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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 2 |
| 3 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Naveen Garg Satendra Tewari Aditya Kapoor Deepak Kumar Gupta Nakul Sinha | 2000 | International Journal of Cardiology2000，，1： | 1 |
| 4 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 1 |
| 5 | Effect of Subsoiling and Preparatory Tillage on Sugar Yield, Juice Quality and Economics of Sugarcane (Saccharum species hybrid) in Sugarcane Plant-Ratoon Cropping System显示文摘 | Satendra Kumar Saini S K Amit Bhatnagar | 2012 | Society for Sugar Research & Promotion2012，14，4： | 1 |
| 6 | Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases显示文摘The highly conserved abundant nuclear protein poly(ADP-ribose)polymerase-1(PARP-1)is activated by DNA damage.PARP-1 activation is associated in DNA repair,cell death and inflammation.Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases,the attention towards PARP-1 as a | Chandra Shaker Sriram Ashok Jangra Rajaram Mohanrao Madhana Satendra Singh Gurjar Pritam Mohan Babul Kumar Bezbaruah | 2015 | Neural Regeneration Research2015，10，1： | 1 |
| 7 | Improvement of performance of Electromagnetic welding process by use of driver materials显示文摘 | S.V. Desai Satendra Kumar P. Satyamurthy J.K. Chakravartty D.P. Chakravarthy | 2011 | International Journal of Applied Electromagnetics and Mechanics2011，，2： | 1 |
| 8 | Thermal oxidation of CP Ti — An electrochemical and structural characterization显示文摘 | Satendra Kumar T.S.N. Sankara Narayanan S. Ganesh Sundara Raman S.K. Seshadri | 2010 | Materials Characterization2010，，6： | 1 |
| 9 | Thermal oxidation of CP-Ti: Evaluation of characteristics and corrosion resistance as a function of treatment time显示文摘 | Satendra Kumar T.S.N. Sankara Narayanan S. Ganesh Sundara Raman S.K. Seshadri | 2009 | Materials Science & Engineering C2009，，6： | 1 |
| 10 | Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury显示文摘To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury. | Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，11： | 1 |
| 11 | Reversal of acetaminophen induced subchronic hepatorenal injury by propolis extract in rats显示文摘 | Monika Bhadauria Satendra Kumar Nirala | 2008 | Environmental Toxicology and Pharmacology2008，，1： | 1 |
| 12 | Influence of fluoride ion on the electrochemical behaviour of β-Ti alloy for dental implant application显示文摘 | Satendra Kumar T.S.N. Sankara Narayanan S. Saravana Kumar | 2010 | Corrosion Science2010，，5： | 1 |
| 13 | Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine显示文摘 | Jun-Quan Zhao Guo-Zhen Du You-Cai Xiong Yi-Fu Wen Monika Bhadauria Satendra Kumar Nirala | 2007 | Archives of Pharmacal Research2007，，12： | 1 |
| 14 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Naveen Garg Satendra Tewari Aditya Kapoor Deepak Kumar Gupta Nakul Sinha | 2000 | International Journal of Cardiology2000，，1： | 1 |
| 15 | 查看详情显示文摘 | Satendra Kumar Sankara Narayanan T S N | | 0，，05： | 1 |
| 16 | Attenuation of beryllium induced hepatorenal dysfunction and oxidative stress in rodents by combined effect of gallic acid and piperine显示文摘 | Jun-Quan Zhao Guo-Zhen Du You-Cai Xiong Yi-Fu Wen Monika Bhadauria Satendra Kumar Nirala | 2007 | Archives of Pharmacal Research2007，，12： | 1 |
| 17 | Synergistic effects of ferritin and propolis in modulation of beryllium induced toxicogenic alterations显示文摘 | Satendra Kumar Nirala Monika Bhadanria | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 18 | Hepatic endogenous defense potential of propolis after mercury intoxication显示文摘Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent. | Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA | 2008 | Integrative Zoology2008，3，4： | 0 |
| 19 | Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats显示文摘Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(P.daemia) against anti-tuberculosis drugs(ATDs) induced liver injury.Methods:Wistar albino rats were divided into seven groups of six animal in each.The ATDs and P.daemia extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were performed.Results:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin level.Increased lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure.Administration of P.daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner.Histological and ultra-structural observations substantiated biochemical findings.Conclusions:P.daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. | Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 0 |
| 20 | sp^(2)碳用于3D打印技术综述:材料、性能和应用显示文摘3D打印可以改变现有的生产方法,是第四次工程革命中的一项现代技术。它从成型原理上提出了分层制造、逐层叠加成型的新颖生产方法,从根本上简化了制造工艺,实现了大规模定制生产。然而,这一新技术仍存在许多问题。除了纯石墨烯外,sp^(2)碳具有好的亲水性,3D打印难度较小。sp^(2)碳还可在3D打印中的各种阶段应用。纯石墨烯的疏水性使其难以在水系介质中打印和加工。毛细管油墨的发展使得纯石墨烯的3D打印成为可能。本文综述了sp^(2)碳的3D打印技术的最新进展。首先简要概述了3D打印技术,随后概述了sp^(2)碳的3D打印及其在各种方面的应用。最后,讨论了这一新领域的发展前景和机遇。 | Satendra Kumar Manoj Goswami Netrapal Singh Sathish Natarajan Surender Kumar | 2022 | 新型炭材料(中英文)2022，37，6： | 0 |
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