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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Electrodeposited and selenized (CuInSe2) (CIS) thin films for photovoltaic applications显示文摘 | Fernandez A M Calixto M E Sebastian P J | 1998 | Solar Energy Materials &Solar Cells1998，52，34： | 2 |
| 3 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 4 | Postoperative blood salvage and reinfusion in spinal surgery:blood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Olalla E | 2000 | Eu Spine J2000，9，6： | 1 |
| 5 | Nonlinear FE analysis of steel-concrete composite structures 显示文摘 | Sebastian W M McConnel R E | 2000 | Journal of Structural Engineering2000，126，6： | 1 |
| 6 | Characterization of co-electrodeposited and selenized CIS (CuInSe2) thin films显示文摘 | Fernandez A M Sebastian P J Calixto M E | 1997 | Thin Solid Films1997，298，12： | 1 |
| 7 | Comparativeassessment of bacterial inoculation and propionic acidtreatment of aerobil stability and microbial populationsof ensiled high-moisture ear corn显示文摘 | Sebastian S Philliy L E Fellner V | 1996 | Journal of Animalsciencr1996，74，： | 1 |
| 8 | Feedback control for optimal process operation 显示文摘 | Sebastian E | 2007 | Journal of Process Control2007，17，3： | 1 |
| 9 | The effects of supplemental microbial phytase on the performance and utilization of dietary calcium,phosphorus,copper,and zinc in broiler chickens fed corn-soybean diets显示文摘 | SEBASTIAN S TOUCHBURN S P CHAVEZ E R | 1996 | Poult Sci1996，75，： | 1 |
| 10 | Compositional and optoelectronic properties of CIS and CIGS thin films formed by electrodeposition显示文摘 | Calixto M E Sebastian P J Bhattacharya R N Noufi R | 1999 | Solar Energy Materials and Solar Cells1999，59，1： | 1 |
| 11 | Com- positional and optoelectronic properties of CIS and CIGS thin films formed by electrodeposition 显示文摘 | CALIXTO M E SEBASTIAN P J BHATTACHARY R N | 1999 | Solar Energy Materials & Solar Cells1999，59，： | 1 |
| 12 | How does sodium sulfate crystallize?: Implications for the decay and testing of building materials 显示文摘 | Rodriguez-Navarro C Doehne E Sebastian E | 2000 | Cem Concr Res2000，30，15： | 1 |
| 13 | Current insights in- to the role of HIF- 1 in cutaneous wound healing显示文摘 | Andrikopoulou E Zhang X Sebastian R | 2011 | Curr Mol Med2011，11，3： | 1 |
| 14 | Structure, composition and electrical properties of YSZ films deposited by ultrasonic spray pyrolysis显示文摘 | RAMIREZ E B HUANOSTA A SEBASTIAN J P HUERTA L ORTIZ A ALONSO J C | 2007 | Journal of Materials Science2007，42，3： | 1 |
| 15 | Association of late-life changes in blood pressure and cognitive status显示文摘BackgroundDisagreement 在血压和认知缺陷在在变化之间的协会上存在。我们试图检验在收缩、心脏舒张的血压( SBP 和 DBP )的4年的变化是否从一件基于人口的德国样品(年老的 60-87 年)的 854 个参加者在老人的一件代表性的样品和纵的数据的 women.MethodsAnalysis 与认知地位被联系与标准认知屏蔽和血被执行迫使大小。在 SBP 和 DBP 的变化的效果(10 mmHg 和 5 mmHg 分别地作为回归效果联合起来测量) 用非参量、线性的回归 modeling.ResultsNo 在认知地位上被评估清楚的协会在 SBP 或在 DBP 和认知分数在变化之间被看见。小效果为性别和高血压了解在层化以后被发现。明确地,在 SBP 的更大的减少在知道他们的高血压的那些人与更高认知的分数被联系(在 SBP 的 10 mmHg 减少, β=− 0.26, 95% CI:− 0.51 到 − 0.02 ) 并且有控制高血压的人(在 SBP 的 10 mmHg 减少, β=− 0.44, 95% CI:− 0.92 到 − 0.03 ) 。DBP 的另外更大的增加与控制高血压在人与更高认知的分数被联系(DBP 的 5 mmHg 增加, β= 0.67, 95% CI:0.19-1.15 ) 。为知道他们的高血压的女人,在 DBP 的更大的减少与更高认知的分数被联系(在 DBP 的 5 mmHg 减少, β=− 0.26;95%CI:− 0.51 到 − 0.01 ) 在血压的 .ConclusionsChanges 仅仅微弱地与认知地位被联系。明确地,在 SBP 的减少在知道他们医学上被控制的高血压和特别那些的男人与更高认知的分数被联系。 | Maria E Lacruz Daniel Tiller Alexander Kluttig Karin H Greiser Sebastian Nuding Karl Werdan Johannes Haerting | 2016 | Journal of Geriatric Cardiology2016，13，1： | 1 |
| 16 | Nonlinear FE analysis of steel-concrete composite structures显示文摘 | Sebastian W M McConnel R E | 2000 | Journal of Structural Engineering ASCE2000，126，6： | 1 |
| 17 | Apparent digestibility of protein and amino acids in broiler chickens fed a corn-soybean diet supplemented with microbial phytase显示文摘 | Sebastian S Touchburn S P Chavez E R | 1997 | Poult Sci1997，76，： | 1 |
| 18 | Cyclophilin A is required for TRIM5α-mediated resistance to HIV-1 in Old World monkey cells显示文摘 | Berthoux L Sebastian S Sokolskaja E | 2005 | PNAS2005，102，14： | 1 |
| 19 | Dissolution of natural ser- pentinite in mineral and organic acids 显示文摘 | Sebastian T Hannu R Sanni E | 2007 | Mineral processing2007，83，1： | 1 |
| 20 | 查看详情显示文摘 | Schaefer T Chan W K Sebastian R Schurko R Hruska F E | | 0，，： | 1 |
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