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| 1 | On adjacent-vertex-distinguishing total coloring of graphs显示文摘In this paper, we present a new concept of the adjacent-vertex-distinguishing total coloring of graphs (briefly, AVDTC of graphs) and, meanwhile, have obtained the adjacent-vertex-distinguishing total chromatic number of some graphs such as cycle, complete graph, complete bipartite graph, fan, wheel and tree. | ZHANG Zhongfu, CHEN Xiang’en, LI Jingwen, YAO Bing, LU Xinzhong & WANG Jianfang College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China Department of Computer, Lanzhou Normal College, Lanzhou 730070, China Institute of Applied Mathematics, Lanzhou Jiaotong University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Science China Mathematics2005，48，3： | 173 |
| 2 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 3 | 瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究显示文摘目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14 mmol/L(160 mg/dl),<6.50 mmol/L(250 mg/dl)、TG<4.52 mmol/L(400 mg/dl)者以2:1随机接受瑞舒伐他汀10 mg/d 或阿托伐他汀10mg/d 治疗。12周后瑞舒伐他汀组 LDL-C 未达到 ATPⅢ治疗目标者,予瑞舒伐他汀20 mg 延续治疗8周。结果 304例进入随机治疗阶段,瑞舒伐他汀10 mg/d 组201例,阿托伐他汀10 mg/d 组103例。意向治疗人群290例,符合方案人群263例。瑞舒伐他汀组治疗12周后血 LDL-C 显著下降,下降幅度为45.6%,显著大于阿托伐他汀组的39.0%(P<0.001)。瑞舒伐他汀组患者 LDL-C 达标率也较阿托伐他汀组(78.0%比72.7%)有增高趋势,且在高危人群中优势更为明显(56.5%比35.0%),但差异未达到统计学意义。瑞舒伐他汀降低 TG(-22.8%)以及升高 HDL-C(+6.6%)和ApoA-1(+12.5%)的幅度与阿托伐他汀组差别无统计学意义(分别为-16.6%,+4.3%和+9.8%)。29例患者接受20 mg/d 瑞舒伐他汀延续治疗,22例完成治疗患者中10例(45.5%)LDL-C达标。研究中未发现药物相关的严重不良反应事件。结论本组研究显示瑞舒伐他汀10 mg 降低LDL-C 的疗效优于同等剂量的阿托伐他汀,治疗3个月安全性与之类似。 | Rosuvastatin Registration Clinical Trial Group.Cardiovascular Institute and Fu Wai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China | 2007 | 中华心血管病杂志2007，35，3： | 117 |
| 4 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells显示文摘MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation. | WEI ZHANG, Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China | 2002 | Cell Research2002，12，1： | 107 |
| 5 | Remarks on Urban Spatial Growth Management Research | CHEN Jinfu,Professor,Director,Teaching & Research Office on Urban Planning,Architecture and Urban Planning School,Huazhong University of Science and Technology PhD Candidate,College of Public Administration,Huazhong University of Science and Technology,Wuhan,P.R.China.REN Lijuan,Postgraduate,Architecture and Urban Planning School,Huazhong University of Science and Technology,Wuhan,P.R.China.YU Cheng,Postgraduate,Architecture and Urban Planning School,Huazhong University of Science and Technology,Wuhan,P.R.China.XU Xiaolei,Postgraduate,Architecture and Urban Planning School,Huazhong University of Science and Technology,Wuhan,P.R.China.LI Xinyan,Lecturer,Architecture and Urban Planning School,Huazhong University of Science and Technology,Wuhan,P.R.China. | 2010 | China City Planning Review2010，19，2： | 180 |
| 6 | Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia显示文摘AIM: To evaluate the protective effect and mechanism ofglutamine on the intestinal barrier function in totalparenteral nutrition (TPN) rats with trauma or endotoxemia.
METHODS: To perform prospective, randomized andcontrolled animal experimentation of rats with surgicaltrauma, TPN and endotoxemia, thirty-four male, adultSprague Dawley rats were divided into four groups: control group (n=8), TPN group (n=9), trauma and endotoxemia group (LPS, n=8) and trauma plus endotoxemia supplemented with glutamine in TPN solution group (Gin.group, n=9). All groups except the control group were given TPN solutions in 7-day experimental period. For Gin group, 1 000 mg/kg/d of glutamine was added to TPN solution during day 1-6. On the 7th day all the animals were gavaged with lactulose (66 mg) and mannitol (50 mg)in 2 mi of normal saline. Then 24 h urine with preservative was collected and kept at -20 ℃. On day 8, under intraperitoneal anesthesia using 100 mg/kg ketamin, the intestine, liver, mesenteric lymph nodes and blood were taken for examination.
RESULTS: The body weight of LPS group decreased most among the four groups. The structure of small intestinal mucosa in TPN group, LPS group and Gln group showed impairments of different degrees, and the damage of small intestinal mucosa in Gln group was remarkably alleviated.The concentrations of interleukins in small intestine mucosa were lower (for IL-4 and IL-6) or the lowest (IL-10) in Gln group. The IgA level in the blood plasma and the mucosa of Gln group was the highest among all of the groups. The urine lactulose/mannitol test showed that the intestinal permeability in LPS group was lower than that in TPN group (P<0.001), but there was no difference between LPS group and Gln group. The rate of bacterial translocation in Gln group was lower than that in LPS group (P<0.02).
CONCLUSION: Prophylactic treatment with glutamine could minimize the increments of intestinal permeability and bacterial translocation caused by trauma and endotoxemia in rats treated with TPN. | Lian-An Ding Jie-Show Li Clinical College of Nanjing University Medical School,305 East Zhongshan Road,Nanjing 210002 Jiangsu Province,China | 2003 | World Journal of Gastroenterology2003，9，6： | 89 |
| 7 | METAMORPHIC MECHANISMSAND THEIR CONFIGURATION MODELS显示文摘The concept of metamorphic mechanisms is presented, configuration models and configuration transformations relating to a set of new matrix operations are discussed and proposed. The configuration of a metamorphic mechanism reflects the connectivity change in the mechanism during motions which results in mobility change and presents the characteristics of the mechanism which is discussed in various applications particularly in decorative artifacts. The characteristics is further investigated with mobility analysis. | Dai Jiansheng (Department of Mechanical Engineering, School of Physical Sciences and Engineering, King’s College, University of London,Strand,London WC2R 2LS, United kingdom) Zhang Qixian (Robotics Research Institute,Beijing University of Aeronautics and | 2000 | Chinese Journal of Mechanical Engineering2000，13，3： | 61 |
| 8 | Magnetostratigraphy of the late Cenozoic Laojunmiao anticline in the northern Qilian Mountains and its implications for the northern Tibetan Plateau uplift显示文摘Cenozoic sediments in the foreland basin--Jiuquan Basin in west Hexi Corridor recorded tectonic uplift information of the Qilian Mountains. High resolution paleomagnetic dating of the Laojunmiao (LJM) section across the central LJM anticline in the southern Jiuquan Basin reveals ages of the Getanggou Member, Niugetao Member in the Shulehe Formation, the Yumen Conglomerate, Jiuquan Conglomerate and Gobi Formation at >13-8.3 Ma, 8.3-4.9 Ma, 3.66-0.93 Ma, 0.84-0.14 Ma and 0.14-0 Ma, respectively. Sedimentary evolution study suggests that the Qilian Mountains should begin to rise gradually since ~8-6.6 Ma, accompanied by sedimentary environments changing from lacustrine mudstones-sandstones to alluvial conglomerates. Rapid uplift of the Qilian Mountains began at ~3.66 Ma, followed by a series of stepwise or intermittent intensive uplifts at about <1.8-1.23 Ma, 0.93-0.84 Ma and 0.14 Ma, which finally resulted in the present high Qilian Mountains. | FANG Xiaomin1,2, ZHAO Zhijun3,2, LI Jijun2, YAN Maodu2, PAN Baotian2, SONG Chunhui2 & DAI Shuang2 1. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China 2. Key Laboratory of Western China’s Environmental Systems, Ministry of Education & College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 3. College of Geography, Nanjing Normal University, Nanjing 210097, China | 2005 | Science China Earth Sciences2005，48，7： | 61 |
| 9 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 10 | Biomass carbon stocks in China's forests between 2000 and 2050:A prediction based on forest biomass-age relationships显示文摘China's forests are characterized by young forest age,low carbon density and a large area of planted forests,and thus have high potential to act as carbon sinks in the future.Using China's national forest inventory data during 1994-1998 and 1999-2003,and direct field measurements,we investigated the relationships between forest biomass density and forest age for 36 major forest types.Statistical approaches and the predicted future forest area from the national forestry development plan were applied to estimate the potential of forest biomass carbon storage in China during 2000-2050.Under an assumption of continuous natural forest growth,China's existing forest biomass carbon(C) stock would increase from 5.86 Pg C(1 Pg=1015 g) in 1999-2003 to 10.23 Pg C in 2050,resulting in a total increase of 4.37 Pg C.Newly planted forests through afforestation and reforestation will sequestrate an additional 2.86 Pg C in biomass.Overall,China's forests will potentially act as a carbon sink for 7.23 Pg C during the period 2000-2050,with an average carbon sink of 0.14 Pg C yr-1.This suggests that China's forests will be a significant carbon sink in the next 50 years. | XU Bing,GUO ZhaoDi,PIAO ShiLong & FANG JingYun* Department of Ecology,College of Urban and Environmental Sciences,and Key Laboratory for Earth Surface Processes of the Ministry of Education,Peking University,Beijing 100871,China | 2010 | Science China(Life Sciences)2010，53，7： | 61 |
| 11 | 正余弦变换的数值滤波算法显示文摘基于正余弦变换是汉克尔变换的特例 ,运用成熟的快速汉克尔变换理论 ,导出了正余弦变换的数值滤波算法 ,并给出了各 2 5 0个滤波系数。以有解析解的李普希兹积分为例 ,与现有的算法作了试算对比 ,证明该算法的计算精度高 。 | WANG Hua-jun (Information Science & Engineering College, Huaqiao University, Quanzhou Fujian 362011, China) | 2004 | 工程地球物理学报2004，1，4： | 67 |
| 12 | 层次分析法的标度研究显示文摘近年来,由美国著名的运筹学家T.L.Saaty所提出的一种实用的决策方法——层次分析法在我国得到了广泛的应用。但是,在实际应用中,根据Saaty给出的判断标度进行两两比较、构造判断矩阵,有可能导致排序上的错误的结论。 | He Kun (Petrochemical Technology College, ECUST, Shanghai 200540) | 1997 | 系统工程理论与实践1997，17，6： | 64 |
| 13 | Iron-doped Mn-Ce/TiO_2 catalyst for low temperature selective catalytic reduction of NO with NH_3显示文摘The catalysts of iron-doped Mn-Ce/TiO 2(Fe-Mn-Ce/TiO 2) prepared by sol-gel method were investigated for low temperature selective catalytic reduction(SCR) of NO with NH 3.It was found that the NO conversion over Fe-Mn-Ce/TiO 2 was obviously improved after iron doping compared with that over Mn-Ce/TiO 2.Fe-Mn-Ce/TiO 2 with the molar ratio of Fe/Ti = 0.1 exhibited the highest activity.The results showed that 96.8% NO conversion was obtained over Fe(0.1)-Mn-Ce/TiO 2 at 180°C at a space velocity of 50,000 hr 1.Fe-Mn-Ce/TiO 2 exhibited much higher resistance to H 2 O and SO 2 than that of Mn-Ce/TiO 2.The properties of the catalysts were characterized using X-ray diffraction(XRD),N 2 adsorption,temperature programmed desorption(NH 3-TPD and NOx-TPD),and Xray photoelectron spectroscopy(XPS) techniques.BET,NH3-TPD and NOx-TPD results showed that the specific surface area and NH3 and NOx adsorption capacity of the catalysts increased with iron doping.It was known from XPS analysis that iron valence state on the surface of the catalysts were in Fe3+ state.The doping of iron enhanced the dispersion and oxidation state of Mn and Ce on the surface of the catalysts.The oxygen concentrations on the surface of the catalysts were found to increase after iron doping.Fe-Mn-Ce/TiO2 represented a promising catalyst for low temperature SCR of NO with NH3 in the presence of H2 O and SO2. | Boxiong Shen ,Ting Liu,Ning Zhao,Xiaoyan Yang,Lidan Deng College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China. | 2010 | Journal of Environmental Sciences2010，22，9： | 63 |
| 14 | Current treatment for liver metastases from colorectal cancer显示文摘The liver is the commonest site of distant metastasis ofcolorectal cancer and nearly half of the patients withcolorectal cancer ultimately develop liver involved duringthe course of their diseases. Surgery is the only therapythat offers the possibility of cure for patients with hepaticmetastatic diseases. Five-year survival rates after resectionof all detectable liver metastases can be up to 40 %.Unfortunately, only 25 % of patients with colorectal livermetastases are candidates for liver resection, while the othersare not amenable to surgical resection. Regional therapiessuch as radiofrequency ablation and cryotherapy may beoffered to patients with isolated unresectable metastasesbut no extrahepatic diseases. Hepatic artery catheterchemotherapy and chemoembolization and portal veinembolization are often used for the patients with extensiveliver metastases but without extrahepatic diseases, whichare not suitable for regional ablation. For the patients withmetastatic colorectal cancer beyond the liver, systemicchemotherapy is a more appropriate choice. Immunotherapyis also a good option when other therapies are used incombination to enhance the efficacy. Selective internalradiation therapy is a new radiation method which can beused in patients given other routine therapies Without effects. | Lian-Xin Liu Wei-Hui Zhang Hong-Chi Jiang Department of Surgery, the First Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China | 2003 | World Journal of Gastroenterology2003，9，2： | 61 |
| 15 | Mesozoic subduction-accretion zone in northeastern South China Sea inferred from geophysical interpretations显示文摘A segment of Mesozoic subduction-accretion zone was inferred across the northeastern South China Sea at approximately NE45° orientation. Basic evidence includes the following: A belt of peek gross horizontal Bouguer gravity gradient (PGHGBA) is comparable in size and intensity to that of the Manila subduction-accretion zone. A belt of high positive magnetic anomalies appears to the north and sub-parallel to the PGHGBA, representing the volcanic arc associated to the subduction zone. The PGHGBA crosses obliquely both Cenozoic structures and present seafloor topography, indicating a pre-Cenozoic age. The segment is offset left-laterally by NW-running strike-slip faults, in concord with the Mesozoic stress field of South China. In addition, the existence of the subduction zone is supported by wide-angle seismic data obtained in different years by different institutions. At approximate localities, a north-dipping ramp of Moho surface is indicated by records of ocean-bottom seismometers, and a strong reflector about 8 km beneath the Moho reflector is indicated by both OBS and long-cable seismic records. The identification of a segment of Mesozoic subduction zone in NE South China Sea fills nicely the gap of the Great Late Mesozoic Circum SE Asia Subduction-acrretion Zone, which extended from Sumatra, Java, SE Kalimantan to N Palawan, and from Taiwan, Ryukyu to SW Japan. | ZHOU Di1, WANG Wanyin2, WANG Jialin3, PANG Xiong4, CAI Dongsheng5 & SUN Zhen1 1. Key Laboratory of Marginal Sea Geology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guang- zhou 510301, China 2. College of Geological and Topographical Engineering, Chang’an University, Xi’an 710054, China 3. Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 4. China National Offshore Oil Co. Limited – Shenzhen Branch, Shenzhen 518067, China 5. China National Offshore Oil Co. Limited – Research Center, Beijing 100027, China | 2006 | Science China Earth Sciences2006，49，5： | 52 |
| 16 | D(β)-vertex-distinguishing total coloring of graphs显示文摘A new concept of the D(β)-vertex-distinguishing total coloring of graphs, i.e., the proper total coloring such that any two vertices whose distance is not larger than β have different color sets, where the color set of a vertex is the set composed of all colors of the vertex and the edges incident to it, is proposed in this paper. The D(2)-vertex-distinguishing total colorings of some special graphs are discussed, meanwhile, a conjecture and an open problem are presented. | ZHANG Zhongfu,LI Jingwen,CHEN Xiang’en,YAO Bing, WANG Wenjie & QIU Pengxiang Institute of Applied Mathematic, Lanzhou Jiaotong University, Lanzhou 730070, China College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China | 2006 | Science China Mathematics2006，49，10： | 54 |
| 17 | Plausible impact of global climate change on water resources in the Tarim River Basin显示文摘Combining the temperature and precipitation data from 77 climatological stations and the climatic and hydrological change data from three headstreams of the Tarim River: Hotan, Yarkant, and Aksu in the study area, the plausible association between climate change and the variability of water resources in the Tarim River Basin in recent years was investigated, the long-term trend of the hydrological time series including temperature, precipitation, and streamflow was detected, and the possible association between the El Ni(n)o/Southern Oscillation (ENSO) and these three kinds of time series was tested. The results obtained in this study show that during the past years, the temperature experienced a significant monotonic increase at the speed of 5%, nearly 1℃ rise; the precipitation showed a significant decrease in the 1970s, and a significant increase in the1980s and 1990s, the average annual precipitation was increased with the magnitude of 6.8 mm per decade. A step change occurred in both temperature and precipitation time series around 1986, which may be influenced by the global climate change. Climate change resulted in the increase of the streamflow at the headwater of the Tarim River, but the anthropogenic activities such as over-depletion of the surface water resulted in the decrease of the streamflow at the lower reaches of the Tarim River. The study result also showed that there is no significant association between the ENSO and the temperature, precipitation and streamflow. | CHEN Yaning & XU Zongxue Xinjiang Institute of Ecology & Geography, Chinese Academy of Sciences, Urumqi 830011, China College of Environmental Sciences, Beijing Normal University, Beijing 100875, China | 2005 | Science China Earth Sciences2005，48，1： | 56 |
| 18 | Vegetation and soil carbon storage in China显示文摘This study estimated the current vegetation and soil carbon storage in China using a biogeochemical model driven with climate, soil and vegetation data at 0.5°latitude-longitude grid spatial resolution. The results indicate that the total carbon storage in China's vegetation and soils was 13.33 Gt C and 82.65 Gt C respectively, about 3% and 4% of the global total. The nationally mean vegetation and soil carbon densities were 1.47 kg C/m2 and 9.17 kg C/m2, respectively, differing greatly in various regions affected by climate, vegetation, and soil types. They were generally higher in the warm and wet Southeast China and Southwest China than in the arid Northwest China; whereas vegetation carbon density was the highest in the warm Southeast China and Southwest China, soil carbon density was the highest in the cold Northeast China and southeastern fringe of the Qinghai-Tibetan Plateau. These spatial patterns are clearly correlated with variations in the climate that regulates plant growth and soil organic matter decomposition, and show that vegetation and soil carbon densities are controlled by different climatic factors. | LI Kerang, WANG Shaoqiang & CAO MingkuiInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Department of Geography, Maryland University, College Park,MD 20742, USA Correspondence should be addressed to Li Kerang | 2004 | Science China Earth Sciences2004，47，1： | 60 |
| 19 | Influence of the impounding process of the Three Gorges Reservoir up to water level 172.5m on water eutrophication in the Xiangxi Bay显示文摘The water level of the Three Gorges Reservoir(TGR) rose to 172.5 m in two stages from September to November,2008.The hydrodynamic parameters and water quality parameters(e.g.flow velocity,temperature,turbidity and nutrient content) had been continuously monitored to reveal the influence of the impounding process of the TGR on the water eutrophication in the Xiangxi Bay(XXB).The maximal daily rise of the water level of the TGR was about 2.38 m.The water exchange between the mainstream(the Changjiang River) and the XXB of the TGR was enhanced by density current,and its main characteristics were a density-stratified flow in different directions.The water exchange reduced the differences of the water quality parameters(for example,temperature,turbidity,nutrient level,pH,etc.) between the mainstream and the XXB during the impounding process.Meanwhile,the water stability index in the mainstream remained small but it was lowered in the XXB.The main causes included the dilution by water of lower concentration of the chlorophyll a(Chl.a) entering from the mainstream,the decline of the water stability,and the increase of suspended silt,which induced the Chl.a to decrease in the XXB during the impounding process.The grade of the water eutrophication changed from middle eutrophic level to mesotrophic state in the process.However,as available nutrients were imported into the XXB from the mainstream during the impounding process the risk of water eutrophication increases in the XXB in the future. | YANG ZhengJian1,LIU DeFu1,JI DaoBin1,2 & XIAO ShangBin1,3 1 College of Civil & Hydroelectric Engineering,China Three Gorges University,Yichang 443002,China 2 School of Water Resources & Hydropower Engineering,Wuhan University,Wuhan 430072,China 3 Institute of Earth Environment,Chinese Academy of Sciences,Xi’an 710075,China | 2010 | Science China(Technological Sciences)2010，53，4： | 58 |
| 20 | Changes of NF-kB,p53,Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells:role of reactive oxygen species显示文摘AIM: To identify whether JTE-522 can induce apoptosis inAGS cells and ROS also involved in the process, and toinvestigate the changes in NF-kB, p53, bcl-2 and caspase in the apoptosis process.METHODS: Cell culture, MTT, Electromicroscopy, agarosegel electrophoresis, lucigenin, Western blot andelectrophoretic mobility shift assay (EMSA) analysis wereemployed to investigate the effect of JTE-522 on cellproliferation and apoptosis in AGS cells and relatedmolecular mechanisms.RESULTS: JTE-522 inhibited the growth of AGS cells andinduced the apoptosis. Lucigenin assay showed the generationof ROS in cells under incubation with JTE-522. The inc eareasedROS generation might contribute to the induction of AGS cellsto apoptosis. EMSA and Westem blot revealed that NF-kBactivity was almost completely inhibited by preventing thedegradation of IkBα. Additionally, by using Western blot weconfirmed that the level of bcl-2 was decreased, whereas p53showed a great increase following JTE-522 treatment. Theirchanges were in a dose-dependent manner.CONCLUSION: These findings suggest that reactive oxygenspecies, NF-kB, p53, bcl-2 and caspase-3 may play animportant role in the induction of apoptosis in AGS cellsafter treatment with JTE-522. | Hong-Liang Li Xiao-Hong Li Yan-Qing L Chun-Ling Ye Xian-Da Ren,Department of Pharmacology,Jinan University Pharmacy College,Guangzhou 510632,Guangdong,China Dan-Dan Chen,Department of Cardiology,First Affiliated Hospital,Zhongshan University,Guangzhou 510089,Guangdong,China Hai-Wei Zhang,Department of Pathology,Jinan University Medical College,Guangzhou 510632,Guangdong,China | 2002 | World Journal of Gastroenterology2002，8，3： | 58 |
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