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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 3 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 4 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 5 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 6 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 7 | Postoperative blood salvage and reinfusion in spinal surgery:blood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Olalla E | 2000 | Eu Spine J2000，9，6： | 1 |
| 8 | Adsorptive separation of light olefins from paraffins 显示文摘 | Douglas M Ruthven Sebastian C Reyes | 2007 | Microporous and Mesoporous Materials2007，104，： | 1 |
| 9 | FbpC is not Essential for Iron Acquisition in Neisseria Gonorrhoeae显示文摘 | Sebastian S Genco C A | | 0，，： | 1 |
| 10 | Sedative and sleep-en hancing properties of linarin, a flavonoid-isolated from Valeriana offi c inalis 显示文摘 | Sebastian F C~istina W Alejandro C | 2004 | Pharmacology Biochemistry and Behavior2004，77，2： | 1 |
| 11 | Regio selective butylation of toluene on mordenite catalysts influence of acidity显示文摘 | Sebastian C P Shivanand P Sharanappa N | 2004 | J Mol Catal A:Chem2004，223，12： | 1 |
| 12 | Isolation and char- acterization of exosomes from cell culture supernatants and biological fluids显示文摘 | Clotilde T Aled C Sebastian A | 2006 | Cell Biology2006，3，22： | 1 |
| 13 | How does sodium sulfate crystallize?: Implications for the decay and testing of building materials 显示文摘 | Rodriguez-Navarro C Doehne E Sebastian E | 2000 | Cem Concr Res2000，30，15： | 1 |
| 14 | Structure, composition and electrical properties of YSZ films deposited by ultrasonic spray pyrolysis显示文摘 | RAMIREZ E B HUANOSTA A SEBASTIAN J P HUERTA L ORTIZ A ALONSO J C | 2007 | Journal of Materials Science2007，42，3： | 1 |
| 15 | Regio selective butylation of toluene on mordenite catalysts influence of acidity显示文摘 | Sebastian C P Shivanand Pai Sharanappa N | 2004 | Journal of Molecular Catalysis A:Chemical2004，223，： | 1 |
| 16 | How does sodium sulfate crystallize? Implications for the de- cay andtesting of building materials显示文摘 | RODRIGUEZ-NAVARRO C DOEHNE E SEBASTIAN E | 2000 | Cement and Concrete Research2000，30，10： | 1 |
| 17 | Study of Cogging Torque in Permanent Magnet Machines显示文摘 | C studer A Keyhani T Sebastian | 1997 | IEEE IAS Annual Meeting New Orleans1997，，： | 1 |
| 18 | Relationship of gas phase permea- bility to uhrastructure of white spruce wood 显示文摘 | Sebastian L P Cte W A Skaar C | 1965 | Journal of Forest Product1965，15，9： | 1 |
| 19 | Positive Resolution of Childhood Sexual Abuse Experiences: The Role of Coping, Benefit-Finding and Meaning-Making显示文摘 | Wright M O Emily C Sebastian K | 2007 | Journal of Family Violence2007，22，7： | 1 |
| 20 | An integrated AFLP and RFLP Brassica oleracea linkage map from two morphologically distinct doubled-haploid mapping population 显示文摘 | Sebastian R L Howell E C King G : | 2000 | Theoretical and Applied Genetics2000，100，1： | 1 |
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