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| 1 | Characteristics of Obesity and Its Related Disorders in China显示文摘Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences.Abdominal obesity,also known as central obesity,refers to the presence of excess fat in the abdominal area.Obesity,especially abdominal obesity,contributes to many metabolic disorders including metabolic syndrome (MetS),type 2 diabetes (T2DM) and cardiovascular diseases (CVD).The incidence of obesity has increased dramatically in recent years worldwide.In China,more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS.The pathogenesis underlying the abdominal obesity remains unclear.The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments (lifestyle changes,pharmacological interventions and surgical therapies) before a serious consequence becomes clinically apparent.In this review,we discuss the prevalence,pathogenesis and clinic features of obesity in China. | WEI-PING JIA ,CHEN WANG,SHAN JIANG,AND JIE-MIN PAN Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute,Shanghai Clinical Center of Diabetes,Shanghai 200233,China | 2010 | Biomedical and Environmental Sciences2010，23，1： | 46 |
| 2 | 上海市15年妊娠合并心脏病的临床资料分析显示文摘目的:探讨妊娠合并心脏病的变化趋势。方法:对上海市10所教学医院1981~1995年住院分娩的妊娠合并心脏病患者的临床资料进行回顾性分析。结果:379065例分娩中,合并心脏病2680例,发病率为0.71%;死亡15例,病死率为0.56%,死亡专率为3.96/10万,占孕产妇总死亡数的12.40%。将15年分为1981~1985年、1986~1990年、1991~1995年3个时期观察,心脏病孕妇的死亡率分别占总死亡数的4.48%、22.86%及21.05%。先天性心脏病孕妇1333例,占49.74%;风湿性心脏病孕妇759例,占28.32%,前者与后者之比为1.761,从3个时期的资料来看,二者的比例分别为1.271,2.371及2.811。心功能Ⅰ级与Ⅱ级者共占妊娠合并心脏病患者总数的85.45%,发生心力衰竭者为7.60%。妊娠合并心脏病的围产儿死亡率为7.76‰。分娩方式常采用剖宫产。结论:妊娠合并心脏病至今仍是孕产妇死亡的主要原因之一。应建立孕前咨询中心,根据其心脏病种类及分型、心功能状况进行评分,以判定该患者能否妊娠。 | Luo Laimin, Dai Zhongying. Shanghai Sixth People’s Hospital, Shanghai 200233 | 1997 | 中华妇产科杂志1997，32，6： | 35 |
| 3 | Early intrajejunal nutrition: bacterial translocation and gut barrier function of severe acute pancreatitis in dogs显示文摘Objective: To evaluate the effect of early intrajejunalnutrition in attenuating bacterial and/or endotoxintranslocation and improving gut barrier function ofsevere acute pancreatitis (SAP) in dogs.Methods: 15 dogs were divided into parenteral nutrition(PN) group(7 dogs)and early intrajejunal nutrition(EIN) group(8). EIN was delivered nutrients via a nee-dle jejunostomy catheter feeding at 48h after operation.SAP model was induced by injecting 1 ml/kg of com-bined solution of 5% sodium taurocholate and 8000-10000 BAEE units trypsin/ml into the pancreas via thepancreatic duct. Systemic blood samples were ob-tained before and 1, 3, 5, 7 d following SAP, and culturedby aerobic as well as anaerobic bacterial growth. Systemicplasma and portal vein endotoxin levels were quantifiedby the chromogenic limulus amebocyte lysate (LAL)technique. Portal vein blood and specimens of tissuefrom the mesenteriolum and mesocolon lymph nodes,lung, pulmonary portal lymph nodes, pancreatitis tissueand periopancreas tissue were adopted before the experi-ment was finished. Aliquots of the homogenata were cul-tured as blood mentioned above to determine the magnitudeof the bacteria DNA, protein and the villi, the thickness ofmucosa, and the whole bowel wall of the ileum and trans-verse colon were measured.Results: The study showed that the levels of systemicplasma endotoxin and the magnitude of bacterialtranslocation to the portal and systemic blood and dis-tant organ were reduced significantly in the EINgroup as compared with the TPN group. The contentsof protein and DNA, the height of villi, the thicknessof mucosa and whole bowel wall of the ileum andtransverse colon in the EIN group were higher thanthose in the PN group.Conclusion: Our results suggested that EIN is safe andeffective to be adopted by intrajejunal delivery of nu-trients in SAP, decreases the occurrence of gut bacterialtranslocation, and improves the gut barrier function. | Huan-Long Qin Zhen-Dong Su Qi Gao Qing-Tian Lin From the Department of Surgery, Shanghai Sixth People’s Hospital, Shanghai, 200233, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 20 |
| 4 | Effect of N-desulfated heparin on hepatic/renal ischemia reperfusion injury in rats显示文摘AIM: To investigate the effect of N-desulfated heparin onhepatic/renal ischemia and reperfusion injury in rats.METHODS: Using rat models of 60 minutes hepatic or renalischemia followed by 1 h,3 h,6 h and 24 h reperfusion,animalswere randomly divided into following groups,the shamoperated controls,ischemic group receiving only normalsaline,and treated group receiving N-desulfated heparin ata dose of 12 mg/kg at 5 minutes before reperfusion. P-selectin expression was detected in bepatic/renal tissueswith immunohistochemistry methodRESULTS: P-selectin expression, serum ALT, AST, BUN andCr levels were significantly increased during 60 minuteischemia and 1 h, 3 h, 6 h and 24 h reperfusion,while theincrement was significantly inhibited,and hepatic/renalpathology observed by light microscopy was remarkablyimproved by treatment with the N-desulfated heparin.Furthermore,the heparin was found no effects on PT and KPTT.CONCLUSION: P-selectin might mediate neutrophilinfiltration and contribute to hepatic/renal ischemia andreperfusion. The N-desulfated heparin might preventhepatic/renal damage induced by ischemia and reperfusioninjury without significant anticoagulant activity. | Tong Zhou Wei Song Feng Wang Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Jin-Lian Chen Department of Gastroenterology,Shanghai Sixth People’s Hospital,Shanghai 200233,China Ming-Jun Zhang Animal Laboratory,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Pei-Hua Ni,Department of Biochemistry,Shanghai Second Medical University,Shanghai 200025 Jian-Guo Geng Institute of Biochemistry and Cell Biology,Shanghai 200030,China | 2002 | World Journal of Gastroenterology2002，8，5： | 20 |
| 5 | Deep seismic reflection profiling revealing the complex crustal structure of the Tongling ore district显示文摘The deep seismic profiling across the Tongling ore district reveals a complex crustal structure. Strong contrasting dipping layered reflections (4—11 s, TWT),which dominate the lower crust of the northern part of the profile, are interpreted as the underplating of the basalt related to extensional tectonism. In the south of the profile, the Yangtze craton is characterized by strong reflections in the middle crust, showing a distinct two-layer crustal structure. Over the region of the Tongling uplift, there appear the complex arc shape reflections, suggesting folded, faulted and intruded structures, and the transparent zone below them reveals the existence of batholith. The south dipping strong reflections between the upper crust and lower crust (4—7 s, TWT) suggest a detachment between them. The detachment provided space for the magma intrusion, and caused the formation of the batholith. The Yangtze craton has a clear Moho re-flection, while the Tongling uplift has a weak Moho, whereas below the reflective lower crust in the northern part of the profile, there are sub-Moho reflections. The abrupt variation of the Moho characteristics within a short distance indicates the complexity of magmatic activity. | L5 Qingtian1, HOU Zengqian1, ZHAO Jinhua1, SHI Danian1, WU Xuanzhi1, CHANG Yinfo1, PEI Rongfu1,HUANG Dongding2 & KUANG Chaoyang2 1. Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China 2. The Sixth Geophysical Exploration Brigade, Petroleum Bureau of East China, Nanjing 210009, China | 2004 | Science China Earth Sciences2004，47，3： | 18 |
| 6 | Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry显示文摘AIM:To elucidate the underlying mechanisms of metastasis and to identify the metabolomic markers of gastric cancer metastasis.METHODS:Gastric tumors from metastatic and nonmetastatic groups were used in this study.Metabolites and different metabolic patterns were analyzed by gas chromatography,mass spectrometry and principal components analysis (PCA),respectively.Differentiation performance was validated by the area under the curve (AUC) of receiver operating characteristic curves.RESULTS:Twenty-nine metabolites were differentially expressed in animal models of human gastric cancer.Of the 29 metabolites,20 were up-regulated and 9 were down-regulated in metastasis group compared to non-metastasis group.PCA models from the metabolite profiles could differentiate the metastatic from the nonmetastatic specimens with an AUC value of 1.0.These metabolites were mainly involved in several metabolic pathways,including glycolysis (lactic acid,alaline),serine metabolism (serine,phosphoserine),proline metabolism (proline),glutamic acid metabolism,tricarboxylic acid cycle (succinate,malic acid),nucleotide metabolism (pyrimidine),fatty acid metabolism (docosanoic acid,and octadecanoic acid),and methylation(glycine).The serine and proline metabolisms were highlighted during the progression of metastasis.CONCLUSION:Proline and serine metabolisms play an important role in metastasis.The metabolic profiling of tumor tissue can provide new biomarkers for the treatment of gastric cancer metastasis. | Jin-Lian Chen,Jun-Duo Hu,Jing Fan,Jing Hong,Department of Gastroenterology,Shanghai Sixth People’s Hospital,Shanghai Jiao Tong University,Shanghai 200233,China Hui-Qing Tang,Jian-Zhong Gu,Shanghai Laboratory Animal Center,Chinese Academy of Sciences,Shanghai 201615,China | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 7 | Moleucle action mechunisms of NM-3 on human gastric cancer SGC-7901 Cells in vivo or in vitro显示文摘AIM: To study the moleucle action mechunisms of NM-3 on the growth of human gastric cancer SGC-7901 cells in vivo or in vitro.METHODS: SGC-7901 from human non-differentiated gastric cancer cell line was cultured with NM-3 at 100 mg/ml for 24 h. We observed its inhibitory rate and the density of micro-vascular growth in grafted mice with human gastric cancer SGC-7901. The apoptosis of human gastric cancer SGC-7901 was revealed in NM-3 treatment group by using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-fluorescene nick end labeling (TUNEL)method and flow cytometry analysis.RESULTS: The growth of SGC-7901 cells was markedly inhibited compared with control growp, which was smaller than that in normal saline control group (4.17 g±0.22 g VS 9.45 g±1.38 g, P<0.01). The level of apoptosis of human gastric cell line SGC-7901 was obviously increased in NM-3treatment group at 1 mg.L-1 for 24 h. NM-3 inducing apoptotic index in NM-3 plus carboplatin group was 3.5 times that of carboplatin control group (TUNEL: 27.98±6.12 % VS 12.94±2.12 %, FACScan: 26.86±5.69 % VS11.86±1.09 %,P<0.01). Western blot analysis showed that the apoptotic index of human gastric cancer was elevated for 12, 24 and 36 h with an evident time-effect relationship in groups at 100 mg.L-L. NM-3 enhanced the inhibitive effects and sensitivity of chemotherapy for human gastric cancer in nude mice. These results suggested that NM-3 played a key inhibitive role in the growth of grafted human gastric cancer in nude mice.CONCLUSION: NM-3 can inhibit the growth of human gastric cancer cell line SGC-7901, and enhance the sensitivity of carboplatin on SGC-7901 and induced its apoptosis. | Jin-Shui Zhu Bo Shen Jin-Lian Chen Guo-Qiang Chen Xiao-Hu Yu Hua-Fang Yu Zu-Ming Zhu, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China Guo-Qiang Chen, Shanghai Experimental Animal Center, Chinese Academy of Sciences, Shanghai 200233, China | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 8 | Short-segment Barrett's esophagus and cardia intestinal metaplasia:A comparative analysis显示文摘AIM:To investigate the endoscopy and histology of short-segment Barrett's esophagus (SSBE) and cardia intestinal metaplasia (CIM),and their correlation with Helicobacter pylori (H. pylori) gastritis and gastroesophageal reflux disease (GERD). METHODS:Biopsy specimens were taken from 32 SSBE patients and 41 CIM patients with normal appearance of the esophagogastric junction. Eight biopsy specimens from the lower esophagus,cardia,and gastric antrum were stained with hematoxylin/eosin,Alcian blue/periodic acid-Schiff,Alcian blue/high iron diamine and Gimenez dye. Results were graded independently by one pathologist. RESULTS:The SSBE patients were younger than the CIM patients (P < 0.01). The incidence of dysplasia and incomplete intestinal metaplasia subtype was higher in SSBE patients than in CIM patients (P < 0.01). H. pylori infection was correlated with antral intestinal metaplasia (P < 0.05),but not with reflux symptomatic,endoscopic,or histological markers of GERD in CIM patients. SSBE was correlated with reflux symptomatic and endoscopic esophagitis (P < 0.01),but not with H. pylori infection and antral intestinal metaplasia. CONCLUSION:Dysplasia risk is significantly greater in SSBE patients than in CIM patients. CIM is a manifestation of H. pylori-associated and multifocal atrophic gastritis,whereas SSBE may result from GERD. | Ying Chang,Digestive Endoscopic Center,Shanghai Sixth Hospital,Shanghai Jiao Tong University,Shanghai 200233,China Bin Liu,Department of Emergence Surgery,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi Province,China Gui-Sheng Liu,Department of Gastroenterology,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi Province,China Tao Wang,Department of Gastroenterology,First Hospital of Xi’ an Jiaotong University,Xi’an 710061,Shaanxi Province,China Jun Gong,Department of Gastroenterology,Second Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi Province,China | 2010 | World Journal of Gastroenterology2010，16，48： | 3 |
| 9 | Effect of Initial Microstructure on Warm Deformation Behavior of 45 Steel显示文摘In order to investigate the effect of initial microstructure on warm deformation behavior, some specimens of 45 steel were annealed and some quenched. Then the specimens were isothermally compressed on a Gleeble 3500 machine. The deformation temperature range was 550 to 700 ℃ and the strain rate range was 0.001 to 0.1 s-1. An optical microscope (OM) and a transmission electron microscope (TEM) were used to study the microstructures. The results show that the microstructure of annealed specimens is ferrite and pearlite and that of quenched specimens is martensite. The flow stress of quenched specimens is higher than that of annealed ones at 550 ℃ when strain rates are greater than 0.001 s-1. However, at 600 to 700 ℃ and strain rate of 0.001 s-1, the whole flow curves of quenched specimens are below that of annealed ones. Under the rest conditions, the flow stress of quenched specimens is higher at the beginning of compression and then the opposite is true after the strain is greater than a critical value. The microstructure examination proves that the tempering and dynamic recrystallization easily occur in the specimens with martensite during warm compression, which results in the above phenomena. | ZHAO Xin1, YANG Xiao-ling2, JING Tian-fu3 (1. The Sixth Department, Zhengzhou Institute of Aeronautics, Zhengzhou 450015, Henan, China 2. Zhengzhou Zhongxing Basic Constructions Development Co Ltd, Zhengzhou 450015, Henan, China 3. State Key Laboratory of Metastable Materials Science and Technology, Qinhuangdao 066004, Hebei, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，8： | 3 |
| 10 | Ultrasonography in predicting and screening liver cirrhosis in children:A preliminary study显示文摘AIM: To evaluate the value of ultrasonography in predicting and screening liver cirrhosis in children.METHODS: Twenty-eight children with liver cirrhosis of various etiologies were examined by routine ultrasonography.A percutaneous liver biopsy guided by ultrasound was also performed on each patient, and the results of liver biopsy and ultrasonography were compared.RESULTS: When compared with the biopsy results,ultrasonography in combination of clinical and laboratory findings gave accurate diagnoses of children liver cirrhosis.Although ultrasound imaging of children with liver cirrhosis revealed abnormal characteristics, these images were not specific to this disease, thus reinforcing the necessity of ultrasound-guided liver biopsy in the diagnosis of children liver cirrhosis.CONCLUSION: Ultrasonography is reliable in the diagnosis of children liver cirrhosis, and its usefulness should be stressed in the screening and follow-up of high-risk pediatric patients. | Jia-An Zhu Bing Hu, Department of Ultrasound in Medicine, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China | 2003 | World Journal of Gastroenterology2003，9，10： | 3 |
| 11 | At what order does MP theory give exact geometries显示文摘 | He Y Cremer D Molecular geometries at sixth order Moller-Plesset perturbation theory | 2000 | Journal of physical chemistry A2000，104，32： | 2 |
| 12 | Hydrothermal Solidification of Diatomite and Its Heat Insulating Property显示文摘To meet the commercial requirements of inorganic heat insulators,the mixture of diatomite and Ca(OH)2 are evenly dispersed,mold-compacted,and then hydrothermally solidified due to the formation of tobermorite under an autoclaved process.Systematic investigations of the preparation conditions(including mix ratio,autoclaved factors,mold pressure,etc)were carried out to optimize the serving properties of such tobermorite-based products.As a result,a compressive strength of more than 30 MPa was realized for the specimen in high density(about 1.30(g·cm-3)).On the contrary,the specimen in light weight for example 0.63(g·cm-3)typically showed a thermal conductivity of around 0.12(W·m-1·K-1).The present work developed a feasible way to produce and to control the serving properties of diatomite-based heat insulators by a process of hydrothermal solidification,in which the optimized value of Ca/Si ratio was proposed to be 0.6~0.7,while the water content is 25% in weight,and hydrothermal reaction is performed at 180 ℃ for no more than 24 hours. | TONG Yu1,GAO Jian1,XIA Feng1,XU Dawei2,SONG Lili3,YANG Wenrui1,ZENG You1(1.School of Materials Science and Engineering,Shenyang Jianzhu University,Shenyang,China,110168 2.China Construction Sixth Engineering Division Co.,Ltd.,Tianjin,China,300451 3.Beijing Division,Jiangsu Zheng He Tat Hong Equipment Rental Co.,Ltd.,Beijing,China,100102) | 2012 | 沈阳建筑大学学报(自然科学版)2012，28，1： | 2 |
| 13 | Parenteral versus early intrajejunal nutrition:Effect on pancreatitic natural course,entero-hormones release and its efficacy on dogs with acute pancreatitis显示文摘AIM: To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion and its efficacy on dogs with acute pancreatitis.METHODS: An acute pancreatitis model was induced by injecting 1 ml/kg of combined solution (2.5% sodium taurocholate and 8 000-10 000 BAEE units trypsin/mi) into the pancreas via pancreatic duct. Fifteen dogs were divided into parenteral nutrition (PN) group and EIN group. Two groups were isonitrogenous and isocaloric. EIN was used at postoperative 24 h. Serum glucose, calcium, amylase and lysosomal enzymes were determined before and 1, 4, 7 d after acute pancreatitis was induced. All the dogs were injected 50 uCi 125I-BSA 4 h before sacrificed on the 7th day.The 125I -BSA index of the pancreas/muscle, pancreas/blood,and pancreas pathology score (PPS) were determined. The peripheral plasma cholecystokinin (CCK), secretin (SEC) and gastrin were measured by ELISA and RIA, and was quantitative analysis of pancreatic juice and amylase,pancreatolipase and HCO3-, Cl-, Na+ and K+ performed by an autochemical analyzer at 30, 60, 120 and 180 min after beginning PN or EIN on the first day.RESULTS: There was no difference between two groups in the contents of serum calcium, amylase and lysosomal enzymes, 125I-BSA index of pancreas/muscle and pancreas/blood and PPS. The contents of CCK and gastrin in EIN were higher than those in PN group at 60 and 120 min (P<0.05).The content of SEC post-infusion of nutrition solution was higher than that of pre-infusion of nutrition solution in both groups, and only at 60 min SEC in EIN group was higher than that in PN group. The content of gastrin in EIN was higher than that in PN group at 120 and 180 min (P<0.05).The changes of pancreatic juice, amylase, pancreatolipase and HCO3-, Cl-, Na+ and K+ between two groups did not reach significantly statistical difference (P>0.05).CONCLUSION: EIN does not stimulate entero-hormone and pancreatic juice secretion, and enzyme-protein synthesis and release. EIN has no effect on the natural course of acute pancreatitis. | Huan-Long Qin Zhen-Dong Su Lei-Guang Hu Zai-Xian Ding Qing-Tian Lin, Department of Surgery, Sixth People’s Hospital, Shanghai Jiaotong University Shanghai 200233, China | 2003 | World Journal of Gastroenterology2003，9，10： | 2 |
| 14 | 大别山区痴呆病病因的遗传学研究显示文摘 | Station of Sanitation and Bpedemic Prevention of Anching District Anhni ProvinceInstitute of Genetics of Fu Dan University ShanghaiThe Sixth People’s Hospital of Shanghai | 1979 | 遗传学报1979，，03： | 1 |
| 15 | Making of anhydrite cement from waste gypsum显示文摘 | Manjit Sixth Mridul Garg | 2000 | Cement and Concrete Research2000，30，： | 1 |
| 16 | detection,Evaluation and Treatment of High Blood Pressure显示文摘 | The Sixth Report of the Joint National Committee on Prevention | 1997 | ArchIntem Med1997，157，21： | 1 |
| 17 | Half versus full vacuun suction drainage after modified radical mastectomy for breast cancer prospective randomized clinical- trial显示文摘 | Chimamai Singhal V Sixth J | 2005 | BMC Cancer2005，5，1： | 1 |
| 18 | Residen perception of the Environment impacts Of Tourism显示文摘 | Theory of Visitor-Resident Irritants the Sixth Annual Conference on Research Association San Diego Juanitta C Pauline J | 1987 | hnnals of Tourism Research1987，14，： | 1 |
| 19 | The jnc prevention,detection, evaluation,and treatment of high blood pressure and the national high blood pressure education program coordinating commitee显示文摘 | The sixth report (jncvi) | 1997 | Arch inter reed1997，157，24： | 1 |
| 20 | The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Detection Evaluation and Treatment of High Blood Pressure | 1997 | Arch Intern Med1997，157，： | 1 |
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