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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | Hepatocellular Carcinoma-Cause,Treatment and Metastasis显示文摘In the recent decades, the incidence of hepatocellular carcinoma (HCC) has been found to be increasing in males in some countries. In China, HCC ranked second of cancer mortality since 1990s. Hepatitis B and C viruses (HBV and HCV) and dietary aflatoxin intake remain the major causative factors of HCC. Surgery plays a major role in the treatment of HCC, particularly for small HCC. Downstaging unresectable huge HCC to smaller HCC and followed by resection will probably be a new approach for further study. Liver transplantation is indicated for small HCC, however, some issues remain to be solved.Different modes of 'regional cancer therapy for HCC' have been tried. Systemic chemotherapy has been disappointing in the past but the future can be promising.Biotherapy, such as cytokines, differentiation inducers,anti-angiogenic agents, gene therapy and tumor vaccine will probably play a role, particularly in the prevention of tumor recurrence. HCC invasiveness is currently the major target of study. Tremendous works have been done at the molecular level, which will provide clues for biomarker of HCC progressionas well as targets for intervention. | Zhao-You Tang Liver Cancer Institute & Zhongshan Hospital of Fudan University Professor of Surgery Chairman.Liver Cancer Institute of Fudan University(previous Liver Cancer Institute of Shanghai Medical University)136 Yixueyuan Road,Zhongshan Hospital,Shanghai 200032,China. | 2001 | World Journal of Gastroenterology2001，7，4： | 213 |
| 3 | Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97显示文摘ALM To establish clone cells with different metastatic potential for the study of metastasis-related mechanisms. METHODS Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97. andbiological characteristics of the target clones selected by in vivo screening were studied.``RESULTS Two clones with high MHCC97-H and IowMHCC9--L1 metastatic potential were isolated from theparent cell line. Compared with MHCC97-L. MHCC97-H hadsmaller cell size average cell diameter 43 um vs 50 μmand faster in vitro and in vivo growth rate tumor celldoubling time was 34.2 h vs 60.0 h. The main ranges ofchromosomes were 5.5 58 in MHCC97-H and 57 62 inMHCC97-L. Boyden chamber in vitro invasion assay demonstrated that the number of penetrating cells through the artificial basement membrane was 137.5 - 11 .0) cellsfield for MHC_C99--H vs 17.7 - 6.3) field for MHCC97-L.The proportions of cells in GO Gl phase. S phase, and G_ M phase for MHCC97-H MHCC97-L were 0.56 6.65.0.28 0.25 and 0.l6 0.10, respectively, as measured by flow cytometry. The serum AFP levels in nude mice 5 wk after orthotopic implantation of tumor tissue were ( 24666 μg. L for MHCC97-H and (91- 66) μg' L 1 for MHCC97L. The pulmonary metastatic rate was 100% (10-10) vs40% 4- 10).``CONCLUSION Two clones of the same genetic background but with different biological behaviors were established, which could be valuable models for investigation on HCC metastasis. | Yan Li Zhao-You Tang Sheng-Long Ye Yin-Kun Liu Jie Chen Qiong Xue Jun Chen Dong-Mei Gao Wei-Hua Bao Liver Cancer Institute and Zhongshan Hospital of Fudan University (Former Liver Cancer Institute of Shanghai Medical University),Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 111 |
| 4 | 应用20项新生儿行为神经测定预测窒息儿的预后显示文摘1989年1月~1991年12月全国13个单位协作研究新生儿20项行为神经测定(NBNA)于足月窒息儿的应用。145例中随访至1~2岁125例。结果显示:7天NBNA<35分36例中44.4%预后不良;12~14天NBNA<35分14例中78.6%预后不良,而>35分者98.3%正常。7天NBNA评分预测预后的敏感性和特异性分别为88,9%和82.6%,12~14天为84.6%和97.4%。其预测预后的价值优于Sarnat分度、头颅CT和B超。本方法实用、经济、可靠,值得推广。 | BaoXiu-lan YuRen-jie LiZhuo-suan(Department of Pediairics. Peking Unton Medical coliege Hospitol, Beijing 100730.) | 1994 | 中华儿科杂志1994，32，4： | 115 |
| 5 | 我国胆石病十年来的变迁显示文摘作者报道了由全国胆道外科学组组织的来自7个省市、33所医院3911例胆结石手术病例的第二次全国临床调查资料并与十年前首次调查的结果(中华外科杂志1987,25:321~329)比较。调查证实:胆石病仍是我国普外临床的多发病,约占同时期住院患者的11.5%;多见于50岁以上的女性;女:男约2.57:1。约80%的单一部位结石分布于胆囊,以胆固醇类结石为主;而以胆色素类为主的胆管结石仅占10%。与十年前相比,胆囊:胆管结石从1.5:1上升至7.36:1;胆固醇:胆色素结石从1.4:1升至3.4:1。调查还发现:上述关于结石类型及结石部位上的变化与近十年来胆道蛔虫及胆道感染率的显著下降及饮食结构的变化有关。 | Zhu Xueguang Zhang Shengduo HuangZhiqiang et al. People′s Hospital,Beijing Medical U-niversity,Beijing100044. | 1995 | 中华外科杂志1995，33，11： | 155 |
| 6 | 慢性乙型肝炎防治指南显示文摘慢性乙型肝炎是我国常见的慢性传染病之一,严重危害人民健康.为进一步规范慢性乙型肝炎的预防、诊断和治疗,中华医学会肝病学分会和中华医学会感染病学分会组织国内有关专家,在参考国内外最新研究成果的基础上,按照循证医学的原则,制订了<慢性乙型肝炎防治指南>(以下简称<指南>).其中推荐的意见所依据的证据共分为3个级别5个等次[1],文中以括号内斜体罗马数字表示. | Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China | 2005 | 中华肝脏病杂志2005，13，12： | 1932 |
| 7 | 肝衰竭诊疗指南显示文摘肝衰竭是临床常见的严重肝病症候群,病死率极高。多年来,各国学者对肝衰竭的定义、分类、诊断和治疗等问题不断进行探索,但迄今尚无一致意见。2005年美国肝病学会发布了对急性肝衰竭处理的建议,国内迄今尚无肝衰竭的诊断治疗指南。为适应临床工作需要,规范我国肝衰竭的诊断和治疗活动,中华医学会感染病学分会和中华医学会肝病学分会组织国内有关专家,制订了我国第一部《肝衰竭诊疗指南》(以下简称《指南》)。本指南的制定遵守了循证医学原则,借鉴了国内外最新研究成果,力求与国际接轨。其中推荐意见所依据的证据共分为3个级别5个等级(表1),文中以括号内斜体罗马数字表示。 | Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association | 2006 | 中华肝脏病杂志2006，14，9： | 827 |
| 8 | 肝衰竭诊疗指南显示文摘 | Liver Failure and Artficial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association | 2006 | 实用肝脏病杂志2006，9，6： | 188 |
| 9 | 瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究显示文摘目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14 mmol/L(160 mg/dl),<6.50 mmol/L(250 mg/dl)、TG<4.52 mmol/L(400 mg/dl)者以2:1随机接受瑞舒伐他汀10 mg/d 或阿托伐他汀10mg/d 治疗。12周后瑞舒伐他汀组 LDL-C 未达到 ATPⅢ治疗目标者,予瑞舒伐他汀20 mg 延续治疗8周。结果 304例进入随机治疗阶段,瑞舒伐他汀10 mg/d 组201例,阿托伐他汀10 mg/d 组103例。意向治疗人群290例,符合方案人群263例。瑞舒伐他汀组治疗12周后血 LDL-C 显著下降,下降幅度为45.6%,显著大于阿托伐他汀组的39.0%(P<0.001)。瑞舒伐他汀组患者 LDL-C 达标率也较阿托伐他汀组(78.0%比72.7%)有增高趋势,且在高危人群中优势更为明显(56.5%比35.0%),但差异未达到统计学意义。瑞舒伐他汀降低 TG(-22.8%)以及升高 HDL-C(+6.6%)和ApoA-1(+12.5%)的幅度与阿托伐他汀组差别无统计学意义(分别为-16.6%,+4.3%和+9.8%)。29例患者接受20 mg/d 瑞舒伐他汀延续治疗,22例完成治疗患者中10例(45.5%)LDL-C达标。研究中未发现药物相关的严重不良反应事件。结论本组研究显示瑞舒伐他汀10 mg 降低LDL-C 的疗效优于同等剂量的阿托伐他汀,治疗3个月安全性与之类似。 | Rosuvastatin Registration Clinical Trial Group.Cardiovascular Institute and Fu Wai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China | 2007 | 中华心血管病杂志2007，35，3： | 117 |
| 10 | 睡眠呼吸暂停人群高血压患病率的多中心研究显示文摘目的调查我国睡眠呼吸暂停人群高血压患病情况和影响因素。方法纳入2004至2006年全国20家三甲医院呼吸内科门诊就诊的2297例患者,男:女为1310:211,均经过询问病史、体格检查和多导睡眠监测。统一使用中华医学会呼吸病学分会睡眠呼吸疾病学组编制的《睡眠呼吸暂停与高血压发病情况问卷调查表》对受试者进行问卷和规范的血压测量。应用 SPSS 11.0软件包进行数据分析,采用 X^2检验比较高血压患病率。结果呼吸暂停低通气指数(AHI)<5次/h 组(213例)的高血压患病率(23.5%)明显低于 AHI≥5次/h 组(2084例)的高血压患病率(49.3%);阻塞性睡眠呼吸暂停低通气综合征(OSAHS)人群的高血压患病率为56.2%(569/1012);有高血压家族史人群的高血压患病率为63.7%(450/706),明显高于无家族史者39.4%(627/1591)的患病率;AHI≥5次/h 组的高血压患病几率是 AHI<5次/h 组的3倍(OR=3.167,95%CI 为2.953~5.426,P<0.01);受试人群的高血压患病率随 AHI 增加而增加,自 AHI 16~20次/h 起患病率增高幅度明显加大,AHI 66~70次/h 以后呈下降趋势。经计算得出公式:高血压患病率=0.3199+0.0042×AHI;高血压患病的 OR 值=1.018+0.017×AHI,同时,受试者的高血压患病率随睡眠最低血氧饱和度的减低而明显增高,随嗜睡指数增高而明显增高。受试人群的 AHI 为独立于年龄、性别、体重指数和高血压家族史之外的高血压危险因素。结论睡眠呼吸暂停人群的高血压患病率明显高于无睡眠呼吸暂停人群,睡眠呼吸暂停与高血压患病率有密切的相关关系,是独立于年龄、体重指数和高血压家族史的高血压患病危险因素。 | Sleep Breathing Disorder Group of Respiratory Diseases Branch,Chinese Medical Association | 2007 | 中华结核和呼吸杂志2007，30，12： | 123 |
| 11 | 慢性乙型肝炎防治指南(2010 年版)显示文摘为规范慢性乙型肝炎的预防、诊断和治疗,中华医学会肝病学分会和感染病学分会于2005年组织国内有关专家制订了《慢性乙型肝炎防治指南》。近5年来,国内外有关慢性乙型肝炎的基础和临床研究取得很大进展,为此我们对该指南进行更新。 | Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association | 2011 | 传染病信息2011，24，1： | 95 |
| 12 | 急性病毒性心肌炎的药物治疗观察显示文摘目的 全国十二家大型医院协作观察中西医结合治疗急性病毒性心肌炎疗效。方法 对 10 2 8例临床诊断为急性病毒性心肌炎患者随机各分两组 ,治疗组 60 2例 ,用中西医结合 (黄芪、牛磺酸、泛葵利酮、抗心律失常药等)治疗 ;对照组 4 2 6例 ,用常规 (极化液、抗心律失常药等 )治疗。结果 中西医结合治疗组临床症状改善、外周血肠道病毒阴转、心电图ST T改变及房室传导阻滞、阵发性心房颤动、窦房传导阻滞等恢复均优于对照组(P <0 .0 1、0 .0 5 ) ;对早搏及心功能改善两组间无统计学差异(P <0 .0 5 )。结论 在目前对急性病毒性心肌炎无特效药物治疗的情况下 ,采用中西医结合治疗可作为一种治疗手段。 | Collaborative Group of “Key National Medical Projects for the Ninth Five Year Plan Research” (Correspondence: YANG Yingzhen, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital,Shanghai Medical University,Shanghai 200032) | 1999 | 中华心血管病杂志1999，27，6： | 94 |
| 13 | 慢性乙型肝炎防治指南(2010年版)显示文摘为规范慢性乙型肝炎的预防、诊断和治疗,中华医学会肝病学分会和感染病学分会于2005年组织国内有关专家制订了《慢性乙型肝炎防治指南》[1]。近5年来.国内外有关慢性乙型肝炎的基础和临床研究取得了很大进展.为此我们对该防治指南进行了更新。 | Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. | 2011 | 胃肠病学2011，16，6： | 111 |
| 14 | Study on the prevalence of benlgn prostatic hyperplasia and prostatic cancer in China显示文摘StudyontheprevalenceofbenlgnprostatichyperplasiaandprostaticcancerinChinaGuFang-liu(顾方六)InstituteofUrology,BeijingMedicalUniv... | $$$$ Gu Fang-liu(顾方六)Institute of Urology,Beijing Medical University,Beijing 100083,China | 1994 | 生殖医学杂志1994，3，S1： | 116 |
| 15 | 中华医学会感染与抗微生物治疗策略高峰论坛:甲氧西林耐药金黄色葡萄球菌感染的治疗策略——专家共识显示文摘中华医学会感染与抗微生物治疗高峰论坛:甲氧西林耐药金葡菌感染的治疗策略于2011年4月17日在长沙举行。60余位来自感染科、呼吸科、血液科、重症医学、皮肤科、普外科、烧伤科、肾病科、儿科等临床学科及医学检验科的资深专家就甲氧西林耐药金葡菌感染的病原诊断和治疗的相关问题进行了广泛深入讨论,拟定了“甲氧西林耐药金葡菌感染的治疗策略一专家共识”的内容纲要。目前国内尚缺少基于充分临床实践(循证医学)证据的治疗耐甲氧西林金葡菌(MRSA)感染的指南或专家共识可供参考。 | Expert panel of Chinese Medical Association Forum on the Strategies for the Management of Methicillinresistant Staphylococcus aureus Infections | 2011 | 中国感染与化疗杂志2011，11，6： | 94 |
| 16 | 不稳定性心绞痛、急性非Q波心肌梗死不同抗栓疗法的对比研究显示文摘目的 观察不同抗栓方案对急性冠状动脉综合征心脏事件、出血风险和预后的影响。方法 本研究为前瞻性、多中心、随机、开放试验 ,入选患者随机分为静脉滴注普通肝素组和皮下注射低分子量肝素组。入选对象为不稳定性心绞痛或非Q波心肌梗死 ,入选前 4 8小时以内至少有一次心绞痛发作 ,ST段无抬高。肝素 10 0IU/kg静注 ,续 10 0 0IU/h ,维持活化的部分凝血活酶时间 (APTT)或活化的全血凝固时间 (ACT)于正常的 1 5~ 2 0倍 ,连续 7日。低分子量肝素 0 4~ 0 6ml,每日两次皮下注射 ,连续 7日。主要观察终点 :随访治疗 3 0日内发生急性心肌梗死、心脏性或非心脏性死亡和药物治疗无法控制心绞痛 ,需行急性血运重建术。住院至少 7日 ,随访至治疗后 3 0日。结果 本研究共入选符合条件的患者 4 0 2例 ,两组在性别、年龄、心血管危险因素和心绞痛发作方面差异无显著性。治疗后 7日 ,两组用药期间平均胸痛发作次数差异无显著性 ,但肝素组有更多的患者需口服硝酸甘油缓解胸痛 ;病死率在低分子量肝素组较普通肝素组低 ,两组比较P值为 0 0 62 ,复合终点事件 (死亡、心肌梗死和紧急血管重建 )在低分子量肝素组明显下降。低分子量肝素组出血事件明显少于肝素组。治疗开始后 3 0日 ,低分子量肝素组死亡和复合终点事? | Clinical Collaborative Study Group of Low Molecular Weight Heparin (Correspondent: HU Dayi, XU Juntang. Beijing Red Cross Chaoyang Hospital, Beijing University of Medical Sciences, Beijing 100020, China) | 2000 | 中华心血管病杂志2000，28，1： | 172 |
| 17 | 家庭血压监测中国专家共识显示文摘自动的电子血压计正在进入家庭。家庭血压监测已成为血压管理的重要组成部分。近年来,美国、欧洲与日本相继制定了家庭血压监测指南。我国家庭血压监测的研究工作正处起步阶段,尚不能完全根据我国相关研究的结果制定指南。随着高血压患者家庭血压管理意识的迅速提高,许多家庭拥有了自动的电子血压计,同时也在进行家庭血压测量。为了促进家庭血压监测的健康发展,需要对家庭血压监测进行适当的规范。因此,参考国外有关指南并经广泛、深入的讨论,制定本共识文件。就血压计的选择与校准、血压测量的频率(次数)与时间(天数)以及家庭血压的正常值等重要问题提出了建议。 | Chinese Hypertension Committee of the Chinese Medical Doctors Association, Chinese Hypertension League, Chinese Society of Cardiology of the Chinese Medical Association | 2012 | 中华高血压杂志2012，20，6： | 83 |
| 18 | 中国进展期乳腺癌共识指南(CABC 2015)显示文摘在2013年出版的《首届中国进展期乳腺癌共识指南(草案)》(CABC1)的基础上,本指南进一步更新了进展期乳腺癌诊疗过程的一般原则、相关的定义、疗效的评估、不良反应的管理及不同治疗方法的基本策略等内容;专家组系统阅读国内外各种关于进展期乳腺癌的临床研究(包括回顾性的资料分析),整理并总结了各种相关指南,召开会议组织专家进行了多次讨论,将在循证医学基础上达成的专家共识整理成文,为从事乳腺癌专业的医生,尤其是以治疗进展期乳腺癌为主要专业的医生,提供参考。 | China Medical Women′s Association of Clinical Oncology | 2015 | 癌症进展2015，13，3： | 84 |
| 19 | 2018 Chinese Guidelines for Prevention and Treatment of Hypertension——A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension显示文摘Table of Contents Preamble 1 Prevalence of hypertension in Chinese population 1.1 Prevalence,incidence and epidemic trend of hypertension in Chinese population 1.2 Awareness,treatment and control of Hypertension in China 1.3 Important risk factors for hypertension in Chinese population 2 Hypertension and cardiovascular risk 2.1 Relationship between blood pressure and cardiovascular risk 2.2 Cardiovascular risk characteristics of hypertension population in China 3 Diagnostic evaluation 3.1 Medical history 3.2 Physical examination 3.3 Laboratory examinations 3.4 Genetic analysis 3.5 BP measurement 3.6 Evaluation of target organ damage. | Joint Committee for Guideline Revision Chinese Hypertension League Chinese Society of Cardiology Hypertension Committee of the Chinese Medical Doctor Association Hypertension Branch of the China Association for the Promotion of International Exchanges of Health Care Hypertension Branch of the Chinese Geriatrics Society Li–Sheng LIU | 2019 | Journal of Geriatric Cardiology2019，16，3： | 95 |
| 20 | Intestinal endotoxemia as a pathogenetic mechanism in liver failure显示文摘Liver injury induced by various pathogenic factors (such as hepatitis virus, ethanol, drugs and hepatotoxicants, etc.)through their respective special pathogenesis is referred to as 'primary liver injury' (PLI). Liver injury resultedfrom endotoxin (lipopolysaccharide, LPS) and the activation of Kupffer cells by LPS while intestinal endotoxemia (IETM) occurred during the occurrence and development of hepatitis is named the 'secondary liver injury' (SLI).The latter which has lost their own specificities of primary pathogenic factors is ascribed to IETM. The 'secondary liver injury' is of important action and impact on development and prognosis of hepatitis. More severe IETM commonly results in excessive inflammatory responses, with serious hepatic necrosis,further severe hepatitis and even induces acute liver failure.The milder IETM successively precipitates a cascade,including repeated and persistent hepatocytic impairment accompanied by infiltration of inflammatory cells, hepatic fibrosis, cirrhosis and hepatocarcinoma. Generally, the milder IETM ends with chronic hepatic failure. If PLI caused by various pathogenic factors through their independent specific mechanismis regarded as 'the first hit' on liver, then SLI mediated by different chemical mediators from KCs activated by IETM in the course of hepatitis is 'the second hit' on liver. Thus, fusing and overlapping of the primary and scondary liver injuries determine and influeuce the complexity of the illness and outcome of the patient with hepatitis. For this reason, the viewpoint of 'SLI' induced by the 'second hit' on liver inflicted by IFTM suggests that medical professionals should attach great importance to both 'PLI'and 'SLI' caused by IETM. That is, try to adjust the function of KSs and eliminate endotoxemia of the patient. | De-Wu Han,Institute of Hepatology,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，6： | 170 |
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