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| 1 | Specific endoscopic features of ulcerative colitis complicated by cytomegalovirus infection显示文摘AIM:To identify specific colonoscopic findings in patients with ulcerative colitis (UC) complicated by cyto-megalovirus (CMV) infection.METHODS: Among UC patients who were hospitalized due to exacerbation of symptoms, colonoscopic findings were compared between 15 CMV-positive patients and 58 CMV-negative patients. CMV infection was determined by blood test for CMV antigenemia. Five aspects of mucosal changes were analyzed (loss of vascular pattern, erythema, mucosal edema, easy bleeding, and mucinous exudates) as well as five aspects of ulcerative change (wide mucosal defect, punched-out ulceration, longitudinal ulceration, irregular ulceration, and cobble-stone-like appearance). Sensitivity, specificity, positive predictive value, and negative predictive value of each finding for CMV positivity were determined.RESULTS: The sensitivity of irregular ulceration for positive CMV was 100%. The specificity of wide mucosal defect was 95%. Punched-out ulceration and lon-gitudinal ulceration exhibited relatively high sensitivity and specificity (more than 70% for each).CONCLUSION:Specific colonoscopic findings in patients with UC complicated by CMV infection were identified. These findings may facilitate the early diagnosis of CMV infection in UC patients. | Hideyuki Suzuki Jun Kato Motoaki Kuriyama Sakiko Hiraoka Kenji Kuwaki Kazuhide Yamamoto | 2010 | World Journal of Gastroenterology2010，16，10： | 19 |
| 2 | Amino Acid Export in Plants: A Missing Link in Nitrogen Cycling显示文摘到他们被要求的身体的部分的从来源机关的营养素的出口(例如水池机关) 是一个基本生物过程。氨基酸的出口,在植物的最丰富的氮种类之一长途的运输纸巾(即木部和韧皮部) ,是为在植物的氮的合适的分发的一个必要过程。生理的研究在植物房间膜检测了多重氨基酸出口系统的存在。然而,令人惊讶地,很少对氨基酸出口商的分子的身份被知道,部分由于技术困难妨碍出口商蛋白质的鉴定。在这短评论,我们将在植物关于氨基酸出口系统总结我们的当前的知识。几研究描述了能够的植物氨基酸 transporters 双向, facilitative 运输,更早生理的研究识别的活动暗示。而且,在可得到的氨基酸 transporter 序列的数字的最近的扩大表明了在从有很多 uncharacterized 的另外的有机体的氨基酸出口商之间的进化关系种蛋白质,其中一些可能也作为氨基酸出口商工作。另外,可以调整氨基酸的出口的基因被发现了。这些通常认为的 transporter 和管理者蛋白质的研究可以在理解帮助逃犯在植物的氨基酸出口的分子的机制。 | Sakiko Okumoto Guillaume Pilot | 2011 | Molecular Plant2011，4，3： | 13 |
| 3 | Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count显示文摘AIM:To determine the difference in clinical outcome between ulcerative colitis(UC)patients with Mayo endoscopic subscore(MES)0 and those with MES 1.METHODS:UC patients with sustained clinical remission of 6 mo or more at the time of colonoscopy were examined for clinical outcomes and the hazard ratios of clinical relapse according to MES.Parameters,including blood tests,to identify predictive factors for MES 0and slight endoscopic recurrence in clinically stablepatients were assessed.Moreover,a receiver operating characteristic curve was generated,and the area under the curve was calculated to indicate the utility of the parameters for the division between complete and partial mucosal healing.All P values were two-sided and considered significant when less than 0.05.RESULTS:A total of 183 patients with clinical remission were examined.Patients with MES 0(complete mucosal healing:n=80,44%)were much less likely to relapse than those with MES 1(partial mucosal healing:n=89,48%)(P<0.0001,log-rank test),and the hazard ratio of risk of relapse in patients with MES 1 vs MES0 was 8.17(95%CI:4.19-17.96,P<0.0001).The platelet count(PLT)<26×104/μL was an independent predictive factor for complete mucosal healing(OR=4.1,95%CI:2.15-7.99).Among patients with MES 0 at the initial colonoscopy,patients of whom colonoscopy findings shifted to MES 1 showed significant increases in PLT compared to those who maintained MES 0(3.8×104/μL vs-0.6×104/μL,P<0.0001).CONCLUSION:The relapse rate differed greatly between patients with complete and partial mucosal healing.A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT. | Asuka Nakarai Jun Kato Sakiko Hiraoka Toshihiro Inokuchi Daisuke Takei Yuki Moritou Mitsuhiro Akita Sakuma Takahashi Keisuke Hori Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，48： | 11 |
| 4 | Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status显示文摘AIM:To clarify the impact of cytomegalovirus(CMV)activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis(UC)patients.METHODS:UC patients with flare-up were divided into CMV-positive and-negative groups according to the CMV antigenemia assay.The main treatment strategy provided for the patients in the CMV-positive group comprised a dose reduction of corticosteroids and administration of ganciclovir.RESULTS:The median number of days to initial remission was significantly greater for the patients in the CMV-positive group(21 d vs 16 d,P=0.009).However,the relapse rate after remission and colectomy rate during more than 30 mo of observation did not differ between the two groups.Multivariate analysis revealed that administration of ganciclovir was the only independent factor for avoiding colectomy in patients of the CMV-positive group.CONCLUSION:CMV antigen status did not significantly affect the long-term prognosis in UC patients under treatment with appropriate antiviral therapy. | Toshihiro Inokuchi Jun Kato Sakiko Hiraoka Hideyuki Suzuki Asuka Nakarai Tomoko Hirakawa Mitsuhiro Akita Sakuma Takahashi Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，2： | 6 |
| 5 | CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists显示文摘AIM: To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists.METHODS: One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insufflation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist (EC) group and a less experienced colonoscopist (LEC) group. Study measurements included a 100-mm visual analogue scale (VAS) for patient pain during and after colonoscopyexaminations, in addition to insertion to the cecum and withdrawal times.RESULTS: Examination times did not differ, however, VAS scores in the CO2 group were signifi cantly better than in the air group (P < 0.001, two-way ANOVA) from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group (P = 0.29), however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group (P = 0.023) immediately after colonoscopies and up to 4 h afterwards.CONCLUSION: CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs. | Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka Saito Kazuhide Yamamoto | 2009 | World Journal of Gastroenterology2009，15，41： | 5 |
| 6 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 7 | Clinicopathologic Analysis of Combined Hepatocellular-Cholangiocarcinoma According to the Latest WHO Classification显示文摘 | Jun Akiba Osamu Nakashima Satoshi Hattori Ken Tanikawa Miki Takenaka Masamich Nakayama Reiichiro Kondo Yoriko Nomura Keiko Koura Kousuke Ueda Sakiko Sanada Yoshiki Naito Rin Yamaguchi Hirohisa Yano | 2013 | The American Journal of Surgical Pathology2013，，4： | 3 |
| 8 | New model for cardiomyocyte sheet transplantation using a virus-cell fusion technique显示文摘AIM: To facilitate close contacts between transplanted cardiomyocytes and host skeletal muscle using cell fusion mediated by hemagglutinating virus of Japan envelope(HVJ-E) and tissue maceration. METHODS: Cardiomyocytes(1.5 × 106) from fetal rats were first cultured. After proliferation, some cells were used for fusion with adult muscle fibers using HVJ-E. Other cells were used to create cardiomyocyte sheets(area: about 3.5 cm2 including 2.1 × 106 cells), which were then treated with Nile blue, separated, and transplanted between the latissimus dorsi and intercostal muscles of adult rats with four combinations of HVJ-E and/or Na OH maceration: G1: HVJ-E(+), Na OH(+), Cardiomyocytes(+); G2: HVJ-E(-), NaO H(+), Cardiomyocytes(+); G3: HVJ-E(+),Na OH(-), Cardiomyocytes(+); G4: HVJ-E(-), Na OH(-), Cardiomyocytes(-). At 1 and 2 wk after transplantation, the four groups were compared by detection of beating domains, motion images using moving target analysis software, action potentials, gene expression of MLC-2v and Mesp1 by reverse transcription-polymerase chain reaction, hematoxylin-eosin staining, and immunostaining for cardiac troponin and skeletal myosin.RESULTS: In vitro cardiomyocytes were fused with skeletal muscle fibers using HVJ-E. Cardiomyocyte sheets remained in the primary transplanted sites for 2 wk. Although beating domains were detected in G1, G2, and G3 rats, G1 rats prevailed in the number, size, motion image amplitudes, and action potential compared with G2 and G3 rats. Close contacts were only found in G1 rats. At 1 wk after transplantation, the cardiomyocyte sheets showed adhesion at various points to the myoblast layer in the latissimus dorsi muscle. At 2 wk after transplantation, close contacts were seen over a broad area. Part of the skeletal muscle sarcoplasma seemed to project into the myocardiocyte plasma and some nuclei appeared to share both sarcoplasmas.CONCLUSION: The present results show that close contacts were acquired and facilitated the beating function, thereby providing a new cellular transplantation method using HVJ-E and NaO H maceration. | Yuto Takahashi Daihachiro Tomotsune Sakiko Takizawa Fengming Yue Mika Nagai Tadayuki Yokoyama Kanji Hirashima Katsunori Sasaki | 2015 | World Journal of Stem Cells2015，7，5： | 3 |
| 9 | Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse显示文摘AIM: To assess the risk of relapse in ulcerative colitis(UC) patients in clinical remission using mucosal status and fecal immunochemical test(FIT) results. METHODS: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores(MESs) and FIT results.RESULTS: Patients with an MES of 0(n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3(n = 100, 52%)(HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result(fecal hemoglobin concentrations ≤ 100 ng/m L) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score(HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse(HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing(MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk. | Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada Hiroyuki Okada | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 10 | Baseball pitching kinematics,joint loads,and injury prevention显示文摘There is a need for the prevention of upper extremity injuries that affect a large number of competitive baseball players.Currently available evidence alludes to three possible ways to prevent these injuries:1) regulation of unsafe participation factors,2) implementation of exercise intervention to modify suboptimal physical characteristics,and 3) instructional intervention to correct improper pitching techniques.Of these three strategies,instruction of proper pitching technique is under-explored as a method of injury prevention.Therefore,the purpose of this review was to explore the utility of pitching technique instruction in prevention of pitching-related upper extremity injuries by presenting evidence linking pitching technique and pitching-related upper extremity injuries,as well as identifying considerations and potential barriers in pursuing this approach to prevent injuries.Various kinematic parameters measured using laboratory-based motion capture system have been linked to excessive joint loading,and thus pitching-related upper extremity injuries.As we gain more knowledge about the influence of pitching kinematics on joint loading and injury risk,it is important to start exploring ways to modify pitching technique through instruction and feedback while considering the specific skill components to address,mode of instruction,target population,duration of program,and ways to effectively collaborate with coaches and parents. | Sakiko Oyama | 2012 | Journal of Sport and Health Science2012，1，2： | 2 |
| 11 | Ultra-thin fatigue-free Bi4Ti3O12 films for nonvolatile ferroelectric memories显示文摘 | KIJIMA Takeshi SATOH Sakiko MATSUNAGA Hironori | 1996 | Jpn J Appl Phys1996，35，2： | 2 |
| 12 | Amygdala activity in responseto forward versus backward dynamic facial expressions显示文摘 | Wataru S Takanori K Sakiko Y | 2010 | BrainRes2010，1315，： | 1 |
| 13 | Serum Folate and Homocysteine Levels Are Associated With Colon Tumorigenesis in End-Stage Renal Disease Patients显示文摘 | Eisuke Kaji Jun Kato Shunsuke Saito Keita Harada Kenji Kuwaki Masashi Tatsukawa Tamiya Morikawa Sakiko Hiraoka Hiroshi Matsushima Kazuhide Yamamoto | 2011 | Nutrition and Cancer2011，，2： | 1 |
| 14 | Morphological and histological examination of polyphenic wing formation in the pea aphid Acyrthosiphon pisum (Hemiptera, Hexapoda)显示文摘 | Asano Ishikawa Sakiko Hongo Toru Miura | 2008 | Zoomorphology2008，，2： | 1 |
| 15 | Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats显示文摘 | Makoto Ema Sakiko Fujii Mutsuko Hirata-Koizumi Mariko Matsumoto | 2007 | Reproductive Toxicology2007，，3： | 1 |
| 16 | Orthodontic treatment for a patient with a unilateral cleft lip and palate and congenitally missing maxillary lateral incisors and left second premolar显示文摘 | Kiyoshi T Jae HP Sakiko O | | 0，，03： | 1 |
| 17 | Iron chelation by chlorogenic acid as a natural antioxidant 显示文摘 | Yasuhisa K Sakiko K Takushi Y | 1998 | Biosoi Biotechnol Biochem1998，62，1： | 1 |
| 18 | Efficacy of Edaravone, a Free Radical Scavenger, on Left Ventricular Function and Structure in Diabetes Mellitus显示文摘 | Tetsuya Hayashi Tatsuhiko Mori Koichi Sohmiya Yoshikatsu Okada Sakiko Inamoto Nobuaki Okuda Hiroshi Mori Yasushi Kitaura | 2003 | Journal of Cardiovascular Pharmacology2003，，6： | 1 |
| 19 | Enhanced tolerance to drought stress intransgenic rice plants overexpressing a small heat-shock protein,sHSP17显示文摘 | Yutaka Sato Sakiko Yokoya | 2008 | Plant Cell Report2008，27，： | 1 |
| 20 | Chronic administration of oren- gedoku- to (T J15) inhibits is- chemia- induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil显示文摘 | Hideaki Kabuto Masato Asanuma Sakiko Nishibayashi | 1997 | Neuro- chemical Research1997，22，1： | 1 |
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