinomas, the expression of ezrin protein correlated with the status of H pylori and survival. There was no correlation between expression of ezrin with TNM stage and histological grade of gastric carcinomas (P > 0.05). CONCLUSION: The low expression of ezrin implicates the loss of adhesion in diffuse carcinomas. Furthermore, overexpression of ezrin in carcinomas with H pylori infection may be a genuine specific pathway in which H pylori may cause/initiate gastric carcinoma. | Nebil Bal Sedat Yildirim Tarik Z Nursal Filiz Bolat Fazilet Kayaseluk | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 4 | Acute right lower abdominal pain in women of reproductive age:Clinical clues显示文摘AIM:To study possible gynecological organ pathologies in the differential diagnosis of acute right lower abdominal pain in patients of reproductive age.METHODS:Following Clinical Trials Ethical Committee approval,the retrospective data consisting of physical examination and laboratory findings in 290 patients with sudden onset right lower abdominal pain who used the emergency surgery service between April2009 and September 2013,and underwent surgery and general anesthesia with a diagnosis of acute appendicitis were collated.RESULTS:Total data on 290 patients were obtained.Two hundred and twenty-four(77.2%)patients had acute appendicitis,whereas 29(10%)had perforated appendicitis and 37(12.8%)had gynecological organ pathologies.Of the latter,21(7.2%)had ovarian cyst rupture,12(4.2%)had corpus hemorrhagicum cyst rupture and 4(1.4%)had adnexal torsion.Defense,Rovsing’s sign,increased body temperature and increased leukocyte count were found to be statistically significant in the differential diagnosis of acute appendicitis and gynecological organ pathologies.CONCLUSION:Gynecological pathologies in women of reproductive age are misleading in the diagnosis of acute appendicitis. | Sinan Hatipoglu Filiz Hatipoglu Ruslan Abdullayev | 2014 | World Journal of Gastroenterology2014，20，14： | 8 |
| 5 | Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension显示文摘Objective:Yes associated protein 1(YAP1)is a member of the Hippo pathway,acting as a transcriptional coactivator.To elucidate the role of YAP1 and phosphorylated(p)YAP1 in prostate cancer(PCa)tumorigenesis,we investigated their expression in clinical samples of PCa and cell lines.Methods:Fifty-four tumor,adjacent nontumor,and prostate intraepithelial neoplasia(PIN)tissues from patients with PCa after radical prostatectomy were selected from a retrospective cohort and studied using immunohistochemistry(IHC).Protein and m RNA expression levels of YAP1 were evaluated by Western blot analysis and quantitative real-time reverse transcription PCR,respectively,in cancer cell lines.Publicly available gene expression datasets were downloaded to analyze YAP1 m RNA and protein levels in PCa tissue samples.Results:IHC analysis of PCa tissues revealed that YAP1 staining intensities were moderate to weak in the nucleus and cytoplasm of tumor cells,whereas adjacent normal epithelia showed strong staining.We observed that benign prostates were characterized by higher expression levels of both nuclear(P=0.004)and cytosolic(P=0.005)YAP1.p YAP1 staining was weak in the cytoplasm and absent in the nucleus of all the tissues investigated.YAP1 expression was an indicator of extraprostatic extension(EPE).The level of YAP1 was negatively correlated with the level of the androgen receptor(AR)in The Cancer Genome Atlas dataset and Western blot analysis of cell lines.Conclusions:Our study suggested that YAP1 expression is heterogeneous in PCa tissue samples;therefore,YAP1 might play different roles in different aspects of PCa progression.This might involve AR–YAP1 interplay in PCa. | Filiz Kisaayak Collak Ummuhan Demir Seyma Ozkanli Esra Kurum Pinar Engin Zerk | 2017 | Cancer Biology & Medicine2017，14，4： | 8 |
| 6 | Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels显示文摘AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. | Celal Ulasoglu Banu Isbilen Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 7 | Effect of laparoscopic abdominal surgery on splanchnic circulation: Historical developments显示文摘With the developments in medical technology and increased surgical experience,advanced laparoscopic surgical procedures are performed successfully.Laproscopic abdominal surgery is one of the best examples of advanced laparoscopic surgery(LS).Today,laparoscopic abdominal surgery in general surgery clinics is the basis of all abdominal surgical interventions.Laparo scopica bdomina l surgery is associated with systemic and splanchnic hemodynamic alterations.Inadequate splanchnic perfusion in critically ill patients is associated with increased morbidity and mortality.The underlying pathophysiological mechanisms are still not well understood.With experience and with an increase inthe number and diversity of the resulting data,the pathophysiology of laparoscopic abdominal surgery is now better understood.The normal physiology and pathophysiology of local and systemic effects of laparoscopic abdominal surgery is extremely important for safe and effective LS.Future research projects should focus on the interplay between the physiological regulatory mechanisms in the splanchnic circulation(SC),organs,and diseases.In this review,we discuss the effects of laparoscopic abdominal surgery on the SC. | Sinan Hatipoglu Sami Akbulut Filiz Hatipoglu Ruslan Abdullayev | 2014 | World Journal of Gastroenterology2014，20，48： | 5 |
| 8 | Rare pancreas tumor mimicking adenocarcinoma: Extramedullary plasmacytoma显示文摘Neoplastic proliferation of plasma cells is called plasma cell dyscrasias, and these neoplasms can present as a solitary neoplasm or multiple myeloma. Extramedullary plasmacytoma, in particular pancreatic plasmacytoma, is a rare manifestation of multiple myeloma. Although computerized tomography is useful for the diagnosis of extramedullary plasmacytoma, there are no specific radiologic markers that distinguish it from adenocarcinoma. Histological confirmation by biopsy is necessary for accurate diagnosis and management of the tumor. Endosonography is the most sensitive method for the diagnosis of pancreatic tumors, and the use of fine needle aspiration by endosonography is associated with a lower risk for malignant seeding and complications. Here, we report a case of pancreatic plasmacytoma in newly identified multiple myeloma as diagnosed by endosonography. Endosonography is a reliable and rapid method for the diagnosis of extramedullary plasmacytoma. Therefore, endosonographic fine needle aspiration should be the first choice for histological evaluation when pancreatic plasmacytoma is suspected. Ideally, the pathology would be performed at the same site as endosonographic biopsy. | Filiz Akyuz Davut Sahin Umit Akyuz Sezai Vatansever | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 4 |
| 9 | Antioxidant systems in chick embryo development. Part 1.Vitamin E,carotenoids and selenium显示文摘Chick viability is known to be an important factor determining profitability of the poultry industry. Chick embryo tissues contain a high proportion of highly polyunsaturated fatty acids in the lipid fraction and therefore need antioxidant defence. The antioxidant system of the developing embryo and newly hatched chick includes the antioxidant enzymes(superoxide dismutase, glutathione peroxidase, catalase), water-soluble antioxidants(ascorbic acid, taurine, carnitine, glutathione, etc.), fat-soluble antioxidants(vitamin E, carotenoids, coenzyme Q) as well as selenium(Se). In fact, the high levels of endogenous antioxidants within the egg and embryonic tissues can clearly serve as a major adaptive mechanism for the protection of the tissue during the oxidative stress experienced at hatching. It has been shown that among different nutrients in the maternal diet which could significantly affect chick embryo development and their viability in the early posthatch life, natural antioxidants have been suggested to play a central role. Our data indicate that increased supplementation of the maternal diet can substantially increase concentrations of vitamin E, carotenoids(especially canthaxanthin) and Se in developing chick tissues and significantly decrease susceptibility to lipid peroxidation being effective nutritional tools to deal with various commercial stresses in poultry production. | Peter F.Surai Vladimir I.Fisinin Filiz Karadas | 2016 | Animal Nutrition2016，，1： | 4 |
| 10 | The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome显示文摘AIM:To examine the mechanism of the development of pseudoexfoliation (PSX) syndrome via both cytokine formation and endothelial vasorelaxing and growth factors that will provide us new therapeutic insights for the treatment. METHODS:This is a cross sectional study included two groups; Group 1:control patients with nuclear cataract(n =20, aged 51-80 years). Group 2:PSX patients with nuclear cataract (n=18, aged 50-90 years). Patients with other ophthalmic problems and systemic diseases were excluded. Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and interleukin-1β (IL-1β) and nitrotyrosine levels were determined through serum samples by Enzyme-linked immunosorbent assay (ELISA) method. Nitrite-nitrate levels were measured with photometric endpoint determination. RESULTS:There were no significant differences between the groups in terms of age, VEGF, IL-1β, nitrite-nitrate and nitrotyrosine. The significant results were the mean IL-6 levels that were higher in PSX group 2 (37.68± 29.52 pg/mL) compared to that in control group 1 (15.32± 10.08 pg/mL) (P <0.001). CONCLUSION:Several interacting and extending biochemical pathways may lead to the promotion of VEGF and IL-6 expressions. IL-6 which is the only altered marker in our study may indirectly cause an increase of vascular permeability and neovascularization. We suggest inflammation as a factor that can be involved in etiopathogenesis of PSX. | Zuhal Yildirim Filiz Yildirim Nil Irem Ugun Aylin Sepici-Dinel | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 3 |
| 11 | Gastroesophageal reflux in asymptomatic obese subjects:An esophageal impedance-pH study显示文摘AIM:To investigate the relationship between reflux and body mass index(BMI) in the asymptomatic obese population using the impedance-p H technique.METHODS:Gastroesophageal reflux is frequent in the obese population.However,the relationship between acid reflux and BMI in asymptomatic obese people is unclear.Forty-six obese(BMI > 25 kg/m2) people were enrolled in this prospective study.We evaluated the demographic findings and 24-h impedance p H values of the whole group.Gas,acid(p H < 4),weak acid(p H = 4-7) and weak alkaline(p H ≥ 7) reflux parameters were analyzed.RESULTS:The mean age of patients was 49.47±12.24 years,and half of them were men.The mean BMI was 30.64±3.95 kg/m2(25.14-45.58 kg/m2).BMI of 23 was over 30 kg/m2.Seventeen patients had a comorbidity(hypertension,diabetes mellitus,or ischemic heart disease).Endoscopic examination revealed esophagitis in 13 of the 28 subjects(10Grade A,3 Grade B).The subjects were divided into two groups according to BMI(<30 and>30 kg/m2).Demographic and endoscopic findings,and impedance results were similar in these two groups.However,there was a positive correlation between BMI and total and supine p H<4 episodes(P=0.002,r=0.414;P=0.000,r=0.542),p H<4 reflux time(P=0.015,r=0.319;P=0.003,r=0.403),and De Meester score(P=0.012,r=0.333).CONCLUSION:Acid reflux is correlated with BMI in asymptomatic obese individuals. | Filiz Akyüz Ahmet Uyanikoglu Fatih Ermis Serpil Arici ümit Akyüz Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Yeditepe University Bülent Baran Binnur Pinarbasi Nurdan Gul | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 12 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 13 | Atom transfer radical polymerization through N-chlorosulfonamides 显示文摘 | Senkal Filiz B Hizal | 2001 | J Polym Sci Part A: Poly Chem2001，39，： | 2 |
| 14 | A review on protein–phenolic interactions and associated changes显示文摘 | Tugba Ozdal Esra Capanoglu Filiz Altay | 2013 | Food Research International2013，，2： | 2 |
| 15 | Food impaction in older age:Think about an eosinophilic esophagitis显示文摘Eosinophilic esophagitis is an inflammatory condition of esophagus.It is generally seen in childhood and young population.Men are more commonly affected than women.However,it is not common in an advanced age.Eosinophilic esophagitis decreases the ability of the esophagus to stretch and accommodation against foods.Therefore,the major symptom in adults with eosinophilic esophagitis is difficulty in swallowing solid food(dysphagia).Specifically,the food gets stuck in the esophagus after it is swallowed.Less common symptoms include heartburn and chest pain.Because of this,it may be incorrectly diagnosed as a gastroesophageal reflux disease.Here,we reported a case presented with food impaction at advanced age.As a conclusion,eosinophilic esophagitis is a rare entity that must be remembered in advance aged patients presenting with food impaction. | Umit Akyüz Filiz Akyüz Kamil zdil Hasan Altun Ahmet Faruk Agan Aysegül Agan | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 2 |
| 16 | A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation显示文摘 | Kamer Dere Ilker Sucullu Ersel Tan Budak Suleyman Yeyen Ali Ilker Filiz Sezai Ozkan Guner Dagli | 2010 | European Journal of Anaesthesiology2010，，7： | 2 |
| 17 | Effects of Pentoxifylline on TNF-α Production by Peripheral Blood Mononuclear Cells in Patients with Nonalcoholic Steatohepatitis显示文摘 | Deniz G. Duman Filiz Ozdemir Esra Birben Ozlem Keskin Emel Ek?io?lu-Demiralp Cigdem Celikel Omer Kalayci Cem Kalayci | 2007 | Digestive Diseases and Sciences2007，，10： | 1 |
| 18 | Aliphatic and polycyclic aromatic hydrocarbons in the surface sediments from the Eastern Aegean: assessment and source recognition of petroleum hydrocarbons显示文摘 | L. Tolga Gonul Filiz Kucuksezgin | 2012 | Environmental Science and Pollution Research2012，，1： | 1 |
| 19 | Adsorption of dark coloured compounds from peach pulp by using powdered-activated carbon显示文摘 | Feride Naime Arslanogˇlu Filiz Kar Nurhan Arslan | 2004 | Journal of Food Engineering2004，，2： | 1 |
| 20 | 资本流动与金融稳定:货币政策和宏观审慎对策(下)1显示文摘发表在国际清算银行(BIS)2013年一季度《中央银行国际期刊》上的'资本流动与金融稳定:货币政策和宏观审慎对策'一文,通过分析在开放经济DSGE模型下货币政策和宏观审慎政策之间的相互影响,指出在发生引起资本流入的金融冲击时,宏观审慎措施作为货币政策有效补充的作用能够得以充分彰显,同时,在'最优简单规则'下,宏观审慎措施可以改善社会福利。此外,本文还认为若要将宏观审慎工具作为单独政策工具,汇率机制的作用至关重要。 | D. Filiz Unsal 梁婷 穆蕾 王芳 刘迪 | 2014 | 西部金融2014，，5： | 1 |
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