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| 1 | Phage treatment of Bob G Blas human infec tions显示文摘 | Stephen del et T Abedon Sarah J Kuhl al | 2011 | Bacteriophage2011，1，2： | 1 |
| 2 | Inteviewing Young Children: Effects of probe structures and focus of rapport-building talk on the qualities of young children's eyewitness statements 显示文摘 | Cindy H Sarah AL | 2004 | Canadian Journal of behavioural Science2004，，36： | 1 |
| 3 | Formation of 3-chloropropane-1,2-diol in systems simulating processed foods显示文摘 | Pavel Calta Jan Velí?ek Marek Dole?al Sarah Hasnip Colin Crews Zuzana Réblová | 2004 | European Food Research and Technology2004，，6： | 1 |
| 4 | Mortality from cardiovascular disease more than 10 years after radiotherapyfor breast cancer:nationwide cohort study of 90 000 Swedish women显示文摘 | Sarah Darby Paul McGale Richard Peto et aL | 2003 | British Medical Journal2003，326，： | 1 |
| 5 | The 29 June 2000 supcrccll observed during STEPS Part I: Kinematics and Microphysics显示文摘 | SARAH A T MILLER L J WIENS K C ct al | 2005 | J Atmo Sci2005，62，12： | 1 |
| 6 | Laparoscopic appendicectomy in pregnancy: A systematic review of the published evidence显示文摘 | Humphrey G.M. Walker Ahmad Al Samaraee Sarah J. Mills M. Reza Kalbassi | 2014 | International Journal of Surgery2014，，： | 1 |
| 7 | Phase II trial of bortezomib plus doxorubicin in hepatocellular carcinoma (E6202): a trial of the Eastern Cooperative Oncology Group显示文摘 | Kristen K. Ciombor Yang Feng Al Bowen Benson Yingjun Su Linda Horton Sarah P. Short John Sae Wook Kauh Charles Staley Mary Mulcahy Mark Powell Katayoun I. Amiri Ann Richmond Jordan Berlin | 2014 | Investigational New Drugs2014，，5： | 1 |
| 8 | β-Catenin Regulates Mesenchymal Progenitor Cell Differentiation During Hepatogenesis显示文摘 | Tove Berg Stijn DeLanghe Denise Al Alam Sarah Utley Joaquin Estrada Kasper S. Wang | 2010 | Journal of Surgical Research2010，，： | 1 |
| 9 | Reproductive tract infections: prevalence and risk factors in rural Bangladesh 显示文摘 | Sarah H Linda M Jyotsnamoy C ct al | 2002 | Bulletin of the World Health Organization2002，80，3： | 1 |
| 10 | Produc- tion of cellulose nanoeLwstals using hydrobromic acid and click reac- lions tin their surface 显示文摘 | Sadeghifar Hasan Filpponen llari Clarke Sarah P el al | 2011 | Journal of Materials Science2011，46，22： | 1 |
| 11 | Relation between peripheral blood leukocyte counts and respiratory symptoms atopy lung function and airway responsiveness in adults 显示文摘 | Sarah AL Lan DP Stnger JR | 2001 | Chest2001，119，： | 1 |
| 12 | Resveratrol acts as a mixed agonist / antagonist for estrogen receptors alpha and beta 显示文摘 | Jennifer L Bowers Valentyn V Tyulmenkov Sarah C Jernigan el al | 2000 | Endocrinology2000，141，10： | 1 |
| 13 | Regulation of Writ Signaling during Adipogenesis 显示文摘 | Christina NB Sarah ER Kenneth AL | 2002 | J Biol Chem2002，277，30： | 1 |
| 14 | The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study显示文摘 | Elisa De Franco Sarah E Flanagan Jayne AL Houghton Hana Lango Allen Deborah JG Mackay I Karen Temple Sian Ellard Andrew T Hattersley | 2015 | The Lancet . 2015 (9997)2015，，9997： | 1 |
| 15 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
| 16 | Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes显示文摘 | Andrew C Newby Sarah J el al | 2009 | Thromb Haem- ost2009，101，6： | 1 |
| 17 | IL-15 has innate antitumoractivity independent of NK and CD8 T cell 显示文摘 | Elizabeth D Sarah R Maria F M ef al | 2010 | J Leukocyte Biology2010，88，3： | 1 |
| 18 | Life Long Learning: The Prison Library as a Bridge to Participation 显示文摘 | Dorien Brosens Liesbeth De Donder Sarah Dury et al | 2015 | Procedia-Social and Behavioral Sciences2015，，191： | 1 |
| 19 | Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells显示文摘Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) cells.Methods: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 and in vitro non-toxic concentrations of various statins upon cell growth inhibition, cell cycle effects, and apoptosis induction. Mechanistic studies involved analysis of Rheb prenylation required for mTOR activation.Results: A strong synergy of CHR2863 with the statins simvastatin, fluvastatin, lovastatin, and pravastatin was demonstrated in U937 cells and two CHR2863-resistant sublines. This potent synergy between simvastatin and CHR2863 was also observed with a series of other human AML cell lines (e.g., THP1, MV4-11, and KG1), but not with acute lymphocytic leukemia or multiple solid tumor cell lines. This synergistic activity was: (i) specific for APis (e.g., CHR2863 and Bestatin), rather than for other cytotoxic agents;and (ii) corroborated by enhanced induction of apoptosis and cell cycle arrest which increased the sub-G1 fraction. Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation;this was experimentally confirmed by impaired Rheb prenylation by simvastatin.Conclusion: These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells. | Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters | 2023 | Cancer Drug Resistance2023，6，3： | 0 |
| 20 | Intelligent Solution System for Cloud Security Based on Equity Distribution:Model and Algorithms显示文摘In the cloud environment,ensuring a high level of data security is in high demand.Data planning storage optimization is part of the whole security process in the cloud environment.It enables data security by avoiding the risk of data loss and data overlapping.The development of data flow scheduling approaches in the cloud environment taking security parameters into account is insufficient.In our work,we propose a data scheduling model for the cloud environment.Themodel is made up of three parts that together help dispatch user data flow to the appropriate cloudVMs.The first component is the Collector Agent whichmust periodically collect information on the state of the network links.The second one is the monitoring agent which must then analyze,classify,and make a decision on the state of the link and finally transmit this information to the scheduler.The third one is the scheduler who must consider previous information to transfer user data,including fair distribution and reliable paths.It should be noted that each part of the proposedmodel requires the development of its algorithms.In this article,we are interested in the development of data transfer algorithms,including fairness distribution with the consideration of a stable link state.These algorithms are based on the grouping of transmitted files and the iterative method.The proposed algorithms showthe performances to obtain an approximate solution to the studied problem which is an NP-hard(Non-Polynomial solution)problem.The experimental results show that the best algorithm is the half-grouped minimum excluding(HME),with a percentage of 91.3%,an average deviation of 0.042,and an execution time of 0.001 s. | Sarah Mustafa Eljack Mahdi Jemmali Mohsen Denden Mutasim Al Sadig Abdullah M.Algashami Sadok Turki | 2024 | Computers, Materials & Continua2024，78，1： | 0 |
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