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| 1 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 4 | APPROACHES FOR SUSTAINABLE MANUFACTURING显示文摘Sustainable development is a holistic approach harmonizing ecological, economical and socio-political needs with respect to the superior objective of enhancing human living standards. Thereby the availability of natural resources and the conservation of the ecosystems have to be considered that future generations have the possibility to meet their own needs. A long-term economical development demands the transition from a source-sink economy to a cycle economy as a result of limited resources, limited environmental capacities to absorb waste and emissions as well as increasing needs of a growing population. A reference model for sustainability in manufacturing is presented and used to illustrate sustainable approaches with respect to management, technology, process and product. Adaptation of products and components is a vital element for supporting efficient reuse of products and components. Consequently adaptation contributes to the ambitious goals of sustainability. Technological enablers for adaptation as modularity, information and communication technology are exemplarily introduced. Moreover, approaches for disseminating knowledge in sustainability are given. | GüNTHER Seliger SEBASTIAN Kernbaum MARCO Zettl | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 3 |
| 5 | Comparison of estimators of variance for forest inventories with systematic sampling-results from artificial populations显示文摘Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar. | Steen Magnussen Ronald EMcRoberts Johannes Breidenbach Thomas Nord-Larsen Göran Ståhl Lutz Fehrmann Sebastian Schnell | 2020 | Forest Ecosystems2020，7，2： | 2 |
| 6 | High Density Tungsten-CopperLiquid Phase Sintered Composites From Coreduced Oxide Pow-ders显示文摘 | Sebastian K V Tendolker G S | 1979 | Powder Metall&Powder Tech1979，15，1： | 1 |
| 7 | Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study显示文摘 | Peserico A Stadtler G Sebastian M | 2008 | Br J Dermatol2008，158，： | 1 |
| 8 | Delayed umbilical cord clamping for reducing anaemia in low birthweight infants:implications for developing countries显示文摘 | PATRICK F VAN R SEBASTIAN G | 2006 | Annals of Tropical Paediatrics2006，26，： | 1 |
| 9 | Long-term outcomes of low-dose catheter-directed thrombolytic thera- py: a 5-year single-center experience 显示文摘 | Sebastian A J Robinson G J Dyet J F | 2010 | J Vase Interv Radiol2010，21，7： | 1 |
| 10 | Significance of Morphological Abnormalities Detected by MRI in Patients Undergoing Successful Ablation of Right Ventricular Outflow Tract Tachycardia 显示文摘 | Sebastian G Gerhard K Herbert F | 1997 | Circulation1997，96，3： | 1 |
| 11 | Sol-gel template synthesis of highly ordered MnOz nanowire arrays显示文摘 | Wang X Y Huang W G P J Sebastian | 2005 | J Power Sources2005，140，1： | 1 |
| 12 | Characterisation of odour-active compounds in aged rum显示文摘 | Jorge A. Pino Sebastian Tolle Recep G?k Peter Winterhalter | 2011 | Food Chemistry2011，，3： | 1 |
| 13 | Technical, economical, and climate-related aspects of biochar production technologies: A literature review 显示文摘 | SEBASTIAN M BRUNO G PETER Q | 2011 | Environmental Science & Technology2011，45，： | 1 |
| 14 | Influence of Neoadjuvant Therapy with Epirubicin and Docetaxel on the Expression of HER2/neu in Patients with Breast Cancer显示文摘 | Susanne Taucher Margaretha Rudas Robert M. Mader Michael Gnant Emanuel Sporn Peter Dubsky Sebastian Roka Thomas Bachleitner Florian Fitzal Daniela Kandioler Catharina Wenzel Günther G. Steger Martina Mittlb?ck Raimund Jakesz | 2003 | Breast Cancer Research and Treatment2003，，3： | 1 |
| 15 | Oropharyngeal Dysphagia: Neurogenic Etiology and Manifestation 显示文摘 | Swapna Sebastian Prem G Nair Philip Thomas | 2015 | Indian Journal of Otolaryngology and Head & Neck Surgery2015，67，1： | 1 |
| 16 | Impairments of the protein C system and fibrinolysis in infection-associated stroke 显示文摘 | Richard F Sebastian F Andras G | 1996 | Stroke1996，2711，18： | 1 |
| 17 | Ca4La2Ti5O17:a novel low loss dielectric ceramics in the CaO-La2O3-TiO2system显示文摘 | REJINI R SUBODH G SEBASTIAN M T | 2008 | J Mater Sci:Mater Electron2008，19，： | 1 |
| 18 | Safety of injectable autologous human fibroblasts显示文摘 | SEBASTIAN J LACOMBE G | 2000 | Bull Exp Biol Med2000，130，8： | 1 |
| 19 | An integrated AFLP and RFLP Brassica oleracea linkage map from two morphologically distinct doubled-haploid mapping population 显示文摘 | Sebastian R L Howell E C King G : | 2000 | Theoretical and Applied Genetics2000，100，1： | 1 |
| 20 | Appearance-based person reidentification in camera networks: problem overview and current approaches 显示文摘 | Doretto G Sebastian T Tu P | 2011 | Journal of Ambient Intelligence and Humanized Computing(S 186g-5137)2011，2，2： | 1 |
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