|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases. | Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci | 2014 | World Journal of Clinical Oncology2014，5，3： | 18 |
| 2 | Prevalence and risk factors of stress-induced gastrointestinal bleeding in critically ill children显示文摘AIM: To assess the frequency and the risk factors of stress-induced gastrointestinal (GI) bleeding in children admitted to a pediatric intensive care unit (PICU).METHODS: The medical records of children aged between 1 month and 15 years admitted to the PICU between January 2002 and December 2002 were reviewed.Demographic data, indications for PICU admission, principle diagnosis, and basic laboratory investigations were recorded. Previously described factors for stress ulcer bleeding (mechanical ventilation, sepsis, acute respiratory distress syndrome, renal insufficiency, coagulopathy,thrombocytopenia, and intracranial pathology) were used as independent variables in a multivariate analysis.RESULTS: One hundred and seventy of two hundred and five medical records were eligible for review. The most common indication for PICU admission was respiratory failure (48.8%). Twenty-five children received stress ulcer bleeding prophylaxis with ranitidine. The incidence of stress ulcer bleeding was 43.5%, in which 5.3% were clinically significant bleeding. Only mechanical ventilation and thrombocytopenia were significantly associated with stress ulcer bleeding using the univariate analysis.The odds ratio and 95% confidence intervals were 5.13(1.86-14.12) and 2.26 (1.07-4.74), respectively. However, the logistic regression analysis showed that mechanicai ventilation was the only significant risk factor with the odds ratio of 14.1.CONCLUSION: The incidence of gastrointestinal bleeding was high in critically ill children. Mechanical ventilation was an important risk factor for gastrointestinal bleeding. | Chookhuan Nithiwathanapong Sanit Reungrongrat Nuthapong Ukarapol | 2005 | World Journal of Gastroenterology2005，11，43： | 6 |
| 3 | Phosphodiesterase-3 inhibitor (cilostazol) attenuates oxidative stress-induced mitochondrial dysfunction in the heart显示文摘BackgroundCilostazol 是是的 3 phosphodiesterase 禁止者以前表明了阻止 tachyarrhythmia 的出现并且改进 defibrillation 功效的一种类型。然而,为这有益的效果的机制仍然是不清楚的。因为心脏的线粒体被显示了玩,在致命的心脏的心律不齐和那个氧化压力的一个关键角色是到心律不齐产生的主要贡献者之一,我们在严重氧化 stress.MethodsMitochondria 下面在心脏的线粒体上测试了 cilostazol 的效果从老鼠心被孤立并且与 H 对待 2导致氧化应力的 O 2。在各种各样的集中, Cilostazol 被用来学习它的保护的效果。药理学干预,包括一个 mitochondrial 渗透转变毛孔(mPTP ) blocker, cyclosporine A (CsA ) ,和一条内部膜阴离子隧道(IMAC ) blocker, 4 ′ -chlorodiazepam (CDP ) ,被用来在心脏的线粒体上调查 cilostazol 的机械学的角色。心脏的 mitochondrial 当当由阻止 mitochondrial 去极暴露了到氧化应力时,心脏的 mitochondrial function.ResultsCilostazol 的指示物保存了心脏的 mitochondrial 功能,反应的氧种类( ROS )生产,胀大的 mitochondrial 膜潜力变化和 mitochondrial 被决定, mitochondrial 胀大,并且减少 ROS production.ConclusionsOur 调查结果建议 cilostazol 的效果以前报导了的那 cardioprotective 能由于它的 | Siriporn C. Chattipakom Savitree Thummasorn Jantira Sanit Nipon Chattipakorn | 2014 | Journal of Geriatric Cardiology2014，11，2： | 3 |
| 4 | Effect of methylmercury on LPO levels, SH groups and activities of GSH-Px, SOD, XOD in liver of rats显示文摘In recent years, lipid peroxidation has been considered as the initial step for foreign toxic substances to damage cells. In this paper, the effects of methylmercury (MeHg) on LPO (lipid peroxide) levels, SH (sulfhydryl) groups and activities of GSH\|Px (glutathione peroxidase), SOD (superoxide dismutase), XOD (xanthine oxidase) in liver of rats treated with doses of MeHg at different intervals were studied by TBA, Ellman Reagent, NBT colorimetric methods and chemilluminescence. Meanwhile, the contents of FR (free radical)and MeHg in the liver of female rats were measured by ESR and GC. Results showed that the LPO levels in the experimental group increased significantly over those of the control group ( p<0.05— p<0.001) , reaching maximum point on the first poisoning day. Both male and female rats showed marked positive dose\|effect relations (Male: Y=261.4±49.4X, r=0.94, p<0.02; Female : Y=255.0±73.0X, r=0.99, p<0.001 ). N-SH (nonprotein sulfhydryl), P\|SH (protein sulfhydryl), T-SH (total sulfhydryl) contents and GSH\|Px activities decreased significantly (p<0.05-p<0.001). For GSH\|Px, both groups reached minimum value on the first poisoning day. In female rats, activities of SOD and XOD increased markedly ( p<0.02-p<0.01 ) although the contents of FR showed no significant changes. The contents of MeHg was determined by GC, and it ranged from 0.0081—0.0191 ppm. | LIU Jin\|yu 1, GUAN Ming 1, SUN Zhi\|wei 1, LIN Xiu\|wu 1, CAO Peng\|yuan 2, MENG Xiang\|dong 2 (1. Norman Bethune University of Medical Sciences, Changchun 130021, China 2. Sanitation and Antiepidemic Station of Jilin Province, Changchun, Chin | 2000 | Journal of Environmental Sciences2000，12，S1： | 2 |
| 5 | Response to cadmium in higher plants显示文摘 | L Sanità di Toppi R Gabbrielli | 1999 | Environmental and Experimental Botany1999，，2： | 2 |
| 6 | 大别山区痴呆病病因的遗传学研究显示文摘 | Station of Sanitation and Bpedemic Prevention of Anching District Anhni ProvinceInstitute of Genetics of Fu Dan University ShanghaiThe Sixth People’s Hospital of Shanghai | 1979 | 遗传学报1979，，03： | 1 |
| 7 | Kinetics of adsorption on carbon from solution显示文摘 | Weber W J J Morriss J C Sanit J | 1963 | Journal of the Sanitary Engineering Division American Society of Civil Engineers1963，89，1： | 1 |
| 8 | Calcium-in- duced cardiac mitochondrial dysfunction is predominantly mediated by cyclosporine A-dependent mitochondrial per- meability transition pore 显示文摘 | Yarana C Sripetehwandee J Sanit J | 2012 | Arch Med Res2012，43，5： | 1 |
| 9 | Response to cadmium in higher plants显示文摘 | SANIT(A) DI T GABBRIELLI R | 1999 | Environmental and Experimental Botuny1999，41，： | 1 |
| 10 | 双鸭山市大骨节病区换粮防病措施效果的流行病学研究显示文摘 | Shuangyashan Sanitation Antiepidemic Station Department of Kaschin Beck Disease Harbin Medical College | 1982 | 中国地方病学杂志1982，，01： | 1 |
| 11 | Poly (methyl methacrylate-co-butyl acrylate)/organophosphate-modified montmorillonite composites显示文摘 | Sanit Sirapanichart Pathavuth Monvisade Punnama Siriphannon | 2011 | Iran Polym J2011，20，10： | 1 |
| 12 | 双鸭山市大骨节病区换粮防病措施效果的流行病学研究显示文摘 | Shuangyashan Sanitation Antiepidemic Station Department of Kaschin Beck Disease Harbin Medical College | 1982 | 中国地方病学杂志1982，，01： | 1 |
| 13 | 桂林市生活垃圾的调查分析显示文摘由于在桂林市进行了中德垃圾收运处置技术示范工程 ,需要对桂林市生活垃圾成分进行调查 ,介绍了调查分析需用的仪器 ,调查方法和分析结果。 | German Cologne Water Research Company,Guilin Environmental Sanitation Bureau,541001 Guilin | 2001 | 环境卫生工程2001，9，1： | 1 |
| 14 | Study on Micronucleus Frequency in PeripheralLymphocytes in Workers of Match Factories显示文摘This paper reports the results of the study of micronucleus frequency in peripheral lymphocytes in workers exposed to soft wood dust (poplar and linden wood) in match factories. 298 workers exposed to soft wood dust in three match factories were defined as exposure group and 45 waiters in a restaurant as control group. The frequency of micronucleus in peripheral lymphocytes was examined and the control’s 95% confidential upper limit≥ 4‰ was defined as the standard to determine the positivity. The positive rate in the exposure group was 36.2% while that in the control group was only 4.4%; the difference is significant (P <0.01). As the coefficient of correlation between length of work and positive rate was 0.86 (P <0.01 ), a dose/time-response is in existence. Meanwhile, the analysis of relation between quantity of smoking and positive rate eliminated the effect of smoking on variation of positive rates. In this paper, we also discussed the relation between positive rates and wood dust concentrations in different worksites and we think that the volatile and unsteady substances in soft wood dust are micronucleus-inducing | JIANG ZHI-CHENG SU YI-LAN ZHANG JIE DENG YI-FU MA ZHAO-HUA DONG QUANG-LEI(Department of Occupational Health, Capital Institute of Medicine, Beijing)(Ningpo City Sanitation and Anti-epidemic Station, Zhejiang Province)(Chongwen District Sanitation and | 1994 | Biomedical and Environmental Sciences1994，7，2： | 1 |
| 15 | Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload显示文摘 | Sripctchwandee J Kenknight SB Sanit J | 2013 | Acta Physiol (Oxf)2013，，： | 1 |
| 16 | Response to cadmium in carrot in vitro plants and cell suspension cultures显示文摘 | SANIT DI T L LAMBARDI M PAZZAGLI L | 1998 | Plant Science1998，137，： | 1 |
| 17 | Calcium-induced car- diac mitochondrial dysfunction is predominantly mediated by cy- closporine A-dependent mitochondrial permeability transition pore 显示文摘 | Yarana C Sripetchwandce J Sanit J | 2012 | ArchMedRes2012，43，5： | 1 |
| 18 | The intellectual capital dimensions of Ducatts turnaround: exploring knowledge assets grounding-a change management program显示文摘 | SCHIUMA G LERRO A SANITATE D | 2008 | International Journal of Innovation Manage- ment2008，12，2： | 1 |
| 19 | Incidence of Staphylococcus aureus and associated risk factors in Nham, a Thai fermented pork product显示文摘 | Nipa Chokesajjawatee Sarinya Pornaem Young-Gun Zo Sanit Kamdee Plearnpis Luxananil Srianant Wanasen Ruud Valyasevi | 2009 | Food Microbiology2009，，5： | 1 |
| 20 | Response to Cadmium in vitro liants and cell suspension cultures显示文摘 | SANIT T L LAMBARDI M | 1998 | Plant Sci1998，137，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员