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| 1 | Role of different imaging modalities of vascular calcification in predicting outcomes in chronic kidney disease显示文摘Vascular calcification(VC) is common among patientswith chronic kidney disease(CKD).The severity of VC is associated with increased risk of cardiovascular events and mortality.Risk factors for VC include traditional cardiovascular risk factors as well as CKD-related risk factors such as increased calcium and phosphate load.VC is observed in arteries of all sizes from small arterioles to aorta,both in the intima and the media of arterial wall.Several imaging techniques have been utilized in the evaluation of the extent and the severity of VC.Plain radiographs are simple and readily available but with the limitation of decreased sensitivity and subjective and semi-quantitative quantification methods.Mammography,especially useful among women,offers a unique way to study breast arterial calcification,which is largely a medial-type calcification.Ultrasonography is suitable for calcification in superficial arteries.Analyses of wall thickness and lumen size are also possible.Computed tomography(CT) scan,the gold standard,is the most sensitive technique for evaluation of VC.CT scan of coronary artery calcification is not only useful for cardiovascular risk stratification but also offers an accurate and an objective analysis of the severity and progression. | Sinee Disthabanchong Sarinya Boongird | 2017 | World Journal of Nephrology2017，6，3： | 8 |
| 2 | Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells显示文摘AIM: To investigate whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in chol-angiocarcinoma cells (CCA) and the role of reactive oxygen generation in sensitizing the cells. METHODS: Four human cell lines with different NQO1 activity were used; the human CCA cell lines, KKU-100, KKU-OCA17, KKU-M214, and Chang liver cells. NQO1 activity and mRNA expression were determined. The cells were pretreated with dicoumarol at relevant concentrations before treatment with gemcitabine. Cytotoxicity was determined by staining with fluorescent dyes. Oxidant formation was examined by assay of cellular glu-tathione levels and reactive oxygen species production by using dihydrofluorescein diacetate. Measurement of mitochondrial transmembrane potential was performed by using JC-1 fluorescent probe. Western blotting analysis was performed to determine levels of survival related proteins. RESULTS: Dicoumarol markedly enhanced the cytotoxicity of gemcitabine in KKU-100 and KKU-OCA17, the high NQO1 activity and mRNA expressing cells, but not in the other cells with low NQO1 activity. Dicoumarol induced a marked decrease in cellular redox of gluta-thione in KKU-100 cells, in contrast to KKU-M214 cells. Dicoumarol at concentrations that inhibited NQO1 activity did not alter mitochondrial transmembrane potential and production of reactive oxygen species. Gemcitabine alone induced activation of NF-κB and Bcl-XL protein expression. However, gemcitabine and dicoumarol combination induced increased p53 and decreased Bcl-XL levels in KKU-100, but not in KKU-M214 cells. CONCLUSION: NQO1 may be important in sensitizing cells to anticancer drugs and inhibition of NQO1 may be a strategy for the treatment of CCA. | Benjaporn Buranrat Auemduan Prawan Upa Kukongviriyapan Sarinya Kong-petch Veerapol Kukongviriyapan | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 3 | Incidence of Staphylococcus aureus and associated risk factors in Nham, a Thai fermented pork product显示文摘 | Nipa Chokesajjawatee Sarinya Pornaem Young-Gun Zo Sanit Kamdee Plearnpis Luxananil Srianant Wanasen Ruud Valyasevi | 2009 | Food Microbiology2009，，5： | 1 |
| 4 | Role of the CHADS 2 Score in the Evaluation of Thromboembolic Risk in Patients With Atrial Fibrillation Undergoing Transesophageal Echocardiography Before Pulmonary Vein Isolation显示文摘 | Sarinya Puwanant Brandon C. Varr Kevin Shrestha Sarah K. Hussain W.H. Wilson Tang Ruvin S. Gabriel Oussama M. Wazni Mandeep Bhargava Walid I. Saliba James D. Thomas Bruce D. Lindsay Allan L. Klein | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 5 | Antiviral medicinal plants found in Lanna traditional medicine显示文摘Traditional medicine uses a multitude of plants to create medicinal formulations,some of which show antiviral properties that may be of benefit in treating emerging viral diseases,including Covid-19.Lanna,an ancient Kingdom in Northern Thailand,with a thriving culture that continues to this day and has a rich history of traditional medicine using local plants that is still practiced today.To find potential antiviral medicinal candidates,we examined ancient manuscripts,interviewed traditional healers practicing today,and inventoried current traditional medicines to catalogue 1400 medicinal formulations used in Lanna traditional medicine.We then narrowed this list to find those traditionally used to treat diseases that in their original use and descriptions most likely map to those we know today to be viral diseases.We identified the plants used in these formulations to create a list of 64 potential antiviral herbal candidates drawn from this ancient Lanna wisdom and matched these to the scientific literature to see which of these plants had already been shown to possess antiviral properties,generating a list of64 potential antiviral medicinal candidates from Lanna traditional medicine worth further investigation for treating emerging viral diseases. | Jakaphun Julsrigival Panee Sirisa-ard Sarinya Julsrigival Nararat Akarchariya | 2021 | Chinese Herbal Medicines2021，13，4： | 1 |
| 6 | Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis显示文摘Objective:To investigate anti-tumor effect of rice bran hydrolysates(RBH)on proliferation,migration,invasion,and angiogenesis of cholangiocarcinoma(CCA)cells,and elucidate the underlying mechanisms.Methods:RBH was prepared from Tubtim Chumprae rice(Oryza sativa L.)by hydrothermolysis followed by protease digestion.Phenolic content in RBH was analyzed by high-performance liquid chromatography.Human CCA cells,KKU-156,KKU-452,and KKU-100,were used to study the effects of RBH on proliferation,migration,invasion,and adhesion by wound healing,Transwell chamber,and fibronectin cell adhesion assays.Angiogenesis was evaluated using human umbilical vein endothelial cells.Proteins associated with cancer progression were analyzed by immunobloting assays.Results:RBH contained carbohydrates,proteins,lipids,and various phenolic compounds and flavonoids.RBH did not inhibit CCA proliferation,but strongly suppressed migration,invasion,adhesion of CCA cells,and the formation of tube-like capillary structures of human umbilical vein endothelial cells.Moreover,RBH downregulated phosphorylation of FAK,PI3K,and Akt,suppressed NF-κB nuclear translocation,decreased the expression of ICAM-1,vimentin and vascular endothelium growth factor(VEGF),and increased the expression of E-cadherin.Conclusions:RBH suppresses CCA cell migration and invasion and decreases expression of proteins involved in cancer metastasis.RBH is a potential food supplement for cancer prevention. | Suphanthip Phusrisom Laddawan Senggunprai Auemduan Prawan Sarinya Kongpetch Upa Kukongviriyapan Supawan Thawornchinsombut Sirithon Siriamornpun Theeraphan Chumroenphat Ronnachai Changsri Veerapol Kukongviriyapan | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，7： | 0 |
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