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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Role of staging laparoscopy in peri-pancreatic and hepatobiliary malignancy显示文摘Even after extensive preoperative assessment,staging laparoscopy may allow avoidance of non-therapeutic laparotomy in patients with radiographically occult metastatic or locally unresectable disease.Staging laparoscopy is associated with decreased postoperative pain,a shorter hospital stay and a higher likelihood of receiving systemic therapy compared to laparotomy but its yield has decreased with improvements in imaging techniques.Current uses of staging laparoscopy include the following:(1) In the staging of pancreatic adenocarcinoma,laparoscopic staging allows for the identif ication of sub-radiographic metastatic disease in locally advanced cancer in approximately 30% of patients and,in radiographically resectable cancer,may identify metastatic disease in 10%-15% of cases;(2) In colorectal liver metastases,selective use of laparoscopic staging in patients with a clinical risk score of over 2 identifies unresectable disease in approximately 20% of patients;(3) In hepatocellular carcinoma,laparoscopic staging could be selectively used in high-risk patients such as those with clinically apparent liver cirrhosis and in patients with major vascular invasion or bilobar tumors;and(4) In biliary tract malignancy,staging laparoscopy may be used in all patients with potentially resectable primary gallbladder cancer and in selected patients with T2/T3 hilar cholangiocarcinoma.Because of the decreasing yield of SL secondary to improvements in imaging techniques,staging laparoscopy should be used selectively for patients with pancreatic and hepatobiliary malignancy to avoid unnecessary non-therapeutic laparotomy and to improve resource utilization.Each individual surgeon should apply his or her threshold as to whether staging laparoscopy is indicated according to the quality of preoperative imaging studies and the availability of resources at their own institution. | Sebastien Gaujoux Peter J Allen | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 12 |
| 3 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 4 | Electronic energy transfer to the S2 level of the acceptor in functionalised boron dipyr romethenedyes显示文摘 | Anthony H Laura J M Sebastien G | 2009 | Chem Eur J2009，15，18： | 1 |
| 5 | Exploiting exopolysaccharides from lactic acid bacteria显示文摘 | Laure Jolly Sebastien J F Vincent | 2002 | Antonie van Leeuwenhoek2002，82，： | 1 |
| 6 | Effect of Exogenous Lipase on Dough Lipids During Mixing of Wheat Flours显示文摘 | Sebastien J etc | 1998 | Cereal Chemistry1998，75，5： | 1 |
| 7 | Living radical polymerization of isoprene via the RAFT process显示文摘 | VARANGKANA J SEBASTIEN P | 2007 | Macromolecules2007，40，： | 1 |
| 8 | An integrated overview of seed development in Arabidopsis thaliana ecotype WS显示文摘 | SEBASTIEN B J P B MARTINE M LOC L | 2002 | Plant Physiology and Biochemistry2002，40，： | 1 |
| 9 | Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells显示文摘 | Rashid S Tamir Corbineau Sebastien Hannan Nick Marciniak Stefan J Miranda Elena Alexander Graeme Huang-Doran Isabel Griffin Julian Ahrlund-Richter Lars Skepper Jeremy Semple Robert Weber Anne Lomas David A Vallier Ludovic | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 10 | Extraaxonal neurofilaments do not exacerbate disease caused by mutant Cu, Zn superoxide dismutase 显示文摘 | Sebastien C D Jurgen M Julien J P | 2000 | Neurobiol Dis2000，7，： | 1 |
| 11 | The role of NFAT transcrip tion factors in integrin-mediated carcinoma invasion 显示文摘 | Sebastien J Cristina L Leslie M | 2002 | Nat Cell Biol2002，4，7： | 1 |
| 12 | Possible cause of excess sludge reduction in an oxic-settling-anaerobic activated sludge process (OSA process) 显示文摘 | Chen Guang-hao Kyoung J Sebastien S | 2003 | Water Research2003，37，16： | 1 |
| 13 | Divergence in 813C of dark respired C02 and bulkorganic matter occurs during the transition betweenheterotrophy and autotrophy in Phaseolus vulgaris plants显示文摘 | BATHELLIER C BADECK F W COUZI P SeBASTIEN H CAROLINE M GHASHGHAIE J | 2008 | New Phytologist2008，，177： | 1 |
| 14 | DiffAni: visualizing dynamicgraphs with a hybrid of difference maps and animation显示文摘 | Sebastien R McGuffin M J | | IEEETransactions on Visualization and Computer Graphics0，19，12： | 1 |
| 15 | The Permian Moradi Formation of northern Niger:Paleosol morphology,petrography and mineralogy显示文摘 | NEIL J Tabor ROGER M H Smith J Sebastien Steyer | | 0，，2011： | 1 |
| 16 | Controlled electro-implementation of fluoride in titanium implant sur- faces enhances cortical bone formation and mineralization 显示文摘 | Sebastien F T L Marina R Havard J H | 2010 | Acta Biomater2010，6，3： | 1 |
| 17 | Influence of insecticide Bacillus thuringiensis subsp, israelensis treatments on resistance and enzyme activities in Aedes rusticus larvae (Diptera: Culicidae)显示文摘 | Sebastien B Margot P Sylvaine J | 2012 | Biological Control2012，62，2： | 1 |
| 18 | Transforming Growth Factor-β1 Is a Negative Modulator of Adult Neurogenesis显示文摘 | Frank-Peter Wachs Beate Winner Sebastien Couillard-Despres Thorsten Schiller Robert Aigner Jürgen Winkler Ulrich Bogdahn Ludwig Aigner | 2006 | Journal of Neuropathology and Experimental Neurology2006，，4： | 1 |
| 19 | A comparison of steady state and rate based models for packed reactive distillation columns显示文摘 | Peng J Sebastien L Thomas F E | 2002 | Industrial & Engineering Chemistry Research2002，41，11： | 1 |
| 20 | Dense matter with eXTP显示文摘In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s. | Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
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