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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 4 |
| 4 | Appendectomy and Clostridium difficile colitis:Relationships revealed by clinical observations and immunology显示文摘Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon.These advances have been made despite long standing clinical observations that the appendectomy is a safe and effective procedure.However,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(C.difficile)-associated colitis,and probably other diseases associated with an altered microbiome.At the same time,appendectomy does not apparently put patients at risk for an initial onset of C.difficile-associated colitis.These clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of C.difficile-associated colitis.Further,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics. | Nathan L Sanders R Randal Bollinger Ryan Lee Steven Thomas William Parker | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 5 | Response of bacterioplankton and phytoplankton to organic carbon and inorganic nutrient additions in contrasting oceanic ecosystems显示文摘 | Caron D A Lira E L Sanders R W | 2000 | Aquatic Microbial Ecology2000，22，： | 1 |
| 6 | Fastand simple Monte Carlo algorithm for side chain optimization in proteins:application to model building by homology显示文摘 | Holm L Sander C | 1992 | Proteins1992，14，2： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | The intramuscular nerve of the human lateral cricoarytenoid muscle 显示文摘 | Sanders l Mu L Biller HF | 1993 | Aeta Otolaryngol (Stockh)1993，113，： | 1 |
| 9 | Absolute oral bioavailability and residues of florfenicol in the rainbow trout (Oncorynchus mykiss)显示文摘 | Pinault L P Millot L K Sanders P J | 1997 | J Vet Pharmacol Therap1997，20，1： | 1 |
| 10 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 11 | Microparticles: major transport vehicles for distinct microRNAs in circulation 显示文摘 | Diehl P Fricke A Sander L | 2012 | Cardiovasc Res2012，93，4： | 1 |
| 12 | International Software Piracy: Analysis of key issues and impacts显示文摘 | Gopal R D Sanders G L | 1998 | Information Systems Research1998，9，4： | 1 |
| 13 | Fundamental impor- tance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node显示文摘 | Sanders L Rakovic S Lowe M | 2006 | J Physiol2006，571，3： | 1 |
| 14 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 1 |
| 15 | Depot-related gene expression in human subcutaneous and omental adipocytes显示文摘 | Montague CT Prins JB Sanders L | 1998 | Diabetes1998，47，9： | 1 |
| 16 | Analysis of lycopcne geometrical isomers in biological microsamples by liquid chromatography with coulometric array detection显示文摘 | M G Ferruzzi M L Nguyen L C Sander | 2001 | Journal of Chromatography B2001，760，： | 1 |
| 17 | Diffusion - limited aggregation:A kinetic critical phenomenon显示文摘 | Witten T A Sander L M | 1981 | Phys Rev Lett1981，47，19： | 1 |
| 18 | Localization of matrix metalloproteinase MMP-2 to the surface of inasive cells by interaction with integrin α2β3显示文摘 | Broods P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 1 |
| 19 | An atomic goals in the correction of female stress urinary incontinence显示文摘 | Mostwin J L Genadry R Sanders R | 1996 | J Endourol1996，10，： | 1 |
| 20 | Nitrogen Content of Winter Wheat During Growth and Maturation显示文摘 | DAIGGER L A SANDER D H PETERSON G A | 1976 | Agronomy Journal1976，68，5： | 1 |
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