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| 1 | Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective显示文摘Cell-substrate interactions play a crucial role in the design of better biomaterials and integration ofimplants with the tissues. Adhesion is the binding process of the cells to the substrate through interactionsbetween the surface molecules of the cell membrane and the substrate. There are severalfactors that affect cell adhesion including substrate surface chemistry, topography, and stiffness. Thesefactors physically and chemically guide and influence the adhesion strength, spreading, shape and fate ofthe cell. Recently, technological advances enabled us to precisely engineer the geometry and chemistry ofsubstrate surfaces enabling the control of the interaction cells with the substrate. Some of the mostcommonly used surface engineering methods for eliciting the desired cellular responses on biomaterialsare photolithography, electron beam lithography, microcontact printing, and microfluidics. Thesemethods allow production of nano- and micron level substrate features that can control cell adhesion,migration, differentiation, shape of the cells and the nuclei as well as measurement of the forces involvedin such activities. This review aims to summarize the current techniques and associate these techniqueswith cellular responses in order to emphasize the effect of chemistry, dimensions, density and design ofsurface patterns on cell-substrate interactions. We conclude with future projections in the field of cellsubstrateinteractions in the hope of providing an outlook for the future studies. | Menekse Ermis Ezgi Antmen Vasif Hasirci | 2018 | Bioactive Materials2018，3，3： | 13 |
| 2 | Electroporation: A New Approach Enhancing Antitumor Effects of Cytoxan显示文摘Electrochemotherapy (ECT) is a novel cancer treatment in which electric pulses (EPs) inducing cell membrane pored (electroporation) are used as a means of delivering antitumor drugs to the cytoplasm of cancer cells. In vitro, with scan electromicroscope (SEM) and Trypan blue staining examination, the best parameter of EPs of electroporation is studied by the S-180 cells exposed to EP with various voltages, pulses , capacitance. The best parameter of EP of electroporation is 600V/cm, 6 pulses, 10 μF. In the in vivo study, ECT is studied with the Cytoxan (CTX) injected directly into the tumor followed immediately by a local EP at the tumor site. Four parameters, which include the tumor inhibitory ratio, the curing ratio and the vas capillare of tumor, the tumor’s histopathological characteristics are determined and compared among the ECT group, the control group, the EP-only group and the drug-only group. The results indicate that the antitumor effect of CTX is significantly enhanced by electroporation. | 杨孔 YUE Bisong Wang Zishu ZOU Fangdong Zhao Ermi WANG Baoyi Zhang Hong | 2003 | High Technology Letters2003，9，3： | 5 |
| 3 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 4 | Gastroesophageal reflux in asymptomatic obese subjects:An esophageal impedance-pH study显示文摘AIM:To investigate the relationship between reflux and body mass index(BMI) in the asymptomatic obese population using the impedance-p H technique.METHODS:Gastroesophageal reflux is frequent in the obese population.However,the relationship between acid reflux and BMI in asymptomatic obese people is unclear.Forty-six obese(BMI > 25 kg/m2) people were enrolled in this prospective study.We evaluated the demographic findings and 24-h impedance p H values of the whole group.Gas,acid(p H < 4),weak acid(p H = 4-7) and weak alkaline(p H ≥ 7) reflux parameters were analyzed.RESULTS:The mean age of patients was 49.47±12.24 years,and half of them were men.The mean BMI was 30.64±3.95 kg/m2(25.14-45.58 kg/m2).BMI of 23 was over 30 kg/m2.Seventeen patients had a comorbidity(hypertension,diabetes mellitus,or ischemic heart disease).Endoscopic examination revealed esophagitis in 13 of the 28 subjects(10Grade A,3 Grade B).The subjects were divided into two groups according to BMI(<30 and>30 kg/m2).Demographic and endoscopic findings,and impedance results were similar in these two groups.However,there was a positive correlation between BMI and total and supine p H<4 episodes(P=0.002,r=0.414;P=0.000,r=0.542),p H<4 reflux time(P=0.015,r=0.319;P=0.003,r=0.403),and De Meester score(P=0.012,r=0.333).CONCLUSION:Acid reflux is correlated with BMI in asymptomatic obese individuals. | Filiz Akyüz Ahmet Uyanikoglu Fatih Ermis Serpil Arici ümit Akyüz Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Yeditepe University Bülent Baran Binnur Pinarbasi Nurdan Gul | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 5 | Reclassification of Oligodon ningshaanensis Yuan, 1983(Ophidia:Colubridae) into a New Genus, Stichophanes gen. nov. with Description on Its Malacophagous Behavior显示文摘The complete mitochondrial cytb gene and the partial nuclear c-mos gene of Oligodon ningshaanensis Yuan, 1983 were sequenced and used for reconstructing the phylogenetic relationship of this taxon amongst alethinophidian snakes. Its strong affinity to the New World subfamily Dipsadinae and the Old World species Thermophis baileyi was inferred. Hemipenial morphology found by authors conflicts with the original description and its similarity with those of the dipsadid snakes is in accordance with our molecular results. Feeding tests show that O. ningshaanensis is a malacophagous predator, which is another matchless character for this species. This behavior is described and compared with other known slug- and snail-feeding snakes. The discovery of the particular position of our subject indicates that erecting a new genus is necessary accommodate this unique species. | Xiaohe WANG Kevin MESSENGER Ermi ZHAO Chaodong ZHU | 2014 | Asian Herpetological Research2014，5，3： | 3 |
| 6 | Current Helicobacter pylori treatment in 2014显示文摘Helicobacter pylori is one of the most commonly seen bacterium worldwide.It's in the etiology of multiple gastrointestinal diseases,ranging from gastritis to gastric carcinoma.The antimicrobial therapies,which are frequently prescribed empirically,are losing their effectivity as a result of the increasing antimicrobial resistance.As the standard triple therapy is now leftespecially in areas with high-clarithromycin resistance due to decreased eradication rates,quadruple therapies are recommended in most regions of the world.Alternatively,concomitant,sequential and hybrid therapies are used.There is still a debate going on about the use of levofloxacin-based therapy in order to prevent the increase in quinolone resistance.If no regimen can achieve the desired eradication rate,culture-guided individualized therapies are highly recommended.Probiotics,statins and n-acetylcysteine are helpful as adjuvant therapies in order to increase the effectiveness of the eradication therapy.Herein,we focused on different eradication regimens in order to highlight the current Helicobacter pylori treatment. | Fatih Ermis Elif Senocak Tasci | 2015 | World Journal of Methodology2015，5，2： | 3 |
| 7 | The complete mitochondrial DNA sequence and the phylogenetic position of Achalinus meiguensis (Reptilia: Squamata)显示文摘The mitochondrial genome complete sequence of Achalinus meiguensis was reported for the first time in the present study. The complete mitochondrial genome of A. meiguensis is 17239 bp in length and contains 13 protein-coding genes, 22 tRNA, 2 rRNA, and 2 non-coding regions (Control regions). On the basis of comparison with the other complete mitochondrial sequences reported, we explored the characteristic of structure and evolution. For example, duplication control regions independently occurred in the evolutionary history of reptiles; the pseudo-tRNA of snakes occurred in the Caenophidia; snake is shorter than other vertebrates in the length of tRNA because of the truncations of TΨC arm (less than 5 bp) and 'DHU' arm. The phylogenic analysis by MP and BI analysis showed that the phylogenetic position of A. meiguensis was placed in Caenophidia as a sister group to other advanced snakes with the exclusion of Acrochordus granulatus which was rooted in the Caenophidia. Therefore we suggested that the subfamily Xenodermatinae, which contains A. meiguensis, should be raised to a family rank or higher rank. At the same time, based on the phylogenic statistic test, the tree of Bayesian was used for estimating the divergence time. The results showed that the divergence time between Henophidia and Caenophidia was 109.50 Mya; 106.18 Mya for divergence between Acrochordus granulatus and the other snakes of the Caenophidia; the divergence time of A. meiguensis was 103 Mya, and Viperidae diverged from the unilateral of Elapidae and Colubridae was 96.06 Mya. | WANG GuangLi HE ShunPing HUANG Song HE Miao ZHAO ErMi | 2009 | Chinese Science Bulletin2009，54，10： | 2 |
| 8 | Atonomous wind energy conversion system with a simple controller for maximum-power transfer 显示文摘 | Ermis A Ertan M Akpinar H B | 1992 | Electric Power Applications IEE Proceedings B1992，139，5： | 2 |
| 9 | Distal humeral coronal plane fractures: management, complications and outcome显示文摘 | Mehmet Oguz Durakbasa Gurkan Gumussuyu Mutlu Gungor Mehmet Nurullah Ermis | 2012 | Journal of Shoulder and Elbow Surgery2012，，： | 2 |
| 10 | Surgically induced astigmatism after superotemporal and superonasal clear corneal incisions in phacoemulsification显示文摘 | Ermis SS Inan UU Ozturk F | 2004 | J Cataract Refract Surg2004，30，6： | 1 |
| 11 | Effect of fluorosis on dentine shear bondstrength of a self - etching bonding system 显示文摘 | Ermis RB Gokay N | | J Oral Rehabil0，，： | 1 |
| 12 | Bored strength ff se|t' - etch adhesives to dentin prepared with three diffren! diamond burs 显示文摘 | Ermis RB De Munek J Cardoso MY st al | 2008 | Dent Mater2008，24，7： | 1 |
| 13 | Effect of hydraulic diameter on condensation of R134a in flat,extruded aluminum tubes显示文摘 | R L Webb K Ermis | 2001 | Enhanced Heat Transfer2001，8，： | 1 |
| 14 | Relationship between serum T glutamyhransferase levels and acute exacerbation of chronic ob- structive pulmonary disease显示文摘 | Ermis H Celik MR Gulbas G | 2013 | Pol Arch Med Wewn2013，123，1： | 1 |
| 15 | Assessment of percutaneous coronary intervention on regional and global left ventricular function in patients with chronic total occlusions显示文摘 | Ermis C Boz A Tholakanahalli V | 2005 | Can J Cardiol2005，21，3： | 1 |
| 16 | Impact of upgrade to cardiac resynchronizatien therapy on ventricular arrhythmia frequency in patients with imphtsble cardioverter-defibrillators显示文摘 | Ermis C Seutter R Ahu AX | 2005 | J Am Coll Cardiol2005，46，12： | 1 |
| 17 | Two-year clinical evaluation of four polyacid-modifiedresin composiles and aresin-modified glass-ionomer cement in ClassV lesions显示文摘 | Ermis RB | 2002 | Quintessence Int2002，33，7： | 1 |
| 18 | Catecholamine response during haemodynamically stable upright posture in individuals with and without tilt table induced vasovagal syncope 显示文摘 | Benditti DG Ermis C Padanitam B | 2003 | Europace2003，5，： | 1 |
| 19 | Performance optimization of induction motors during voltage-controlled soft starting 显示文摘 | ZENGINOBUZ G CADIRCI I ERMIS M | 2004 | IEEE Transactions on Energy Conversion2004，19，2： | 1 |
| 20 | Dandy-Walker malfor- mation : a review of 78 cases diagnosed by prenatal sonog- raphy 显示文摘 | Has R Ermis H Yuksel A | 2004 | Fetal Diagn Ther2004，19，4： | 1 |
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