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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Surgical strategies in the therapy of non-small cell lung cancer显示文摘Lung cancer represents the leading cause of cancer mortality worldwide. Despite improvements in preoperative staging, surgical techniques, neoadjuvant/adjuvant options and postoperative care, there are still major difficulties in significantly improving survival, especially in locally advanced non-small cell lung cancer(NSCLC). To date, surgical resection is the primary mode of treatment for stage?Ⅰ?and Ⅱ NSCLC and has become an important component of the multimodality therapy of even more advanced disease with a curative intention. In fact, in NSCLC patients with solitary distant metastases, surgical interventions have been discussed in the last years. Accordingly, this review displays the recent surgical strategies implemented in the therapy of NSCLC patients. | Feras Al-Shahrabani Daniel Vallbhmer Sebastian Angenendt Wolfram T Knoefel | 2014 | World Journal of Clinical Oncology2014，5，4： | 10 |
| 3 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 4 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 5 | Low dielectric loss PTFE/CeO2 ceramic composites for microwave substrate applications显示文摘 | ANJANA P S SEBASTIAN M T SUMA J | 2008 | Applied Ceramic Technology2008，5，2： | 1 |
| 6 | Biochemical and molecular characterization of a mutation that confers a decreased raffinosaccharide and phytic acid phenotype on soybean seeds 显示文摘 | Hize W D Carlson T J Kerr P S Sebastian S A | 2002 | Plant Physiology2002，128，： | 1 |
| 7 | Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15显示文摘 | SEBASTIAN B KAKIZUKA A HUNTER T | 1993 | Proc Natl Acad Sci USA1993，90，8： | 1 |
| 8 | On aligning curves 显示文摘 | Sebastian T B Klein P N Kimia B B | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，1： | 1 |
| 9 | Isolation and char- acterization of exosomes from cell culture supernatants and biological fluids显示文摘 | Clotilde T Aled C Sebastian A | 2006 | Cell Biology2006，3，22： | 1 |
| 10 | Pooled analysis of the efficacy and safety of self-expanding metal stenting in malig- nant colorectal obstruction 显示文摘 | Sebastian S Johnston S Geoghegan T | 2004 | Am J Gastroenterol2004，99，10： | 1 |
| 11 | Age-dependentaccumulation of soluble amyloid p (Ap) oligomers reversesthe neuroprotective effect of soluble amyloid precursor protein-(sAPP) by modulating phosphatidylinositol 3-kinase (PI3K) /Akt-GSK-3 pathway in Alzheimer mouse model 显示文摘 | Sebastian J Manuel T Marisa V | 2011 | J BiolChem2011，286，18： | 1 |
| 12 | Issues in reducing the cogging torque of mass-produced permanent-magnet brushless DC motor显示文摘 | Islam M S Mir S Sebastian T | 2004 | IEEE Transactions on Industry Applications2004，40，3： | 1 |
| 13 | Pooled analysis of the efficacy and safety of self-ex- panding metal stenting in malignant colorectal ob- struction显示文摘 | SEBASTIAN S JOHNSTON S GEOGHEGAN T | 2004 | Am J Gastroenterol2004，99，： | 1 |
| 14 | Pooled analysis of the efficacy and safety of self-expanding metal slanting in malignant colorectal显示文摘 | Sebastian S Johnston S Geoghegan T | 2004 | Am J Gastroenterol2004，99，10： | 1 |
| 15 | Protective effect of Phyllanthus fraternus against ethanol induced mitochondrial dysfunction 显示文摘 | Sebastian T Setty OH | 1999 | Alcohol1999，17，1： | 1 |
| 16 | Recognition of shapes by editing their shock graphs显示文摘 | Sebastian T B Klein P N and Kimia B B | 2004 | IEEE Transactions on Pattern Analysis & Machine Intelligence2004，26，5： | 1 |
| 17 | The Stemocleidomastoid island myocutaneous flap for cancer reconstruction 显示文摘 | Sebastian P Cherian T Ahamed MI | 1994 | Arch Otolaryngol Head Neck Surg1994，120，6： | 1 |
| 18 | Low loss dielectric materials for LTCC applications:a review显示文摘 | SEBASTIAN M T JANTUNEN H | | 0，，02： | 1 |
| 19 | Nasolabial flaps in oral reconstruction: an analysis of 224 cases显示文摘 | Varghese B T Sebastian P Cherian T | 2001 | Br J Plast Surg2001，54，6： | 1 |
| 20 | Analysis of induced EMF waveforms and torque ripple in a brushless permanent magnet machine 显示文摘 | SEBASTIAN T | 1999 | IEEE Transactions on Magnetics1999，32，1： | 1 |
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